Dalpiciclib combined with pyrotinib and endocrine therapy in women with ER-positive, HER2-positive advanced breast cancer: A prospective, multicenter, single-arm, phase 2 trial. by Jian Zhang, Yanchun Meng, Biyun Wang, Xinhong Wu, Hongmei Zheng, Jing Hu, Wei Liu, Wenyan Chen, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li, Sujie Ni, Zhengyan Yu, Lichun Sun, Yun Wang, Qiang Peng, Song Wang, Xin Hu, Jianfei Wang, Yijia Wu, Xichun Hu

“…Of interest, no objective response was observed in three patients with detected BRCA mutations (n = 2) or increased 68Ga-HER2 affibody uptake over the initial two cycles (n = 2). …”
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ON DISCRETE STRUCTURE OF GEOLOGIC MEDIUM AND CONTINUAL APPROACH TO MODELING ITS MOVEMENTS by Sh. A. Mukhamediev

“…Authors who support the second opinion, either explicitly or implicitly assume that the block structure of the geologic medium, which is detectable by geological methods, makes a direct and unambiguous impact on all other mechanical properties of the geologic medium and, above all, on the nature of its movements.Based on results obtained by interpreting the data collected in our long-term field studies of rock fracturing, mathematical processing of GPS-measurements, and theoretical models, we agree with the concept of the geologic medium’s block structure, but argue that the geologic block-structure property is not acquired but congenital. …”
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Association between A body shape index and bone mineral density in middle-aged and elderly adults: a retrospective analysis of NHANES 2005–2018 by Zhi-Zhuang Wang, Guo-Liang Ma, Bo Xu, Xin Chen, Bo-Wen Yang, Xiao-Kuan Qin, Wei-Li Duan, Wei-Li Duan, Min-Shan Feng, He Yin, Kai Sun, Li-Guo Zhu, Li-Guo Zhu

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Multi-Target Mechanism of Compound Qingdai Capsule for Treatment of Psoriasis: Multi-Omics Analysis and Experimental Verification by Qiao Y, Li C, Chen C, Wu P, Yang Y, Xie M, Liu N, Gu J

“…The traditional Chinese medicine, Compound Qingdai Capsule (CQC), has shown potential benefits in treating psoriasis in clinical settings. Despite its efficacy, the molecular mechanisms underpinning its therapeutic action remain unclear.Purpose: This study aimed to unravel the molecular mechanism of Compound Qingdai Capsule for psoriasis based on the psoriasis pathogenic pathway network, integrating multi-omics analysis, systems pharmacology, machine learning modeling, and animal experimentation.Methods: Psoriasis pathogenic pathway network was constructed through employing bioinformatics analysis and psoriasis-related multi-omics data mining. …”
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The effect of dexmedetomidine on acute kidney injury after elective major abdominal surgery : a retrospective single-center propensity score matched study by Haibei Liu, Rong Luo, Liu Qian, Yujun Zhang, Wensheng Zhang, Juan Tan, Ling Ye

“…However, though additional prospective data are needed, our study found that administering dexmedetomidine with a loading dose may be associated with lower rates of AKI, potentially indicating a renoprotective effect of loading-dose dexmedetomidine in this setting.…”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…Owing to the challenges in using MEMS, the number of participants with sufficient data for primary end-point analysis was 112 (CAU, n = 55; CBT, n = 57). …”
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Clinical manifestations and prognosis of giant cell arteritis: A retrospective cohort study by E. E. Filatova, N. M. Bulanov, A. D. Meshkov, O. O. Borodin, I. O. Smitienko, E. V. Chachilo, A. A. Nartov, A. L. Filatova, A. V. Naumov, P. I. Novikov, S. V. Moiseev

“…Clinical, laboratory and instrumental data, three sets of classification criteria were used to confirm the diagnosis: the American College of Rheumatology (ACR) 1990, the revised ACR criteria of 2016 and/or the new ACR and European Alliance of Associations for Rheumatology (EULAR) 2022 criteria. …”
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Whole genome sequencing revealed high proportions of ST152 MRSA among clinical Staphylococcus aureus isolates from ten hospitals in Ghana by Beverly Egyir, Christian Owusu-Nyantakyi, Alfred Bortey, Grebstad Rabbi Amuasi, Felicia Amoa Owusu, William Boateng, Hawawu Ahmed, Justice Kwesi Danso, Agnes Akosua Gyamaah Oclu, Quaneeta Mohktar, Georgina Tetteh-Ocloo, Harold Amegbletor, Kwabena Fosu, Francis Kwame Morgan Tetteh, Solomon Asante-Sefa, Oliver Nangkuu Deberu, Kennedy Mensah Osei, Joana Twasam, Sarkodie Kodom, Esther Gyinae, James Sampah, Nicholas Dzifa Dayie, Noah Obeng-Nkrumah, William Addo Mills-Pappoe, Gifty Boateng, Pernille Nilsson, Harriet Affran Bonful, Bright Adu, Rene S. Hendriksen

