Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in Drosophila blastoderm embryos by Allison E. Schloop, Sharva Vijayakumar Hiremath, Razeen Shaikh, Sadia Siddika Dima, Leslie Lizardo, Amrit Bhakta, Cranos M. Williams, Gregory T. Reeves

“…Summary: The NF-κB/IκBα pathway regulates key cellular processes, including development, immunity, and inflammation. …”
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PDCL3 promotes the vasculogenic mimicry of glioma-associated mesenchymal stem cells through VEGFR-2 in glioma environment by Yihao Wang, Zhen Liu, Dongye Yi, Sujie Gu, Zesheng Peng, Haofei Wang, Peng Lv, Wei Xiang, Xiaobing Jiang, Peng Fu

“…However, the biological properties and molecular mechanisms underlying this process remain poorly understood. In the glioma microenvironment, our data revealed that the upregulation of Phosducin-like 3 (PDCL3) in GA-MSCs influences the expression of the downstream Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) and pericyte markers, indicating a transformational relationship between GA-MSCs and pericytes. …”
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Update of the safety assessment of N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amines (FCM No 19) and N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine hydrochlorides (FCM No 20) for their use in... by EFSA Panel on Food Contact Materials (FCM), Claude Lambré, Riccardo Crebelli, Maria daSilva, Konrad Grob, Evgenia Lampi, Maria Rosaria Milana, Marja Pronk, Mario Ščetar, Georgios Theodoridis, Els Van Hoeck, Nadia Waegeneers, Claudia Bolognesi, Ronan Cariou, Laurence Castle, Emma Di Consiglio, Roland Franz, Detlef Wölfle, Zainab Al Harraq, Eric Barthélémy, Daniele Comandella, Julia Fontán Vela, Blanka Halamoda, Gilles Rivière

“…Based on the provided data, the FCM Panel concluded that the FCM substance No 19, N,N‐bis(2‐hydroxyethyl)alkyl(C8‐C18)amine, is not of safety concern for the consumer if (i) the substance is used at up to 0.1% w/w as polymer production aid and as processing aid to manufacture polyolefin materials and articles of thickness up to 1 mm that are intended for contact with all types of food except infant foods. …”
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Xpert Ultra stool testing to diagnose tuberculosis in children in Ethiopia and Indonesia: a model-based cost-effectiveness analysis by Peter J Dodd, Nyashadzaishe Mafirakureva, Rina Triasih, Debebe Shaweno, Jens Levy, Eveline Klinkenberg, Petra de Haas, Ineke Spruijt, Nastiti Kaswandani, Ahmed Bedru, Melaku Gebremichael, Edine W Tiemersma

“…The simple one-step (SOS) stool method enables processing for Xpert testing at the primary healthcare (PHC) level. …”
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Investigating the gut bacteria structure and function of hibernating bats through 16S rRNA high-throughput sequencing and culturomics by Jian Zhou, Ying Liu, Tao Gu, Jingzhu Zhou, Fengming Chen, Shijun Li

“…We captured three hibernating bat species—Pipistrellus (PB), Rhinolophus (RB), and Myotis (MB)—in Liping County, collecting rectal samples for 16S rRNA amplicon sequencing. Data processing involved Trimmomatic, Flash, and Qiime2 for operational taxonomic unit (OTU) standardization and species annotation via the Greengenes database. …”
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The impact of REM-sleep behavior disorder on people with Parkinson’s disease and their partners by Eva M. Prins, Angelique Pijpers, Noortje Verbeek, Sirwan K. L. Darweesh, Angelika D. Geerlings, Marjan J. Meinders, Bastiaan R. Bloem, Karin D. van Dijk, Lisanne J. Dommershuijsen

“…Quantitatively, we analyzed data from the PRIME-NL Parkinson Evaluation study, including 829 PwP and 452 partners, using multivariable regression models to examine the association between screen-positive RBD and HRQoL. …”
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Advancing food security: The role of machine learning in pathogen detection by Helen Onyeaka, Adenike Akinsemolu, Taghi Miri, Nnabueze Darlington Nnaji, Clinton Emeka, Phemelo Tamasiga, Gu Pang, Zainab Al-sharify

“…However, challenges persist, particularly with data quality, model interpretability, and regulatory compliance. …”
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SGF29 nuclear condensates reinforce cellular aging by Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu

“…Abstract Phase separation, a biophysical segregation of subcellular milieus referred as condensates, is known to regulate transcription, but its impacts on physiological processes are less clear. Here, we demonstrate the formation of liquid-like nuclear condensates by SGF29, a component of the SAGA transcriptional coactivator complex, during cellular senescence in human mesenchymal progenitor cells (hMPCs) and fibroblasts. …”
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Cobalt(II) and Nickel(II) Cubane {M₄O₄} Complexes Derived from Di-2-pyridyl Ketone and Benzoate: Syntheses, Structure and Magnetic Properties by Carolina Pejo, Santiago Valiero, Carlos Rojas-Dotti, Guilherme P. Guedes, Joan Cano, Miguel A. Novak, Raúl Chiozzone, Maria G. F. Vaz, Ricardo González

