Investigating the Mechanism of IFN‐γ‐Inducible Lysosomal Thiol Reductase‐Mediated Inhibition of Breast Cancer Cell Proliferation by Qin Liu, Xiaoning Yuan, Youcheng Shao, Xiaoqing Guan, Kaixiang Feng, Mengfei Chu, Le Chen, Hui Li, Hanhui Liu, Jingwei Zhang, Yihao Tian, Lei Wei

“…Abstract Background Breast cancer has become a severe threat to human health, making it imperative to identify effective drugs and therapeutic targets. …”
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Simulating the effects of drip and flood irrigation on the leaching, migration, and redistribution of heavy metals in contaminated soil by Muyesaier Tudi, Linsheng Yang, Li Wang, Binggan Wei, Lijuan Gu, Jiangping Yu, Hairong Li, Yuan Xue, Fang Wang, Linfeng Li, Qiming Jimmy Yu, Huada Daniel Ruan, Des Connell

“…The correlation tests and one-way analysis of variance were used for data analysis. Results: Compared to flood irrigation, drip irrigation resulted in higher leaching; as high as twice of heavy metal redistribution across soil columns. …”
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A hybrid model for refining gross primary productivity estimation by integrating multiple environmental factors by Zhilong Li, Ziti Jiao, Zheyou Tan, Chenxia Wang, Jing Guo, Sizhe Chen, Ge Gao, Fangwen Yang, Xin Dong

“…In contrast, machine learning has the natural potential to detect intricate patterns and relationships among various environmental variables. …”
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COVID-19 Exacerbates Neurovascular Uncoupling and Contributes to Endothelial Dysfunction in Patients with Mild Cognitive Impairment by Cameron D. Owens, Camila B. Pinto, Zsofia Szarvas, Mihaly Muranyi, Ana Clara da C. Pinaffi-Langley, Anna Peterfi, Peter Mukli, Sam Detwiler, Lauren Olay, Zalan Kaposzta, Kenneth Smith, Angelia C. Kirkpatrick, Faddi Saleh Velez, Stefano Tarantini, Anna Csiszar, Zoltan I. Ungvari, Calin I. Prodan, Andriy Yabluchanskiy

“…The effect of COVID-19 on NVC responses has yet to be addressed in older adults who are vulnerable to dementia progression. …”
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The effects of perfluoroalkyl substance pollution on microbial community and key metabolic pathways in the Pearl River Estuary by Wei Lin, Junlin Zhao, Xingqi Wu, Jiakun Jiang, Chunyang Zhou, Jiating Zheng, Cheng Zhang, Ying Guo, Li Wang, How Yong Ng, Song Li, Shengrui Wang

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Developmental regulators in promoting genetic transformation efficiency in maize and other plants by Yilin Jiang, Xun Wei, Meirui Zhu, Xiaoyan Zhang, Qingping Jiang, ZiXiao Wang, Yanyong Cao, Xueli An, Xiangyuan Wan

“…In this study, we conducted an in-depth analysis of 1669 literary works to investigate the potential of developmental regulators (DRs) in enhancing the efficiency of plant genetic transformation, with a concentration on their use in maize. Through multi-omics data analysis, we identified 12 homologous DRs from various species that are potentially applicable to maize. …”
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Trends and differences in the rates of autopsy in the United States, 2003 to 2020: A nationwide analysis by Dean M. Nelson, BBiomed, MD, Stephanie J. Rowe, BBiomed, MD, Adam Trytell, MBBS (Hons), Louise Fahy, MB BCh, BAO, Kelila Freedman, MSc, Andreas Pflaumer, MD, FHRS, Dion Stub, MBBS, PhD, Andre La Gerche, MBBS, PhD, Elizabeth D. Paratz, MBBS, PhD

