The association between the Glutathione S-transferase polymorphisms and addiction to opioids and methamphetamine in the Iranian population by Mohammad Reza Eskandarion, Mohammad Reza Eskandarion, Simin Jafaripour, Farid Heidari, Elham Talebi, Maryam Rezakhani Taleghani, Neda Maserat, Maryam Forutan, Raheb Ghorbani, Jaber Gharehdaghi, Reza Shirkoohi, Reza Raoofian

“…Considering the oxidative stress induced by morphine and methamphetamine and the potential of GST as a therapeutic option for SUD, we aimed to investigate the association of common genetic variations of two genes from GST family, GSTT1 and GSTM1, with addiction to morphine and METH in Iranian population.Material and methodsA total of 160 blood and urine samples were randomly collected from 50 opiums and 30 methamphetamine users and 80 healthy controls. All samples were processed by thin layer chromatography (TLC), high performance liquid chromatography, and Gas Chromatography-Mass Spectrometry (GC-MS) techniques to detect opium alkaloids (morphine, codeine, papaverine, noscapine, etc.), methamphetamine stimulants, and other legal and illegal drugs. …”
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Exosome-related genes influence the progression of stroke through neuroinflammatory responses by Boyan Zhao, Boyan Zhao, Jianing Wu, Mingyang Han, Xuan Rong, Jin Jin, Shiya Liu, Cheng Zhang, Ruotian Zhang, Xin Chen, Fei Peng, Xingli Dong, Shiguang Zhao, Shiguang Zhao

“…Enrichment analyses were conducted to examine biological processes. CIBERSORT and MCPcounter were applied to assess immune infiltration, and Principal Component Analysis was utilized to explore the associations of feature genes and hub genes with immune cells. …”
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Sustaining forest biodiversity: Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems by Rhiannon Gloor, Marek Svitok, Martin Mikoláš, Jeňýk Hofmeister, Josef Halda, Pavel Janda, Francesco Maria Sabatini, Lucie Zemanová, Arne Buechling, Daniel Kozák, Matej Ferenčík, Michal Frankovič, Martin Dušátko, Miroslav Svoboda

“…Mixed modelling revealed that natural historical disturbance processes have decades-long effects on forest structural attributes, which had both congruent and divergent impacts on lichen community richness and composition. …”
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Can Zinc Oxide Nanoparticles Alleviate the Adverse Effects of Salinity Stress in <i>Coffea arabica</i>? by Jegnes Benjamín Meléndez-Mori, Yoiner K. Lapiz-Culqui, Eyner Huaman-Huaman, Marileydi Zuta-Puscan, Manuel Oliva-Cruz

“…An increase in proline content ranging from 33% to 77% was detected in stressed plants treated with ZnO-NPs, in contrast to stressed plants that did not receive the application. …”
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Circulating exosomes with unique lipid signature in relapsing remitting multiple sclerosis by Claudia Palazzo, Ilaria Asci, Silvia Russo, Cinzia Buccoliero, Vincenzo Mangialardi, Pasqua Abbrescia, Onofrio Valente, Maddalena Ruggieri, Damiano Paolicelli, Simona Lobasso, Antonio Frigeri

“…The specific phospholipid marker of exosomal membranes, bis(monoacylglycero)phosphate (BMP), was clearly detected in both MALDI lipid profiles, with no significant differences in its content between the two sample groups. …”
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Edible caterpillars (Gonimbrasia belina and Gynanisa maja) as emerging source of nutrients and bioactive compounds by Chrysantus M. Tanga, Brian O. Ochieng, Dennis Beesigamukama, Changeh J. Ghemoh, Cynthia Mudalungu, Xavier Cheseto, Isaac M. Osuga, Sevgan Subramanian, Segenet Kelemu

“…These findings suggests that both edible caterpillars contain sufficient nutrients and therapeutic compounds, which when integrated into human food products, either whole, in-part, or processed will greatly contribute towards countering nutritional insecurity and improve livelihoods of people in many countries.…”
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6-O-alkyl 4-methylumbelliferyl-β-D-glucosides as selective substrates for GBA1 in the discovery of glycosylated sterols by Stef Bannink, Kateryna O. Bila, Joosje van Weperen, Nina A.M. Ligthart, Maria J. Ferraz, Rolf G. Boot, Daan van der Vliet, Daphne.E.C. Boer, Herman S. Overkleeft, Marta Artola, Johannes M.F.G. Aerts

