Tolerance and heteroresistance to echinocandins in Candida auris: conceptual issues, clinical implications, and outstanding questions by Erika Shor, David S. Perlin, Dimitrios P. Kontoyiannis

“…The clinical significance of these mechanisms remains unclear, with limited data correlating them with treatment failures. Research is needed to understand their mechanisms and impact, develop streamlined and robust methods to detect them in clinical settings, and explore mitigation strategies. …”
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BESPOKE study protocol: a multicentre, prospective observational study to evaluate the impact of circulating tumour DNA guided therapy on patients with colorectal cancer by Scott Kopetz, Axel Grothey, Shifra Krinshpun, Meenakshi Malhotra, Paul Billings, Angel Rodriguez, Alexey Aleshin, Sarah Sawyer, Michelle Munro, Pashtoon Murtaza Kasi, Jessica Guilford, Sascha Ellers, Jacob Wulff, Nicole Hook, Allyson Koyen Malashevich, Solomon Moshkevich

“…This study protocol investigates the clinical utility of ctDNA for optimal use of adjuvant chemotherapy in patients with surgically resected CRC and to detect early disease progression in the surveillance setting.Methods and analysis This is a multicentre prospective, observational cohort study. …”
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Incidental findings on brain imaging and blood tests: results from the first phase of Insight 46, a prospective observational substudy of the 1946 British birth cohort by Jonathan M Schott, Chandrashekar Hoskote, David L Thomas, Ashvini Keshavan, Sarah-Naomi James, Nick Fox, Sachit Shah, Sarah E Keuss, Thomas D Parker, Christopher A Lane, David M Cash, Sarah M Buchanan, Heidi Murray-Smith, Andrew Wong, Kirsty Lu, Jessica Collins, Daniel G Beasley, Ian B Malone, Anna Barnes, Marcus Richards

“…Objective To summarise the incidental findings detected on brain imaging and blood tests during the first wave of data collection for the Insight 46 study.Design Prospective observational sub-study of a birth cohort.Setting Single-day assessment at a research centre in London, UK.Participants 502 individuals were recruited from the MRC National Survey of Health and Development (NSHD), the 1946 British birth cohort, based on pre-specified eligibility criteria; mean age was 70.7 (SD: 0.7) and 49% were female.Outcome measures Data regarding the number and types of incidental findings were summarised as counts and percentages, and 95% confidence intervals were calculated.Results 93.8% of participants completed a brain scan (n=471); 4.5% of scanned participants had a pre-defined reportable abnormality on brain MRI (n=21); suspected vascular malformations and suspected intracranial mass lesions were present in 1.9% (n=9) and 1.5% (n=7) respectively; suspected cerebral aneurysms were the single most common vascular abnormality, affecting 1.1% of participants (n=5), and suspected meningiomas were the most common intracranial lesion, affecting 0.6% of participants (n=3); 34.6% of participants had at least one abnormality on clinical blood tests (n=169), but few reached the prespecified threshold for urgent action (n=11).Conclusions In older adults, aged 69-71 years, potentially serious brain MRI findings were detected in around 5% of participants, and clinical blood test abnormalities were present in around one third of participants. …”
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Retrospective cohort study of adult patients with cystic fibrosis supported with venovenous extracorporeal membrane oxygenation (VV ECMO) at a large German cystic fibrosis center by Achim Grünewaldt, Gernot Rohde

“…The purpose of this study was to evaluate the role of extracorporeal membrane oxygenation (ECMO) in this clinical setting. Methods In this descriptive retrospective monocentric cohort study, we collected data by using electronic medical records from all patients with CF who received ECMO therapy during the period 2012–2021. …”
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Observational Constraints on Basin‐Scale Runoff: A Request for Both Improved ESMs and Streamflow Reconstructions by H. Douville

“…Yet, results are fairly sensitive to the selected reconstruction thus highlighting the need for reliable and homogeneized gridded runoff data sets or river discharge measurements. Moreover, climate models do not account for water withdrawals, whose effect on observed runoff should also be removed in order to detect and attribute the hydrological effect of climate change. …”
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Technical note: A weighing forest floor grid lysimeter by H. Paulsen, M. Weiler

“…This technical note describes the setup of the lysimeter and presents performance metrics from laboratory results and initial field data.</p>…”
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A case of macular damage following micropulse laser treatment for central serous chorioretinopathy by Jianli Wei, Lishuang Chen

“…We recommend using reduced power settings (250–300 mW, 5% duty cycle) for subretinal hyperreflective material-associated central serous chorioretinopathy to enhance safety.…”
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ConBGAT: a novel model combining convolutional neural networks, transformer and graph attention network for information extraction from scanned image by Duy Ho Vo Hoang, Huy Vo Quoc, Bui Thanh Hung

