Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats by Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger

“…Abstract Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a metaphyseal femoral defect in an osteoporotic rat model. …”
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The Zweymüller primary stem is a reliable, effective, and less invasive implant in revision hip arthroplasty for Paprosky type I and II defects by Antonino G. Battaglia, Rocco D'Apolito, Benjamin T. K. Ding, Stefano Tonolini, Joil Ramazzotti, Luigi Zagra

“…Methods: We retrospectively evaluated 113 patients (115 hips) with intraoperative Paprosky type I (n = 86) or II (n = 29) defects, who underwent femoral revision with Alloclassic Zweymüller SL stem for one-stage aseptic revision or two-stage septic revision from January 2011 to December 2020. …”
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Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection by Kamel Alraei, Jameel Sharqawi, Somaya Harcher, Ibrahim Ghita

“…We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period. In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects. …”
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The Effect of an Enamel Matrix Derivative (Emdogain) Combined with Bone Ceramic on Bone Formation in Mandibular Defects: A Histomorphometric and Immunohistochemical Study in the Ca... by Reza Birang, Mohammad Shah Abouei, Sayed Mohammad Razavi, Peyaman Zia, Ahmad Soolari

“…The purpose of this study was to evaluate the combination of an enamel matrix derivative (EMD) and an osteoconductive bone ceramic (BC) in improving bone regeneration. …”
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MATLAB Application for User-Friendly Design of Fully Convolutional Data Description Models for Defect Detection of Industrial Products and Its Concurrent Visualization by Fusaomi Nagata, Shingo Sakata, Keigo Watanabe, Maki K. Habib, Ahmad Shahrizan Abdul Ghani

“…In particular, a systematic threshold determination method is proposed to obtain the best performance for defect detection from FCDD models. Also, through three different kinds of defect detection experiments, the usefulness and effectiveness of FCDD models in terms of defect detection and its concurrent visualization are quantitatively and qualitatively evaluated by comparing conventional transfer learning-based CNN models.…”
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Biological Behavior of Bioactive Glasses SinGlass (45S5) and SinGlass High (F18) in the Repair of Critical Bone Defects by Dayane Maria Braz Nogueira, Marcelie Priscila de Oliveira Rosso, Paulo Sérgio da Silva Santos, Manoel Damião Sousa-Neto, Alice Corrêa Silva-Sousa, Cleverson Teixeira Soares, Carlos Henrique Bertoni Reis, Jéssica de Oliveira Rossi, Cleuber Rodrigo de Souza Bueno, Daniela Vieira Buchaim, Rogério Leone Buchaim, Mariana Schutzer Ragghianti Zangrando

“…This study evaluated the osteogenic potential of the bioactive glasses SinGlass (45S5) and SinGlass High (F18) in regenerating critical bone defects in rat calvaria. …”
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Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation‐induced skin defects by remodeling pathological environment by Zhongyi Sun, Haibo Liu, Mengting Yin, Ningning Cheng, Wencheng Liu, Kangkang Zhao, Hua Zeng, Xuming Chen, Zijie Wang, Xuhui Zhou, Xinyu Zhao, Feng Chen

“…The radiation induced skin defect animal model is established to evaluate the RISD repair efficacy of our MSR@MN patch in comparison with γPGA‐MSR ointment and commercial product Orgotein. …”
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Comparison of two plates and screw osteosynthesis configurations in a rat model of critical sized femoral defects to reduce implant related failures by Marc Saab, Anne-Sophie Drucbert, Nicolas Blanchemain, Feng Chai

“…Abstract This study aimed to compare the failure rates of two different sizes of plates and screws to stabilize critical-sized (7 mm) femoral defects in male Sprague‒Dawley rats (aged 10 weeks). …”
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Comparing efficacies of autologous platelet concentrate preparations as mono-therapeutic agents in intra-bony defects through systematic review and meta-analysis by Shailesh Varshney, Anshuman Dwivedi, Vibha Dwivedi

“…Mean differences (MD) of Clinical Attachment level (CAL), Probing Pocket depth (PPD), and Defect Depth Reduction (DDR) between the Experimental and Control groups were used for calculating pooled effect sizes. …”
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Effect of an α-calcium sulfate hemihydrate/treated dentin matrix composite to regenerate bone in critically sized SD rat calvarial defects by Mengmeng Wang, Bingyan Li, Wenshuai Li, Zelong Hu, Haojie Fu, Rui Li

