Qualitative changes in clinical records after implementation of pharmacist-led antimicrobial stewardship program: a text mining analysis by Keisuke Sawada, Shuji Kono, Ryo Inose, Yuichi Muraki

“…Methods We conducted a retrospective observational analysis of data documented in clinical records by ward pharmacists in a 313-bed community hospital from April 2014 to March 2022. …”
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Clonidine and dexmedetomidine for controlled hypotension during functional endoscopic sinus surgery: a comparative study by Erick Namegabe Mugabo, Yvette Masime Kulimushi, Gregor Pollach, Rania Abdelazim Sabra, Ragab Saad Beltagy, Furaha Nzanzu Blaise Pascal

“…Dexmedetomidine produce more hypotension and bradycardia compared to clonidine which may be preferable for controlled hypotension in the setting of ambulatory surgery. However, considering the small sample of this study which could not detect small but clinically differences between both drugs, there is a need for a much larger and multicenter study to confirm these findings. …”
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Feasibility and Safety of Anlotinib Plus Docetaxel versus Docetaxel Monotherapy in Patients with Previously Immunotherapy-Treated NSCLC: A Retrospective Exploratory Study by Li DW, Li YD, Jin H

“…Grade 3 or above adverse events were detected in 51.2% and 44.2%, respectively, with similar safety profiles between the groups.Conclusion: Anlotinib plus docetaxel demonstrated preliminary efficacy and a tolerable safety profile in patients with previously immunotherapy-treated advanced NSCLC, providing a potential therapeutic option in the post-immunotherapy setting. …”
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Alternative splicing in ovarian cancer by Liwei Wei, Yisheng Li, Jiawang Chen, Yuanmei Wang, Jianmin Wu, Huanming Yang, Yi Zhang

“…Abstract Ovarian cancer is the second leading cause of gynecologic cancer death worldwide, with only 20% of cases detected early due to its elusive nature, limiting successful treatment. …”
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The reliability and validity of a non-wearable indoor positioning system to assess mobility in older adults: A cross-sectional study. by Isabel B Rodrigues, Patricia Hewston, Jonathan Adachi, Sayem Borhan, George Ioannidis, Alexa Kouroukis, Carolyn Leckie, Andrea Lee, Alexander Rabinovich, Parthipan Siva, Rachel Swance, Suleman Tariq, Lehana Thabane, Alexandra Papaioannou

“…<h4>Background</h4>Detecting early changes in walking speed can allow older adults to seek preventative rehabilitation. …”
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Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex by Elisa Crisci, Andrew R. Kick, Lizette M. Cortes, John J. Byrne, Amanda F. Amaral, Kim Love, Hao Tong, Jianqiang Zhang, Phillip C. Gauger, Jeremy S. Pittman, Tobias Käser

“…PRRSV-2 was present in 53 out of 55 pigs, and the other five pathogens (PCMV, PPIV, <i>B. bronchiseptica</i>, <i>G. parasuis</i>, and <i>M. hyorhinis</i>) were detected in BAL samples. Results: Although the uncontrolled settings of field trials complicated data interpretation, multivariate correlation analyses highlighted valuable lessons: (i) high weaning weight predicted animal resilience to disease and high weight gains correlated with the control of the PRRSV-2 field strain; (ii) most pigs cleared MLV strain within 7 weeks, and the field PRRSV-2 strain was the most prevalent lung pathogen during PRDC; (iii) all pigs developed a systemic PRRSV IgG antibody response which correlated with IgG and IgA levels in BAL; (iv) the induction of anti-field strain-neutralizing antibodies by MLV PRRSV-2 vaccination was both late and limited; (v) cellular immune responses were variable but included strong systemic IFN-γ production against the PRRSV-2 field strain; (vi) the most detected lung pathogens correlated with PRRSV-2 viremia or lung loads; (vii) within the six detected pathogens, two viruses, PRRSV-2 and PCMV, significantly correlated with the severity of the clinical outcome. …”
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Field evaluation of the Bioline Malaria Ag P.f/Pan rapid diagnostic test: causes of microscopy discordance and performance in Uganda by Kisakye Diana Kabbale, Bienvenu Nsengimaana, Francis D. Semakuba, Brian A. Kagurusi, Caroline Mwubaha, Innocent Wiringilimaana, Thomas Katairo, Shahiid Kiyaga, Monica Mbabazi, Samuel Gonahasa, Moses R. Kamya, Stephen Tukwasibwe, Sam L. Nsobya, Victor Asua, Daudi Jjingo, Bosco Agaba, Catherine Maiteki-Sebuguzi, Jimmy Opigo, Kylie Hilton, Sarah G. Staedke, Grant Dorsey, Melissa D. Conrad, Bryan Greenhouse, Isaac Ssewanyana, Jessica Briggs

