Triglyceride-glucose index as a superior marker of insulin resistance for predicting long-term major adverse cardiovascular events following coronary artery bypass grafting in Chin... by Xiangfei Sun, Zhenguo Wu, Dachuan Guo, Sha Chen, Chunfei Song, Xiangzhen Ran, Li Liu, Yerui Zhang, Xiaoyu Liu, Guangqing Cao, Jianmin Yang

“…Abstract Insulin resistance (IR) has emerged as a risk factor for coronary artery disease (CAD), but there are currently insufficient data on the association of non-insulin-based IR indexes [triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride and glucose (TyG) index, and metabolic score for IR (METS-IR)] with the postoperative prognosis in patients undergoing coronary artery bypass grafting (CABG). …”
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Sustainable development of Cuban agricultural economy: Policy and practice by Lihua Hu, Chengjiu Wang, Ping He

“…The sustainable development practice of Cuba's agricultural economy has provided valuable experience for the sustainable development of global agriculture. …”
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Nationwide implementation of the international multidisciplinary best-practice for locally advanced pancreatic cancer (PREOPANC-4): study protocol by T. F. Stoop, L. W. F. Seelen, F. R. van ’t Land, A. C. van der Hout, J. C. M. Scheepens, M. Ali, A. M. Stiggelbout, B. M. van der Kolk, B. A. Bonsing, D. J. Lips, D. J. A. de Groot, E. van Veldhuisen, E. D. Kerver, E. R. Manusama, F. Daams, G. Kazemier, G. A. Cirkel, G. van Tienhoven, G. A. Patijn, H. N. Lelieveld-Rier, I. H. de Hingh, I. E. G. van Hellemond, J. H. Wijsman, J. I. Erdmann, J. S. D. Mieog, J. de Vos-Geelen, J. W. B. de Groot, K. R. D. Lutchman, L. J. Mekenkamp, L. W. Kranenburg, L. P. M. Beuk, M. W. Nijkamp, M. den Dulk, M. B. Polée, M. Y. V. Homs, M. L. Wumkes, M. W. J. Stommel, O. R. Busch, R. F. de Wilde, R. T. Theijse, S. A. C. Luelmo, S. Festen, T. L. Bollen, U. P. Neumann, V. E. de Meijer, W. A. Draaisma, B. Groot Koerkamp, I. Q. Molenaar, C. L. Wolfgang, M. Del Chiaro, M. G. H. Katz, T. Hackert, J. A. C. Rietjens, J. W. Wilmink, H. C. van Santvoort, C. H. J. van Eijck, M. G. Besselink, for the Dutch Pancreatic Cancer Group

“…The existing prospective LAPC Registry and PACAP PROMs (NCT03513705) will be used for data collection. In qualitative interviews, treatment preferences, values, and experiences of LAPC patients, their relatives, and healthcare professionals will be assessed for the development of shared decision-making supportive tools. …”
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Whole exome sequencing enhances diagnosis of hereditary bronchiectasis by Wangji Zhou, Yixuan Li, Haixia Zheng, Miao He, Miaoyan Zhang, Qiaoling Chen, Christopher Situ, Yaqi Wang, Ting Zhang, Keqi Chen, Jinrong Dai, Shuzhen Meng, Xueqi Liu, Aohua Wu, Yaping Liu, Kai-Feng Xu, Xinlun Tian, Xue Zhang

“…Historically, diagnosing this condition has been difficult due to the inaccessibility of diagnostic services coupled with a lack of awareness of the syndrome. …”
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Opinion of the Italian Association of Myology on Ataluren for the Treatment of Nonsense Mutation Duchenne Muscular Dystrophy by Luca Bello, Pietro Riguzzi, Emilio Albamonte, Guja Astrea, Roberta Battini, Andrea Barp, Angela L. Berardinelli, Enrico S. Bertini, Noemi Brolatti, Claudio Bruno, Stefania Corti, Adele D’Amico, Maria Grazia D’Angelo, Gianfranco Dallavalle, Rocco Liguori, Lorenzo Maggi, Francesca Magri, Michelangelo Mancuso, Riccardo Masson, Eugenio Mercuri, Carlo Minetti, Sonia Messina, Tiziana Mongini, Olimpia Musumeci, Vincenzo Nigro, Marika Pane, Chiara Panicucci, Marina Pedemonte, Antonella Pini, Luisa Politano, Stefano Previtali, Federica Ricci, Giulia Ricci, Lucia Ruggiero, Valeria Sansone, Gabriele Siciliano, Antonio Trabacca, Federica Trucco, Daniele Velardo, Elena Pegoraro, Giacomo P. Comi

