Exemplar Hospital Initiation Trial to Enhance Treatment Engagement (EXHIT ENTRE): protocol for CTN-0098 an open-label randomized comparative effectiveness trial of extended-release... by Gavin Bart, Kelly S. Barth, Paulette Baukol, Eva Enns, Udi E. Ghitza, Jacklyn Harris, Eve Jelstrom, Jane M. Liebschutz, Kara M. Magane, Delia Voronca, Zoe M. Weinstein, P. Todd Korthuis

“…Addiction consultation services (ACS) initiate medications for opioid use disorder (MOUD) in hospital settings and arrange post-hospital follow-up for ongoing MOUD care. …”
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Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations by Cristiane S. R. Fonteles, Julia Enterria-Rosales, Ying Lin, John W. Steele, Ramiro A. Villarreal-Leal, Jing Xiao, Daniel I. Idowu, Beck Burgelin, Bogdan J. Wlodarczyk, Richard H. Finnell, Bruna Corradetti

“…Conclusions: The present data confirms the potential application of EXOs and MIMs as suitable tools for prevention and treatment of NTDs and proposes MIMs as prospective vehicles to prevent congenital malformations caused by in utero exposure to drugs.…”
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CLINICAL EVALUATION OF THE DENTOALVEOLAR SYSTEM IN EXCESSIVE TOOTH ABRASION AND TEMPOROMANDIBULAR DISORDERS by N.S. Magera

“…The revealed features in the diagnosis of patients with excessive tooth abrasion, other occlusal disorders in the settings of temporomandibular disorders should be taken into account in their treatment and, especially, in the provision of prosthetics to such patients. …”
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Infections and antibiotic resistance in Malawian children 6-59 months old hospitalized with severe acute malnutrition by Dr Bryan Vonasek, Ms. Mwawi Nyirongo, Mr. Alexander Kondwani, Dr. Anthony Garcia-Prats, Ms. Tiwonge Kamvaunamwali, Ms. Doris Ng'oma, Mr. James Kaphatika, Mr. Amazing-Grace Tepeka, Dr. Mercy Kumwenda, Dr. Emily Ciccone, Dr. Tisungane Mvalo

“…The World Health Organization (WHO) therefore recommends that all children hospitalized with SAM receive empiric intravenous broad-spectrum antibiotics. Most data on the burden of infections in children with SAM are outdated given recent dramatic changes in antimicrobial resistance (AMR) and HIV epidemiology. …”
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Candida and Bacterial Skin Colonisation of Critically-ill Patients in Two Tertiary Healthcare Facilities in Zambia by Prof Geoffrey Kwenda, Dr John Mwaba, Ms Chalwe Sokoni, Mr Christone Kaile, Ms Faith Kabansa, Mr Darlingtone Mwenya, Ms Tshiama Mirriam Mwamba, Ms Ruth Mpembe, Dr Sabelle Jallow, Ms Rudzani Mashau, Prof Nelesh Govender, Miss Chalwe Sokoni

“…Given the prevalence of multidrug-resistant organisms, the dominance of bacterial colonization in these settings presents serious challenges for infection control. …”
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Effectiveness of a tailored forest package of interventions, including topical repellents, in reducing malaria incidence in Myanmar by Kyawt Mon Win, John E. Gimnig, Nay Yi Yi Linn, Feliciano Monti, Nu Nu Khin, William A. Hawley, Jimee Hwang, Ryan E. Wiegand, Ersin Topcuoglu, Alexander Moran, Khin Lin, Hsu Thadar, Aye Aye Myint, Kyaw Myint Tun

“…While there is evidence that networks of community-based malaria workers and insecticide-treated nets (ITNs) can reduce malaria transmission in a variety of settings, evidence for the effectiveness of other interventions, such as topical repellents, is limited. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Power calculation based on a two-sample t-test at 12 weeks detecting a 3-point difference in QIDS-SR between drug and placebo (at p < 0.05) with a standard deviation (SD) of 7 (based CEQUEL study data). …”
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Key geological and engineering technologies and research directions for shale gas exploration and development in western Hubei Province, China by Guangyou Zhu, Jineng Jin, Qilin Xiao, Lei Wang, Guanglong Sheng, Jun Tang, Jianghui Meng, Zhiyuan Lu, Can Chen

