TRIM21 promotes type I interferon by inhibiting the autophagic degradation of STING via p62/SQSTM1 ubiquitination in systemic lupus erythematosus by Li Chen, Ma Ang, Bai Yu, Liu Zitao, Tian Linghan, Wang Ziyuan, Ma Huaishun, Chen Zhengpu, Gao Zhengheng, Feng Shijie, Fu Ping

“…Our results demonstrate that TRIM21 overexpression stabilizes STING by suppressing autophagic degradation, whereas TRIM21 depletion accelerates this clearance process. Mechanistically, TRIM21 catalyzes the K63-linked polyubiquitylation of the selective autophagy receptor p62/SQSTM1, disrupting its interaction with STING. …”
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Dynamics of level of the tumor-associated marker SCCA in neoadjuvant superselective intra-arterial chemotherapy in patients with cervical squamous cell carcinoma by N. S. Sergeeva, N. V. Marshutina, Kh. R. Maltsagova, T. A. Karmakova, I. I. Alentov, S. V. Mukhtarulina, T. I. Dezhkina, A. G. Rerberg, A. D. Kaprin

“…Evaluation of a tumor-associated marker SCCA (squamous cell carcinoma antigen) level is used in cervical squamous cell carcinoma (CC) to predict the course of the tumor process, monitor the effectiveness of chemo- and chemoradiotherapy, and for preclinical detection of recurrence in follow-up of patients after the completion of primary treatment. …”
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Photothermal Therapeutic Gold Nanoparticles Loaded with PD-L1 siRNA Enhanced Killing of NSCLC Cells by Immune Cells by Gao L, Yang LH, Jiang FC, Ye WY, Chen X, Liu ZJ, He RQ, Huang WY, Feng ZB, Kong JL, Lai ZF, Chen G

“…Combining ICB therapy with other strategies that is able to stimulate tumor immunogenicity or increase infiltration of T cells aroused great concern in cancer therapy.Results: Herein, we constructed a kind of AuNP@NH2-PEG-SH/PD-L1 siRNA nanoparticle complex which showed prominent photothermal therapeutic (PTT) effects triggered by NIR laser and could efficiently deliver PD-L1 siRNA into NSCLC cells (knock-down efficiency were 75.8% and 83% in HCC827 and A549 cells). During the process of photothermal stimulation, discrepancies in heat shock protein expression were observed in NSCLC cells. …”
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Machine learning framework for oxytetracycline removal using nanostructured cupric oxide supported on magnetic chitosan alginate biocomposite by Hassan Rasoulzadeh, Hossein Azarpira, Mojtaba Pourakbar, Amir Sheikhmohammadi, Alieh Rezagholizade-shirvan

“…These findings emphasize the importance of optimizing parameters X2 and X3 in the removal process and suggest that optimizing these parameters can lead to improved removal efficiency. …”
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Validation of a comprehensive long-read sequencing platform for broad clinical genetic diagnosis by Siddhartha Sen, Hillary P. Handler, Alec Victorsen, Zach Flaten, Aidan Ellison, Todd P. Knutson, Sarah A. Munro, Ryan J. Martinez, Charles John Billington, Jennifer J. Laffin, Sarah Bray, Pawel Mroz, Sophia Yohe, Andrew C. Nelson, Matthew Bower, Bharat Thyagarajan

“…The implementation of a unified comprehensive technique that can simultaneously detect a broad spectrum of genetic variation would substantially increase efficiency of the diagnostic process. …”
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Tumor cell-released autophagosomes (TRAPs) induce PD-L1-decorated NETs that suppress T-cell function to promote breast cancer pulmonary metastasis by Jing Chen, Ning Pan, Li-Xin Wang, Xiaohe Zhou, Chengdong Wu, Xuru Wang, Xiaotong Sun, Bohao Chen, Shiya Zheng, Yiting Wei, Yuyang Wu, Fengjiao Zhu, Jinpeng Chen, Huabiao Chen

