Epidemiologia de 118 casos de esclerose múltipla com seguimento de 15 anos no centro de referência do Hospital da Restauração de Pernambuco Epidemiology of 118 cases of multiple sc... by Maria Lúcia Brito Ferreira, Maria Íris Moraes Machado, Maria Lúcia Vilela, Maria José Guedes, Luis Ataíde Jr, Silvana Santos, Sílvia Gomes Laurentino

“…<br>The prevalence of multiple sclerosis (MS) has a considerable variability all over the world. …”
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Systematic literature review of real-world evidence on overall survival in cancer patients before and after the approval of anti-PD-(L)1 therapy by Dweeti Nayak, Katherine G. Akers, Andrew M. Frederickson, Yves P.V. Mbous, Raquel Aguiar-Ibáñez

“…BackgroundThe development and regulatory approval of anti-programmed death (ligand) 1 (anti-PD-(L)1) agents, based on positive clinical trial results, has dramatically changed clinical practice and treatment paths in oncology. …”
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Investigating the Role of GDF-15 in Diabetes and Obesity: A Comprehensive Analysis of a Cohort from the KDEP Study by Jehad Abubaker, Mohamed Abu-Farha, Ahmed N. Albatineh, Irina Al-Khairi, Preethi Cherian, Hamad Ali, Ibrahim Taher, Fahad Alajmi, Mohammed Qaddoumi, Muhammad Abdul-Ghani, Fahd Al-Mulla

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Abstract 169: Antiplatelet regimens after pseudoaneurysm embolization with phosphorylcholine coated flow diverters: a series of 180 cases by Michael T. Bounajem, Anna Kuhn, Ahmed Abdelsalam, Gustavo Cortez, Rawad Abbas, Mubashir Pervez, Hamzah Saei, Shane Burke, Ameer Hassan, Adel Malek, Varun Naragum, Guilherme C. Dabus, Stavropoula Tjoumakaris, Pascal Jabbour, Ricardo A. Hanel, Robert M. Starke, Juan Vivanco Suarez, Santiago Ortega Gutierrez, Mudassir Farooqui, Mohamed Salem, Brian Jankowitz, Philipp Taussky, Craig Kilburg, Ajit S. Puri, Ramesh Grandhi

“…Introduction Indications for flow diversion for the treatment of cerebral aneurysms have increased remarkably in recent years.1 This has been particularly useful for aneurysms that are difficult to treat via endosaccular or open approaches, such as pseudoaneurysms.2 Flow diversion, however, typically requires dual antiplatelet therapy (DAPT), which can contribute to greater morbidity particularly in patients with ruptured aneurysms or other comorbidities.3 The third‐generation iteration of the Pipeline Embolization Device (PED) incorporates Shield technology, a phosphorylcholine coating designed to reduce thrombogenicity via mimicry of native cell membranes.4 In light of this reduced thrombogenicity, there have been reports of early transition to single antiplatelet therapy (SAPT), or other variations on DAPT, in patients treated with PED Shield. …”
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Vitamin D deficiency and diabetic retinopathy risk in patients with newly diagnosed type 2 diabetes mellitus: a retrospective analysis by Kuo-Chuan Hung, Kuo-Chuan Hung, Li-Chen Chang, Ying-Jen Chang, Ying-Jen Chang, Chun-Ning Ho, Chun-Ning Ho, Jheng-Yan Wu, Wei-Cheng Liu, Wei-Cheng Liu, I-Wen Chen

“…This study aimed to investigate the association between VDD at the time of type 2 diabetes mellitus (T2DM) diagnosis and subsequent risk of developing diabetic retinopathy (DR).MethodsThis retrospective cohort study used data from the TriNetX Research Network to analyze adult patients newly diagnosed with T2DM between January 2020 and December 2022. …”
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Mechanism of immune escape mediated by T cell depletion induced by TOX signaling pathway in cervical cancer microenvironment by LIU Dan, ZHANG Guxiang, XIE Dan, XU Yan, XIE Chengfang, TANG Yuxi

