Pilon Fractures: An Ideal Model to Understand Biological Factors Implicated in the Pathogenesis of Posttraumatic Osteoarthritis by Jeffrey A. Foster MD, Jarod T. Griffin MD, Maaz Muhammad MD, Carlos R. Sierra-Arce MS, Wyatt G.S. Southall BS, Jacob S.W. Borgida BS, Robert K. Wagner MD, Ahmed Ismaeel PhD, John J. McCarthy PhD, Thuan V. Ly MD, Arjun Srinath MD, MPH, David C. Landy MD, PhD, Arun Aneja MD, PhD

“…Methods: Bilateral ankles of patients with unilateral pilon fracture were aspirated for synovial fluid at the time of external fixation and/or open reduction internal fixation (ORIF). After processing, synovial fluid samples were sequenced for small RNA analysis. …”
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Gene Flow and Abundance of a Tropical Fruit Fly in a Horticultural Landscape Mosaic in Eastern Australia Is Limited by Cleared Grazing Land and Area‐Wide Management by James L. Ryan, Anthony R. Clarke, Alexander M. Piper, Susan Fuller, Peter J. Prentis

“…ABSTRACT Landscape ecology and genetics provide important analytical frameworks for investigating the effect of environmental features on ecological processes. Few empirical studies, however, have simultaneously tested how landscape characteristics influence spatial patterns of gene flow and abundance of pest insects in heterogeneous environments. …”
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By modulating miR‐525‐5p/Bax axis, LINC00659 promotes vascular endothelial cell apoptosis by Xizheng Zhu, Beijia Chen, Hui Xu

“…Endothelial cells play a crucial role in the processes vasoconstriction, platelet activation, and blood coagulation and are an integral part of the vascular response to injury resulting in thrombus formation. …”
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HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. by Xizhi Feng, Karthik Krishnan, Daryl L Richie, Vishukumar Aimanianda, Lukas Hartl, Nora Grahl, Margaret V Powers-Fletcher, Minlu Zhang, Kevin K Fuller, William C Nierman, Long Jason Lu, Jean-Paul Latgé, Laura Woollett, Simon L Newman, Robert A Cramer, Judith C Rhodes, David S Askew

“…In yeast and other fungi, the accumulation of unfolded proteins is detected by the ER-transmembrane sensor IreA/Ire1, which responds by cleaving an intron from the downstream cytoplasmic mRNA HacA/Hac1, allowing for the translation of a transcription factor that coordinates a series of adaptive responses that are collectively known as the unfolded protein response (UPR). …”
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The effect of Remicade Trough Level on Disease Activity in a Selected Sample of Iraqi Rheumatoid Arthritis Patients by Reem G Hussein, Mohammed Qasim Yahya Malallah A. Al-Atrakji

“…Infliximab is a chimeric monoclonal IgG antibody that specifically targets tumor necrosis factor, a crucial material associated with pathogenic processes. Remicade is an original medication of infliximab. …”
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Relationship between apoptosis markers and the severity of coronary atherosclerosis and clinical and paraclinical characteristics of patients with coronary artery disease by E. A Zakharyan, I. I Fomochkina

“…All subjects were studied for the serum level of apoptosis markers Bcl-2, Bax, Bcl-2/Bax, TRAIL and p53. Statistical processing was carried out using the Statistica 10.0 software. …”
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Laser confocal microscopy of corneal nerve fibers in patients with burning eye syndrome and dry eye disease by T. N. Safonova, Z. V. Surnina, E. S. Medvedeva

“…The method of laser confocal microscopy of the cornea can be used to detect changes in corneal nerve fibers associated with the occurrence of neuropathic pain syndrome.…”
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Deep learning-based automated tool for diagnosing diabetic peripheral neuropathy by Qincheng Qiao, Juan Cao, Wen Xue, Jin Qian, Chuan Wang, Qi Pan, Bin Lu, Qian Xiong, Li Chen, Xinguo Hou

“…Subsequently, an image processing algorithm was designed to automatically extract and quantify various morphological parameters of CNFs. …”
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Redox metabolic disruptions in the honey bee brain following acute exposure to the pyrethroid deltamethrin by Máté Mackei, Fanni Huber, Barnabás Oláh, Zsuzsanna Neogrády, Gábor Mátis

“…Moreover, pronounced lipid peroxidation was detected in the highest-dose group, as indicated by increased malondialdehyde (MDA) levels; however, H2O2 levels were unchanged, suggesting the effective activation of ROS-scavenging adaptation mechanisms. …”
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Ophthalmological manifestations and plasma markers of inflammation in Ebola survivors in post-treatment era by Jean-Claude Mwanza, Alexis K. Kahindo, Justin Mbusa-Kombi, Martial V. Mumbere, Richard O. Kitenge, David R. McIlwain, Jean Christophe S. Mulangu, Placide K. Mbala, Daniel Okitundu, Bruno J. Giordani, Michael J. Boivin, Alla Sikorskii, Nelly N. Kabedi, Jessica G. Shantha, Steven Yeh, Dieudonne N. Mumba, Desire Tshala-Katumbay