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Cardiovascular and Thromboembolic Events in Children and Adults With Glomerular Disease: Findings From the Cure GlomeruloNephropathy (CureGN) Network by Shikha Wadhwani, Sarah A. Mansfield, Abigail R. Smith, Bruce M. Robinson, Eman Abdelghani, Amira Al-Uzri, Isa F. Ashoor, Sharon M. Bartosh, Aftab S. Chishti, Salim S. Hayek, Michelle A. Hladunewich, Bryce A. Kerlin, Siddharth S. Madapoosi, Laura H. Mariani, Amy K. Mottl, Michelle N. Rheault, Michelle M. O’Shaughnessy, Christopher John Sperati, Tarak Srivastava, David T. Selewski, Chia-shi Wang, Craig S. Wong, Donald J. Weaver, Jr., Myda Khalid

“…Data from 2,545 children and adults (23% MCD, 23% MN, 25% FSGS, 29% IgAN/IgAV) was analyzed. …”
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High-risk human papillomavirus testing in first-void urine as a novel and non-invasive cervical cancer screening modality—a Danish diagnostic test accuracy study by Mette Tranberg, Severien Van Keer, Jørgen Skov Jensen, Pia Nørgaard, Line Winther Gustafson, Anne Hammer, Pinar Bor, Karen Omann Binderup, Christina Blach, Alex Vorsters

“…Yet, the wide variation in the clinical accuracy of hrHPV testing in urine for detecting high-grade cervical intraepithelial neoplasia (CIN2 + /CIN3 +) across studies and clinical settings highlights the importance of local piloting and validation. …”
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Emaciated enigma: Decline in body conditions of common dolphins in the Celtic Seas ecoregion by Sofia Albrecht, Cóilín Minto, Emer Rogan, Rob Deaville, Jim O'Donovan, Mags Daly, Stephanie Levesque, Simon Berrow, Andrew Brownlow, Nicholas J. Davison, Orla Slattery, Luca Mirimin, Sinéad Murphy

“…Here, nine morphometric body condition indices were applied to long‐term common dolphin stranding data sets originating from Ireland and the UK. We report a recent decline in the nutritional health of common dolphins in the Celtic Seas ecoregion comparing animals from 2017 to 2019 to animals from 1990 to 2006, with an increase in cases of animals dying due to starvation. …”
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Plasmid-driven clonal expansion of multidrug-resistant monophasic Salmonella Typhimurium in a Global Food Trade Hub by Dingjie Huang, Ziqi Wu, Yixiang Jiang, Lulu Hu, Rui Cai, Xi Yang, Chen Du, Shiting Chen, Panpan Yang, Bingchan Guo, Xiaolu Shi, Shuang Wu, Yinghui Li, Zhemin Zhou, Qinghua Hu

“…Shenzhen, a major port city with a heavily imported food supply, offers a critical setting to examine the spread and adaptation of multidrug-resistant Salmonella 1,4,[5],12:i: – (S. 1,4,[5],12:i:-). …”
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Prevention of mother-to-child transmission of hepatitis B virus: protocol for a one-arm, open-label intervention study to estimate the optimal timing of tenofovir in pregnancy by François Nosten, Rose McGready, Verena Carrara, Stephan Ehrhardt, Chaisiri Angkurawaranon, Nan Guo, Yuanxi Jia, Marieke Bierhoff, Kenrad E Nelson, Podjanee Jittamala, Wanitda Watthanaworawit, Clare Ling, Fuanglada Tongprasert, Michele van Vugt, Marcus Rijken, Chloe Lynne Thio

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SinoMAKS—protocol of a randomised controlled trial to evaluate the Chinese version of the non-pharmacological, multimodal MAKS intervention for people with mild to moderate dementi... by Yu Liu, Olaf Gefeller, Jian Su, Ming Zhong, Elmar Graessel, André Kratzer, Petra Scheerbaum, Julia-Sophia Scheuermann, Yaping Ding, Jianwen Lu

