Diagnosing prostate cancer in the PSA gray zone through machine learning and transrectal ultrasound video by Qin Wu, Chengyi Wu, Maoliang Zhang, Jie Yang, Junxiang Zhang, Yun Jin, Yanhong Du, Xingbo Sun, Liyuan Jin1, Kai Wang, Zhengbiao Hu, Xiaoyang Qi1, Jincao Yao, Zhengping Wang, Dong Xu

“…Conclusions: The four machine learning models each had diagnostic value for detecting prostate cancer in patients within the PSA “gray zone”, with the RF model demonstrating the highest predictive performance.…”
Get full text

MTMR14 depletion aggravates intrapulmonary inflammation and emphysema in experimental COPD through activating macrophage M1 polarization by Jiaheng Zhang, Yuan Zhan, Zhesong Deng, Shanshan Chen, Ruonan Yang, Yating Zhang, Hao Fu, Qian Huang, Jixing Wu, Yiya Gu, Jungang Xie

“…Results Based on analysis from open-access single-cell sequencing data, MTMR14 was down-regulated in macrophages of COPD patients, which was confirmed in clinical specimens, animal and cell models. …”
Get full text

Neutrophil Percentage-to-Albumin Ratio and Neutrophil-to-Albumin Ratio as novel biomarkers for non-alcoholic fatty liver disease: a systematic review and meta-analysis by Amr Ali Mohamed Abdelgawwad El-Sehrawy, Maryam Jafari, Ahmed Hussein Zwamel, Pegah Rashidian, Suhas Ballal, Rishiv Kalia, Anima Nanda, Laxmidhar Maharana, Sepide Javankiani, Mohammad Hashemi, Ehsan Amini-Salehi

“…These ratios reflect key aspects of systemic inflammation and nutritional status, offering clinical value in early detection and risk stratification. However, given the limited number of studies available—particularly for NAR—further research is needed to confirm these findings, establish standardized thresholds, and assess their performance across diverse populations and clinical settings. …”
Get full text

Hospital-acquired catheter-associated urinary tract infections in critical care unit dogs with high rates of multidrug-resistant organisms by Pojchanicha Aponrat, Osathee Detkalaya, Naruemon Phlongtong, Natnicha Eksatit, Suppada Kananub, Sarawan Kaewmongkol, Gunn Kaewmongkol

“…The high rate of MDRO among critical care dogs underscores the urgent need for judicious antibiotic use and the need for enhanced diagnostic methods in critical care settings. This study proposes that serial bacterial cultures combined with modified urine sediment examinations can better manage CAUTI detection and reduce the growth of MDROs in veterinary practice. …”
Get full text

The predictive value of the TG/HDL index for metabolic syndrome and its components: A cross-sectional study in the PERSIAN Guilan Cohort Population by Amirali Ebrahimi, Farahnaz Joukar, Kourosh Mojtahedi, Saman Maroufizadeh, Soheil Hassanipour, Mohammad Reza Naghipour, Mehrnaz Asgharnezhad, Fariborz Mansour-Ghanaei

“…Methods: This cross-sectional analysis included 10,520 adults aged 35–70 from the GCS. Data were collected through structured questionnaires, anthropometric measurements, and biochemical studies. …”
Get full text

Shaoyao Gancao decoction alleviates paclitaxel-induced cognitive impairment by activating PTEN/PI3K/AKT pathway to inhibit NETs formation by Xu Ying, Su Yue, Hu Yuwen, Li Xiang, Zhou Ziyan, Yuan Ningning, Ji Xiaowei, Jiang Ruoyu, Wang Wenzhu, Zhang Yafeng, Zhai Guojie, Cheng Xiaolan

“…The regulation of SGD on PTEN/PI3K/AKT pathway was detected by Western blot. Finally, Mendelian randomization was performed using genome-wide association analysis data of PTEN and cognitive disorders in OpenGWAS database. …”
Get full text