“…Background and purpose: Immune checkpoint blockade (ICB) has become a promising strategy for treating cervical cancer (CC), but terminal T cell depletion still limits the therapeutic efficacy of ICB. …”
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Spatiotemporal Dynamics and Simulation of Landscape Ecological Risk and Ecological Zoning Under the Construction of Free Trade Pilot Zones: A Case Study of Hainan Island, China by Yixi Ma, Mingjiang Mao, Zhuohong Xie, Shijie Mao, Yongshi Wang, Yuxin Chen, Jinming Xu, Tiedong Liu, Wenfeng Gong, Lingbing Wu

“…This study takes Hainan Island (HI), China, as a case study and utilizes multi-source data to quantitatively evaluate land use and land cover change (LULCC) and the evolution of the LER in the study area from 2015 to 2023. …”
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Effectiveness of community-based management models in chronic obstructive pulmonary disease: a systematic review and meta-analysis by Miao Zhan, Jing Chen, Hongying Zhang

“…Community-based management models have received attention because of their convenience, affordability, and accessibility; however, their effectiveness has not been comprehensively and systematically evaluated.MethodsThis study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) and comprehensively searched for randomized controlled trials (RCTs) in the China National Knowledge Infrastructure, Wangfang Data, VIP Database, SinoMed, Cochrane Library, PubMed, and Web of Science from the inception to 6 May 2025. …”
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Intención de volver a participar en un evento deportivo en el medio natural: prácticas verdes y cali-dad de resultado como antecedentes (Intention to re-participate in a natural en... by Karla Chaves-Castro, Guillermo Morán-Gámez, Román Nuviala, Antonio Fernández-Martínez

“…In recent years, the offer of sports services carried out in nature has increased, causing a great impact on the places where they are held. …”
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Influence of metabolism-related comorbidities and insulin resistance on new onset of chronic kidney disease in a health check-up population: a two-stage retrospective cohort study by Yang Zhang, Xin Shen, Guang Yang, Ying Ding, Jiahui Zhao, Qingli Cheng, Bokai Cheng, Yansong Zheng

“…Therefore, we aimed to investigate how IR, assessed via the estimated glucose disposal rate (eGDR), and metabolism-related comorbidities influence new-onset CKD.Research design and methods This two-stage retrospective cohort study (cross-sectional and longitudinal analyses) used data from health check-up participants at the Chinese People’s Liberation Army General Hospital (2009–2021). …”
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The associations among serum vitamin D concentration, systemic immune-inflammation index, and lifestyle factors in Chinese adults: a cross-sectional analysis by Feiin Chan, Chongsong Cui, You Peng, You Peng, You Peng, Zhenjie Liu, Zhenjie Liu, Zhenjie Liu, Zhenjie Liu

“…IntroductionVitamin D is a crucial lipid-soluble hormone that has been demonstrated to be closely associated with systemic chronic inflammation and various diseases, including metabolic disorders, cardiovascular conditions, autoimmune diseases, cancer, and aging. …”
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An Empirically Validated Framework for Automated and Personalized Residential Energy-Management Integrating Large Language Models and the Internet of Energy by Vinícius Pereira Gonçalves, Andre Luiz Marques Serrano, Gabriel Arquelau Pimenta Rodrigues, Matheus Noschang de Oliveira, Rodolfo Ipolito Meneguette, Guilherme Dantas Bispo, Maria Gabriela Mendonça Peixoto, Geraldo Pereira Rocha Filho

“…The growing global demand for energy has resulted in a demand for innovative strategies for residential energy management. …”
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The Influence of Zero‐Profile Implant Selection on the Outcomes of Anterior Cervical Discectomy and Fusion by Xing‐Jin Wang, Jun‐Bo He, Ting‐Kui Wu, Bei‐Yu Wang, Xin Rong, Quan Gong, Hao Liu

