Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…For the first time, the synthetic CB1 cannabinoids AM-404, arvanil, and olvanil significantly altered cancer cells in forming missile-like shapes to induce tunneling nanotube (TNT) communications in PANC-1 cells. …”
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FROM FARCE TO HYPE (ISSUES OF MODERN INTERNET COMMUNICATION) / ОТ БАЛАГАНА ДО ХАЙПА (ПРОБЛЕМЫ СОВРЕМЕННОЙ ИНТЕРНЕТ-КОММУНИКАЦИИ)... by SЕMЕNОVА ELENA А. / СЕМЕНОВА Е.А.

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Evaluation of the Occurrence of Initial Failures from Stress Concentrators in Welded Joints and Structural Elements by K. А. Molokov, V. V. Novikov, M. Dabalez

“…Introduction. Data on the occurrence of initial failures obtained through testing on standard samples cannot always be extrapolated to real welded joints and structures. …”
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Prediction and validation of mechanical properties of self-compacting geopolymer concrete using combined machine learning methods a comparative and suitability assessment of the be... by Kennedy C. Onyelowe, Ahmed M. Ebid, Paul Awoyera, Viroon Kamchoom, Evelin Rosero, María Albuja, Carlos Mancheno

“…For these reasons, the present research work has applied the intelligent learning abilities of eight (8) ensemble-based and one (1) symbolic regression machine learning methods to predict the strengths (compressive-Fc, flexural-Ff and splitting tensile-Ft) of SCGPC with the “Orange Data Mining” software version 3.36. In this research paper, the influence of the industrial wastes like ground granulated blast furnace slag (GGBS) and fly ash (FA) and alkali activators such as (NaOH and Na2SiO3) on the performance self-compacting geopolymer concrete (SCGPC) in terms of strength has been studied. …”
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Strategic advances in Vat Photopolymerization for 3D printing of calcium phosphate-based bone scaffolds: A review by Roberto Fagotto-Clavijo, Irene Lodoso-Torrecilla, Anna Diez-Escudero, Maria-Pau Ginebra

“…The need to tailor porosity, pore size, and geometric design to achieve both mechanical integrity and biological functionality is emphasized by a review of data published in the recent literature. This review demonstrates that advanced geometries like Triply Periodic Minimal Surfaces and nature-inspired designs, achievable with exceptional precision by this technology, enhance mechanical and osteogenic performance. …”
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The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Blockchain is essentially a public ledger, where groups of transactions or events are recorded and stored in a chain-like data structure; this approach creates a fast yet secure way to transfer funds. …”
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Ultradiffuse Dwarf Galaxies Hosting Pseudobulges by Yu Rong, Hong-Xin Zhang, Cheng Cheng, Qi Guo, Weiyu Ding, Zichen Hua, Huiyuan Wang, Xu Kong

“…By analyzing data from DESI Legacy Imaging Survey of the dwarf galaxies in the Arecibo Legacy Fast Alfa Survey, we have identified five ultradiffuse galaxies (UDGs) featuring central pseudobulges. …”
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In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…Moreover, our data indicate that miR-429 represents a potential therapeutic target against photoreceptor degeneration.…”
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PM_2.5 Exposure as a Risk Factor for Optic Nerve Health in Type 2 Diabetes Mellitus by Tianyi Yuan, Minna Cheng, Yingyan Ma, Haidong Zou, Haidong Kan, Xia Meng, Yi Guo, Ziwei Peng, Yi Xu, Lina Lu, Saiguang Ling, Zhou Dong, Yuheng Wang, Qinping Yang, Wenli Xu, Yan Shi, Cong Liu, Senlin Lin

“…Considering the close relationship between the optic nerve and the central nervous system, these findings may also reflect broader neurodegenerative processes.…”
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The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial by R.D. Singh, J.T.J.M. van Dijck, T.A. van Essen, H.P. Nix, R.J.G. Vreeburg, H.F. den Boogert, G.C.W. de Ruiter, B. Depreitere, W.C. Peul

“…Moreover, the COVID-19 pandemic added additional hurdles like delayed medical-ethical approval, a decline in eligible patients and repeated trial halts during the peaks of the pandemic. …”
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Comparative transcriptomic analysis of mouse macrophages infected with live attenuated vaccine strains of Mycobacterium tuberculosis by Raja Veerapandian, Barbara Yang, Areanna Carmona, Melina J. Sedano, Victoria Reid, Victoria Reid, Rodrigo Jimenez, Rodrigo Jimenez, Jessica Chacon, Chinnaswamy Jagannath, Enrique I. Ramos, Enrique I. Ramos, Shrikanth S. Gadad, Shrikanth S. Gadad, Subramanian Dhandayuthapani, Subramanian Dhandayuthapani

“…The transcriptomic data were compared with similar data obtained from macrophages infected with Mtb H37Rv and BCG. …”
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The Impact of Audit Quality on Organizational Capital and Financing Capacity by Somaye Fathi, Mahdi Bahar Moghadam, Kazem Shamsadini