“…With n=200, effects with an effect size of Cohen’s d=0.45 and a power of 1-β = 0.80 can be detected. Screening and data collection at baseline, t6 and t12 will be conducted via face-to-face contact by proxy raters in the nursing homes (i.e., trained nursing staff not involved in the intervention) and master students as external testers for the performance tests on cognition and activities of daily living. …”
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Farm-to-fork changes in poultry microbiomes and resistomes in Maputo City, Mozambique by Natalie Olson, Frederica Lamar, Hermógenes Mucache, José Fafetine, Joaquim Saíde, Amélia Milisse, Denise R. A. Brito, Kelsey J. Jesser, Karen Levy, Matthew C. Freeman, Maya L. Nadimpalli

“…Poultry may be an important source of foodborne, antimicrobial-resistant bacteria to consumers in settings with limited water, sanitation, and hygiene infrastructure. …”
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RECOMMENDED TACTICS FOR THE EVALUATION OF POTENTIALLY MALIGNANT DISORDERS IN THE ORAL CAVITY by S.V. Kolomiiets, K.O. Udaltsova, V.I. Shynkevych

“…Dentists are the specialists who are able to detect malignant tumors and refer patients to the oncologists. …”
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Noise Levels Due to Commercial and Leisure Activities in Urban Areas: Experimental Validation of a Numerical Model Fed with Crowd Density Estimation Using Computer Vision by Óscar Ramón-Turner, Jacob D. R. Bordón, Asunción González-Rodríguez, Javier Lorenzo-Navarro, Modesto Castrillón-Santana, Guillermo M. Álamo, Román Quevedo-Reina, Carlos Romero-Sánchez, Antonio T. Ester-Sánchez, Cristina Medina, Fidel García, Orlando Maeso, Juan J. Aznárez

“…To verify the model, several protocols have been developed for collecting experimental data. In a first phase, these experimental measurements were carried out in controlled environments, using loudspeakers as noise sources. …”
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Neuropsychological outcome of indoor rehabilitation in post-COVID-19 condition—results of the PoCoRe study by Michael Jöbges, Melanie Tempfli, Melanie Tempfli, Christoph Kohl, Christoph Herrmann, Stefan Kelm, Alexa Kupferschmitt, Alexa Kupferschmitt, Alexa Kupferschmitt, Ida Montanari, Nike Walter, Gerhard Suetfels, Thomas Loew, Volker Köllner, Volker Köllner, Thilo Hinterberger

“…Further research is warranted to optimize screening tools and enhance neuropsychological care for PCC patients in both rehabilitation and outpatient settings.…”
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CREATING THE KULTUK POLYGON FOR EARTHQUAKE PREDICTION: VARIATIONS OF (234U/238U) AND 87SR/86SR IN GROUNDWATER FROM ACTIVE FAULTS AT THE WESTERN SHORE OF LAKE BAIKAL by S. V. Rasskazov, E. P. Chebykin, A. M. Ilyasova, E. N. Vodneva, I. S. Chuvashova, S. A. Bornyakov, A. K. Seminsky, S. V. Snopkov, V. V. Chechel'nitsky, N. A. Gileva

“…These two faults that limit the Sharyzhalgai block of the crystalline basement of the Siberian craton in the south are conjugated in the territory of the Kultuk polygon (Fig 1). Forty sets of samples taken from 27 June 2012 to 28 January 2014 were analysed, and data on 170 samples are discussed in this paper.Methods. …”
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Absence of community-acquired Candida auris colonization among newly hospitalized participants without recent healthcare exposure from a cross-sectional study in Dhaka, Bangladesh by Gazi Md. Salahuddin Mamun, Tanzir Ahmed Shuvo, Sanzida Khan, Syeda Mah-E-Muneer, Md. Aminul Islam, Dilruba Ahmed, Kabid Ahmed, Debashis Sen, Kamal Hossain, Md. Nazmul Islam, Aninda Rahman, Mohammad Monir-Uz-Zaman, Md. Mustafizur Rahman, Fahmida Naz Mustafa, Md. Salim, Rubina Yasmin, Md. Shafiur Rahman, Tarak Nath Kundu, Mostafa Kamal, Farzana Sohael, Sakina Shab Afroz, Mahmudur Rahman, Fahmida Chowdhury

“…No C. auris colonization was detected in the axillary or groin in any enrolled participant. …”
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Quality Improvement Project to Change Prescribing Habits of Surgeons from Combination Opioids Such as Hydrocodone/Acetaminophen to Single-Agent Opioids Such as Oxycodone in Pediatr... by Muhammad Aishat, Alicia Segovia, Throy Campbell, Lorrainea Williams, Kristy Reyes, Tyler Hamby, David Farbo, Meredith Rockeymoore Brooks, Artee Gandhi

“…Data were monitored for three periods: one-year pre-intervention, one-year post-intervention, and one-year sustainment periods. …”
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