PPARβ/δ prevents inflammation and fibrosis during diabetic cardiomyopathy by Adel Rostami, Xavier Palomer, Javier Pizarro-Delgado, Emma Barroso, Brenda Valenzuela-Alcaraz, Fátima Crispi, J. Francisco Nistal, María A. Hurlé, Raquel García, Walter Wahli, Manuel Vázquez-Carrera

“…Finally, our results suggest that the beneficial effects of PPARβ/δ activation are mediated by the inhibition of mitogen-activated protein kinases (MAPK) activity and subsequent downregulation of the transcriptional activities of NF-κB and AP-1. Overall, the data suggest that PPARβ/δ agonists might be useful in preventing inflammation and fibrosis progression in DCM.…”
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Epidemic characteristics and effectiveness of vaccine intervention on rotavirus infection: a real-world observational study in Zhejiang Province, China by Ziping Miao, Yuxia Du, Anqi Dai, Mengya Yang, Can Chen, Rui Yan, Jian Gao, Yijuan Chen, Kexin Cao, Daixi Jiang, Xiaobao Zhang, Xiaoyue Wu, Mengsha Chen, Yue You, Wenkai Zhou, Dingmo Chen, Jiaxing Qi, Shiyong Zhao, Xianyao Lin, Shigui Yang, RIDPHE Group, Shigui Yang, Xudong Zhou, Peige Song, Ning Zhang, Hao Lei, Junfang Xu, Jianbing Wang

“…BackgroundRotavirus infection, the most common cause of infant infectious diarrhoea and related deaths worldwide, has imposed a high disease burden in China, especially in Zhejiang Province. …”
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The preoperative hemoglobin, albumin, lymphocyte, and platelet score (HALP) as a prognostic indicator in patients with non-small cell lung cancer by Qiteng Liu, Qiteng Liu, Qiteng Liu, Qiteng Liu, Hailun Xie, Hailun Xie, Hailun Xie, Wenjuan Cheng, Tong Liu, Tong Liu, Tong Liu, Chenan Liu, Chenan Liu, Chenan Liu, Heyang Zhang, Heyang Zhang, Heyang Zhang, Shiqi Lin, Shiqi Lin, Shiqi Lin, Xiaoyue Liu, Xiaoyue Liu, Xiaoyue Liu, Haiying Tian, Haiying Tian, Haiying Tian, Xiangrui Li, Xiangrui Li, Xiangrui Li, Xin Zheng, Xin Zheng, Xin Zheng, Yue Chen, Yue Chen, Yue Chen, Jinyu Shi, Jinyu Shi, Jinyu Shi, Hong Zhao, Hong Zhao, Hong Zhao, Hanping Shi, Hanping Shi, Hanping Shi