“…The marketing authorization has been recently withdrawn by the European Commission following a recommendation from the Committee for Medicinal Products for Human Use of the European Medicines Agency. …”
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The triglyceride-glucose index and risk of cognitive impairment: a systematic review and meta-analysis with inclusion of two national databases by Ying Yang, Ying Yang, Pai Peng, Pai Peng, Huadong Huang, Huadong Huang, Yanan Zhao, Yanan Zhao, Yating Li, Yating Li, Xiao Xu, Shixie Jiang, Yanrong Yang, Gaofeng Pan, Yanting Wen, Dan Wu, Shanping Chen, Lei Feng, Tangming Peng, Jiang Wang, Jiang Wang, Zheng Li

“…All data was combined to compute Odd Ratios (ORs).Results15 studies were included in the meta-analysis (participants: 5604303). …”
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Magnesium (Mg∕Ca, <i>δ</i>²⁶Mg), boron (B∕Ca, <i>δ</i>¹¹B), and calcium (Ca²⁺) geochemistry of <i>Arctica islandica</i> and <i>Crassostrea virginic... by B. Alvarez Caraveo, B. Alvarez Caraveo, M. Guillermic, M. Guillermic, M. Guillermic, A. Downey-Wall, L. P. Cameron, J. N. Sutton, J. A. Higgins, J. B. Ries, K. Lotterhos, R. A. Eagle, R. A. Eagle

“…<p>The geochemistry of biogenic carbonates has long been used as proxies to record changing seawater parameters. …”
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Long-term Outcome After Nonvascularized Rectus Fascia Transplantation in Solid Organ Transplantation: A Global Multicenter IIRTA Survey by Nele Van De Winkel, MD, Ewout Muylle, BSc, Emilio Canovai, MD, PhD, Irum Amin, MD, Andrew Butler, MD, PhD, Rodrigo Vianna, MD, Gennaro Selvaggi, MD, Pablo Farinelli, MD, Gabriel Gondolesi, MD, Carmelo Loinaz, MD, PhD, Iago Justo, MD, PhD, Hector Vilca-Melendez, MD, Ulrika Skogsberg Dahlgren, MD, Gustaf Herlenius, MD, PhD, Alireza Shamsaeefar, MD, Hamed Nikoupour, MD, Antoine Dubois, MD, Marc Miserez, MD, PhD, André D’Hoore, MD, PhD, Robert Venick, MD, Jacques Pirenne, MD, PhD, Laurens J. Ceulemans, MD, PhD

“…This survey reports long-term outcome after NVRF Tx, with herniation in a limited number of patients, no suspicion of clinical rejection and no additional infection and mortality. NVRF Tx has proven to be a useful option, belonging to the standard armamentarium for AW closure after SOT.…”
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New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plur... by Isabela Ribeiro, Joaquim Gascon, Sergi Sanz, Faustino Torrico, Dolors Soy, Cristina Alonso-Vega, Julio A Urbina, María-Jesús Pinazo, Jimy José Pinto, Virginia R Gonzalez, Gimena Rojas, Lourdes Ortiz, Wilson Garcia, Daniel Lozano, Rosa A Maldonado, Rana Nagarkatti, Alain Debrabant, Alejandro Schijman, M Carmen Thomas, Manuel Carlos López, Katja Michael, Igor C Almeida

“…Moreover, the high incidence of adverse events (AEs) with both drugs has hampered their widespread use. Trials in CCD adults showed that quantitative PCR (qPCR) assays remain negative for 12 months after standard-of-care (SoC) BZN treatment in ~80% patients. …”
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Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis by Xinbo Xu, Xiao Fei, Huan Wang, Xidong Wu, Yuan Zhan, Xin Li, Yan’an Zhou, Chunxi Shu, Cong He, Yi Hu, Jianping Liu, Nonghua Lv, Nianshuang Li, Yin Zhu

“…Activin A receptor type I (ACVR1), known for encoding the type I receptor for bone morphogenetic proteins (BMPs), has been identified as a cancer diver gene across various tumors. …”
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TCF7 enhances pulmonary hypertension by boosting stressed natural killer cells and their interaction with pulmonary arterial smooth muscle cells by Li-Wei Wu, Min Chen, Dai-Ji Jiang, Chen-Yu Jiang, Yi-Wei Liu, Bei Feng, Chen-Fei Shi, Xu Huang, Xu Zhang, Xiao-He Xu, Xing-Liang Zhou, Yi Shen, Tian-Yu Liu, Lin-Cai Ye, Yang-Yang He, Hao Zhang, Yi Yan