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Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes by Anders Berglund, Kosj Yamoah, Steven A. Eschrich, Rana Falahat, James J. Mulé, Sungjune Kim, Jaime Matta, Julie Dutil, Gilberto Ruiz‐Deya, Carmen Ortiz Sanchez, Liang Wang, Hyun Park, Hirendra N. Banerjee, Tamara Lotan, Kathryn Hughes Barry, Ryan M. Putney, Seung Joon Kim, Clement Gwede, Jacob K. Kresovich, Youngchul Kim, Hui‐Yi Lin, Jasreman Dhillon, Ratna Chakrabarti, Jong Y. Park

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A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome by Xiaoxiao Wang, Yingxue Liu, Guanghui Yuan, Jingjie Yang, Xiaowen Liu, Shuyuan Chen, Huaiqian Dou, Panpan Lu, Linfang Han, Duan Li, Cuifang Hao

“…ELISA and Co-IP were used to detect the effects of variants on protein secretion and interactions. …”
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Herd Immunity to the Measles, Mumps and Rubella Viruses Among the Belgradian Population in May, 2024 by Anna Y. Popova, Vyacheslav S. Smirnov, Svetlana A. Egorova, Luka Dragačević, Angelica M. Milichkina, Jelena Protić, Ekaterina M. Danilova, Irina V. Drozd, Marija Petrušić, Ojuna B. Zhimbaeva, Elizaveta S. Glazkova, Nataša Gutić, Valeri A. Ivanov, Edward S. Ramsay, Oleg V. Kotsar, Vyacheslav Y. Smolensky, Areg A. Totolian

“…Between 2021 and 2023, there were no registered cases of rubella detected in Serbia, which indicates a high level of immunity. …”
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Blue Vane and Pan Traps Are More Effective for Profiling Multiple Facets of Bee Diversity in Subtropical Forests by Ting-Ting Xie, Ming-Qiang Wang, Yi Li, Cheng-Yong Su, Dan Zhang, Qing-Song Zhou, Ze-Qing Niu, Feng Yuan, Xiu-Wei Liu, Ke-Ping Ma, Chao-Dong Zhu, Jia-Sheng Hao, Douglas Chesters

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Therapeutic role of miR-26a on cardiorenal injury in a mice model of angiotensin-II induced chronic kidney disease through inhibition of LIMS1/ILK pathway by Weijie Ni, Yajie Zhao, Jinxin Shen, Qing Yin, Yao Wang, Zuolin Li, Taotao Tang, Yi Wen, Yilin Zhang, Wei Jiang, Liangyunzi Jiang, Jinxuan Wei, Weihua Gan, Aiqing Zhang, Xiaoyu Zhou, Bin Wang, Bi-Cheng Liu, Yuanyuan Ji

“…Chronic kidney disease (CKD) is associated with common pathophysiological processes, such as inflammation and fibrosis, in both the heart and the kidney. …”
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Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential by Keskin C, Aslan S, Baran MF, Baran A, Eftekhari A, Adıcan MT, Ahmadian E, Arslan S, Mohamed AJ

“…The MTT assay was used to investigate AO-AgNPs’ cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines.Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. …”
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Collaborative Care to Improve Quality of Life for Anxiety and Depression in Posttraumatic Epilepsy (CoCarePTE): Protocol for a Randomized Hybrid Effectiveness-Implementation Trial by Heidi M Munger Clary, Beverly M Snively, Christian Cagle, Richard Kennerly, James N Kimball, Halley B Alexander, Gretchen A Brenes, Justin B Moore, Robin A Hurley

“…In step 2 of the intervention, individuals with <50% symptom reduction by 10 weeks will receive an added 8-session remote cognitive behavioral therapy program. The study is powered to detect a moderate improvement in emotional quality of life. …”
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Modeling regional aboveground carbon stock dynamics affected by land use and land cover changes by A.D. Malik, M.C.W. Arief, S. Withaningsih, P. Parikesit

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Assessment of apoptosis and cell proliferation in patients with intrauterine pathology: A prospective study by Mikhail M. Damirov, Oksana B. Yurchenko, Natalya V. Borovkova, Alexandr P. Ierusalimskiy, Mayya V. Storozheva, Galina A. Nefedova

“…In patients with SMUF, no changes in the regulation of apoptotic cell death were detected, while a decrease in stem cell growth factor was noted. …”
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Familial cerebral cavernous malformations: Rio de Janeiro study and review of the recommendations for management Malformação cavernosa cerebral familiar: um estudo no Rio de Janeir... by Flávio Domingues, Emerson L. Gasparetto, Ricardo Andrade, Fabio Noro, Antônio Eiras, Judith Gault, Carlos Eduardo Silva Correia, Jorge Marcondes de Souza

“…CONCLUSIONS: The Project of Familial Cerebral Cavernous Malformations of Rio de Janeiro detected mutations of the gene CCM1 in the first four families studied. …”
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