“…The Cox regression model was used for univariate and multivariate analyses.ResultsThe study included 2,053 patients with detailed biological information and follow-up data, consisting of 1,346 men (65.6%) and 707 women (34.4%). …”
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ViSHWaS: Violence Study of Healthcare Workers and Systems—a global survey by Faisal Nawaz, Daniel Martin Simadibrata, Vikas Bansal, Ramesh Adhikari, Mariam Elsaban, Rahul Kashyap, Priyadarshini Bhattacharjee, Jorge Salluh, Hassan Dawood Alli, Joanna Lee, Dattatreya Mukherjee, Tanja Kovačević, Mohammad Yasir Essar, Christos Tsagkaris, Genesis Camacho-Leon, Faizan Ahmad, Akshat Banga, Hans Mautong, Razan Alamoudi, Umme Habiba Faisal, Gaurang Bhatt, Tanya Amal, Ayushi Mendiratta, Bhaswanth Bollu, L V Simhachalam Kutikuppala, Ivan Huespe, Aisha Khalid, Mohammed Amir Rais, Alisha Lakhani, Piyush Garg, Harsha Pattnaik, Raghu Gandhi, Ramesh Pandit, Pierre Ciza N, Nimsi Barrios, Kelly Meza, Susan Okonkwo, Amuza Dhabuliwo, Hafeez Hamza, Arash Nemat, Anne Kampa, Rakhtan K Qasba, Pranjal Sharma, Taru Dutt, Pratikkumar Vekaria, Faisal A Nawaz, Salim Surani, L V Simhachalam Kutikuppala, Divya Randhawa, Rakhtan Qasba, Trupti Pandit, Ayesha Khalid, Ravina Verma, Kush Shah, John Counsell, Naresh Dasari, Melissa Schlenker, Raghavendra Tirupathi, Gowthami Sai Jagirdhar, Nancy Nagib, Benjamin Schlenker, Taha Mansoor, N Pierre Ciza, Leydi Del Lema, Susan Sheila, Bello Saifullah Muhammad, Barakat Kolawole, L V Kutikuppala, Keidy Zamora, Bikona Ghosh, Sama Soliman, Zainab Ayoob, Lina Almahmoud, Dohha Mohammed, Oyindamola Obadare, Era Mae Ramirez, Kalloush Shahed, Mohammed Yasir Essar, Sarya Swed, Temaa Alklani, Ishimwe Florent, Goodluck Nchasi, Daren Poh How, Mohamed Elfagieh, Moath Almekhlafi, Reshon Hadmon, Anasonye Emmanuel, Yosra Magdi Makki, Rodrigue Ndabashinze, Hussein Dawoud, Dimitrios Kantas, Daniella Myriam Pierre, Zeynep Pelin Orhan, Usama Oguz, Hedys Selene Mogollón, Ramesha Remy, Marija Vukoja, Srdjan Gavrilovic, Alicja Rydzewska Rosolowska, Umme Faisal, Franz Lopez, Salem Ramirez, Lisdamys Morera Gonzalez, Mohammed Alkawak, Marco Antonio Villar, Kelly Maza, Shehu Bledi, Jonida Naska

“…The under-reporting of violence against healthcare workers (HCWs) globally highlights the need for increased public awareness and education.Methods The Violence Study of Healthcare Workers and Systems study used a survey questionnaire created using Research Electronic Data Capture (REDCap) forms and distributed from 6 June to 9 August 2022. …”
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Competing risk and random survival forest models for predicting survival in post-resection elderly stage I–III colorectal cancer patients by Qian Zhang, Rongxuan Xu, Wenchong Zhen, Xueting Bai, Zihan Li, Yixin Zhang, Wei Wu, Zhihan Yao, Xiaofeng Li

“…Older patients (≥ 65 years) with stage I–III CRC between 2010 and 2015 were selected from the Surveillance, Epidemiology and End Results (SEER) database. In addition, data from 2018–2021 in the database is extracted as an external validation set. …”
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Comparison of carbohydrate contents and endogenous hormones in sweet cherry flower buds between different altitude areas in Hangzhou by ZHANG Chen, LIU Hui, RUAN Ruoxin, LUO Huifeng, HUANG Kangkang, XI Dujun, PEI Jiabo, SHEN Guozheng

“…Grey relation analysis (GRA) and GRA-SVM model were used to analyze the correlation degree between flower bud weight and the flower bud inclusion index. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…Referred to as mental health and behavioural problems (MHBP), these can lead to exclusion from everyday family life, educational and community activities, poor quality of life and increased stress for family members as well as high costs in service use and lost opportunities. Previous research has shown elevated rates of MHBP at all ages among autistic people, affecting up to two-thirds of individuals, but at the inception of this programme, it was not known whether these problems persisted over time in the same individuals, nor what are the risk factors for persistence. …”
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Evaluating yield and land equivalent ratio in mixcropping of balangu (Lallemantia royleana Benth.) and chickpea (Cicer arietinum L.) affected by weed competition by Ebrahim Eizadi-Darbandi, Arash Maghsoudi, Elnaz Molaei

“…Introduction Intercropping is considered to be important for a lot of reasons like optimizing water and soil resource uses, increasing water use efficiency, increasing pest, diseases and weed control efficiency, decrease pesticide application, increasing total production and land equivalent ratio and sustainability in agroecosystems. …”
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The influence of work environment and work facilities on Employee Performance With Work Motivation As an Intervening Variable by Anna Anna, Agus Sukoco

