Real-world waitlist randomised controlled trial of gameChange VR to treat severe agoraphobic avoidance in patients with psychosis: a study protocol by Daniel Freeman, Ly-Mee Yu, Thomas Kabir, José Leal, Sinéad Lambe, Anthony Morrison, Kate Chapman, Aitor Rovira, Felicity Waite, Julia Jones, Emma Cousins, John Sainsbury, Natalie Rouse, Eloise Prouten, Victoria Altoft, Heather Peel, Jack Myrick

“…The target estimand is the treatment policy estimand and all primary and secondary analyses will be carried out incorporating data from all participants including those who do not complete treatment.Ethics and dissemination The trial has received ethical approval from the NHS Health Research Authority and Health and Care Research Wales (25/WA/0081). …”
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Impact of a Heating Voucher on Health Outcomes in COPD Patients: A Randomised Controlled Trial by Viggers HE, Ingham TR, Chapman RB, Crane J, Currie AB, Davies C, Keall M, Howden-Chapman PL

“…Of the 520 participants assigned to a wave, partial or better data was achieved for 424; 215 of those were randomised to the early intervention group, and 209 to receive the intervention later.Results: Despite the modest increase in energy use by study households, reported previously, there was no significant difference between study arms in the frequency of exacerbation of COPD (0.089, p=0.5875, 95% CI − 1.406– 1.584) nor hospitalisations. …”
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Long-term efficacy and safety of netakimab in the treatment of ankylosing spondylitis: results of Phase III international, multicenter, randomized double-blind clinical trial BCD-0... by V. I. Mazurov, Sh. F. Erdes, I. Z. Gaydukova, T. V. Dubinina, A. M. Pristrom, E. V. Kunder, N. F. Soroka, A. A. Kastanayan, T. V. Povarova, E. S. Zhugrova, T. V. Plaksina, P. A. Shesternya, T. V. Kropotina, O. V. Antipova, E. A. Smolyarchuk, O. A. Tsyupa, D. I. Abdulganieva, S. A. Lapshina, D. G. Krechikova, I. G. Gordeev, O. B. Nesmeyanova, E. P. Ilivanova, A. V. Strelkova, A. V. Eremeeva, A. V. Zinkina-Orikhan

“…The paper gives the data obtained during 52-week follow-up of AS patients in the phase III ASTERA study.Objective: to study the efficacy and safety of NTK when used long in patients with active AS.Patients and methods. …”
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Calibration and Verification of the AquaCrop Model in Simulating the Yield, Dry Matter and Water Productivity of Grain Corn (Zea mays L.) under Different Irrigation Methods and Nit... by zhaleh zarei, Hassan Heidari, Saeid Jalali Honarmand, Ali Bafkar

“…At the end of the experiment, the data measured in the first and second years were used for calibration and validation, respectively. …”
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Comparative clinical and economic analysis of pozaconazol (Noxafil) for invasive mycoses (IM) prevention in patients with severe neutropenia during treatment of acute myeloid leuke... by I. S. Krysanov, N. N. Klimko, V. Yu. Ermakova, V. S. Krysanova

“…A model was constructed that takes into account the use of various mediactions: posaconazole, voriconazole and fluconazole. …”
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Exploring Bacillus velezensis in a biomedical context: a systematic review by Eduarda Guimarães Sousa, Gabriela Munis Campos, Ludmila Silva Quaresma, Thaís Fernandes Mendonça Mota, Nédia de Castilhos Ghisi, Gabriel Camargos Gomes, Rhayane Cristina Viegas Santos, Beatriz Gamarano Rocha de Souza, Éric Guédon, Siomar de Castro Soares, Joyce da Cruz Ferraz Dutra, Vasco Ariston de Carvalho Azevedo

“…A total of 1585 records were identified after the screening process. Of these, 151 were used for scientometric analysis, and 13 were used for data analysis based on in vitro and in vivo studies. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Analysis was inductive using thematic analysis of transcribed interview data. …”
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Real-world study of efficacy and safety of PD-1 antibody monotherapy and combination therapy in pediatric lymphoma patients by Yingxia Lan, Zizheng Xiao, Yi Que, Yi Wang, Ye Hong, Juan Wang, Suying Lu, Junting Huang, Feifei Sun, Zijun Zhen, Juan Liu, Jiaqian Xu, Yanpeng Wu, Lanying Guo, M. James You, Jia Zhu, Yizhuo Zhang

