Brain glucose metabolism in patients with traumatic brain injury undergoing rehabilitation: a longitudinal 18F-FDG PET study by Valeria Pingue, Valeria Pingue, Irene Bossert, Daniela D’Ambrosio, Antonio Nardone, Antonio Nardone, Giuseppe Trifirò, Nicola Canessa, Nicola Canessa, Diego Franciotta

“…BackgroundMeasuring 18F-FDG PET-detected brain glucose uptake provides reliable information on metabolic tissue abnormalities, cells dysfunction, and neurovascular changes after traumatic brain injury (TBI).ObjectivesWe aimed to study the relationship between post-traumatic brain glucose metabolism and functional outcomes in the so far unexplored field of longitudinally 18F-FDG PET-monitored patients undergoing rehabilitation after moderate-to-severe TBI.MethodsFourteen patients consecutively admitted to our unit in the post-acute phase after TBI underwent 18F-FDG-PET scans performed before and 6 months after inpatient rehabilitation program. …”
Get full text

Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors by Alfred Zippelius, Petra Herzig, Pratiksha Gulati, Christian Klein, Marta Trüb, Kirsten D Mertz, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Marina Natoli, Klas Hatje, Fabian Junker, Zhiwen Jiang, Iakov I Davydov, Markus Germann, Daniel Marbach, Adrian Zwick, Patrick Weber, Stefan Seeber, Lothar Tietze, Laura Codarri-Deak, Henry Kao

“…Interestingly, LAG-3 protein upregulation was detected as a unique pharmacodynamic effect mediated by PD1-LAG3, but not by PD1-TIM3 or anti-PD-1.Conclusions Our in vitro system reliably assessed responses to bispecific antibodies co-targeting PD-1 together with LAG-3 or TIM-3 using patients’ tumor infiltrating immune cells and revealed transcriptional and phenotypic imprinting by bispecific antibody formats currently tested in early clinical trials.…”
Get full text

Molecular profile of non-small cell lung cancer in a predominantly Black African population in Kenya: A single institution review by Sitna Mwanzi, Shahin Sayed, Swati Das, Jonathan Wawire, Priscilla Njenga, Jasmit Shah, Asim Jamal Shaikh

“…Testing for epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangement, c-ros oncogene 1 (ROS1) rearrangement and programmed death ligand 1 (PDL 1) testing are now highly recommended for all patients with NSCLC. …”
Get full text

The Impact of a Mobile Money–Based Intervention on Maternal and Neonatal Health Outcomes in Madagascar: Cluster-Randomized Controlled Trial by Lisa Bogler, Bítia Vieira, Harizaka Emmanuel Andriamasy, Zavaniarivo Rampanjato, Sebastian Vollmer, Till Bärnighausen, Andriamampianina Ralisimalala, Julius Valentin Emmrich, Samuel Knauss

“…Maternal health care is particularly suitable for a savings program using mobile money due to the predictable timing and costs of delivery. …”
Get full text

Associations between the SMARS score derived from CT and MRI with histopathological features in HCC by Daniele Romeo, Theresa Richter, Anne-Kathrin Höhn, Hans-Michael Tautenhahn, Daniel Seehofer, Uwe Scheuermann, Timm Denecke, Hans-Jonas Meyer

“…The pathological specimens were analyzed for programmed death ligand 1 (PD-L1), Glypican-3, CD3-tumour infiltrating lymphocyte, CD68 positive cells, CD34 positive microvessel density (MVD). …”
Get full text

Targeting the nuclear orphan receptor NR4A1: a key target in lung cancer progression and therapeutic resistance by Minhan Jin, Minhan Jin, Yuhui Wang, Mingze Song, Wenfei Guo, Shirong Li, Zeqing Pu

“…Lung cancer is often detected late and has a complex pathogenesis, so early diagnosis and intervention of lung cancer are essential. …”
Get full text

Electronic Sensor-Based Automated Irrigation System for Rice Cultivated Under Alternate Wetting and Drying Technique by Mukesh Kumar, Ramesh Kumar Sahni, Abhishek M. Waghaye, Manoj Kumar, Ravindra D. Randhe

“…The controller has been programmed for different growth stages that need to be set manually during the cropping period. …”
Get full text

Morphofunctional Characteristic of Edema-Swelling of the Cerebral Cortex of White Rats After Severe Traumatic Brain Injury Without the Use of L-Lysine Escinate and Against the Back... by I. P. Koshman, S. S. Stepanov, A. Y. Shoronova, A. G. Kalinichev, V. A. Akulinin, D. B. Avdeyev, V. I. Sergeyev

“…Consequently, morphometric signs of hydropic dystrophy after STBI were detected in both studied groups during the 15 days of observation.Conclusion The degree of SSC nervous tissue hydration increased after STBI. …”
Get full text

Exploring the effect of different tea varieties on the quality of Sichuan Congou black tea based on metabolomic analysis and sensory science by Liran Yang, Xueping Luo, Qi Wang, Mingli Liu, Jingna Yan, Congming Wang, Yuanhua Xian, Kangli Peng, Kunyi Liu, Bin Jiang