“…DFT and CASSCF/NEVPT2 calculations were also performed to support the fitting of experimental magnetic data.…”
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Human and environmental feature-driven neural network for path-constrained robot navigation using deep reinforcement learning by Nabih Pico, Estrella Montero, Alisher Amirbek, Eugene Auh, Jeongmin Jeon, Manuel S. Alvarez-Alvarado, Babar Jamil, Redhwan Algabri, Hyungpil Moon

“…These features encompass data about the robot, humans, static obstacles, and path constraints. …”
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Crosstalk between macrophages and mesenchymal stem cells shape patterns of osteogenesis and immunomodulation in mineralized collagen scaffolds by Vasiliki Kolliopoulos, Maxwell Polanek, Melisande Wong Yan Ling, Aleczandria Tiffany, Kara L. Spiller, Brendan A.C. Harley

“…This work illuminates a critical need to further understand these processes in more clinically relevant cell models to inform biomaterial design.…”
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Evaluation of the Influence of <i>Tanacetum vulgare</i> Extract on Cognitive Functions and Hippocampal BDNF Expression by Borislava Lechkova, Michaela Shishmanova-Doseva, Niko Benbassat, Reneta Gevrenova, Pepa Atanassova, Nadya Penkova, Lyudmil Peychev, Petar Hrischev, Zhivko Peychev, Stanislava Ivanova

“…However, the literature data on its effects on cognitive function are scarce. …”
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Identifying enablers for a circular healthcare supply chain: An integrated fuzzy DEMATEL-MMDE approach with hesitant information by Deepak Agrawal, Sumit Gupta, Chandni Dusad, M.L. Meena, G.S. Dangayach, Sandeep Jagtap

“…The CE defies the conventional take-make-dispose process and advocates for optimized resource use throughout its entire lifecycle. …”
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Development and validation of a disulfidptosis-related genes signature for predicting outcomes and immunotherapy in acute myeloid leukemia by Han Gong, Han Gong, Ying Zhang, Xusheng Wu, Yiming Pan, Yiming Pan, Mingwei Wang, Mingwei Wang, Xiaofeng He, Jing Liu, Zhong Liu, Zhong Liu, Ling Li

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Marine Prosperity Areas: a framework for aligning ecological restoration and human well-being using area-based protections by Octavio Aburto-Oropeza, Valentina Platzgummer, Erica M. Ferrer, Catalina López-Sagástegui, Rocío de Guadalupe Abud Mirabent, América Ávalos Galindo, Fabio Favoretto, Alfredo Giron-Nava, Isabel Mendoza Camacho, Claudia Núñez Sañudo, Marisol Plascencia de La Cruz, Alejandro Robles

“…This concept leverages a suite of tried-and-true community-based intervention and investment strategies to strengthen and expand access to environmental science, social goods and services, and the financial perks of the blue economy. This data-driven framework may be of interest to stakeholders who support traditional area-based conservation models, but also to those who have been historically opposed to MPAs or have been excluded from past conservation processes.…”
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A low-cost, open-source device to evaluate limb stiffness in a rabbit model of cerebral palsy by Preston R. Steele, Preston R. Steele, Joel Feldmann, Joel Feldmann, Katharina A. Quinlan, Katharina A. Quinlan, Marin Manuel, Marin Manuel

“…BackgroundMovement disorders such as cerebral palsy (CP) are frequently associated with joint and muscle stiffness, often evaluated using subjective clinical methods like the Modified Ashworth Scale or Tardieu Scale. …”
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An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo by Giorgia Gazzaroli, Camilla Tavani, Serena Filiberti, Maria Luisa Massardi, Marta Turati, Giulia Garattini, Thomas S. Peat, Giuseppe Pieraccini, Andrea Angeli, Claudiu T. Supuran, Fabrizio Carta, Arianna Giacomini, Roberto Ronca

“…Abstract Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic and stem-like features, drug resistance and recurrence. …”
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Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters by Yili Zhang, Xiangyun Guo, Kai Sun, Liang Wang, Siyuan Huang, Yiwen Gan, Jinran Qin, Qingqing Liu, Yan Li, Zikai Jin, Liguo Zhu, Xu Wei

“…We used compounds and targets, applying Summary data-based Mendelian Randomisation (SMR) analysis for biological process and molecular function enrichment. …”
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OVERVIEW OF CLASS-I TRIPARTITE MOTIF (TRIM) PROTEINS SPECIFICALLY TRIM67 by S. N. Panhwar, C. Huang, Q. Luo, X. Yu, L. Jia, W. Liu, Z. Chen

“…This review emphasized data on Class-I TRIM genes, including TRIM1, TRIM9, TRIM36, TRIM46, TRIM67, TRIM18, and TRIM76. …”
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A Comprehensive Survey on Digital Twin: Focusing on Security Threats and Requirements by Hyeran Mun, Kyusuk Han, Ernesto Damiani, Hyun Ku Yeun, Tae-Yeon Kim, Luigi Martino, Chan Yeob Yeun

“…Integration with technologies like artificial intelligence (AI), big data, edge computing, and the Internet of Things (IoT) has propelled the development of DTs. …”
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