Microbiota-derived resveratrol metabolites: New biomarkers of red wine consumption are inversely associated with inflammation in a longitudinal study of a Mediterranean population by Francesc M. Campins-Machado, Rosa Casas, Rosa M. Lamuela-Raventós, Polina Galkina, Miguel Ángel Martínez-González, Montserrat Fitó, Emilio Ros, Ramon Estruch, Inés Domínguez-López, Maria Pérez

“…Biomarkers of consumption offer advantages compared to FFQ data, since they provide objective and more accurate information about nutrient intake and metabolism. …”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. by Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty

“…In BLSA, we found that CA and CDCA were detectable in postmortem brain tissue samples and were marginally higher in AD samples compared to CON. …”
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Risk of developing drug abuse in administration of a new hexaazaisowurtzitane derivative-based analgesic (experimental study) by S. G. Krylova, T. N. Pove’teva, K. A. Lopatina, Yu. V. Nesterova, E. P. Zueva, O. G. Afanas’eva, P. V. Kulpin, E. A. Kiseleva, N. I. Suslov, D. A. Kulagina, S. V. Sysolyatin, V. V. Zhdanov

“…No dominant abstinence components and recessive signs of withdrawal syndrome were detected in animals from the thiowurtzine groups. The data obtained in the study (orientation and exploratory behavior, motor activity, emotionality and its vegetative manifestations, grooming, etc.) allow to conclude that thiowurtzine causes no physical dependence in animals after discontinuation of its 5-day administration with naloxone challenge test, as opposed to the reference drug naloxone. …”
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Extracorporeal carbon dioxide removal for the treatment of acute hypoxaemic respiratory failure: the REST RCT by James J McNamee, Ashley Agus, Andrew J Boyle, Colette Jackson, Cliona McDowell, Jeanette Haglund, Danny F McAuley

“…Design A multicentre, randomised, allocation-concealed, open-label, pragmatic clinical trial. Setting Fifty-one intensive care units across the United Kingdom. …”
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HLA-A∗03:01 as predictive genetic biomarker for glatiramer acetate treatment response in multiple sclerosis: a retrospective cohort analysisResearch in context by Brian C. Zhang, Tilman Schneider-Hohendorf, Rebecca Elyanow, Beatrice Pignolet, Simon Falk, Christian Wünsch, Marie Deffner, Erik Yusko, Damon May, Daniel Mattox, Eva Dawin, Lisa Ann Gerdes, Florence Bucciarelli, Lisa Revie, Gisela Antony, Sven Jarius, Christiane Seidel, Makbule Senel, Stefan Bittner, Felix Luessi, Joachim Havla, Matthias Knop, Manuel A. Friese, Susanne Rothacher, Anke Salmen, Fumie Hayashi, Roland Henry, Stacy Caillier, Adam Santaniello, Maria Seipelt, Christoph Heesen, Sandra Nischwitz, Antonios Bayas, Hayrettin Tumani, Florian Then Bergh, Gerd Meyer zu Hörste, Tania Kümpfel, Catharina C. Gross, Brigitte Wildemann, Martin Kerschensteiner, Ralf Gold, Sven G. Meuth, Frauke Zipp, Bruce A.C. Cree, Jorge Oksenberg, Michael R. Wilson, Stephen L. Hauser, Scott S. Zamvil, Luisa Klotz, Roland Liblau, Harlan Robins, Joseph J. Sabatino, Jr., Heinz Wiendl, Nicholas Schwab, Jessa Alexander, Riley Bove, Sergio Baranzini, Bruce A.C. Cree, Eduardo Caverzasi, Richard Cuneo, Stacy J. Caillier, Tiffany Cooper, Ari J. Green, Chu-Yueh Guo, Jeffrey M. Gelfand, Refujia Gomez, Sasha Gupta, Jill Hollenbach, Meagan Harms, Roland G. Henry, Stephen L. Hauser, Myra Mendoza, Jorge R. Oksenberg, Nico Papinutto, Sam Pleasure, Adam Santaniello, Joseph J. Sabatino, Jr., William A. Stern, Michael R. Wilson, Scott Zamvil, Orhan Aktas, Antje Giede-Jeppe, Barbara Gisevius, Markus Kowarik, Friedemann Paul, Veit Rothhammer, Corinna Trebst, Uwe Zettl

“…Both sets of common sequences clonally expanded after GA treatment in a first validation cohort and predicted GA exposure in two further validation cohorts. …”
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Connectivity guided intermittent theta burst stimulation versus repetitive transcranial magnetic stimulation in moderately severe treatment resistant depression by Richard Morriss, Lucy Webster, Luke Ingram, Mohamed Abdelghani, Adriana Anton, Shaun Barber, Peter Bates, Paul Briley, Clement Boutry, Cassandra Brookes, Edward Cox, Beth Hall, Marilyn James, Matthew Keane, Micheal Kurkar, Sudheer Lankappa, Peter Liddle, Hamish McAllister-Williams, Hyerin Oh, Alexander O’Neill-Kerr, Jehill Parikh, Stefan Pszczolkowski, Ana Suazo Di Paola, Louise Thomson, Yvette Walters, Dorothee Auer

“…Sample size calculation A sample size of 266 participants provides 89.3% power to detect a mean difference of 3 points in the HDRS-17 over 26 weeks between the groups at a 5% two-sided significance level assuming a standard deviation (SD) of 8, with a correlation between follow-up measures of 0.7 and 20% data loss/drop-out. …”
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Multimodal versus non-contrast computed tomography for assessment of acute ischaemic stroke: the PRACTISE RCT by Keith W Muir, Salwa El Tawil, Alex McConnachie, Alicia Murray, Ian Ford, Grant Mair, Joanna Wardlaw

“…Design Prospective, randomised controlled clinical trial. Setting Hospital acute stroke services. Participants Adults with clinically suspected acute ischaemic stroke eligible for intravenous thrombolytic therapy. …”
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Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT by Cherry-Ann Waldron, Philip Pallmann, Simon Schoenbuchner, Debbie Harris, Lucy Brookes-Howell, Céu Mateus, Jolanta Bernatoniene, Katrina Cathie, Saul N Faust, Josie Henley, Lucy Hinds, Kerry Hood, Chao Huang, Sarah Jones, Sarah Kotecha, Sarah Milosevic, Helen Nabwera, Sanjay Patel, Stéphane Paulus, Colin VE Powell, Jenny Preston, Huasheng Xiang, Emma Thomas-Jones, Enitan D Carrol

“…Bootstrapping and missing data imputation were performed if justified. Differences in each arm were assessed and used for the computation of an incremental cost-effectiveness ratio (ICER). …”
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