Physical development of adolescents with type 1 diabetes mellitus and the impact of the war in Ukraine on its impairment by Svetlana Turchina, Ganna Kosovtsova, Olga Varodova, Sergey Kalmykov, Yuliya Kalmykova

“…The study was conducted in accordance with the principles of the Declaration of Helsinki and accepted by the Committee on Bioethics and Deontology. …”
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Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo by Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Fumiya Harada, Dedy Ariwansa, Sarita Giri, Jun Sato, Hiroki Nagayasu, Yoshihiro Abiko

“…In vivo, a xenograft tumor formation assay was conducted using male BALB/Slc-nu nude mice, in accordance with the Basel Declaration and The ARRIVE guidelines 2.0. Tumor samples were analyzed by qRT-PCR, and qMSP. …”
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Application of Closed Incision Negative Pressure Wound Therapy in Ventral Hernia Repair Surgery Using a Polypropylene Mesh: A Randomized Clinical Trial by Petr Jelinek, Jan Hrubovcak, Radovan Hajovsky, Jan Velicka, Martin Pies

“…No significant effect of sex or smoking status on SSI was observed. The control group had a shorter mean length of hospital stay. …”
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A pharmacist-led educational and audit & feedback strategy to reduce antibiotic prescription in primary care: the AFA study by A. Soler, A. Huguet, A. Leiva, C. Vicens, F. Bejarano-Romero, E. Sempere, T. Izquierdo, M. M. Parera, R. Seco, M. Fages, A. Medina, L. Castillo-Palomares, E. López-Guerrero, B. A. Ferrer, L. Ugarriza, M. Llarena, L. Gallardo-Alfaro, AFA study investigators

“…Ethics and dissemination The study was approved by the Balearic island, Valencia and IDIAP Jordi Gol Ethical Committee, follows the Declaration of Helsinki, Good Clinical Practice guidelines, and applicable national and European regulations concerning clinical trials and data protection. …”
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High sensitivity C-reactive protein implicates heterogeneous metabolic phenotypes and severity in metabolic dysfunction associated-steatotic liver disease by Hao Wang, Junzhao Ye, Youpeng Chen, Yanhong Sun, Xiaorong Gong, Hong Deng, Zhiyong Dong, Lishu Xu, Xin Li, Bihui Zhong

“…Materials and methods This cross-sectional study included consecutive participants (ultrasound-diagnosed MASLD: 1,006, healthy controls: 582), and 175 patients received liver biopsy., with 733 and 310 patients underwent magnetic resonance imaging proton density fat fraction for liver fat content (LFC) quantification and two-dimensional shear-wave elastography liver stiffness measurements (LSM), respectively. …”
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A phase 3 randomised study of enzalutamide plus leuprolide and enzalutamide monotherapy in high-risk non-metastatic hormone-sensitive prostate cancer with rising PSA after local th... by Ugo De Giorgi, Martin Gleave, Brad Rosbrook, Stephen J Freedland, Qi Shen, Jennifer Sugg, Gabriel P Haas, Neal D Shore

“…Introduction Limited data from controlled clinical trials are available for men who experience biochemical recurrence after definitive therapy for prostate cancer. …”
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Peranan Notaris Dalam Kepastian Hukum Akta Kuasa Menjual Terhadap Objek Jual Beli Yang Pailitkan by Devi Eriyanti, Fully Handayani Ridwan

“… The purpose of this study is to determine the role of the Notary in the legal certainty of the power of attorney to sell the object in bankruptcy and to be able to find out the legal consequences and legal liability. Decision on Declaration of Bankruptcy The debtor by law loses his right to control and manage the assets he owns. …”
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Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial... by Jeffrey J Swigris, Toby M Maher, Tamera J Corte, Aryeh Fischer, Hong Xiao, Lisa Lancaster, Takafumi Suda, Xiaojiang Zhan, Jonathan G Goldin, Scott M Palmer, Hideaki Watanabe, Takashi Ogura, Anne Minnich, Giridhar S Tirucherai, Brandon Elpers, R Adam Smith, Edgar D Charles

“…Patients in both the IPF (n=240) and PF-ILD (n=120) cohorts will be randomised 1:1:1 to receive 30 mg or 60 mg BMS-986278, or placebo, administered orally two times per day for 26 weeks in the placebo-controlled treatment period. The primary endpoint is rate of change in per cent predicted forced vital capacity from baseline to week 26 in the IPF cohort.Ethics and dissemination This study will be conducted in accordance with Good Clinical Practice guidelines, Declaration of Helsinki principles, and local ethical and legal requirements. …”
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Curating a knowledge base for patients with neurosyphilis: a study protocol of a DEep learning Framework for pErsonalized prediction of Adverse prognosTic events in NeuroSyphilis (... by Jun Li, Tian Tian, Huachun Zou, Hanlin Zhang, Jun Zou, Zhen Lu, Junfeng Wang, Liuqing Yang, Bingyi Wang, Leiwen Fu, Siyang Liu, Weibo Wu, Zhipeng Peng

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Implementing a pharmacogenetic-driven algorithm to guide dual antiplatelet therapy (DAPT) in Caribbean Hispanics: protocol for a non-randomised clinical trial by Dagmar F Hernandez-Suarez, Kyle Melin, Frances Marin-Maldonado, Hector J Nunez, Ariel F Gonzalez, Lorena Gonzalez-Sepulveda, Sona Rivas-Tumanyan, Hetanshi Naik, Gualberto Ruaño, Stuart A Scott, Jorge Duconge