“…This study posits that tumor cell-released autophagosomes (TRAPs) play a crucial role in this process.Methods TRAPs were isolated from breast cancer cell lines to analyze their impact on NET formation in both human and mouse neutrophils. …”
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Prognostic potential of tumor lesions of the lower uterine segment in early endometrioid cancer of the uterine body by B. E. Tkachenko, L. S. Mkrtchian, I. A. Zamulaeva, A. B. Galitsyna, E. V. Sheberova, T. А. Agababyan, S. A. Ivanov, A. D. Kaprin

“…Thus, in cases of LUS involvement, the risk of detecting a more common tumor process after histological examination increases 3.9 times compared to cases without LUS involvement. …”
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Pragmatic questionnaire-based evaluation of auditory function in individuals with major neurocognitive disorders and hearing loss in diverse contexts by Panagiotis Alexopoulos, Panagiotis Alexopoulos, Panagiotis Alexopoulos, Panagiotis Alexopoulos, Antonios Alexandros Demertzis, Panagiotis Biris, Polychronis Economou, Eric Frison, Piers Dawes, Iracema Leroi

“…They both address the specific challenges associated with dementia-related hearing assessments by limiting the cognitive load of the evaluation process. Particularly the ultra-brief HHIE-2 may be feasible for use in primary and community healthcare settings in different countries, since in a European cohort it is not affected by the country of residence of the individuals with dementia.…”
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Findings from a disease prioritization and tabletop exercise to evaluate transboundary One Health capacities between Jordan and Iraq by Aishwarya Nagar, Alexander G. Linder, Alanna S. Fogarty, Rachel A. Vahey, Benjamin Wakefield, Kathryn M. Hogan, Rachel Dodeen, Majed Hawaosha, Fatinah Amireh, Saeda Salah, Alaa Hamdallah, Motasem Hsainat, Ahmad Obaidat, Nedal Muhaibesh, Ayman Bani Mousa, Mohammad Alhawarat, Noura Alshraa, Lama Saleh, Mohammad Alraggad, Mohammed J. Ahmed, Aso H. Zangana, Sinan G. Mahdi, Hanan Abdulghafoor Khaleel, Ihab R. Aakef, Hudhaifa A. H. A. Jumiei, Thaer S. Hussein, Ekhlas Hailat, Karim M. A. Zadawi, Claire J. Standley, Erin M. Sorrell

“…Methods This revised methodology included an expanded stakeholder identification process in Phase 1, an interactive tabletop exercise for assessment in Phase 2, and a partner-led strengths, weaknesses, opportunities, and threats analysis in Phase 3. …”
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Classifying schizophrenia using functional MRI and investigating underlying functional phenomena by Yangyang Liu, Bi Wan, Zixuan Liu, Shuaiqi Zhang, Pei Liu, Ningning Ding, Yuxin Wang, Jun Dong, Moiz Kabeer Ahmad, Haisan Zhang

“…The Louvain community detection algorithm and structural equation modeling were used to investigate community relationships and potential causal effects. …”
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An expedited cardiology investigation service helps to bridge the gap between emergency and outpatient care by Jun Yu Chen, Hibba Saeed, Jemimah Joseph, Mostafa Sallam, Joe Bradley, Vinay Reddy-Kolanu

“…This rapid diagnostic process allows ambulatory management for patients with cardiac conditions. …”
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Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke by Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Shensen Zhang, Chao Han, Chengcheng Tan, Yubing Huang, Zhaokai Sun, Liang Wang, Jing Liu

“…In vivo, H2O2 was used in HT22 cells to simulate the OS environment in MCAO, and then its protective effects on HT22 were evaluated by co-culturing with hNSC-Exos, including immunofluorescence staining, western blotting (WB), quantitative real time PCR (qRT-PCR). In the process of exploring specific mechanisms, we utilized RNA sequencing (RNA-seq) to detect the potential induction of mitophagy in OS-induced HT22 cells. …”
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Security decision method for the edge of multi-layer satellite network based on reinforcement learning by Peiliang ZUO, Shaolong HOU, Chao GUO, Hua JIANG, Wenbo WANG