“…Design/methodology/approach: This research approach uses quantitative research, Saturated Sampling method, the population in this study is the technical team of the Health Sector of the Surabaya City Investment and One-Stop Integrated Service Office with a total of 40 people, the measurement scale in this study uses a Likert scale, The data analysis used in this study used static methods with SEM PLS modeling. …”
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Genetic diversity and GWAS analysis of flesh hardness trait in Xinjiang melon germplasm resources by ZHU Wanting, LI Jiangfeng, ZHAN Qianru, SHUA Zhenyang, ZHU Yingchun, GUO Yanxia, LUO Xiang

“…In recent years, the melon planting area has continued to expand, with Xinjiang accounting for one-third of the national production. …”
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An adaptive multiarm randomised trial of biomedical and psychosocial interventions to improve convalescence following severe acute malnutrition in sub-Saharan Africa: Co-SAM trial... by Paul Kelly, Lisa Langhaug, Marko Kerac, Helen Jones, Robert Ntozini, Laura Mwalekwa, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Deophine Ngosa, Nivea Chulu, Ellen Besa, Kuda Mutasa, Andrew J Prendergast, Virginia Sauramba, Eddington Mpofu, Bernard Chasekwa, Andreck Tembo, Gwendolyn Nayame, Sophreen Mwaba, Lydia Kazhila, Babak Choodari-Oskooei, Philip Ayieko, Batsirai Mutasa, Indi Trehan, Florence D Majo, Naume V Tavengwa, Thomas Jaki, Kirkby D Tickell, Benson O Singa, Dalton Wamalwa, Gerard Bryan Gonzales, Judd Walson, Doreen Rwigi, Melanie Smuk, Tim Brown, James Berkley, Sunhurai Mukwambo, Gertrude Tawodzera, Kavita Datta, Wedu Ndebele, Chishala Chabala, Churchil Nyabinda, James M Njunge, Julius Nyaoke, Eric Ochola, Molly Timbwa, Narshion Ngao, Sofia Muyemayema, Louisa Mudawarima, Shepherd Mudzingwa, Mukumbi Mutenda, Lucia K Keter, Tracy Naomi Phiri, Evans Mudibo, Aaron Tembo, Chris Oduol, Isabella Cordani, Sekai Chaparira, Athel Kamuti, Dorothy Murungu, Grace Gerema, Lovemore Chingonda, Courage Chiorera, Brenda Chivare, Gladys Ushe, Winmore Chiroodza, Melody Magonde, Hazel Zifesho, Simbarashe Mukorera, Perpetual Ngalande, Mary Phiri, Andrew Chisanga, Susan Kawinga, Martha Chola, Salia Kanunga, Nasilele Namatama, Florence Zulu, Chambah Ilunga, Catherine Achieng Otieno, Phlona Anyango Amam, Charles Mutinda Nganga, Emmanuel Odhiambo, Eveline Okado, Mary Nyathi, Edward Chabu

“…Children start their intervention package prior to hospital discharge, with follow-up data collection in study clinics at 2, 4, 6, 8, 12 and 24 weeks. …”
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ROR1 CAR-T cells and ferroptosis inducers orchestrate tumor ferroptosis via PC-PUFA2 by Dan Li, Wenjie Zhang, Ruiheng Wang, Shufeng Xie, Yixin Wang, Wanxin Guo, Zixuan Huang, Chaoqun Lu, Liang Shan, Han Liu, Lifang Ma, Xumin Hou, Zhenshu Xu, Jiayi Wang

“…This study investigated the potential of combining receptor tyrosine kinase-like orphan receptor 1 (ROR1)-targeting CAR-T cells with ferroptosis inducers to promote ferroptosis of tumor cells and enhance anti-tumor efficacy. Methods RNA-seq data and immunofluorescence analysis of relapsed NSCLC patient samples were used to explore ROR1 expression. …”
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Transcranial direct current stimulation over the temporal-parietal junction yields no lexical-semantic effects in logopenic primary progressive aphasia: a double-blind sham-control... by Marc Teichmann, Clara Sanches, Angelina Bourbon, Dennis Q. Truong, Marom Bikson, Antoni Valero-Cabré

