Scale-up of CHO cell cultures: from 96-well-microtiter plates to stirred tank reactors across three orders of magnitude by Anne Neuss, Thomas Steimann, Jacinta Sofia Tomas Borges, Robert Dinger, Jørgen Barsett Magnus

“…A lot of studies concern the scale transfer between different-sized stirred tank reactors. However, process development usually starts in even smaller cultivation vessels like microtiter plates or shake flasks. …”
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PhET Simulation Worksheet for Momentum and Impulse Learning Using the POE2WE Model by Muhamad Aqil Ridho, Khusaini Khusaini, Sunaryono Sunaryono

“…Furthermore, student responses to the use of these worksheets during the learning process yielded a score of 89%, categorized as "practical." …”
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Combined method for acoustic cavitation research by A. V. Kotukhov, V. S. Gavrilyuk, V. S. Minchuk, N. V. Dezhkunov

“…At present, the field of applications of powerful ultrasound is expanding intensively, and the improvement of equipment and technological processes continues. With that, the key factor in the effect of ultrasonic vibrations on processes in liquids and liquid-like media is cavitation, i.e. the phenomenon of formation, pulsation and collapse of gas microbubbles under the influence of variable pressure. …”
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Optimizing Artificial Neural Networks Using Mountain Gazelle Optimizer by Muhammed Abdulhamid Karabiyik, Bahaeddin Turkoglu, Tunc Asuroglu

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Enhanced interpretable thyroid disease diagnosis by leveraging synthetic oversampling and machine learning models by Ali Raza, Fatma Eid, Elisabeth Caro Montero, Irene Delgado Noya, Imran Ashraf

“…Hyperthyroidism can lead to increased metabolism, causing symptoms like rapid weight loss, anxiety, irritability, and heart palpitations. …”
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Progressive Conversion Model Applied to the Physical Activation of Activated Carbon from Palm Kernel Shells at the Pilot Scale in a Nichols Furnace and at the Industrial Scale in a... by Ernesto de la Torre, Alex S. Redrovan, Carlos F. Aragón-Tobar

“…The model’s predictions closely matched the experimental data, validating its applicability for process optimization at both the pilot and industrial scales. …”
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Teletandem and project pedagogy in language and culture learning: Challenges and perspectives in new practices of virtual exchange by Rejane M. Gonçalves Maia, Francisco J. Quaresma de Figueiredo

“…They were equipped with theoretical and practical knowledge on applying project-based pedagogy in learning. Like teletandem, project pedagogy is also anchored in the theories of collaboration and socio-interactionism. …”
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Investigating the stochastic higher dimensional nonlinear Schrodinger equation to telecommunication engineering by Aziz Khan, Jan Muhammad, Usman Younas, Rajermani Thinakaran, Thabet Abdeljawad, Manar A. Alqudah

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Characterizing modifications to the mental health gap action programme (mhGAP) intervention guide during implementation in low- and middle-income countries using the framework for... by Harikeerthan Raghuram, Akanksha Jayant Rajguru, Mythili Menon Pathiyil, Aakrushi Brahmbhatt, Anant Bhan, Jessica Spagnolo, John A. Naslund

“…There is a notable lack of reporting on challenges, processes, and outcomes. Recommendations have been made to expand FRAME, namely, sources of knowledge, financial and temporal resources employed during the process of modification. …”
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Zebrafish as a model system for studying reproductive diseases by Wenwen Zha, Weitao Hu, Chenkai Ge, Jianjun Chen, Jianjun Chen, Zigang Cao

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A novel machine learning models for meteorological drought forecasting in the semi-arid climate  region by Chaitanya Baliram Pande, Dinesh Kumar Vishwakarma, Aman Srivastava, Kanak N. Moharir, Fahad Alshehri, Norashidah Md Din, Lariyah Mohd Sidek, Bojan Đurin, Abebe Debele Tolche

“…In conclusion, the study addressed the challenge proposed  by incomplete previous data for monitoring and forecasting regional drought events by employing advanced data imputation techniques, ensemble learning methods, and incorporating robust ML  models like SVM and Matern GPR.…”
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Enhancing Transpiration Estimates: A Novel Approach Using SIF Partitioning and the TL-LUE Model by Tewekel Melese Gemechu, Baozhang Chen, Huifang Zhang, Junjun Fang, Adil Dilawar

