The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout by Zeng Zhang, Zeng Zhang, Zeng Zhang, Zeng Zhang, Peng Wang, Peng Wang, Tianyi Lei, Tianyi Lei, Jianwei Guo, Jianwei Guo, Yi Jiang, Yi Jiang, Yanhui Li, Yanhui Li, Jianxiong Zheng, Jianxiong Zheng, Shunbing Wang, Shunbing Wang, Haimuzi Xu, Haimuzi Xu, Guilin Jian, Guilin Jian, Quanbo Zhang, Quanbo Zhang, Quanbo Zhang, Yufeng Qing, Yufeng Qing, Yufeng Qing

“…BackgroundInterleukin-6 (IL-6) is a pleiotropic cytokine, with specific effects depending on the immune microenvironment. Extensive research has confirmed the pathological roles of the IL-6/JAK2/STAT1/3 signaling pathway in inflammation, autoimmunity, and cancer, as well as its involvement in the pathogenesis of various rheumatic diseases. …”
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An Empirical Analysis of Herding Behavior in the Stock Market: Evidence from Various Economic and Social Conditions in Iran by Majid Aghaei

“…This study utilizes behavioral finance theories and analyzes data related to TSE to investigate investor behavior through the lens of herding behavior. …”
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The effect of nostalgia on the travel decisions of older tourists to visit socially sustainable tourist destinations by Ian Patterson, Adela Balderas-Cejudo

“…Design/methodology/approach – This paper is a conceptual paper and uses a systematic literature review as the main method of secondary data analysis. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xxv] The literature has no consensus on defining vulnerability in the clinical or research setting.…”
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Integral Assessment of the Development Level of Electronic Business in the Regions of the Volga Federal District by M. V. Bikeeva, K. V. Belash

“…The research was based on the data of the Federal State Statistics Service for 2018 for the regions of the Volga federal district, and the results of monitoring the development of the information society in the Russian Federation. …”
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Life cycle assessment of polyethylene packaging and alternatives on the European market by Manfred Tacker, Tasja Hafner-Kuhn, Andrin Gstöhl, Experience Nduagu, Eric Vozzola, Timothee W. Roux, Rafael Auras

“…EoL modeling followed the Circular Footprint Formula, incorporating standard disposal rates. Comparative analysis used published data on packaging and PE markets to model potential scenarios, demonstrating the life cycle GWP impacts of substituting PE-based packaging with alternatives. …”
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Association between relative fat mass and risk of gallstones in adults by Jianjun Wang, Wei He, Ruizi Shi, Yu Huang, Chuan Qin, Xi Chen, Xintao Zeng, Yongwei Huang, Decai Wang

“…Data from the National Health and Nutrition Examination Survey (2017–2020) were used. …”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…Moreover, through using population health and resource data, public health organizations may forecast contingency shortages allowing for the adoption of early measures to mitigate health disparities that might otherwise be amplified from hospital-level contingency allocation decisions. …”
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Identifying barriers and potential solutions to improve equitable access to community eye services: an exploratory sequential mixed methods study protocol by Min Kim, David Macleod, Michael Gichangi, Andrew Bastawrous, Matthew J Burton, Jacqueline Ramke, Oathokwa Nkomazana, Sailesh Mishra, Shalinder Sabherwal, Luke Nelson Allen, Abhishek Roshan, Sarah Karanja, Ari Ho-Foster, Keneilwe Motlhatlhedi, Nigel Bolster, Mohd Javed, Malebogo Tlhajoane, Bakgaki Ratshaa, John Tlhakanelo

“…We will explore their perceptions of barriers and potential service modifications that could boost attendance at eye clinics among people from these ‘left-behind’ groups. We will use a deductive analytic matrix to facilitate the rapid analysis of qualitative data. …”
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Extended Reality (XR) in Pediatric Acute and Chronic Pain: Systematic Review and Evidence Gap Map by Courtney W Hess, Brittany N Rosenbloom, Giulia Mesaroli, Cristal Lopez, Nhat Ngo, Estreya Cohen, Carley Ouellette, Jeffrey I Gold, Deirdre Logan, Laura E Simons, Jennifer N Stinson

“… BackgroundThe use of extended reality (XR), including virtual reality (VR) and augmented reality (AR), for treating pain has accelerated in the last 10 years. …”
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Implementing the Family Talk Intervention among families with a severely ill parent or child with palliative care needs- a longitudinal study of the perspectives of hospital social... by Ingrid Thermaenius, Maja Holm, Maja Holm, Kristofer Årestedt, Camilla Udo, Anette Alvariza, Anette Alvariza, Tina Lundberg, Tina Lundberg, Lars Wallin, Malin Lövgren, Malin Lövgren

“…For the longitudinal analysis of data, Friedman's test was used.ResultsThe HSWs rated the use of FTI high after completing the FTI-education, indicating a positive attitude towards FTI. …”
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Association between triglyceride-glucose index in early pregnancy and risk of preeclampsia: a multicenter retrospective cohort study by Qiong Li, Chenyang Zhao, Miao Liu, Meng Li, Ying Zhang, Chaoyan Yue