“…Transcranial direct current stimulation (tDCS) has generated some promising outcomes in primary progressive aphasia (PPA). …”
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Exercise Leads to Brain Glucose Metabolism Activation, Increased Dopamine D1 Receptor Levels and is Negatively Correlated with Social Behavior by Michael Bobick, Colin Hanna, John Tyler, Patrick Mohr, Huy Lu, Aidan Powell, Kenneth Blum, David Baron, Kai-Uwe Lewandrowski, Igor Elman, Albert Pinhasov, Mark S. Gold, Panayotis K. Thanos

“…Functional connectivity imaging data showed significant glucose metabolic activation within the cuneiform nucleus, which has been previously shown to be critical in defensive behavior. …”
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No tillage with plastic re-mulching enhances yield stability and maintains high water productivity of maize by improving water eco-physiology and root traits in northwest oasis reg... by Liping Wang, Wen Yin, Pan Li, Yao Guo, Lianhao Zhao, Pingxing Wan, Diankai Zhang, Zhilong Fan, Falong Hu, Wei He, Yunyou Nan, Qiang Chai, Baoqing Zhang, Heyu Chen, Mohamed Abdalla, Pete Smith

“…Plastic mulching is widely used in traditional maize production system, but its excessive application has led to diminishing returns in yield improvement and water productivity. …”
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Syntactic Analysis of Spatial Structure Characteristics of Traditional Villages Along the Yellow River in Western Shanxi Province by Chenge GAO, Fang WANG

“…Finally, the K-prototype mixed clustering analysis method is employed to iteratively analyze the data on the global and local, as well as the foreground and background spatial structures of the 33 traditional village samples. …”
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Cytokines as potential biomarkers for the diagnosis of Mycobacterium bovis infection in Mediterranean buffaloes (Bubalus bubalis) by Giulia Franzoni, Federica Signorelli, Piera Mazzone, Anna Donniacuo, Giovanna De Matteis, Francesco Grandoni, Lorena Schiavo, Susanna Zinellu, Silvia Dei Giudici, Javier Bezos, Javier Bezos, Esterina De Carlo, Giorgio Galiero, Francesco Napolitano, Alessandra Martucciello

“…Our data suggest that IL-10, TNF, IL-1α, IL-6, MIP-1β could be useful biomarkers of TB in Mediterranean Buffalo and can improve the TB diagnostic performance in this specie.…”
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Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccines by Lucia Grenga, Fabrice Gallais, Olivier Pible, Jean-Charles Gaillard, Duarte Gouveia, Hélène Batina, Niza Bazaline, Sylvie Ruat, Karen Culotta, Guylaine Miotello, Stéphanie Debroas, Marie-Anne Roncato, Gérard Steinmetz, Charlotte Foissard, Anne Desplan, Béatrice Alpha-Bazin, Christine Almunia, Fabienne Gas, Laurent Bellanger, Jean Armengaud

“…Here, we describe a shotgun tandem mass spectrometry workflow, the data produced can be used to guide optimization of the conditions for viral amplification. …”
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Diversity in the emergency care for febrile children in Europe: a questionnaire study by Enitan D Carrol, Michael Levin, Nienke N Hagedoorn, Henriette A Moll, Federico Martinón-Torres, Maria Tsolia, Dorine Borensztajn, Shunmay Yeung, Anda Balode, Ulrich von Both, Juan Emmanuel Dewez, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Ronald de Groot, Jethro Adam Herberg, Benno Kohlmaier, Emma Lim, Ruud Nijman, Marko Pokorn, Franc Strle, Gerald Wendelin, Dace Zavadska, Werner Zenz

“…There were differences in routine immunisations as well as in additional immunisations that were offered; immunisation rates varied between and within countries.Conclusion Differences in local, regional and national aspects of care exist in the management of febrile children across Europe. This variability has to be considered when trying to interpret differences in the use of diagnostic tools, antibiotics and admission rates. …”
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Effect of music intervention on dental anxiety and fear: A bibliometric analysis of RCTs from 2004 to 2024 by Yena Gan, Jinwei Huang, Sheng Han, He Xu, He Zhu, Duoduo Li, Zening Wei, Feng Sun, Zhigang Cai

“…Music intervention, a non-pharmacological approach, has shown promise in reducing anxiety and enhancing well-being, but further research is needed to explore its application in dental settings and the influence of factors like music type, duration, and volume. …”
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