Optimization of the extraction process and combined determination of antibacterial ingredients of Li Peng by LIU Shuping, WANG Lei

“…Using Lichrospher C₁₈ column (150 mm × 4.6 mm,5 μm), methanol-0.1% phosphoric acid solution as the mobile phase, the flow rate of 1 mL/min, the detection wavelength at 280 nm, column temperature of 30℃ with the gradient elution program, the gallic acid, protocatechuic acid, and quercetin content in Li Peng could be better determined. …”
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Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head by Han Longfei, Fang Weihua, Han Mingli, Zhuang Zhikun, He Mincong, Wei Qiushi

“…Conclusions IRF7, HOOK1, RNPC3, KCNA3, CD48, and SAMD9 as potential genes affecting the progression of SIONFH collapse. Irf7 mediates the fibroblast inflammatory response and affects the collapse process of SIONFH by influencing chondrocyte apoptosis. …”
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PROGRESSION OF POLYCYTHEMIA VERA TO ACUTE MYELOID LEUKEMIA FOLLOWING LONG-TERM HYDROXYUREA THERAPY: A CASE STUDY by Bengisu Ece Duman, Melis Selin Kadıoğlu, Halil İbrahim Yüksel, Birol Güvenç

“…This case underscores the necessity of vigilant monitoring in PV patients receiving long-term cytoreductive therapy to enable early detection of leukemic progression. Alternative treatment approaches, including JAK inhibitors, interferon therapy, and early hematopoietic stem cell transplantation in eligible patients, may play a role in reducing leukemic transformation risk. …”
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GATEKEEPER Platform: Secure Processing Environment for European Health Data Space by Eugenio Gaeta, Muhammad Salman Haleem, Laura Lopez-Perez, Mirko Manea, Maria Fernanda Cabrera Umpierrez, Maria Teresa Arredondo Waldmeyer, Leandro Pecchia, Giuseppe Fico

“…However, there are certain challenges associated with compliance to EHDS, such as secure continuous integration (CI) and continuous delivery (CD), scalability and adaptability towards new technologies and applications, tolerance against IoT cyber-attacks, requirement of advanced data storage methods, processing power, interoperability solutions for data analysis and connectivity. …”
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Modeling and Evaluation of Penetration Process Based on 3D Mechanical Simulation by Xiaohan Chen, Huiying Gong, Bin Yang, Zengshuo Wang, Yaowei Liu, Lu Zhou, Xin Zhao, Mingzhu Sun

“…Initially, a finite element model (FEM) is established to simulate the cell penetration process. The effectiveness of the model is then verified through visual detection and comparison of cell deformation with experimental data. …”
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ɑ1,3-mannosyltransferase promotes the malignant progression of bladder cancer through activating TNF signaling pathway by Mulin Liu, Jingyang Zhang, Siqi Zhu, Wenjun Jiang, Yu Yan, Qin Zheng, Shijun Li

“…Aberrant glycosylation, driven by specific glycosyltransferases (GTs), plays a pivotal role in various carcinogenic processes. However, the role of GTs-related glycobiomarkers and their underlying mechanisms in BCa remain poorly understood. …”
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Receiver Processing of the Multibeam Azimuth Scanning CC-OFDM-MIMO Radar by Devy Kuswidiastuti, L. P. Ligthart, Gamantyo Hendrantoro, Titiek Suryani, Prasetiyono Hari Mukti, Yuyu Wahyu

“…The coherence processing for Doppler detection can be done over one period of symbol, and the Doppler resolution can be improved by coherence processing over one frame period consisting of 12 orthogonal symbols. …”
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Improving the Incident Management Process Based on a Use Case Approach by A. A. Mikryukov, A. V. Kuular

“…The purpose of the study is to improve the incident management process. The article considers the process approach to incident management in case of technical failures and its main stages: detection, response, investigation, elimination, resolution. …”
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Single‐cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood–brain–tumor barrier and tumor progression by Yuzhe Li, Changwu Wu, Xinmiao Long, Xiangyu Wang, Wei Gao, Kun Deng, Bo Xie, Sen Zhang, Minghua Wu, Qing Liu

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Differential expression of αVβ3 and αVβ6 integrins in prostate cancer progression. by Fabio Quaglia, Shiv Ram Krishn, Yanqing Wang, David W Goodrich, Peter McCue, Andrew V Kossenkov, Amy C Mandigo, Karen E Knudsen, Paul H Weinreb, Eva Corey, William K Kelly, Lucia R Languino