“…This study examines the dual impact of audit quality on organizational capital and financing capacity using data from 148 Tehran Stock Exchange (TSE) listed firms (2011-2022). …”
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PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1 by Lvyun Zhu, Ying Qu, Junru Yang, Tong Shao, Jingyu Kuang, Chuanyang Liu, Yanhua Qi, Ming Li, Ming Li, Yingying Li, Sujuan Zhang, Jingyang Wang, Yu Liu, Jiali Liu, Yanming Hu, Lingyun Zhu, Tao Hou

“…Although PD-L2 is also inducible by IFNγ, like PD-L1, it displays a unique spatial distribution within the tumor microenvironment, implying discrete roles in immune evasion. …”
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Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models by Brajesh P. Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Robert W. Wilkinson, Scott A. Hammond, Jim Eyles

“…CD73 is a cell surface 5’nucleotidase (NT5E) and key node in the catabolic process generating immunosuppressive adenosine in cancer. …”
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Analysis of immune cell activation in patients with diabetes foot ulcer from the perspective of single cell by Lehoanganh Vu, Fei Xu, Ting Li, Qikai Hua, Xiaocong Kuang, Yongqiang Jiang, Yanfei Liang, Xing Niu, Yixuan Chen, Chengyu Huang, Weiliang Mo, Kejian Wang, Kaihua Tang, Jianwen Mo, Ke-Er Lu, Yan Mo, Steven Mo, Dengfeng Yang, Jinmin Zhao

“…Methods Single-cell RNA sequencing data were used to create a detailed single-cell ecological landscape of DM and DFU. …”
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Comparative transcriptomes reveal insights into different host responses associated with Fusarium head blight resistance in wheat by Hao Wang, Xiaoying Yang, Tingting Li, Zuchun Li, Jianing Zhao, Zi Wang, Zhenyu Wang, Tingdong Li, Chunhuan Chen, Jixin Zhao, Changyou Wang, Xinlun Liu, Pingchuan Deng, Wanquan Ji

“…Some of these genes have previously been reported to participate in physiological processes related to wheat FHB resistance, including Pm3-like resistance proteins, lactoylglutathione lyase, serine/threonine protein phosphatases, NBS-LRR resistance proteins, glutathione S-transferase (GST), and RPM1 resistance proteins. …”
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3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

“…SMART-seq2 transcriptome sequencing further confirmed that PNMC treatment disrupted global gene expression in 2-cell embryos, with differentially expressed genes enriched in multiple signaling pathways, including those related to autophagy, apoptosis, fertilization, embryonic development, transcription, and mRNA processing. Integration of transcriptome data with open databases revealed that both zygotic genome activation genes and maternal factors experienced significant transcript-level disruptions. …”
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Extracellular Vesicles Present in Bone Marrow Mesenchymal Stromal/Stem Cell Conditioned Media Restore Spermatogenesis in Azoospermic Mice by Rano Zhankina, Afshin Zare, Alireza Afshar, Arezoo Khoradmehr, Mohammad Reza Dorvash, Farhad Rahmanifar, Nader Tanideh, Omid Koohi Hosseinabadi, Ali Arabi Monfared, Shahrokh Zare, Nadiar Mussin, Asset Askerovich Kaliyev, Ulanbek Zhanbyrbekuly, Amin Tamadon

“…The BM-MSC and BMCM therapy groups showed more favorable outcomes compared to other groups. Key exosome factors like Basigin, E3 ubiquitin-protein ligase (UBR2), transforming growth factor beta (TGF-β), hepatocyte growth factor (HGF), and programmed death-ligand 1 (PD-L1) interacted with receptors critical to this process.Conclusion: Our findings indicate that both BMCM enriched with EVs and the administration of AT-MSCs and BM-MSCs effectively induced spermatogenesis in mice with busulfan-induced azoospermia. …”
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Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity by Jingzeng Cai, Jiaqiang Huang, Di Li, Xintong Zhang, Bendong Shi, Qiaohan Liu, Cheng Fang, Shiwen Xu, Ziwei Zhang

“…SelenoM contributes to the modulation of antioxidative stress and inflammation in multiple pathological processes; however, its roles in metaflammation and the proinflammatory macrophage (M1)-like state in adipose tissue have not been determined. …”
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The role of GLP-1 receptor agonists in IBD-related surgery and IBD-related complications of inflammatory bowel disease among patients with metabolic comorbidities: a systematic rev... by Mengqi Yang, Yujia Huo, Yujia Huo, Yujia Huo, Zhining Liu, Guannan Bai, Dongjun He, Lin Zhang, Lin Zhang, Lin Zhang

“…BackgroundGlucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for type 2 diabetes and obesity, and emerging evidence suggests potential immunomodulatory effects. …”
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