Safety and Effectiveness of a Biosimilar Recombinant Growth Hormone in Adults with Growth Hormone Deficiency: Analysis of Final Data from PATRO Adults, an International Post-Market... by Beck-Peccoz P, Höybye C, Simsek S, Stalla G, Murray RD, Esmael A, Urosevic D, Boldea A, Zabransky M

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LC-QTOF-MSE with MS1-based precursor ion quantification and SiMD-assisted identification enhances human urine metabolite analysis by Alongkorn Kurilung, Suphitcha Limjiasahapong, Kwanjeera Wanichthanarak, Weerawan Manokasemsan, Khwanta Kaewnarin, Kassaporn Duangkumpha, Siriphan Manocheewa, Rossarin Tansawat, Roongruedee Chaiteerakij, Intawat Nookaew, Yongyut Sirivatanauksorn, Sakda Khoomrung

“…Although LC-QTOF‑MSE sensitivity is at least nine-fold lower than LC-triple quadrupole MS with multiple reaction monitoring, it remains adequate for quantifying urinary metabolites, particularly those that fragment poorly or yield low‑intensity product ions. For post‑targeted screening and untargeted profiling, an in‑house reference library (the Siriraj Metabolomics Data Warehouse, SiMD), comprising 174 curated metabolite standards, was integrated into the workflow to enhance metabolite identification confidence. …”
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HER2-low status as a distinct breast cancer subtype: myth or truth? Analysis of the WSG trials WSG-ADAPT-HR+/HER2-, WSG-PlanB, and WSG-ADAPT-TN by Gilda Schmidt, Oleg Gluz, Matthias Christgen, Mattea Reinisch, Sherko Kümmel, Ulrike Nitz, Michael Braun, Bahriye Aktas, Kerstin Lüdtke-Heckenkamp, Helmut Forstbauer, Eva-Maria Grischke, Claudia Schumacher, Rolf Mahlberg, Wolfram Malter, Toralf Reimer, Benno Nuding, Andrea Stefek, Rachel Wuerstlein, Monika Graeser, Katarzyna Jóźwiak, Sandy Burmeister, Christine zu Eulenburg, Michael Lauseker, Cornelia Kolberg-Liedtke, Aleix Prat, Peter Schmid, Rick Baehner, Hans Heinrich Kreipe, Erich-Franz Solomayer, Nadia Harbeck, on behalf of the West German Stud y Group investigators

“…Abstract Background New data show that not only HER2-overexpressing breast cancer (BC) tumors but also HER2-low tumors, classically considered as HER2-negative, respond to HER2-targeting antibody–drug-conjugates. …”
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Predicting the spatial demand for public charging stations for EVs using multi-source big data: an example from jinan city, china by Qimeng Ren, Ming Sun

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Is exposure to a climate-related disaster associated with recent experiences of intimate partner violence among women? A post hoc analysis of survey data from rural Samoa by Andrew Copas, Hattie Lowe, Laura J Brown, Jenevieve Mannell, Pepe Tevaga, Papali’i Ene Isaako, Fa’afetai Alisi-Fesili, Louisa Apelu, Kaisarina Moananu, Taiaopo Faumuina, Lewis Sinclair, Helen Tanielu

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Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer by Junyi Li, Shixin Li, Dongpo Zhang, Yibing Zhu, Yue Wang, Xiaoxiao Xing, Juefei Mo, Yong Zhang, Daixiang Liao, Jun Li

“…Through drug sensitivity analysis, potential drugs that are more effective for both high- and low-risk groups have been identified. …”
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SWOT and PESTEL analyses in assessing the sustainability of In-stream wetlands in Egypt by Hany Mostafa

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Benchmarking Open-Source Large Language Models for Sentiment and Emotion Classification in Indonesian Tweets by Arbi Haza Nasution, Aytug Onan, Yohei Murakami, Winda Monika, Anggi Hanafiah

“…This study contributes to NLP in a relatively low-resource language (Bahasa Indonesia) by evaluating zero-shot classification performance on a labeled tweet corpus. …”
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Study on the impact of industrial and commercial capital going to the countryside on non-grain production of cultivated land—based on the provincial panel data of China from 2013 t... by Hongli Yang, Fengjuan Wang

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Molecular and immune landscape of melanoma: a risk stratification model for precision oncology by Miao Sun, Junliang Wu

“…Single-sample gene set enrichment analysis (ssGSEA) was employed to classify patients into high and low immune groups. …”
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Genetic analysis of three patients from two unrelated Chinese families with autosomal recessive spastic ataxia of Charlevoix-Saguenay by Hui Liu, Ranran Li, Chen Chen, Lin Shang, Ying Bai, Duo Chen, Xiangdong Kong, Qianqian Li