“…Abstract Purpose Pediatric lymphoma patients generally demonstrate a favorable long-term survival rate. The use of anti-programmed death-1 (PD-1) monoclonal antibodies has significantly improved the response rates in adult patients with refractory/relapsed lymphoma, particularly those with Hodgkin lymphoma and NK/T cell lymphoma. …”
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European standard clinical practice recommendations for paediatric high-grade gliomas by Elwira Szychot, Géraldine Giraud, Darren Hargrave, Dannis van Vuurden, Jacques Grill, Veronica Biassoni, Maura Massimino, André O. von Bueren, Rejin Kebudi, Maria João Gil-da-Costa, Sophie Veldhuijzen van Zanten, Simon Bailey, Michael Karremann, Stephanie Bolle, Thankamma Ajithkumar, Mechthild Krause, Yasmin Lassen-Ramshad, Geert Janssens, Giovanni Morana, Ulrike Löbel, Shivaram Avula, Brigitte Bison, Maarten Lequin, Kristian Aquilina, Ulrich Thomale, Pelle Nilsson, Sami Bui-Quy Abu Hamdeh, Torsten Pietsch, Pascale Varlet, Thomas S. Jacques, Pieter Wesseling, David Jones, Uri Tabori, Anirban Das, David Mulligan, Francesca Kozmann, Christof M. Kramm

“…Much of the evidence for the use of chemotherapy in pedHGGs is extrapolated from adult data, and the evidence for its use in the paediatric population is still weak. …”
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Polar Ocean Mixing by Internal Tsunamis (POLOMINTS) by Michael Meredith, Katharine Hendry, E. Povl Abrahamsen, J. Alexander Brearley, Emma Young, David Munday, Hugh Venables, Anna Hogg, Benjamin Wallis, Katrien Van Landeghem, Filipa Carvalho, Andrew Yool, Amber Annett, Alberto Naveira Garabato, Mark Inall, Katy Sheen, Andrew Fleming, Estelle Dumont, Oskar Głowacki, Carlos Moffat, Neil Fraser, Sarah Gille, Matthew Alford, Rebecca Jackson, Katherine Retallick

“…There is a pressing need to include the effects of underwater tsunamis in the computer models that are used for projecting future ocean climate and ecosystem conditions and to determine the feedbacks between climate change and the generation of more underwater tsunamis.To answer these questions, our project will deploy innovative techniques for measuring the ocean and ice in close proximity to a calving glacier, including robotic underwater vehicles and remotely-piloted aircraft, and cutting-edge deep-learning techniques applied to satellite data. …”
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Optimization of Inspired Oxygen during Mechanical Ventilation (OPTI-OXYGEN): rationale and design of a pragmatic randomised controlled trial by Taylor B Thompson, Todd W Rice, Guy N Brock, Jonathan Peters, Elliott D Crouser, Matthew Exline, Sonal R Pannu, Jamie Zimmer, Jeffrey C Horowitz

“…Peripheral oxygen saturation (SpO2) is a practical metric that commonly drives oxygen titration protocols and guidelines but has inaccuracies attributable to patient variability that can lead to occult hypoxaemia. …”
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Carcinogenic and non-carcinogenic hazards associated with trace elements and organochlorines from fish consumption in tropical river watershed by D. Dwiyitno, F. Ariyani, G.R. Barokah, D. Yogaswara, R. Grandiosa, E. Frimawaty, H.E. Irianto, Y. Sani

“…The concentrations of selected trace elements and organochlorines in fish species from Citarum Watershed were obtained from fish farms in 3 reservoirs (Saguling, Cirata, and Jatiluhur). Data on food consumption used to estimate the contaminant exposure were obtained from individual food consumption surveys of the National Total Diet Study conducted by the Ministry of Health. …”
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Digital Therapeutics–Based Cardio-Oncology Rehabilitation for Lung Cancer Survivors: Randomized Controlled Trial by Guangqi Li, Xueyan Zhou, Junyue Deng, Jiao Wang, Ping Ai, Jingyuan Zeng, Xuelei Ma, Hu Liao