“…Moreover, significant increases in 6-O-acyl-glycosyl-phytosterols were detected in GD spleens. Our findings suggest uptake of (6-O-acyl)-glycosyl-phytosterols from plant food and subsequent lysosomal processing by GBA1, and comprise the first example of accumulation of an exogenous class of glycolipids in GD. …”
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Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events by Anneli Svensson, Henrik Kjaerulf Jensen, Machteld J. Boonstra, Marianne Tétreault‐Langlois, Pia Dahlberg, Henning Bundgaard, Alex Hørby Christensen, Rebecca T. Rylance, Jesper H. Svendsen, Julia Cadrin‐Tourigny, Anneline S. J. M. te Riele, Pyotr G. Platonov

“…Electrocardiographic abnormalities may be detected before diagnosis and might, although not fulfilling the 2010 Task Force Criteria, be markers of early disease. …”
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3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay by Di Wu, Xiaoqi Guan, Tao Yang, Jiashuai Yan, Biwen Zhu, Junchao Zhou, Yibing Guo, Yuhua Lu

“…Further, biomimetic local stiffness niches were engineered using the digital light-processing (DLP) 3D-printing technology and the desmoplastic bioink (gelatin methacrylate &amp; hyaluronic acid methacrylate, GelMA&HAMA) encapsulating PDAC cells, which permits modulation of mechanical properties without altering the biochemical ligand density. …”
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SULT2B1: a novel therapeutic target in colorectal cancer via modulation of AKT/PKM2-mediated glycolysis and proliferation by Jianxing Ma, Fengyao Sun, Wen Li, Ruihang Du, Mingchan Liu, Qiuya Wei, Boxiong Kang, Siyuan Yan, Chen Wang

“…Chromatin immunoprecipitation (CHIP) assay was utilized to detect the effect of SULT2B1 in regulating transcription. …”
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Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat by Jingru Wang, Weishi Chen, Qiang Zhu, Yao Liu, Zheng Kang, Dingding Liu, Guirong Zeng

“…The pathological processing of social defeat and the therapeutic effects of QYS on it was confirmed through behavioral assessment associated with morphologic observation. …”
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Risk Element Interaction with an Emerging Contaminant in Mammals: The Case of Arsenic and Carbamazepine Orally Taken up by <i>Microtus arvalis</i> L. as a Model Organism by Frank Boahen, Jiřina Száková, Zuzana Čadková, Jana Štanderová, Christiane Schwarz, Martin Gierus, Lukáš Praus, Filip Mercl, Pavel Tlustoš

“…This study assessed As and CBZ accumulation, their biotransformation processes, and antioxidant enzyme defence responses after sole and combined exposure. …”
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Does Freediving Lead to Hippocampal Adaptability to Hypoxia and Maintenance of Episodic Memory? by Julia Micaux, Clément Poiret, Jingwen Zhao, Aya El Hajj, Morgane Tillenon, Abir Troudi Habibi, Franck Mauconduit, Fawzi Boumezbeur, Catherine Chiron, Marion Noulhiane

“…This task specifically targeted HS-related memory processes by distinguishing between three types of items: (i) identical, (ii) similar, and (iii) new. …”
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RBM20 nucleotide sequence variant in a family with a dilated phenotype of left ventricular non-compaction by O. V. Kulikova, R. P. Myasnikov, A. N. Meshkov, E. A. Mershina, A. V. Kiseleva, E. A. Sotnikova, M. M. Kudryavtseva, M. S. Kharlap, M. G. Divashuk, A. A. Zharikova, R. K. Angarsky, S. N. Koretsky, D. А. Filatova, V. E. Sinitsyn, O. M. Drapkina

“…RBM20 is a key splicing regulator that controls the processing of several important transcripts predominantly expressed in striated muscle, especially cardiac tissue. …”
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Volatile organic compounds from typical industries in North China Plain: emissions, air pollution contribution, health risks, and policy implications by Jiqi Zhu, Shoujun Xia, Hejingying Niu, Jian Xu, Yueqian Wang, Xuena Yu, Ling Huang, Kun Zhang, Yangjun Wang, Limin Zeng, Qing Li, Li Li