“…ABSTRACT Objectives Anterior cervical discectomy and fusion (ACDF) has been widely used in the treatment of cervical degenerative disc disease (CDDD). …”
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The global burden of chronic kidney disease attributable to high sodium intake: a comprehensive analysis of trends from 1990 to 2021 and burden prediction to 2040 by Yawen Lu, Lei Wang, Lei Wang, Jianfeng Ma, Yang Hu, Rumeng Zheng, Liping Liu, Kaili Lin, Kun Zhang, Yongfeng Wang, Yongfeng Wang, Yongfeng Wang, Yongfeng Wang, Yongfeng Wang, Sheng Li, Sheng Li, Hengping Li

“…Age-standardized mortality rates (ASMR) and DALY rates (ASDR), alongside the sociodemographic index (SDI), were used to assess regional and demographic variations. …”
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Perfil de fragilidad asociado a factores de riesgo cardiovascular de pacientes candidatos a cirugía cardíaca en un programa de prehabilitación by Juan Carlos Hurtado-Borrego, María Monteagudo-Santamaría, Ignacio Martínez-González-Moro, Carmen María Martínez-Bermúdez

“…Clinical interviews were conducted with each participant, obtaining demographic, health and functional capacity data through the handgrip strength test, timed up and go test, chair stand test and the measurement of maximum inspiratory pressure. …”
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Centrifugation versus filtration-based cell salvage: impact on perioperative bleeding in cardiac surgery—the COLTRANE randomised clinical trial – study protocol by Christine Mouton, Nicolas Nesseler, Antoine Bénard, Mathieu Pernot, Alexandre Ouattara, Antoine Beurton, Alexandre Mansour, Victor-emmanuel Brett, Corinne Batsale, Anais Aitgougam, Anais Cordon, Aurelie Fresselinat, Geraldine Robert, Julien Imbault

“…Individual participant data will be made available on reasonable request to qualified researchers, following review and approval by the study sponsor and ethics committee.Trial registration number ClinicalTrials.gov, NCT06425614.…”
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Tectonic transition and extension at the eastern and western ends of the Altyn Tagh fault: insights from triple junctions by YI Kexin, JOLIVET Marc, GUO Zhaojie

“…Methods  Triple junction analysis, a fundamental method in plate tectonics, is utilized to assess fault properties and fault stability from a kinematic perspective. Additionally, GPS data and seismic source mechanism solutions are analyzed to characterize the current kinematic behaviors and movement directions of the faults.   …”
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The Therapeutic Effect of Combination of Orbital Decompression Surgery and Methylprednisolone Pulse Therapy on Patients with Bilateral Dysthyroid Optic Neuropathy by Jianan Xu, Huijing Ye, Guo Chen, Jingqiao Chen, Rongxin Chen, Huasheng Yang

“…Paired t-test and Wilcoxon matched-pairs signed ranks sum test were used to analyze the data. Result. A prospective cohort of 23 patients with bilateral DON was enrolled in this cohort study. …”
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Targeted therapy for advanced forms of systemic mastocytosis in real clinical practice by D. I. Shikhbabaeva, O. Yu. Vinogradova, A. L. Neverova, M. M. Pankrashkina, M. V. Chernikov, E. O. Detkina, Yu. N. Kobzev, S. G. Malakho, V. V. Ptushkin

“…Midostaurin is a potent                    multikinase inhibitor that is active against KIT regardless of mutation status. Midostaurin has shown its effectiveness in clinical trials, however, we know that data from real clinical practice often differ from clinical studies due to the characteristics of patients (preserved comorbid status, stable disease parameters) traditionally included in clinical trials.Aim. …”
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The Functional Role and Prognostic Significance of TIM-3 Expression on NK Cells in the Diagnostic Bone Marrows in Acute Myeloid Leukemia by Kai Sun, Zong-Yan Shi, Dai-Hong Xie, Ya-Zhe Wang, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin

“…<b>Methods:</b> AML public single-cell RNA sequencing (scRNAseq) data were used to analyze the correlation of transcript levels between <i>HAVCR2</i> (encoding TIM-3) and cytotoxic molecules in NK cells. …”
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