“…In terms of pore evaluation, the pore heterogeneity caused by compaction and rebound can be quantified using ideal shape coefficients and fractal dimensions, both of which are influenced by structural deformations, thereby guiding reservoir classification. For seismic data interpretation, pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques, overcoming the limitation of individual post-stack attributes in typically detecting only major faults. …”
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Comparison of Different HIV-1 Resistance Interpretation Tools for Next-Generation Sequencing in Italy by Daniele Armenia, Luca Carioti, Valeria Micheli, Isabella Bon, Tiziano Allice, Celestino Bonura, Bianca Bruzzone, Fiorenza Bracchitta, Francesco Cerutti, Giovanni Maurizio Giammanco, Federica Stefanelli, Maria Addolorata Bonifacio, Ada Bertoli, Marialinda Vatteroni, Gabriele Ibba, Federica Novazzi, Maria Rosaria Lipsi, Nunzia Cuomo, Ilaria Vicenti, Francesca Ceccherini-Silberstein, Barbara Rossetti, Antonia Bezenchek, Francesco Saladini, Maurizio Zazzi, Maria Mercedes Santoro

“…This work evaluated the concordance among different NGS-GRT interpretation tools in a real-life setting. Methods: Routine NGS-GRT data were generated from viral RNA at 11 Italian laboratories with the AD4SEQ HIV-1 Solution v2 commercial kit. …”
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Artificial intelligence in nursing: an integrative review of clinical and operational impacts by Salwa Hassanein, Salwa Hassanein, Rabie Adel El Arab, Rabie Adel El Arab, Amany Abdrbo, Mohammad S. Abu-Mahfouz, Mastoura Khames Farag Gaballah, Mohamed Mahmoud Seweid, Mohamed Mahmoud Seweid, Mohammed Almari, Husam Alzghoul

“…However, despite these benefits, ethical challenges remain prominent. Key concerns include data privacy risks, algorithmic bias, and the potential erosion of clinical judgment due to overreliance on technology. …”
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Results of the tectonic stress study of the Northern Eurasia regions by L. A. Sim, A. V. Marinin, G. V. Bryantseva, N. A. Gordeev

“…Our studies provide the data on spacious ‘white spots’ in the modern stress maps ofNorthern Eurasia. …”
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Molecular characterization and expression profiles of cytochrome P450 reductase gene in Sogatella furcifera (Hemiptera: Delphacidae) by YU Hang, LIU Su, ZHU Qingzi, ZHOU Wenwu, LIANG Qingmei, SHI Xiaoxiao, ZHU Zijie, ZHU Zengrong

“…Finally, after exposure of deltamethrin, buprofezin and imidacloprid at sublethal concentrations for 6,12 and 24 h, the relative expression levels of SfCPR in the third-instar nymphs were investigated.By searching the transcriptome data sets of S. furcifera, a cDNA fragment encoding putative CPR (named SfCPR) was identified. …”
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Stability of Ceftobiprole Medocaril in Portable Elastomeric Infusion Devices by Beatriz Esteban-Cartelle, Brayan J. Anaya, Covadonga Pérez Menéndez-Conde, Noelia Vicente-Oliveros, Dolores R. Serrano, Ana Álvarez-Díaz, Jesús Fortún-Abete, Pilar Martín-Dávila

“…Since it is newly introduced in therapy, there is limited data on its physicochemical stability for outpatient parenteral antimicrobial therapy (OPAT). …”
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Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarr... by Jennifer Cornick, Jennifer Cornick, Sarah Elwood, James Platts-Mills, Patricia Pavlinac, Patricia Pavlinac, Karim Premji Manji, Christopher R. Sudfeld, Christopher P. Duggan, Christopher P. Duggan, Queen Dube, Naor Bar-Zeev, Karen Kotloff, Karen Kotloff, Samba O. Sow, Sunil Sazawal, Benson Singa, Benson Singa, Judd L. Walson, Judd L. Walson, Farah Naz Qamar, Tahmeed Ahmed, Ayesha De Costa, Elizabeth T. Rogawski McQuade