Breastfeeding trajectory of mothers of preterm infants within 6 months postpartum: A longitudinal study by Na Wu, Yijing Wang, Lijing Ding, Yiting Xu, Xuyan Jia, Keying Huo, Xiao Yao, Wenyan Zhang, Yue Wan, Peimin Xie, Lin Ye, Rong Huang

“…The World Health Organization has set a target of ensuring by 2030 that 70 % of infants younger than age 6 months are exclusively breastfed. …”
Get full text

Peguero-Lo Presti criteria for the diagnosis of left ventricular hypertrophy: A systematic review and meta-analysis. by Zongying Yu, Jie Song, Li Cheng, Shasha Li, Qun Lu, Yafeng Zhang, Xiaoci Lin, Dadong Liu

“…Trials written in English that investigated the Peguero-Lo Presti criteria for detecting LVH were included. Data were independently extracted and analyzed by two investigators.…”
Get full text

Predicting clinical outcomes at hospital admission of patients with COVID-19 pneumonia using artificial intelligence: a secondary analysis of a randomized clinical trial by Caio César Souza Conceição, Camila Marinelli Martins, Mayck Medeiros Silva, Hugo Caire de Castro Faria Neto, Davide Chiumello, Davide Chiumello, Davide Chiumello, Patricia Rieken Macedo Rocco, Fernanda Ferreira Cruz, Pedro Leme Silva

“…Machine-learning tools can help identify patients likely to show clinical improvement based on real-world data. This study used two approaches—least absolute shrinkage and selection operator (LASSO) and CombiROC—to identify predictive variables at hospital admission for detecting clinical improvement after 7 days.MethodsA secondary analysis was conducted on the modified intention-to-treat placebo group from a previous randomized clinical trial (RCT, NCT04561219) of patients with COVID-19. …”
Get full text

Nicotine-induced changes in surface properties of restorative materials and dental enamel: An in vitro study on flavored e-cigarette exposure by Maria Salem Ibrahim, Fatimah M. Alatiyyah, Abdulsalam M. Alsalman, Rayan F. Alzenidi, Ali A. Albattat, Ahmed S. Alkhaldi

“…Before and after the exposure, the samples were tested for microhardness (MH), surface roughness (SR), and color changes (ΔE*). Data were analyzed using one-way and two-way analyses of variance (ANOVA). …”
Get full text

Stability of vaccine strains of seasonal live attenuated influenza vaccines when adapted to MDCK cell culture by Victoria A. Matyushenko, Arina D. Kostromitina, Ekaterina A. Stepanova, Larisa G. Rudenko, Irina N. Isakova-Sivak

“…The study of this MDCK-adapted variant in a mouse experiment showed no effect of the detected mutations on the immunogenic and protective properties of the vaccine. …”
Get full text

Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…The training and test sets included 1930 participants from the advanced-aged initial and second subcohort (RS-I/RS-II; median age: 70.6), while the validation set comprised 754 participants from the middle-aged fourth subcohort (RS-IV; median age: 53.5). …”
Get full text

Lessons learned from the co-development of operational climate forecast services for vineyards management by N. Pérez-Zanón, V. Agudetse, E. Baulenas, P.A. Bretonnière, C. Delgado-Torres, N. González-Reviriego, A. Manrique-Suñén, A. Nicodemou, M. Olid, Ll. Palma, M. Terrado, B. Basile, F. Carteni, A. Dente, C. Ezquerra, F. Oldani, M. Otero, F. Santos-Alves, M. Torres, J. Valente, A. Soret

“…This service aims to help vineyard managers make decisions by anticipating the climate conditions up to three months in advance for a set of essential climate variables. The service includes the requirements of a set of intermediary users, which are disease risk and phenology researchers who feed their impact models with the provided climate forecasts. …”
Get full text

Cardiometabolic risk assessment by anthropometric and biochemical indices in mexican population by Luz Quirino-Vela, Miguel Mayoral-Chavez, Yobana Pérez-Cervera, Yobana Pérez-Cervera, Osiris Ildefonso-García, Elizabeth Cruz-Altamirano, Monserrat Ruiz-García, Juan Alpuche