“…Home-based cardiac telerehabilitation through wearable devices and mobile apps is a substitution for traditional, center-based rehabilitation with equal efficacy and a higher completion rate. However, it has not been widely used in clinical practice. …”
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Diversity and distribution of nitrifying bacteria play an important role in the nitrogen cycle in mangrove sediments by A. Mubaraq, M. Sembiring, E. Widiastuti, E. Fachrial, B. Utomo, M. Turjaman, F. Sidik, Y.I. Ulumuddin, V.B. Arifanti, E.S. Siregar, T. Kajita, S. Proches, M. Basyuni

“…The Preferred Reporting Items for Systematic Reviews and Meta-Analyses method is used as a guide to help report reviews systematically and has a flow chart to show the process of selecting relevant studies. …”
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Ensuring the unity of the federal system of scientific and methodological support for teacher professional development: Opportunities and risks by A. V. Zolotareva, L. V. Bayborodova, M. V. Gruzdev, I. G. Kharisova

“…To collect empirical research data, questionnaires were used. The questionnaires were developed on the basis of a comparative analysis of regulatory and legal documents defining the conceptual foundations for the construction of the unified federal system of scientific and methodological support, as well as an analysis of problems and trends in the continuing teacher training. …”
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Global burden of prostate cancer: age-period-cohort analysis from 1990 to 2021 and projections until 2040 by Feifan Chu, Lumin Chen, Qing Guan, Zujie Chen, Qiwei Ji, Yuning Ma, Jinzhong Ji, Mingxin Sun, Tingyang Huang, Haihan Song, Hao Zhou, Xiuquan Lin, Yichun Zheng

“…Abstract Background Prostate cancer (PCa) is the second most common cancer among men worldwide. This study uses data from the 2021 Global Burden of Disease (GBD) study to estimate the global burden of prostate cancer from 1990 to 2021. …”
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CPAP management of COVID-19 respiratory failure: a first quantitative analysis from an inpatient service evaluation by Abdul Ashish, Alison Unsworth, Jane Martindale, Kanishka Kavuri, Luigi Sedda, Martin Farrier

“…The predictors were age, intubation, hypertension and the residency from care homes, which were found to be statistically significantly associated with patient’s death/discharge.Conclusions CPAP is a simple and cost-effective intervention. It has been established for care of other respiratory disorders but not for COVID-19 respiratory failure. …”
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Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degeneration by Maoqiang Lin, Maoqiang Lin, Shaolong Li, Yabin Wang, Yabin Wang, Guan Zheng, Guan Zheng, Fukang Hu, Fukang Hu, Qiang Zhang, Qiang Zhang, Pengjie Song, Haiyu Zhou, Haiyu Zhou

“…Subsequently, four machine learning algorithms (SVM-RFE, Random Forest, XGB, and GLM) were used to select the method to construct the diagnostic model. …”
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Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-di... by Rui Wang, Jessie P. Bakker, Ronald D. Chervin, Susan L. Garetz, Fauziya Hassan, Stacey L. Ishman, Ron B. Mitchell, Michael G. Morrical, Syed K. Naqvi, Jerilynn Radcliffe, Emily I. Riggan, Carol L. Rosen, Kristie Ross, Michael Rueschman, Ignacio E. Tapia, H. Gerry Taylor, David A. Zopf

“…The results will be published in peer-reviewed journals and presented at academic conferences. The data collected from the PATS study will be deposited in a repository (National Sleep Research Resource, sleepdata.org) after completion of the study to maximise use by the scientific community.Trial registration number NCT02562040; Pre-results.…”
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Chronic lymphocytic leukemia often arises by a multiclonal selection process by Davide Bagnara, Andrea N Mazzarello, Niccolò Cardente, Stefano Vergani, Siddha Kasar, Stacey Fernandes, Gerardo Ferrer, Fabio Ghiotto, Jacqueline C Barrientos, Jonathan E Kolitz, Kanti R Rai, Steven L Alen, Monica Colombo, Franco Fais, Jennifer R Brown, Manlio Ferrarini, Nicholas Chiorazzi

“…Notably, the numbers of ADC documented in these studies has increased as the various technologies evolved. …”
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