“…ST152 was the major clone, with 74% harboring the mecA gene. Other MRSA clones detected were ST5, ST5204, ST852, and ST1. MSSA clones included ST3249, ST152, ST5, ST1, and ST8. …”
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Biomarkers and outcomes in hospitalised patients with COVID-19: a prospective registry by Rajeev Gupta, Yogendra Singh, Kartik Mittal, Raghubir Singh Khedar, Krishnakumar Sharma, Harshad C Ambaliya, Jugal B Gupta, Surendra Singh, Swati Sharma, Alok Mathur

“…Primary outcome was all-cause deaths and secondary outcome was oxygen requirement, non-invasive and invasive ventilation, dialysis, duration of stay in ICU and hospital. Numerical data are presented in median and interquartile range (IQR 25–75). …”
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Understanding the genomic landscape of Klebsiella pneumoniae: insights into bacteraemia across North-West London hospitals between April 2020-December 2021 by Mr Jonah Rodgus, Dr Maria Getino, Dr Yu Wan, Dr Frances Davies, Professor Alison Holmes, Dr Elita Jauneikaite

“…Critically, four distinct carbapenemase genes were identified (n=11), with two OXA-48-like genes (blaOXA-181 [n=2] and blaOXA-48 [n=6]) detected in eight isolates (two from ST15), consistent with national data to suggest a predominance of OXA-48-like genes among carbapenemase genes in England. blaCTX-M-15 (n=92), which confers cefotaxime resistance, was the most common β-lactamase gene, followed by variants of blaTEM-1-D (n=82), which confer resistance to penicillins/first-generation cephalosporins. …”
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An Empirical Framework Characterizing the Metallicity and Star-formation History Dependence of X-Ray Binary Population Formation and Emission in Galaxies by Bret D. Lehmer, Erik B. Monson, Rafael T. Eufrasio, Amirnezam Amiri, Keith Doore, Antara Basu-Zych, Kristen Garofali, Lidia Oskinova, Jeff J. Andrews, Vallia Antoniou, Robel Geda, Jenny E. Greene, Konstantinos Kovlakas, Margaret Lazzarini, Chris T. Richardson

“…The model framework and data sets presented in this paper further provide unique benchmarks that can be used for calibrating binary population synthesis models.…”
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Invasive urodynamic investigations in the management of women with refractory overactive bladder symptoms: FUTURE, a superiority RCT and economic evaluation by Mohamed Abdel-Fattah, Christopher Chapple, Suzanne Breeman, David Cooper, Helen Bell-Gorrod, Preksha Kuppanda, Karen Guerrero, Simon Dixon, Nikki Cotterill, Karen Ward, Hashim Hashim, Ash Monga, Karen Brown, Marcus Drake, Andrew Gammie, Alyaa Mostafa, Rebecca Bruce, Victoria Bell, Christine Kennedy, Suzanne Evans, Graeme MacLennan, John Norrie

“…A self-completed 3-day bladder diary was also collected at baseline and 6 and 15 months post-randomisation. Sample size Outcome data were required on 986 participants per group for 90% power to detect a minimum of 10% superiority of urodynamics over CCA only. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…The obtained TCRβ sequences could be tracked in autologous ex-vivo single-cell transcriptomic data. Our results provide a rationale for pursuing vaccination and T cell transfer strategies targeting IDH1. …”
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Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells by Michele Pezzella, Concetta Quintarelli, Maria C. Quadraccia, Andrea Sarcinelli, Simona Manni, Laura Iaffaldano, Alessio Ottaviani, Roselia Ciccone, Antonio Camera, Maria L. D’Amore, Stefano Di Cecca, Matilde Sinibaldi, Marika Guercio, Mariasole Aurigemma, Pamela De Falco, Valentina Fustaino, Rossella Rota, Silvia Pomella, Matteo Cassandri, Angela Di Giannatale, Chiara Agrati, Veronica Bordoni, Federica Guarracino, Michele Massa, Giada Del Baldo, Marco Becilli, Giuseppe M. Milano, Francesca Del Bufalo, Franco Locatelli, Biagio De Angelis