“…The biological performance was assessed by measuring osteoblast proliferation using the CCK-8 test and evaluating new bone formation in a calvarial bone defect model in rats.ResultsThe compressive strength of the TDM/α-CSH cements decreased with increasing TDM mass ratio, while SEM analysis revealed a distinct three-dimensional porous network structure and increased surface roughness upon thorough mixing. …”
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Self-Reported Health Experiences of Children Living with Congenital Heart Defects: Including Patient-Reported Outcomes in a National Cohort Study. by Rachel Louise Knowles, Valerija Tadic, Ailbhe Hogan, Catherine Bull, Jugnoo Sangeeta Rahi, Carol Dezateux, UK Collaborative Study of Congenital Heart Defects (UKCSCHD)

“…<h4>Background</h4>Understanding children's views about living with congenital heart defects (CHDs) is fundamental to supporting their successful participation in daily life, school and peer relationships. …”
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Liver transplantation outcomes in patients with primary tricuspid regurgitation with coaptation defects: a retrospective analysis in a high-volume transplant center by Kyoung-Sun Kim, Sun-Young Ha, Seong-Mi Yang, Hye-Mee Kwon, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang

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A Review on Bone Tumor Management: Cutting-Edge Strategies in Bone Grafting, Bone Graft Substitute, and Growth Factors for Defect Reconstruction by Sakdejayont S, Chobpenthai T, Suksirivecharuk P, Ninatkiattikul IF, Poosiripinyo T

“…However, limitations such as donor site morbidity and graft availability have prompted the development of alternative approaches.This review evaluates contemporary approaches in bone tumor management, focusing on advancements in bone grafting techniques, bone graft substitutes (eg, ceramics, polymers, bioactive materials), and growth factor-based therapies. …”
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Safety and Efficacy of Transcatheter Occlusion of Perimembranous Ventricular Septal Defect with Aortic Valve Prolapse: A Six-Year Follow-Up Study by Wenqian Zhang, Chaojie Wang, Shenrong Liu, Lingmei Zhou, Junjie Li, Jijun Shi, Mingyang Qian, Shushui Wang, Yu-Mei Xie, Zhiwei Zhang

“…The aim of this study was to evaluate long-term efficacy and safety of transcatheter occlusion of pVSD with AVP. …”
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EVALUATION OF THE PIPELINES BY METHOD FITNESS FOR SERVICE by Ion PANA

“…The paper illustrates such an assessment at Level 1 and 2 for a defect type out of roundness.…”
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Consumption of folic acid fortified foods among Hispanic women of reproductive age in the US: a systematic review by Nicole Villalba, Kayla Byrne, Sunny Abdelmageed, Megan Votoupal, Sandi K. Lam, Roxanna M. Garcia

“…Abstract Background In 1998, the United States (US) implemented mandatory folic acid fortification of enriched cereal grain products (ECGP) to prevent neural tube defects (NTD) in newborns. NTD rates remained highest among Hispanic births. …”
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Prenatal Predictors and Early Postnatal Outcomes in Fetuses Diagnosed with Tricuspid Atresia by Ozge Kahramanoglu, Omer Gokhan Eyisoy, Oya Demirci

“…Restrictive ventricular septal defect (VSD) and the high ductus venosus pulsatility index were significantly associated with lower survival (<i>p</i> = 0.021 and <i>p</i> = 0.034, respectively). …”
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Customized Metal 3D Printed Total Wrist Prosthesis in the Treatment of Severely Destroyed Wrist: Design Rationale and Clinical Applications by Qipei Wei, Chang Liu, Shanlin Chen, Min Liu

“…ABSTRACT Objective Severe destruction of the wrist joint after trauma, disease, or iatrogenic causes can lead to significant bone defects and deformities, limiting the options for surgeries. …”
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Unusual presentation of a patient with partial anomalous pulmonary venous connections without a septal defect: a case report and literature review by Pouya Ebrahimi, Mohammad Hossein Mandegar, Mehrdad Jafari Fesharaki, Negar Ghasemloo, Pedram Ramezani, Tooba Akbari, Fatemeh Naderi

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Defect “steel-melting captivity and swelling” on the inner surface of seamless hot-rolled pipes. Characteristic genetic features, the causes of formation and measures of prevention... by I. A. Kovaleva, N. A. Khodosovskaya

“…Visual evaluation of samples on the inner surface revealed rolled defects significant clusters, close to each other, having a longitudinal orientation. …”
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