“…Linear regression was used to assess trends over time, with a significant coefficient considered evidence of temporal trend. …”
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Incidence, mortality, and DALYs of global pharyngeal cancer: systematic analysis and projections Based on global burden of disease study 2021 by Tianjiao Zhou, Ying Shen, Enhui Zhou, Jingyu Zhang, Xiaoting Wang, Fan Song, Lili Xiao, Chen Xu, Wen Lu, Haibo Ye, Kaiming Su, Hongliang Yi, Weijun Huang

“…Introduction Compared to other head and neck cancers, pharyngeal cancer (PC) has poorer survival, representing a significant health burden. …”
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IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors by Jessica Wagner, Stephen Gottschalk, Giedre Krenciute, Jinghui Zhang, Shannon Lange, Jason Chiang, Liqing Tian, Deanna Langfitt, Peter Vogel, Heather Sheppard, Timothy I Shaw, Jorge Ibanez, Selene C Koo, Elizabeth Wickman, Meifen Lu, Matthew Bell, S Scott Perry, Raghuvaran Shanmugam

“…Background Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted with T cells expressing chimeric antigen receptors (CARs).Methods To determine the expression of the oncofetal version of tenascin C (TNC) encoding the C domain (C.TNC) in pediatric brain and solid tumors, we used quantitative reverse transcription PCR and immunohistochemistry. …”
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Higher vs. Lower DP for Ventilated Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis by Zhen Chen, Xuxia Wei, Genglong Liu, Qiang Tai, Donghua Zheng, Wenfeng Xie, Li Chen, Ganping Wang, Jia-Qi Sun, Siqi Wang, Na Liu, Haijin Lv, Liuer Zuo

“…Objectives. Driving pressure (DP) has recently become a promising mediator for the identification of the effects of mechanical ventilation on outcomes in acute respiratory distress syndrome (ARDS). …”
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A model for the cognitive assessment of physicians by Victor A. Del Bene, Victor A. Del Bene, George Howard, David S. Geldmacher, Elizabeth Turnipseed, Catherine Brown, Catherine Brown, Kathleen Lowry, Trevor Starling, Kate Bryan, T. Charles Fry, Keith A. Jones, Keith A. Jones, Keith A. Jones, Ronald M. Lazar, Ronald M. Lazar

“…IntroductionWith aging in the larger population and physician workforce, there has been growing emphasis on physician cognitive impairment. …”
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2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness by Robyn Ralph, Jocelyne Lew, Tiansheng Zeng, Magie Francis, Bei Xue, Melissa Roux, Ali Toloue Ostadgavahi, Salvatore Rubino, Nicholas J Dawe, Mohammed N Al-Ahdal, David J Kelvin, Christopher D Richardson, Jason Kindrachuk, Darryl Falzarano, Alyson Anne Kelvin

“…We offer a research perspective on the next steps for the generation of vaccines. We also present data on the use of in silico docking in gaining insight into 2019-nCoV Spike-receptor binding to aid in therapeutic development. …”
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EBV AND HHV-6 CIRCULATING SUBTYPES IN PEOPLE LIVING WITH HIV IN BURKINA FASO, IMPACT ON CD4 T CELL COUNT AND HIV VIRAL LOAD by Lassina TRAORE, Ouéogo NIKIEMA, Abdoul Karim OUATTARA, Tegwindé Rébéca COMPAORE, Serge Théophile SOUBEIGA, Birama DIARRA, Dorcas OBIRI-YEBOAH, Pegdwendé Abel SORGHO, Florencia Wendkuuni DJIGMA, Cyrille BISSEYE, Albert Théophane YONLI, Jacques SIMPORE

“…Epstein Barr Virus (EBV) and Human Herpes Virus 6 (HHV-6) are responsible for severe diseases, particularly in immunocompromised persons. There are poor data on the infection with these opportunistic viruses in Burkina Faso. …”
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Dépôts et pratiques symboliques dans l’établissement aristocratique gaulois de Varennes-sur-Seine, la Justice (Seine-et-Marne) by Jean-Marc Séguier, Ginette Auxiette, Fabien Pilon