“…In this preclinical study, we investigated the potential use of iCasp9.2A.GD2.CAR-CD28.4–1BBζ (CAR.GD2) T-cells as a treatment option for patients who have GD2-positive sarcomas and we sought to identify factors shaping hostile tumor microenvironment in this setting. GD2 expression was evaluated by flow-cytometry on primary tumor biopsies of pediatric sarcoma patients. …”
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Phylogeographic and genetic network assessment of COVID-19 mitigation protocols on SARS-CoV-2 transmission in university campus residencesResearch in context by Joel O. Wertheim, Tetyana I. Vasylyeva, Robert J. Wood, Kalen Cantrell, Soraya Piña Contreras, Aryeh Feldheim, Ravi Goyal, Jennifer L. Havens, Rob Knight, Louise C. Laurent, Niema Moshiri, Robert Neuhard, Shashank Sathe, Alysson Satterlund, Angela Scioscia, Angela Y. Song, Robert T. Schooley, Cheryl M. Anderson, Natasha K. Martin, Stefan Aigner, Kristian G. Andersen, Nathan A. Baer, Maryann Betty, Amanda Birmingham, Anelizze Castro-Martinez, Willi Cheung, Peter De Hoff, Kathleen M. Fisch, Alison J. King, Karthik Gangavarapu, Abbas Hakim, Benjamin Henson, Kristen Jepsen, Christina H. Mac, Toan T. Ngo, Kelly N. Nguyen, Tyler R. Ostrander, Sarah Perkins, Ashley Plascencia, Andrea Rivera, Ariana Rivera, Rodolfo A. Salido, Kieran C. Saucedo, Madison Schwab, Allison L. Steedman, Anthony Veder, Alana Weiss, Gene W. Yeo, Mark Zeller

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Tuberculosis prevalence after 4 years of population-wide systematic TB symptom screening and universal testing and treatment for HIV in the HPTN 071 (PopART) community-randomised t... by Eveline Klinkenberg, Sian Floyd, Kwame Shanaube, Linda Mureithi, Thomas Gachie, Petra de Haas, Barry Kosloff, Peter J Dodd, Maria Ruperez, Chali Wapamesa, James Michael Burnett, Nico Kalisvaart, Nkatya Kasese, Redwaan Vermaak, Albertus Schaap, Sarah Fidler, Richard Hayes, Helen Ayles, TREATS study team

“…<h4>Background</h4>Tuberculosis (TB) prevalence remains persistently high in many settings, with new or expanded interventions required to achieve substantial reductions. …”
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Improved Artificial Bee Colony Optimization Underwater Localization Algorithm by Logistic Chaos Mapping and Differential Evolution by Jiaxing CHEN, Yang LIU, Xiaoqian LIU, Zhihua LIU

“…It is relatively straightforward to implement and comprises four phases: population initialization, leading bee, following bee, and detecting bee. The artificial bee colony algorithm offers a novel approach to improving the accuracy of underwater node localization. …”
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Bisoprolol for patients with chronic obstructive pulmonary disease at high risk of exacerbation: the BICS RCT by Graham Devereux, Seonaidh Cotton, Mintu Nath, Nicola McMeekin, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Amanda Lee, Graeme MacLennan, Alyn Morice, John Norrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Olivia Wu, Brian Lipworth

“…Participants were followed up in the study for 52 weeks, and outcome data were collected at 26 and 52 weeks – prior to the COVID-19 pandemic, these were conducted in a face-to-face setting; while, during and after the COVID-19 pandemic, these were primarily conducted by telephone. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Two reviewers extracted data independently using a piloted data extraction form. …”
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Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. I. Observations, Orbital and Physical Properties, and Exozodi Upper Limits by Charles Beichman, Aniket Sanghi, Dimitri Mawet, Pierre Kervella, Kevin Wagner, Billy Quarles, Jack J. Lissauer, Max Sommer, Mark Wyatt, Nicolas Godoy, William O. Balmer, Laurent Pueyo, Jorge Llop-Sayson, Jonathan Aguilar, Rachel Akeson, Ruslan Belikov, Anthony Boccaletti, Elodie Choquet, Edward Fomalont, Thomas Henning, Dean Hines, Renyu Hu, Pierre-Olivier Lagage, Jarron Leisenring, James Mang, Michael Ressler, Eugene Serabyn, Pascal Tremblin, Marie Ygouf, Mantas Zilinskas

“…In 2024 August, we detected an F _ν (15.5 μ m) = 3.5 mJy point source, called S 1, at a separation of 1 $\mathop{.}…”
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