“…Abstract Background Previous evidence has indicated that insulin resistance may be an early pathological state of preeclampsia (PE). …”
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Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK) by Daniil Shimonov, Sri Lekha Tummalapalli, Stephanie Donahue, Vidya Narayana, Sylvia Wu, Lisa S. Walters, Roberta Billman, Barbara Desiderio, Sandra Pressman, Oliver Fielding, Kariel Sweeney, Daniel Cukor, Daniel M. Levine, Thomas S. Parker, Vesh Srivatana, Jeffrey Silberzweig, Frank Liu, Andrew Bohmart

“…Introduction: Multidisciplinary care (MDC) for late-stage chronic kidney disease (CKD) has been associated with improved patient outcomes compared with traditional nephrology care; however, the optimal MDC model is unknown. …”
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The biophysical and crop yield effects of irrigation and their changes in China’s drylands by Shuangshuang Zi, Yan Li, Jingwen Zhang, Chengcheng Hou, Huiqing Lin, Zhengjie Xu, Shan Sang, Jinwei Dong, Bojie Fu

“…Here, we used satellite remote sensing data and statistical models to quantify the biophysical effects of irrigation on land surface temperature (LST), evapotranspiration (ET), crop greenness, and crop yield effects and their spatiotemporal changes in China’s drylands. …”
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Tuberculosis/HIV co-infection in Northeastern Brazil: Prevalence trends, spatial distribution, and associated factors by Livia Fernanda Siqueira Santos, Paulo Henrique Vilarino Carneiro, Maria Aparecida Alves de Oliveira Serra, Leonardo Hunaldo dos Santos, Hamilton Leandro Pinto de Andrade, Livia Maia Pascoal, Ana Cristina Pereira de Jesus Costa, Floriacy Stabnow Santos, Giana Gislanne da Silva de Sousa, Iolanda Graepp Fontoura, Jaisane Santos Melo Lobato, Cláudia Regina de Andrade Arrais Rosa, Laise Sousa Siqueira, Ricardo Alexandre Arcêncio, Mellina Yamamura, Marcelino Santos Neto

“…Prais-Winsten regressions were used for temporal variation analysis, scanning techniques were used to detect spatial clusters, and the Poisson regression model was used to explore the factors associated with the outcome. …”
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Alimentation et gestion de l’eau sur la colline de Fourvière à Lyon : les aménagements hydrauliques, la ville et ses monuments by Aldo Borlenghi, Éric Leroy

“…The extensive confusion between cisterns and reservoirs in the older and recent scientific literature has forced us to include as many criteria as possible in seeking to provide more reliable interpretations of these structures. …”
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Gamma-glutamyl transpeptidase is a promising biological marker of heart failure by A. M. Alieva, I. E.  Baykova, K.  V. Voronkova, N. V. Teplova, L.  M.  Shnakhova, R.  K.  Valiev, D. A. Elmurzaeva, A. M. Rakhaev, M. R.  Kalova, I.  G. Nikitin

“…In the review, we have presented data from experimental and clinical studies indicating a clear link between γ-glutamyl transpeptidase and heart failure. …”
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Plasmodium falciparum and Schistosoma mansoni coinfections among the general population in Ethiopia: a systematic review and meta-analysis by Abebaw Setegn, Gashaw Azanaw Amare, Wagaw Abebe, Wassie Alemayehu Damtie, Gebremariam Wulie Geremew, Abaynesh Fentahun Bekalu, Tekletsadik Tekleslassie Alemayehu, Fentahun Megabiaw, Yenesew Mihret Wondmagegn, Zufan Yiheyis Abriham, Yilkal Abebaw Wassie, Getasew Kibralew, Getu Girmay, Muluneh Assefa, Berihun Agegn Mengistie

“…Stata software version 11 was used for analysis after Microsoft Excel was used to extract the data. …”
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Plant Growth-Promoting Rhizobacteria (PGPR) Reduce Adverse Effects of Salinity and Drought Stresses by Regulating Nutritional Profile of Barley by Sania Zaib, Akmal Zubair, Safdar Abbas, Javed Hussain, Ishaq Ahmad, Samina N. Shakeel

“…With the growing emphasis on sustainable agriculture, food security, and environmental protection, the use of beneficial soil microbes is imperative, as the use of chemicals such as fertilizers, pesticides, and herbicides has resulted in food contamination, disease, weed resistance, and negative environmental consequences, which ultimately impacted human health. …”
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Research on Soybean Seedling Stage Recognition Based on Swin Transformer by Kai Ma, Jinkai Qiu, Ye Kang, Liqiang Qi, Wei Zhang, Song Wang, Xiuying Xu

“…A transfer learning-based Swin-T (Swin Transformer) network is proposed to recognize different stages of the soybean seedling stage. A drone was used to collect images of soybeans at the true leaf stage, the first compound leaf stage, the second compound leaf stage, and the third compound leaf stage, and data enhancement methods such as image rotation and brightness enhancement were used to expand the dataset, simulate the drone’s collection of images at different shooting angles and weather conditions, and enhance the adaptability of the model. …”
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