“…Our approach constructs detailed graphs from text regions within images, utilizing advanced Optical Character Recognition to accurately detect and interpret characters. By combining superior extracted features of CNNs for image and Distilled Bidirectional Encoder Representations from Transformers (DistilBERT) for text, our model achieves a comprehensive and efficient data representation. …”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…One hundred and twenty-six DPCs were conducted [119 ‘opportunistic’ and 7 ‘therapeutic’ (to treat current bacterial infection)]. Data analysis Descriptive data were generated for all clinical settings across the three sites. …”
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Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba

“…Introduction Current tuberculosis triage and predictive tools offer poor accuracy and are ineffective for detecting asymptomatic disease in people living with HIV (PLHIV). …”
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Relationship Between Body Mass Index, Selective Voluntary Motor Control and Functional Independence in Children With Cerebral Palsy by Alaa AL-Nemr

“…Objectives: This study detects the relationship between body mass index (BMI), selective voluntary motor control (SVMC) and functional independence in children with spastic diplegic cerebral palsy (CP). …”
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Excellent Reliability for an Instrumented Test of Ankle Plantarflexion Force by Moez Glaied, Rodney Whiteley

“…# Background/Purpose The assessment of ankle plantarflexion force is commonly required in athletic performance and clinical rehabilitation settings to assess the integrity of the calf and lower limb musculature. …”
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Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study by Lin Lin, Guoyong Wang, Lianzheng Hao, Tingbin Yan

“…ConclusionsThis study provides data-supported insights into the genotypic landscape and evolutionary patterns of HCV in Shandong Province. …”
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Sequence-based GWAS in 180,000 German Holstein cattle reveals new candidate variants for milk production traits by Ana-Marija Križanac, Christian Reimer, Johannes Heise, Zengting Liu, Jennie E. Pryce, Jörn Bennewitz, Georg Thaller, Clemens Falker-Gieske, Jens Tetens

“…Conclusions Our findings proved the power of large samples and sequence-based GWAS in detecting new association signals. In order to fully exploit the power of GWAS, one should aim at very large samples combined with whole-genome sequence data. …”
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Effectiveness of the Better Operative Software Outcomes Tool for Monitoring Cataract Surgery Outcomes in Inhambane Province, Mozambique: Prospective Pilot Diagnostic Accuracy Study by Mónica Lecumberri, Dórcia Mandlate, Vasco Cote, Montserrat Martín-Baranera, Carlos L Moser

“…The BOOST Cataract app was used to collect data on visual acuity (VA) on the first postoperative day and to assess surgical outcomes. …”
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Wearable sensor use for assessing standing balance and walking stability in people with Parkinson's disease: a systematic review. by Ryan P Hubble, Geraldine A Naughton, Peter A Silburn, Michael H Cole

“…<h4>Conclusion</h4>These data support the use of wearable sensors for detecting differences in standing balance and walking stability between people with PD and controls. …”
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REST: a preoperative tailored sleep intervention for patients undergoing total knee replacement – feasibility study for a randomised controlled trial by Simon White, Rachael Gooberman-Hill, Emma Johnson, Joel Glynn, Vikki Wylde, Chris Penfold, Katie Whale, Nicholas Howells, Ashley Blom, Amanda Burston, Wendy Bertram, Dane Rayment

“…Where outcome measures were completed, data completion rates were 80% or higher for outcomes at all time points, apart from the painDETECT: 86% complete at baseline, 72% at presurgery and 67% postsurgery. …”
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Isolation and characterization of mollicute symbionts from a fungus-growing ant reveals high niche overlap leading to co-exclusion by Emily A. Green, Ian Klepacki, Jonathan L. Klassen

“…ABSTRACT Two mollicute species belonging to the Mesoplasma and Spiroplasma genera have been detected in several species of fungus-growing ants using molecular methods. …”
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Advancing a machine learning-based decision support tool for pre-hospital assessment of dyspnoea by emergency medical service clinicians: a retrospective observational study by Wivica Kauppi, Henrik Imberg, Johan Herlitz, Oskar Molin, Christer Axelsson, Carl Magnusson

“…The gradient boosting algorithm had the overall best performance, with excellent calibration of the predictions, and consistently showed higher sensitivity to detect SAE than the other methods. The ROC AUC on test data increased from 0.73 (95% CI 0.70–0.76) with RETTS-A to 0.81 (95% CI 0.78–0.84) using gradient boosting. …”
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Prevalence of major depressive disorder among hemodialysis patients compared with healthy people in Japan using the Structured Clinical Interview for DSM-IV by Tomita T, Yasui-Furukori N, Sugawara N, Ogasawara K, Katagai K, Saito H, Sawada K, Takahashi I, Nakamura K

“…There was a significant difference in potassium level between the two groups, but there were no significant differences in any of the other items.Conclusion: There were significantly more HD patients showing SCID depression than controls in the present study. In clinical settings, the SCID might be useful in surveying cases of depression detected by screening tools among HD patients. …”
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