“…Their analysis is therefore dependent on their contextualization and an archaeological reading of the data, allowing for the reconstruction of singular, possibly repetitive, gestures. …”
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Effect of Zhan Zhuang Qigong on upper limb static tremor and aerobic exercise capacity in patients with mild-to-moderate Parkinson’s disease: study protocol for a randomised contro... by Hang Su, Xiaoyu Jiang, Limin Wang, Linlin Zhang, Qing Wang, Xihua Liu, Xiaoming Xi, Yuxiao Chen, Xinjie Qu, Haihao Cao, Wenyu Sun, Guoming Chen, Huifen Liu, Jiahui Jiang, Hongyan Bi

“…The Committee will be informed of any changes to the trial protocol, such as intervention intensity, outcome indicators and data collection. Study results will be presented as a paper at an international conference or in a journal.Trial registration number ChiCTR2100053529.…”
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Trends and advances in Leptospira, a bibliometric analysis by Wei Wang, Wei Wang, Wei Wang, Yamin Gao, Yamin Gao, Yamin Gao, Jianyu Ji, Jianyu Ji, Jianyu Ji, Zhai Huang, Zhai Huang, Bin Xiong, Bin Xiong, Shulin Xiang, Shulin Xiang

“…This study applies bibliometric analysis to generate a visual knowledge map, identifying research hotspots and forecasting future trends in leptospirosis investigations.MethodsData were extracted from the Web of Science Core Collection (WOSCC), encompassing all publications up to May 1, 2024. …”
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Anemia during pregnancy and adverse pregnancy outcomes: a systematic review and meta-analysis of cohort studies by Rui Wang, Shan Xu, Xiaoyu Hao, Xingyi Jin, Da Pan, Hui Xia, Wang Liao, Ligang Yang, Shaokang Wang, Shaokang Wang

“…Two researcher-authors independently assessed study quality with the Newcastle-Ottawa Scale. After extracting data, we analyzed heterogeneity and used a random-effects model for higher heterogeneity and a fixed-effects model for low heterogeneity in the meta-analysis while also systematically synthesizing and narratively describing findings in the systematic review.ResultsA total of 31 cohort studies were included. …”
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Surgical Capacity Assessment and Leverage in the Palestinian Land (SCALPEL-I) Study: The First Nationwide Plastic Surgery Capacity Evaluation in Palestine by Osaid Alser, MD, MSc(Oxon), Laith Ayasa, MD, Mohammed Alhabil, MD, Shahd Idais, MD, Ayah Almzayyen, MD, Majdeddin MohammedAli, MD, Reem Younes, MD, Heba Alghoul, MD, Muath Alser, MD, Bryce Stash, MD, Roba Khundkar, MD, Timothy Goodacre, MD, Amanda Gosman, MD, Andrea Pusic, MD, Deepak Bharadia, MD

“…A modified PIPES (personnel, infrastructure, procedures, equipment, and supplies) tool was used. Data were analyzed for geographic and private/public disparities. …”
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Metabolomic and transcriptomic analyses reveal MYB-Related genes involved in drought resistance in grafted potatoes via the flavonoid pathway by Yinqiao Jian, Chunyan Gao, Yangyang Shang, Junhong Qin, Shaoguang Duan, Chunsong Bian, Guangcun Li

“…Grafting, a classical horticultural technique, has the potential to enhance resistance to both biotic and abiotic stresses. …”
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Machine learning-guided field site selection for river classification by Zhihao Wang, Gregory Brian Pasternack, Yufang Jin, Costanza Rampini, Serena Alexander, Nikhil Kumar, Rune Storesund, K. Martin Perales, Christopher Lim, Stephanie Moreno, Igor Lacan

“…This leads to an inadequate exploration of stream characteristics, resulting in incomplete or inaccurate classification. Machine learning has been recognized for discovering and extracting streams’ geomorphic patterns efficiently and accurately from data, but its application in field site sampling design is still in its infancy. …”
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