“…Whether natural killer (NK) cells could act as participants in PH and the mechanism by which NK cells moderate pulmonary vascular remodeling has not been fully elucidated. Methods Single-cell RNA sequencing data from lungs of human pulmonary arterial hypertension (PAH) patients and monocrotaline (MCT)-induced PH rat model were retrieved from GEO database or UCSC Cell Browser. …”
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A multicenter analysis of implantable monitoring device-based diagnosis of supraventricular arrhythmia post patent foramen ovale closure: the OCCL-ILR study by Stijn Lochy, Alvise Del Monte, Xavier Galloo, Andreea Motoc, Daniele Plein, Kurt Hermans, Frauke Gorré, Julie Colas-Florial, Liesbeth Rosseel, Philip Muyldermans, Maarten Pauwelyn, Pieter-Jan Palmers, François Delvoye, Evelyne Wirix, Jonas Podevyn, Bram Roosens, Philippe Unger, Steven Droogmans, Jean-François Argacha, Sylvie De Raedt, Gian Battista Chierchia, Bernard Cosyns

“…BackgroundRecent data suggest that the true incidence of atrial fibrillation (AF) after patent foramen ovale (PFO) closure has probably been underestimated, and may differ according to the type of closing device used.ObjectivesOn the basis of continuous rhythm monitoring with an implantable device, this study aims to assess the incidence of  supraventricular arrhythmia following PFO closure with the Occlutech PFO device.MethodsThis is a multicentric analysis of consecutive PFO closure patients treated with an Occlutech device between 01/01/2019 and 20/03/2024, with an implantable loop recorder (IRL) (or a pacemaker or implantable cardioverter defibrillator) implanted for at least 3 months preceding the procedure, and with available follow-up for at least 1month post procedure. …”
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從前瞻因應理論觀點探討翻轉教學策略應用 於退休準備課程在不同需求程度上之 教學成效 Exploring the Application of Flipped Teaching Strategies in Retirement Preparation Courses: An Analysis of Educational Effectiveness From... by 胡夢鯨 Menq-Jing Hwu, 施宇澤 Yu-Ze Shih, 劉霽瑈 Ji-Rou Liu, 陳雅雯 Ya-Wen Chen

“…After a rigorous validation process involving the Delphi method and reliability testing, the scale demonstrated high internal consistency (Cronbach’s α > .92). Data analysis used SPSS 21 for descriptive statistics, t-tests, and Z-score calculations to examine needs and instructional outcomes, providing insights into the effectiveness of the flipped teaching approach. …”
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The utility of dynamic forest structure from GEDI lidar fusion in tropical mammal species distribution models by Patrick Burns, Zaneta Kaszta, Samuel A. Cushman, Samuel A. Cushman, Jedediah F. Brodie, Jedediah F. Brodie, Christopher R. Hakkenberg, Patrick Jantz, Mairin Deith, Matthew Scott Luskin, James G. C. Ball, Jayasilan Mohd-Azlan, David F. R. P. Burslem, Susan M. Cheyne, Susan M. Cheyne, Iding Haidir, Iding Haidir, Andrew James Hearn, Eleanor Slade, Peter J. Williams, David W. Macdonald, Scott J. Goetz

“…Lidar measurements from the Global Ecosystem Dynamics Investigation (GEDI) are shedding light on three dimensional forest structure in regions of the world where this aspect of species habitat has previously been poorly quantified. Here we combine a large camera trap dataset of mammal species in Borneo and Sumatra with a diverse set of geospatial data to predict the probability of occurrence of 47 species. …”
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Influence of ATXN2 intermediate CAG repeats, 9bp duplication and alternative splicing on SCA3 pathogenesis by Marilena Lauerer, Jennifer Faber, Nicolas Casadei, Magda M. Santana, Georg Auburger, Michaela Pogoda, Jakob Admard, Lea Kaupp, Patricia Laura Kos, Mafalda Raposo, Manuela Lima, Luis Pereira de Almeida, Hector Garcia-Moreno, Paola Giunti, Jeroen de Vries, Bart P. van de Warrenburg, Judith van Gaalen, Marcus Grobe-Einsler, Berkan Koyak, Kathrin Reetz, Friedrich Erdlenbruch, Heike Jacobi, Jon Infante, Holger Hengel, Ludger Schöls, Thomas Klockgether, Olaf Rieß, Jeannette Hübener-Schmid, ESMI study group

“…We performed a genetic in-depth analysis of ataxin-2 (ATXN2), a gene that has already been described as a modulator of neurodegenerative diseases. …”
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β-synuclein in cerebrospinal fluid as a potential biomarker for distinguishing human prion diseases from Alzheimer’s and Parkinson’s disease by Bing Xu, Kang Xiao, Xiaoxi Jia, Rundong Cao, Donglin Liang, Ruhan A, Weiwei Zhang, Chunjie Li, Liping Gao, Cao Chen, Qi Shi, Xiaoping Dong