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Integrative modeling of the spread of serious infectious diseases and corresponding wastewater dynamics by Nina Schmid, Julia Bicker, Andreas F. Hofmann, Karina Wallrafen-Sam, David Kerkmann, Andreas Wieser, Martin J. Kühn, Jan Hasenauer

“…However, challenges remain in optimizing sampling protocols, locations, and normalization strategies, particularly in accounting for environmental factors like precipitation.We present an integrative model that simulates the spread of serious infectious diseases by linking detailed infection dynamics with wastewater processes through viral shedding curves. …”
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A cloud-based framework for the quantification of the spatially-explicit uncertainty of remotely sensed benthic habitats by Spyridon Christofilakos, Alina Blume, Avi Putri Pertiwi, Chengfa Benjamin Lee, Dimosthenis Traganos, Peter Reinartz

“…The calculation of the spatially-explicit uncertainty is based on the Shannon Entropy equation and the probability values of a successful prediction according to the ML model. The remote sensing data for this study are sourced from the European Union Copernicus Sentinel-2 twin satellite system and Planet’s cubesat satellite constellation respectively, and have been processed and analyzed through the Google Earth Engine cloud-based platform. …”
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Secretor and non-secretor human milk oligosaccharides differentially modulate immune response in the presence of cow’s milk allergen β-lactoglobulin in an in vitro sensitization mo... by Anneke H. Hellinga, Anneke H. Hellinga, Marit Zuurveld, Marko Mank, Aletta D. Kraneveld, Aletta D. Kraneveld, Johan Garssen, Johan Garssen, Kennedy Spann, Lars Bode, Linette E. M. Willemsen, Belinda van’t Land, Belinda van’t Land

“…IntroductionFood allergies, like cow’s milk allergy, significantly impact children, with sensitization often beginning during the first year of life. …”
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Paleo-Hydrothermal Predecessor to Perennial Spring Activity in Thick Permafrost in the Canadian High Arctic, and Its Relation to Deep Salt Structures: Expedition Fiord, Axel Heiber... by Marcos Zentilli, Christopher R. Omelon, Jacob Hanley, Darren LeFort

“…Abundant sulfides pyrite and marcasite and minor chalcopyrite, sphalerite, and galena occur in masses and veins, much like in base metal deposits known as Mississippi Valley Type; their weathering is responsible for brown Fe oxides forming a gossan. …”
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Pharmacological and non-pharmacological interventions in patients undergoing nasal surgeries for prevention of emergence agitation: a systematic review and network meta-analysis by Gustavo R.M. Wegner, Bruno F.M. Wegner, Henrik G. Oliveira, Luis A. Costa, Luigi W. Spagnol, Valentine W. Spagnol, Gilberto T.F. de Oliveira Filho

“…Bayesian NMA, MetaInsight web app, and Cochrane Foundation Risk of Bias Assessment Tool were applied for data analysis and bias assessment. Results: After a rigorous selection process, 17 Randomized Controlled Trials (RCTs) encompassing 2,122 patients and 14 interventions were included. …”
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Evolutionary measures show that recurrence of DCIS is distinct from progression to breast cancer by Angelo Fortunato, Diego Mallo, Luis Cisneros, Lorraine M. King, Aziz Khan, Christina Curtis, Marc D. Ryser, Joseph Y. Lo, Allison Hall, Jeffrey R. Marks, E. Shelley Hwang, Carlo C. Maley

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Dynamic causal modeling of neural responses to an orofacial pneumotactile velocity array by Yingying Wang, Rebecca Custead, Hyuntaek Oh, Steven M. Barlow

“…The present study aims to characterize the effectivity connectivity elicited by three different saltatory velocities (5, 25, and 65 cm/s) over the lower face using dynamic causal modeling on functional magnetic resonance imaging data of twenty neurotypical adults. Our results revealed the contralateral SI and SII as the most likely sources of the driving inputs within the sensorimotor network for the pneumotactile stimuli, suggesting parallel processing of the orofacial pneumotactile stimuli. …”
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Maternal Western-style diet has a persistent effect on offspring gene expression in skeletal muscle of Japanese macaques by Emily A. Beck, Byron Hetrick, Luis Nassar, Douglas W. Turnbull, Tyler A. Dean, Diana L. Takahashi, Maureen Gannon, Stephanie R. Wesolowski, Kjersti M. Aagaard, Jacob E. Friedman, Paul Kievit, Carrie E. McCurdy

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