“…However, attributing etiology remains challenging in high-burden settings where coinfections are common. The Antibiotics for Children with severe Diarrhea (ABCD) trial provides a unique opportunity to leverage azithromycin treatment response to identify bacterial diarrhea.MethodsWe analyzed data from 6,692 children with watery diarrhea enrolled in ABCD (2017 to 2019) who were randomized to receive azithromycin or placebo. …”
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Diagnostic performance of plasma p-tau217 in a memory clinic cohort using the Lumipulse automated platform by Francisco Martínez-Dubarbie, Armando Guerra-Ruiz, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Álvaro Nevado-Cáceres, María Rivera-Sánchez, Andrea Valera-Barrero, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Enrique Marco de Lucas, Marta Drake-Pérez, Nancy Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez

“…Conclusion Plasma p-tau217 shows excellent results for detecting amyloid pathology at brain level in a clinical setting with an AUC of 0.95. …”
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FTIR-based molecular fingerprinting for the rapid classification of dengue and chikungunya from human sera using machine learning: an observational studyResearch in context by Souvik Das, Subhanita Roy, Aritri Bir, Arindam Ghosh, Tarun Kanti Bhattacharyya, Pooja Lahiri, Basudev Lahiri

“…Vibrational spectroscopy offers a novel, label-free alternative for detecting host molecular changes directly from serum. …”
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Electrocardiogram-Based Artificial Intelligence to Identify Coronary Artery Disease by Shinwan Kany, MD, MSc, Samuel F. Friedman, PhD, Mostafa Al-Alusi, MD, Shaan Khurshid, MD, MPH, Joel T. Rämö, MD, PhD, Daniel Pipilas, MD, James P. Pirruccello, MD, Christopher Reeder, PhD, Anthony A. Philippakis, MD, PhD, Jennifer E. Ho, MD, Mahnaz Maddah, PhD, Patrick T. Ellinor, MD, PhD, Akl C. Fahed, MD, MPH

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Exploring cognitive and neuroimaging profiles of dementia subtypes of individuals with dementia in the Democratic Republic of Congo by Jean Ikanga, Jean Ikanga, Saranya Sundaram Patel, Saranya Sundaram Patel, Megan Schwinne, Caterina Obenauf, Caterina Obenauf, Emmanuel Epenge, Guy Gikelekele, Nathan Tshengele, Immaculee Kavugho, Samuel Mampunza, Lelo Mananga, Charlotte E. Teunissen, Julio C. Rojas, Brandon Chan, Argentina Lario Lago, Joel H. Kramer, Adam L. Boxer, Andreas Jeromin, Emile Omba, Alvaro Alonso, Alden L. Gross

“…ObjectiveThe 2024 Alzheimer’s Association (AA) research diagnostic criteria for Alzheimer’s Disease (AD) considers fluid biomarkers, including promising blood-based biomarkers for detecting AD. This study aims to identify dementia subtypes and their cognitive and neuroimaging profiles in older adults with dementia in the Democratic Republic of Congo (DRC) using biomarkers and clinical data.MethodsForty-five individuals with dementia over 65 years old were evaluated using the Community Screening Instrument for Dementia and the informant-based Alzheimer’s Questionnaire. …”
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Echocardiographic Tissue Characterization Using Radiomics in Patients With Transthyretin-Related Cardiac Amyloidosis by Sara Mori, MD, Noemi Montobbio, MSc, Maria Pia. Sormani, MSc, PhD, Cristina Campi, MSc, PhD, Carlotta Mazzoni, MD, Alessia Argirò, MD, PhD, Giulia Elena Mandoli, MD, Francesca Rubina Ginetti, MD, Margherita Zanoletti, MD, Pier Filippo Vianello, MD, Valeria Rella, MD, Lia Crotti, MD, PhD, Michele Piana, MSc, PhD, Matteo Cameli, MD, PhD, Francesco Cappelli, MD, PhD, Italo Porto, MD, PhD, Luigi Paolo Badano, MD, PhD, Marco Canepa, MD, PhD

“…Five logistic regression models analyzed data from 3 centers (229 ATTR-CA, 224 controls) to assess diagnostic accuracy and area under the curve (AUC) of different sets of radiomic features, with external validation conducted on patients from a fourth center (32 ATTR-CA, 32 controls). …”
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Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome... by Susan Kiiru, Purity Kasiano, John Maina, John Njeru Mwaniki, Edinah Songoro, Samuel Kariuki

“…This is an important addition to the genomic analysis data of multi-drug resistant diarrheal Escherichia coli in Kenya. …”
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