“…The study will be carried out in compliance with the Declaration of Helsinki and International Conference on Harmonization Good Clinical Practice Guidelines. …”
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Engagement of Indigenous peoples in commercial tobacco reform strategies: a scoping review protocol by Andrew Waa, Raglan Maddox, El-Shadan Tautolo, Michelle Kennedy, Patricia Nez Henderson, Hershel Clark, Priscilla Nez, Penney Upton, Andrew Daniel Perusco, Sydney A. Martinez, Sierra Wilcox, Jeyasakthi Venugopal

“…Studies included in the review will be assessed against criteria for Indigenous engagement in research.Ethics and dissemination This protocol was led by Indigenous interests, needs and rights of Indigenous peoples, consistent with the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP), the WHO’s Framework Convention on Tobacco Control and ethical practice. …”
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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

“…The study will comply with the Helsinki Declaration on medical research involving human subjects. …”
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The multi-sectorial emergency response to a cholera outbreak in Internally Displaced Persons camps in Borno State, Nigeria, 2017 by Chikwe Ihekweazu, Moise Chi Ngwa, Alemu Wondimagegnehu, Ifeanyi Okudo, Collins Owili, Uzoma Ugochukwu, Peter Clement, Isabelle Devaux, Lorenzo Pezzoli, Mohammed Abba Jimme, Peter Winch, David A Sack

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Role of inflammation and haemostasis on aetiology and prognosis in young patients with ischaemic stroke: study protocol of the Observational Dutch Young Symptomatic StrokE study—EX... by Roy P C Kessels, Saskia Middeldorp, Ido R van den Wijngaard, Anil Tuladhar, Frank‐Erik de Leeuw, Heleen den Hertog, Renate M Arntz, Esmée Verburgt, Janneke P Spiegelenberg, Inge W M van Uden, Karlijn F de Laat, Frank G van Rooij, Anja van der Kolk, Jenneke Leentjens, Vitória Piai, Mark Roest, Bas de Laat

“…The ‘Observational Dutch Young StrokE study—Extended’ (ODYSSEY-nEXT) aims to enhance our understanding of these complex interactions through detailed phenotyping of the immune and haemostatic system and explore their relationship with long-term prognosis.Methods and analysis The ODYSSEY-nEXT is a multicentre prospective controlled cohort study of patients aged 18–50 years with a first neuroimaging-proven ischaemic stroke or transient ischaemic attack and healthy controls. …”
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Análisis de electromiografía en la sentadilla libre con barra: Revisión sistemática (Electromyography analysis of the free barbell squat: A systematic review) by Víctor Hugo López-Trujillo, Karla Dolores Bustamante-Valles, Ramón Candia-Luján, Raul Josue Najera Longoria

“…Methods: This study was conducted according to The PRISMA declaration and the STROBE guidelines to assess the methodological quality. …”
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MORPHOGENESIS OF BRANCHIOGENIC GLANDS OF THE NECK IN THE FETAL PERIOD OF ONTOGENESIS by О. Білоокий, Т. Хмара, Д. Проняєв, В. Безрук

“… Branchiogenic glands play an important role in the control of calcium and iodine levels and thus have a direct impact on muscle contraction and neurotransmission. …”
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Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight/obe... by Ellen E Blaak, Edith Feskens, Kristine Beaulieu, Graham Finlayson, Julie Anne Nazare, Moon Wilton, Mie Normand, Anne Raben, Catherine Gibbons, Jason C G Halford, Joanne A Harrold, Louise Kjølbæk, Santiago Navas-Carretero, Charo E Hodgkins, Hariklia Moshoyiannis, Beverley O'Hara, Dominic O’Connor, Charlotte Hardman, Eva Almiron-Roig, Maud Alligier, Jose Alfredo Martínez, Corey Scott, Cécile Rannou

“…Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&SE blends and no added sugar). …”
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PANDA study: subtyping of Parkinson’s disease – cohort study protocol by Yan Li, Rui Yang, Zihao Li, Mengfei Cai, Chentao He, Siming Rong, Ziqi Gao, Qibing Luo, Xilie Cui, Piao Zhang, Yuhu Zhang

“…The Prospective Assessments with Neuroimaging and fluid Data Analysis in PD (PANDA) study is a single-centre, longitudinal cohort study designed to explore PD heterogeneity by integrating multimodal neuroimaging, fluid biomarkers and comprehensive clinical assessments.Methods and analysis The PANDA study aims to recruit 500 PD patients and 100 healthy controls (HC) at Guangdong Provincial People’s Hospital from March 2021 to July 2026. …”
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Do deferred emergency payment programmes increase use of injury care services in Cameroon? A trauma registry analysis by Catherine Juillard, Alain Chichom Mefire, Fanny Nadia Dissak-Delon, Rasheedat Oke, Mark T Yost, Kathleen O’Connor, Kibu O Dzemo, Dennis J Zheng, Cindy S Umoh, Ariane S Christie

“…Background Injured patients in Cameroon face high out-of-pocket costs and care discrepancies based on ability to pay. Per government declaration, all Cameroonian hospitals instituted emergency payment deferral (EPD) programmes to mitigate financial barriers to emergency care. …”
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Lung lipids associated with smoking and ECIG use in a cross-sectional study and clinical trial by Joseph P. McElroy, Min-Ae Song, John R. Barr, Michael S. Gardner, Garret Kinnebrew, Zsuzsanna Kuklenyik, Jennifer D. Kusovschi, Jon C. Rees, Benjamin C. Blount, MuChun Tsai, Mark D Wewers, Sahar Kamel, Sarah A. Reisinger, Amarnath Singh, Daniel Y. Weng, Peter G. Shields

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