“…Using non-targeted metabolomics, 4,476 metabolite ion features were detected, and 75 significantly differential metabolites were identified (p < 0.05 and VIP > 1.0). …”
Get full text

Effects of temporal, spatial, and environmental factors on ciliates community in northeastern South China Sea, with notes on co-occurrence patterns of environment, phytoplankton, a... by Weiwei Liu, Zijun Cheng, Shaowei Wen, Gang Li, Zhixin Ke, Daning Li, Yehui Tan

“…These findings suggested that the physical processes play key roles in temp-spatial dynamics of ciliate community in open ocean.…”
Get full text

Gray Matter Differences in Adolescent Psychiatric Inpatients: A Machine Learning Study of Bipolar Disorder and Other Psychopathologies by Renata Rozovsky, Maria Wolfe, Halimah Abdul‐waalee, Mariah Chobany, Greeshma Malgireddy, Jonathan A. Hart, Brianna Lepore, Farzan Vahedifard, Mary L. Phillips, Boris Birmaher, Alex Skeba, Rasim S. Diler, Michele A. Bertocci

“…The most discriminative GMVs that contributed to the classification were in areas associated with movement, sensory processing, and cognitive control. Correlations between these GMVs and self‐reported mania, negative affect, or anxiety were observed in all inpatient groups. …”
Get full text

Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment by Barbara M. Crisol, Matheus B. Rocha, Beatriz Franco, Ana Paula Morelli, Carlos K. Katashima, Scylas J.A. Junior, Fernanda S. Carneiro, Renata R. Braga, Rafael S. Brícola, Graciana de Azambuja, Raul Gobato Costa, Andrea M. Esteves, Marcelo A. Mori, Maria C.G. Oliveira, Dennys E. Cintra, José R. Pauli, Filip J. Larsen, Adelino S.R. da Silva, Eduardo R. Ropelle

Get full text

10-YEARS ANALYSIS OF CRYOBAG FRACTURE IN A LARGE INVENTORY OF CELLULAR THERAPY PRODUCTS: RATES AND RISK FACTORS by AR Belisário, LT Mendonça, RK Andrade, MC Martins, LA Costa, KL Prata

“…Of the 15 fractures, 13 (86.7%) were detected during macroscopic evaluation in the processing facility, and two (13.3%) occurred after the cryobags were released to the transplant center. …”
Get full text

Tuning Frontiers of Efficiency in Tissue P Systems with Evolutional Communication Rules by David Orellana-Martín, Luis Valencia-Cabrera, Bosheng Song, Linqiang Pan, Mario J. Pérez-Jiménez

Get full text

Pathogen identification and biological fungicides screening for Plumbago auriculata blight in China by Ming Liu, Ming Liu, Tiantian Guo, Hao Yan, Yue Yuan, Zhien Xiao, Yuxin Liu, Shaotian Zhang, Fengqing Lyu, Shan Jing, Fuqiang Yin, Fuqiang Yin

Get full text

Estudio preliminar para el diseño de una máquina productora de bloques con suelos estabilizados. // Preliminary study for the design of a block machine producer with stabilized soi... by A. Díaz Nimo, F. Aguilar Parés

“…Nevertheless, before building<br />the prototype you can model the equipment in order to detect problems that can arise in the initial proposal. …”
Get full text

Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria by Meagan S. Kingren, Alexander R. Keeble, Alyson M. Galvan-Lara, Jodi M. Ogle, Zoltán Ungvári, Daret K. St Clair, Timothy A. Butterfield, Allison M. Owen, Christopher S. Fry, Samir P. Patel, Hiroshi Saito

Get full text

Estudio preliminar para el diseño de una máquina productora de bloques con suelos estabilizados. // Preliminary study for the design of a block machine producer with stabilized soi... by A. Díaz Nimo, F. Aguilar Parés

“…Nevertheless, before building<br />the prototype you can model the equipment in order to detect problems that can arise in the initial proposal. …”
Get full text

Differential expression of microRNAs and their target genes in cervical intraepithelial neoplasias of varying severity by T. A. Dimitriadi, D. V. Burtsev, E. A. Dzhenkova, D. S. Kutilin

“…Data analysis was carried out in the Python programming language using the SciPy library. Search for target genes was performed using the TarPmiR algorithm and the overrepresentation of microRNAs in signaling pathways (Over-Representation Analysis) was analyzed. …”
Get full text

Pathomorphological feature of chronic pancreatitis (CP) is the development of pancreatic fibrosis with the accumulation of various collagen types, tubulin, fibronectin, laminin, an... by T.V. Turovskaya, A.M. Gnilorybov, L.V. Vasilyeva, V.B. Kostogryz, M.S. Goncharuk

“…In areas of severe fibrosis Ki-67 expression is detected in the nuclei of at least 25% of PSCs, that corresponds to relatively low levels of proliferation. …”
Get full text