“…We hypothesized that non-conventional indices would demonstrate superior diagnostic performance compared with traditional measures.MethodsWe analyzed data from 1,876 participants aged 20–80 years from the 2022 National Health and Nutrition Survey (ENSANUT). …”
Get full text

Feasibility of virtual T2-weighted fat-saturated breast MRI images by convolutional neural networks by Andrzej Liebert, Dominique Hadler, Chris Ehring, Hannes Schreiter, Luise Brock, Lorenz A. Kapsner, Jessica Eberle, Ramona Erber, Julius Emons, Frederik B. Laun, Michael Uder, Evelyn Wenkel, Sabine Ohlmeyer, Sebastian Bickelhaupt

“…Moderate inter-reader agreement was observed for edema detection on both T2w-FS images (κ = 0.49) and VirtuT2 images (κ = 0.44). …”
Get full text

Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study by Wenjun Wu, Shengsheng Yao, Daming Liu, Yuan Luo, Yihan Sun, Ting Ruan, Mengyou Liu, Li Shi, Chang Liu, Mingming Xiao, Qi Zhang, Zhengshuai Liu, Xingai Ju, Jiahao Wang, Xiang Fei, Li Lu, Yang Gao, Ying Zhang, Liying Gong, Xuanyu Chen, Wanli Zheng, Xiali Niu, Xiao Yang, Huimei Cao, Shijie Chang, Jianchun Cui, Zuoxin Ma

“…Combining ultrasound radiomics with machine learning offers potential for early detection in patients with normal thyroid function. …”
Get full text

Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Background There is some evidence to support approaches to reduce restrictive practices in settings for people with a learning disability who may also have a diagnosis of autism or mental health problems. …”
Get full text

Lung ultrasound (LUS) as a predictor of delirium in elderly patients with COVID-19 during hospitalization: A geriatric vulnerability-stress model by Thomas Fraccalini, MD, Isa Rita Bergoglio, MD, PhD, Gianfranco Fonte, MD, PhD, Andrea Trogolo, MD, Alessandro Maraschi, MD, Thomas Roberts, Beatrice Tarozzo, PsyD, Beatriz Vitorino, MS, Julia Michelin Vecchini, MS, Santoro Mariangela, MD, Monica Traversa, MD, PhD, Teresa Crea, MD, Luciano Cardinale, MD, PhD, Giuseppe Maina, MD, Valerio Ricci, MD, PhD, Elisa Binello, CNO, Reald Turja, NU, Federico Mallamaci, NU, Giovanni Volpicelli, MD

“…Conclusion: While delirium is multifactorial, integrating LUS into routine assessment may improve early detection and management in resource-limited settings, effectively identifying high-risk patients using an accessible bedside investigation. …”
Get full text

Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) [version 2; peer review: 2 approved, 1 approved with reservations] by Andrew Kambugu, Allan Kengo, Christine Sekaggya-Wiltshire, Francis Williams Ojara, Eva Agnes Laker Odongpiny, Reuben Kiggundu, Isabella Kyohairwe, Catriona Waitt, Hope Mackline, Noela Owarwo, Aida N Kawuma, Allan Buzibye, Francis Kakooza

“…People living with HIV (PLWH) are particularly vulnerable to AMR with potential drug-drug interactions between antiretroviral and antimicrobial agents against common organisms like Mycobacterium tuberculosis. There is limited data on the concentrations of commonly used antimicrobial agents in people living with HIV in resource-limited settings. …”
Get full text

Healthcare providers' perspectives on the Canadian Caries Risk Assessment Tool implementation in Indigenous pediatric primary care: a qualitative study by Olubukola O. Olatosi, Robert J. Schroth, Daniella DeMaré, Betty-Anne Mittermuller, Maria Manigque, Jeanette Edwards, Maryam S. Amin, Alexandra Nicolae, Josée Lavoie, Julianne Sanguins, Prashen Chelikani, Peter D. Wong, Jesse Lamoureux, Mary Bertone, Katherine Yerex, Rhonda Campbell, The Working Together for early childhood oral health study team

“…Integrating caries risk assessment (CRA) into primary care settings could improve early detection and intervention. …”
Get full text