“…Abstract Background β-synuclein (β-syn), mainly expressed in central nerve system, is one of the biomarkers in cerebrospinal fluid (CSF) and blood for synaptic damage, which has been reported to be elevated in CSF and blood of the patients of prion diseases (PrDs). …”
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Operational evaluation of the deployment of Malaria/CRP Duo and Dengue Duo rapid diagnostic tests for the management of febrile illness by village malaria workers in rural Cambodia by Marc T. Visser, Dysoley Lek, Bipin Adhikari, Arjun Chandna, Moul Vanna, Sam Ol, Voeurng Bunreth, Chan Davoeung, Yok Sovann, Dafne Umans, Yoel Lubell, Rusheng Chew, Richard J. Maude, Rob W. van der Pluijm, Rupam Tripura, Naomi Waithira, Siv Sovannaroth, Michèle van Vugt, Lorenz von Seidlein, Mavuto Mukaka, Arjen Dondorp, Thomas J. Peto, James J. Callery

“…Abstract Introduction The decline in malaria cases in Cambodia has led to a relative increase in non-malarial febrile illness. …”
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The Cosmic Evolution Early Release Science Survey (CEERS) by Steven L. Finkelstein, Micaela B. Bagley, Pablo Arrabal Haro, Mark Dickinson, Henry C. Ferguson, Jeyhan S. Kartaltepe, Dale D. Kocevski, Anton M. Koekemoer, Jennifer M. Lotz, Casey Papovich, Pablo G. Pérez-González, Nor Pirzkal, Rachel S. Somerville, Jonathan R. Trump, Guang Yang, L. Y. Aaron Yung, Adriano Fontana, Andrea Grazian, Norman A. Grogin, Lisa J. Kewley, Allison Kirkpatrick, Rebecca L. Larson, Laura Pentericci, Swara Ravindranath, Stephen M. Wilkins, Omar Almaini, Ricardo O. Amorín, Guillermo Barro, Rachana Bhatawdekar, Laura Bisigello, Madisyn Brooks, Véronique Buat, Fernando Buitrago, Denis Burgarella, Antonello Calabrò, Marco Castellano, Yingjie Cheng, Nikko J. Cleri, Justin W. Cole, M. C. Cooper, Olivia R. Cooper, Luca Costantin, Isa G. Cox, Darren Croton, Emanuele Daddi, Kelcey Davis, Avishai Dekel, David Elbaz, Vital Fernández, Seiji Fujimoto, Giovanni Gandolfi, Jonathan P. Gardner, Eric Gawiser, Mauro Giavalisco, Carlos Gómez-Guijarro, Yuchen Guo, Ansh R. Gupta, Nimish P. Hathi, Santosh Harish, Aurélien Henry, Michaela Hirschmann, Weida Hu, Taylor A. Hutchison, Kartheik G. Iyer, Anne E. Jaskot, Saurabh W. Jha, Intae Jung, Susan A. Kassin, Vasily Kokorev, Peter Kurczynski, Gene C. K. Leung, Mario Llerena, Arianna S. Long, Ray A. Lucas, Shiying Lu, Elizabeth J. McGrath, Daniel H. McIntosh, Emiliano Merlin, Bahram Mobasher, Alexa M. Morales, Lorenzo Napolitano, Fabio Pacucci, Viraj Pandya, Marc Rafelski, Giulia Rodighiero, Caitlin Rose, Paola Santini, Lise-Marie Seillé, Raymond C. Simons, Lu Shen, Amber N. Straughn, Sandro Tacchella, Anthony J. Taylor, Brittany N. Vanderhoof, Jesús Vega-Ferrero, Benjamin J. Weiner, Christopher N. A. Willmer, Peixin Zhu, Eric F. Bell, Stijn Wuyts, Benne W. Holwerda, Xin Wang, Weichen Wang, Jorge A. Zavala, (CEERS collaboration)

“…As a legacy product for the community, the CEERS team has provided several data releases, accompanied by detailed notes on the data reduction procedures and notebooks to aid in reproducibility. …”
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Mesenchymal stromal cells for steroid-refractory biopsy-proven grade III-IV acute Graft-versus-Host Disease with predominant gastrointestinal involvement by Adomas Bukauskas, Renata Jucaitienė, Mindaugas Stoškus, Vilma Valčeckienė, Greta Bušmaitė, Artūras Slobinas, Artūras Slobinas, Linas Davainis, Inga Šlepikienė, Igoris Trociukas, Valdas Pečeliūnas, Laimonas Griškevičius, Laimonas Griškevičius, Andrius Žučenka, Andrius Žučenka

“…Mesenchymal stromal cells (MSC) have emerged as a promising therapeutic option due to their favorable efficacy and safety profile. However, data on bone marrow (BM)-derived MSC use in biopsy-proven grade III-IV SR-aGVHD with GI involvement, particularly in stage 3-4 cases, remain limited.MethodsThis prospective, observational, single-arm, single-center study assessed the efficacy and safety of BM-derived MSC for treating adult patients with biopsy-proven grade III-IV SR-aGVHD with predominant GI involvement. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…In recent years, there has been significant progress in understanding the molecular pathogenesis and biology of these tumors. …”
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