“…Methods:This paper considers a multi-layer satellite network consisting of low-orbit satellites, medium-orbit satellites, and high-orbit geosynchronous satellites.Among them,the low-orbit satellite nodes are responsible for observation and reconnaissance services (such as meteorological observation, geographic detection, intelligence reconnaissance,etc.),and the medium-orbit satellites are regarded as fog nodes in edge scenarios, and one of them serves as the fog computing processing center, responsible for planning and observing The data compression processing and security encryption are located in the satellite node and the network selection of the data backhaul. …”
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A quantitative LC-MS/MS method for residues analysis of 62 plant growth regulators and the investigation of their effects on the quality of traditional Chinese medicinal: Codonopsi... by Hongxu Zhou, Hongxu Zhou, Yue Ren, Yangli Wang, Jing Su, Xiangmin Zhou, Siyu Huang, Rui Yan, Jun Zeng, Min Chen, En Zhang, Xiaohu Chen

“…In commercial samples, residues of 10 PGRs were detected, while in field trial samples, residues of 7 PGRs were found. …”
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Unexplained False Negative Results in Noninvasive Prenatal Testing: Two Cases Involving Trisomies 13 and 18 by R. Hochstenbach, G. C. M. L. Page-Christiaens, A. C. C. van Oppen, K. D. Lichtenbelt, J. J. T. van Harssel, T. Brouwer, G. T. R. Manten, P. van Zon, M. Elferink, K. Kusters, O. Akkermans, J. K. Ploos van Amstel, G. H. Schuring-Blom

“…Noninvasive prenatal testing (NIPT) validation studies show high sensitivity and specificity for detection of trisomies 13, 18, and 21. False negative cases have rarely been reported. …”
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Pathomorphological analysis of the qualitative composition of the inflammatory infiltrate around the pilosebaceous unit of the scalp in perifolliculitis capitis abscedens et suffod... by O. V. Poslavska, O. L. Statkevych, T. V. Sviatenko, I. S. Shponka

“…Lab Vision Quanto imaging system (TS, USA) was used with detection of the reaction using DAB Quanto Chromogen (TS, USA). …”
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RECURRENCE OF BREAST CANCER AFTER SUBCUTANEOUS MASTECTOMY WITH SIMULTANEOUS RECONSTRUCTION by A. D. Zikiryakhodzhaev, E. A. Rasskazova

“…Regional recurrences detected in 2 (0,3%) cases in the armpit and 1 (0,1%) case in the infraclavicular region. …”
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Tp40: a new potential prognostic and diagnostic marker for syphilis by Jiangchen Yao, Bibo Xie, Xuan Ding, Han Yu, Ting Lin, Junxia Duan, Xiaohong Zhang, Peng Ling, Feijun Zhao

“…The underlying pathogenic mechanisms remain elusive, and during the infection process, the roles of numerous proteins are still unclear. …”
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The State of Artificial Intelligence and its Prospects in Pakistan's Medical Sector by Rohail Akhtar Habib, Yumna Sattar Khan

“…One possible result of AI integration is the early detection of diseases, especially in rural locations where access to expert medical care is limited. …”
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Strain promoted azide alkyne cycloaddition, an efficient surface functionalization strategy for microRNA magnetic separation by Djamila Kechkeche, Sirine El Mousli, Claire Poujouly, Emilie Secret, Vincent Dupuis, Isabelle Le Potier, Marie-Emmanuelle Goriot, Julien Siracusa, Sébastien Banzet, Jean Gamby, Jean-Michel Siaugue

“…In an emergency context, the detection of microRNA (miRNA), which are potential biomarkers of cardiovascular and muscular pathologies is hampered by the time required for the various steps involved: treatment of the patient sample, reverse transcription (RT), and finally polymerase chain reaction (PCR). …”
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