“…Additional copy number variant analysis of the WES data indicated that Patient #1 had a heterozygous gross deletion of chr13q12.12 (chr13:23,808,732 − 24,890,322). …”
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Research and implementation of multi-protocol association scheme on Uu interface in LTE-Advanced network by Lei LI, Zhizhong ZHANG, Bing XI

“…For the explosive growth of mobile data services in LTE-Advanced network and the low efficiency of multi-protocol association analysis process，on the basis of traditional signal monitoring system，a multi-protocol association analysis system of Uu interface in LTE-Advanced network was proposed by using big data technology （storage，processing and analysis）and multi-protocol association analysis technology.Firstly，Layer 1，Layer 2 and Layer 3 of Uu interface data business processes were processed efficiently and analyzed accurately.Then，the user data signaling process and service data flow were related to analyze.Finally，the proposed system was applied to the real network testing of Uu interface data in LTE-Advanced network.Test results show that the multi-protocol association analysis system described above achieves the expected effect and it is meaningful for improving user experiences，efficiently processing big data analytics and the promotion of precision marketing area.…”
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EXPERIMENTAL AND NUMERICAL ASSESSMENT OF A LAST STAGE ST BLADE DAMPING AT LOW LOAD OPERATION by Andrea Bessone, Luigi Carassale, Roberto Guida, Zdeněk Kubín, Antonio Alfio Lo Balbo, Michela Marrè Brunenghi, Lorenzo Pinelli

“…Testing on a downscaled steam turbine in T10MW test plant have been carried out to measure LSB aggregated damping at low load. Also numerical analysis to predict aerodynamic damping have been performed and results have been compared to experimental data, allowing software tool validation at low load.…”
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Surrogate modeling of passive microwave circuits using recurrent neural networks and domain confinement by Kaustab C. Sahu, Slawomir Koziel, Anna Pietrenko-Dabrowska

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Post-marketing safety of anakinra and canakinumab: a real-world pharmacovigilance study based on FDA adverse event reporting system by Hao Liu, Wei Yan, Jinsong Li, Dezhi Yan, Di Luo

“…We aimed to assess the safety signals associated with anakinra and canakinumab by conducting a pharmacovigilance analysis using the FDA Adverse Event Reporting System (FAERS) database.MethodsAdverse reaction data spanning from the first quarter of 2004 to the fourth quarter of 2023 was downloaded from the FAERS database. …”
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The Photometric Variability and Spectrum of the Hot Post-AGB Star IRAS 21546+4721 by Natalia Ikonnikova, Marina Burlak, Alexander Dodin

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Computing ecosystem risk hotspots: A mediterranean case study by Gianpaolo Coro, Laura Pavirani, Anton Ellenbroek

“…Traditional approaches evaluate single stressors, whereas complex models assess cumulative impacts of frequently interacting stressors and offer better accuracy at the expense of low cross-area re-applicability and long implementation times.We introduce a versatile, re-useable, and semi-automated workflow designed for big data-driven ecosystem risk assessment, utilising spatiotemporal data from open repositories. …”
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Prevalence of co-occurring forms of intimate partner violence against women aged 15–49 and the role of education-related inequalities: analysis of Demographic and Health Surveys ac... by Shuangyu Zhao, Shan Liu, Jiuxuan Gao, Ning Ma, Shaoru Chen, Joht Singh Chandan, Rockli Kim, Peter Karoli, John Lapah Niyi, Jayalakshmi Rajeev, Melkamu Aderajew Zemene, Md Nuruzzaman Khan, Hajirani M. Msuya, Chunling Lu, S.V. Subramanian, Feng Cheng, John S. Ji, Kun Tang, Pascal Geldsetzer, Zhihui Li

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Experience of using combined thermal and low-frequency stimulation in patients with lumbar sciatica by R. A. Bodrova, A. A. Ismagilova, A. R. Kamaleeva

“…Materials and methods. A retrospective analysis of statistical data was carried out on 90 patients in the department of medical rehabilitation of patients with dysfunction of the peripheral nervous system and the musculoskeletal system of the treatment and rehabilitation center of the State Autonomous Healthcare Institution "City Clinical Hospital No. 7 named after M. …”
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The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: a systematic review and meta-ana... by Zhongbao Zhou, Yongqiang Wang, Yumeng Chai, Tao Wang, Pu Yan, Yong Zhang, Xudong Yang

“…Background The goal of this meta-analysis intended to identify the efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) as a therapy for erectile dysfunction (ED).Methods This study integrated and analyzed the data using Cochrane method and GRADEpro GDT grading system. …”
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