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E2F8-induced GRPEL2 promoted colorectal cancer progression via targeting TIGAR by Cheng Song, Lei Zhao, Jing Deng, Li Wang, Min Mao, Siyuan Peng, Wei Tang

“…The exact function of GRPEL2 -driven mitochondrial regulation and CRC progression have not been elucidated. Methods RNA-seq data from TCGA database was analyzed to identify biomarkers and therapeutic targets of CRC. …”
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Innovative modeling: a diet-induced quail model for progressive pathological changes in uric acid metabolism disorders by Yi Xu, Yu Wang, Fujun Gao, Chengjin Lu, Shujia Liu, Siying Chen, Xiaomeng Zhang, Zhijian Lin, Bing Zhang

“…Furthermore, serum levels of inflammatory cytokines IL-6, TNF-α, and hs-CRP were elevated considerably throughout the modeling process.ConclusionThis diet-induced quail model successfully recapitulates the progressive pathological stages of human uric acid metabolism disorders, providing a valuable tool for investigating disease mechanisms and evaluating potential therapeutics.…”
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S100A11 as an immune-related exosomal driver of colorectal cancer progression: a novel diagnostic biomarker by Haibo Wang, Rongchao He, Deng Liu, Jun He, Zhong Shen

“…Despite advancements in diagnostic and therapeutic strategies, early detection and effective treatment remain major challenges. …”
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Novel machine learning paradigms-enabled methods for smart building operations in data-challenging contexts: Progress and perspectives by Fan Cheng, Lei Yutian, Mo Jinhan, Wang Huilong, Wu Qiuting, Cai Jiena

“…This review aims to present the progress and perspectives on the effective utilization of novel machine learning paradigms for three major building energy management tasks, i.e., building energy predictions, fault detection and diagnosis, and control optimizations. …”
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Prospective assessment of learning curve and impact of intensive versus progressive training in colonoscopy competence among French residents by Léonard Wintzer-Wehekind, Lionel Moulis, Marine Camus, Geoffroy Vanbiervliet, Robert Benamouzig, Claire Duflos, Ludovic Caillo, Eric Assenat, Marc Barthet, Jean-Michel Gonzalez, Antoine Debourdeau

“…Achievement rates were similar across groups: 50% in the progressive and 65% in the intensive group (p = 0.50). …”
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Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression by Joseph M. Josephides, Chun-Long Chen

“…These results facilitate future research at the interface of genomic instability and replication stress during cancer progression.…”
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Development of a General Composite Scale (GENCOMS) for Progressive Neurodegenerative Diseases and Implications for the Assessment of Disease-Modifying Therapies by Samuel P. Dickson, Craig H. Mallinckrodt, Basia Rogula, Lauren C. Powell, Michele H. Potashman, Vladimir Coric, Gilbert J. L’Italien, Suzanne B. Hendrix

“…Composite scales optimize the sensitivity for detecting clinically meaningful effects that slow disease progression. …”
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Advanced 4-chamber echocardiography techniques enable clinically matched precise characterization of heart disease progression in mice by Ege Kacira, Mariam F. Oueis, Nawal H. Tamimi, Sarah L. Sturgill, Xianyao Xu, Thomas J. Hund, Mark T. Ziolo, Yuchi Han, Isabelle Deschênes, Ji-dong Fu

“…Conclusions: The A4CLAX imaging approach provides clinically comparable, comprehensive echocardiographic evaluation in murine models and offers improved sensitivity for detecting subtle changes in cardiac performance during disease progression.…”
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Development of a model for prediction of relaxation and progression of hormone-resistant form of endometrial hyperplasia in women of reproductive age by D.A. Khaskhachykh

“…The study is aimed at developing a model for predicting recurrence or progression of hormone-resistant endometrial hyperplasia in women of reproductive age. …”
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Mir-615-3p promotes osteosarcoma progression via the SESN2/AMPK/mTOR pathway by Xuecheng Yu, Xin Wang, Fan Xu, Xinyi Zhang, Muyi Wang, Ruikai Zhou, Zhengyi Sun, Xiaohui Pan, Lin Feng, Wanchao Zhang, Yong Sun, Wenting Zhang, Dong Zhou, Yuqing Jiang

“…Analysis of apoptosis was performed based on flow cytometric detection. The potential mechanisms of miR-615-3p in OS progression were investigated through RNA immunoprecipitation (RIP) assays, dual-luciferase reporter assays, qRT-PCR and western blotting. …”
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