“…Results indicate that: (1) Current emission factors of industrial VOCs diverged substantially, with petrochemical (15.93 kg/t) and pharmaceutical (135 kg/t) industries being the most obvious emission sectors. (2) Chemical composition of VOCs varied across different industries, with surface coating emitting 69 % halogenated hydrocarbons, petrochemicals releasing 58 % aromatics, and pharmaceuticals discharging 53 % oxygenated VOCs (OVOCs). (3) Ozone formation potential peaked in surface coating (351.9 mg/m3, aromatics-driven) and olefin-rich organic chemical processes, while secondary organic aerosol potential was dominated by petrochemical aromatics (5,750 μg/m3). (4) Health risks are high in resin and plastic, pharmaceutical, and petroleum industries, with acrolein (HQ = 0.96) and acetaldehyde (cancer risk = 3.9 × 10-7) as priority hazards. (5) Based on detected greenhouse-effect VOCs, Freon-12/11 emissions dominated climate impacts (83 %, 467.1 tCO2-eq) in the petrochemical industry. (6) Entropy-weighted analysis prioritized petroleum for Tier-1 controls. …”
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Gut Microbiota‐Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High‐Altitude by Yongqiang Zhou, Zhexin Ni, Jingjing Liu, Dezhi Sun, Pan Shen, Xi Chen, Gaofu Li, Zhijie Bai, Yangyi Hu, Ningning Wang, Rui Wang, Lina Guan, Yihao Wang, Xianglin Tang, Yungang Lu, Baokun He, Haitao Lu, Wei Zhou, Yue Gao

“…Lower abundances of Veillonella rogosae, Streptococcus rubneri, and gut microbiota‐associated serum metabolites promoted the remodeling of metabolic processes, thereby increasing susceptibility to high‐altitude heart health abnormalities. …”
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Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury by Jason-Alexander Hörauf, Cora Rebecca Schindler, Inna Schaible, Minhong Wang, Birte Weber, André El Saman, Christiane Pallas, Marek Widera, Ingo Marzi, Dirk Henrich, Liudmila Leppik

“…BackgroundExtracellular vesicles (EVs), a heterogeneous group of cell-derived, membrane-enclosed vesicles bearing cell-specific epitopes, have been demonstrated to play a crucial role in neuronal-glial communication and the orchestration of neuroinflammatory processes. However, the existing evidence regarding their function as biomarkers and their role in the pathobiology of traumatic spinal cord injuries (tSCI), particularly in humans, is scarce.ObjectiveThe primary goal of this study was to investigate whether a distinct pattern of EV surface epitopes detected in the plasma of individuals suffering from spinal cord injury is indicative of tSCI.MethodsThe study includes patients with isolated tSCI (n=8), polytrauma patients without tSCI (PT; ISS ≥16, n=8), and healthy volunteers (HV; n=8). …”
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Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters by Antonietta Canna, Silvia Mangia, Shalom Michaeli, Sara Ponticorvo, Maria Claudia Russillo, Valentina Andreozzi, Renzo Manara, Francesco Di Salle, Marina Picillo, Paolo Barone, Fabrizio Esposito, Maria Teresa Pellecchia

“…Abstract Rotating frame relaxation (RFR) techniques provide robust and sensitive quantitative MRI (qMRI) metrics able to detect subtle alterations of brain tissue integrity in multiple neurological disorders. …”
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Increased [¹⁸F]DPA-714 Uptake in the Skeletal Muscle of SOD1^G93A Mice: A New Potential of Translocator Protein 18 kDa Imaging in Amyotrophic Lateral Sclerosis by Cecilia Marini, Mattia Riondato, Edoardo Dighero, Alessia Democrito, Serena Losacco, Laura Emionite, Lucilla Nobbio, Irene Di Patrizi, Mattia Camera, Chiara Ghersi, Maddalena Ghelardoni, Francesco Lanfranchi, Francesca Vitale, Sonia Carta, Sabrina Chiesa, Carola Torazza, Marco Milanese, Matteo Bauckneht, Mehrnaz Hamedani, Federico Zaottini, Angelo Schenone, Carlo Martinoli, Federica Grillo, Gianmario Sambuceti

“…Here, we aimed to verify whether PET imaging of the translocator protein 18 kDa (TSPO) can detect a muscular abnormality in an experimental model of ALS. …”
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Twilight Near-Infrared Radiometry for Stratospheric Aerosol Layer Height by Lipi Mukherjee, Dong L. Wu, Nader Abuhassan, Thomas F. Hanisco, Ukkyo Jeong, Yoshitaka Jin, Thierry Leblanc, Bernhard Mayer, Forrest M. Mims, Isamu Morino, Tomohiro Nagai, Stephen Nicholls, Richard Querel, Tetsu Sakai, Ellsworth J. Welton, Stephen Windle, Peter Pantina, Osamu Uchino

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