A multijurisdictional healthcare-associated outbreak of Ralstonia pickettii from contaminated saline, Australia 2023 by Dr Kelsi Marris, Dr Ned Latham, Dr Caitlin Swift, Sandra Chaverot, Dr Sally Ellis, Narelle Dean, Nerida Russell-Green, Dr Benjamin Armstrong, Vishal Ahuja, Dr Kelly Tsang, Dr Amanda Cuss, Dr Kathy Dempsey, Dr Kate Clezy, Dr Therese Marfori, Dr Gajan Perinpanayagam, Dr Jordan Breed, Frances Sheehan, Dr Karina Kennedy, Dr Jen Kok, Dr Catherine Pitman, Prof Vitali Sintchenko, Dr Anthea Katelaris, Dr Christine Selvey

“…Probable cases had R. pickettii without WGS available.Case exposures were investigated through medical records, clinician interviews, and product procurement data. Microbiological testing of suspected products was conducted, and isolates were sequenced. …”
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Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension by Tiril P. Gurholt, Torbjørn Elvsåshagen, Shahram Bahrami, Zillur Rahman, Alexey Shadrin, Daniel E. Askeland-Gjerde, Dennis van der Meer, Oleksandr Frei, Tobias Kaufmann, Ida E. Sønderby, Sigrun Halvorsen, Lars T. Westlye, Ole A. Andreassen

“…We used magnetic resonance imaging data from n = 32,666 UK Biobank participants, and assessed the association of volumes of the whole brainstem and its main regions with blood pressure. …”
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Multi-omics analysis in primary T cells elucidates mechanisms behind disease-associated genetic loci by Chenfu Shi, Danyun Zhao, Jake Butler, Antonios Frantzeskos, Stefano Rossi, James Ding, Carlo Ferrazzano, Charlotte Wynn, Ryan Malcolm Hum, Ellie Richards, Muskan Gupta, Khadijah Patel, Chuan Fu Yap, Darren Plant, Richard Grencis, Paul Martin, Antony Adamson, Stephen Eyre, John Bowes, Anne Barton, Pauline Ho, Magnus Rattray, Gisela Orozco

“…We refine the mapping of GWAS loci to implicated regulatory elements, such as CTCF binding sites and other enhancer elements, aiding gene assignment. …”
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Therapeutic gene targets and epigenetic modifications in rheumatoid arthritis: Insights from MTX, JAK inhibitors, and LLDT-8 by Jianan Zhao, Yunshen Li, Runrun Zhang, Yu Shan, Chenyang Song, Yaxin Cheng, Yiming Shi, Yixin Zheng, Fuyu Zhao, Junyu Fan, Cen Chang, Yuejuan Zheng, Dongyi He

“…Methylation changes in key genes were examined using the GEO database (GSE46364), and clinical relevance was evaluated using RA patient data from the PEAC database. Results: Compared to the osteoarthritis FLS group, the RA FLS group showed significant differences in 5095 genes (3300 upregulated and 1795 downregulated). …”
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Systematic pan-cancer analysis identified NCOA4 as an immunological and prognostic biomarker and validated in lung adenocarcinoma by An Wang, Yun-ye Mao, Tao Li, Xin Zhou, Yi-bing Bai, Jia-pei Qin, Yi Dong, Ting Wang, Tong Zhang, Zhi-qiang Ma, Yi Hu

“…PPI network and KEGG/GO enrichment analyses implicated NCOA4 in immune-related biological processes and pathways. …”
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Membrane-associated ring–CH–type finger 2 protects against metabolic dysfunction-associated fatty liver disease by targeting fatty acid synthase by Dongsheng Ni, Zhaolai Qi, Shuang Ma, Yuefeng Wang, Dehuan Liang, Xiyue Zhang, Yong Man, Jingzhou Chen, Kefei Dou, Guoping Li

“…Nevertheless, the specific enzyme molecules implicated in this regulatory process remain to be elucidated. …”
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Factors influencing smoking cessation in Lebanese patients with bladder cancer: A cross sectional study by Georges Horkoss, Joey El Khoury, Rami Halabi, Anthony Kanbar, Serge Assaf, Anthony Mina, Sabine El Breidi, Charbel Dabal, Charbel El Hachem, Maher Abdessater, Rodrigue Saad, Antoine Kassis, Raghid El Khoury

“…A sample of patients diagnosed with BCa between 2015 and 2020 were contacted and data was collected between the months of September 2022 and May 2023. …”
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TECHNOLOGY-ASSISTED TEACHING ACTIVITIES IN AN ESAP CONTEXT: AN ECOLOGICAL PERSPECTIVE by Adina-Maria MEZEI

“…După aceea, se ilustrează câteva activități didactice în care sunt implicate instrumente digitale, evaluând unele din beneficiile și/sau dezavantajele lor. …”
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Threshold and Asymmetric Effects of Foreign Direct Investment on Inclusive Growth in Shanghai Cooperation Member Countries by marziyeh hosini, monireh Rafat

“…Considering its contribution and long-term implication, it is a narrow approach to lemmatize the role of FDI in promoting economic growth only. …”
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Identification and validation of a KRAS-macrophage-associated gene signature as prognostic biomarkers and potential therapeutic targets in melanoma by Beichen Cai, Beichen Cai, Beichen Cai, Qian Lin, Qian Lin, Qian Lin, Ruonan Ke, Ruonan Ke, Ruonan Ke, Jiaqi Yu, Jiaqi Yu, Jiaqi Yu, Lu Chen, Lu Chen, Xuejun Ni, Xuejun Ni, Hekun Liu, Xiuying Shan, Xiuying Shan, Biao Wang, Biao Wang, Biao Wang

“…The activation of KRAS signaling pathways is implicated in melanoma progression, yet its role in shaping the tumor microenvironment, particularly in macrophage infiltration, remains poorly understood.MethodsA comprehensive multi-platform approach was employed, analyzing gene expression data from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. …”
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Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors by Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel

“…Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, mechanisms, and therapeutic targeting remain incompletely understood. Recent reports implicate tumour-intrinsic PDL1 signals in the DNA damage response (DDR), including promoting homologous recombination DNA damage repair and mRNA stability of DDR proteins, but many mechanistic details remain undefined. …”
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Plasma Soluble Progenitor Cell Receptors as Biomarkers for Severe Anemia Among Malaria‐Infected Pediatrics: A Prospective Study in Ghana by Charles Nkansah, Samuel K. Appiah, Felix Osei‐Boakye, Emmanuel Appiah‐Kubi, Gabriel Abbam, Samira Daud, Charles A. Derigubah, Simon B. Bani, Moses Banyeh, Kofi Mensah, Ruby Tater, Jennifer Obeng Mensah, Anne Natornaa, Isaac Adjei, Muniru M. Tanko, Gilbert Amankwaa, Peter K. Selleh, Samuel B. Aboagye, Onwuka K. Chima, Sylvanus M. Kpangkpari, Prince Ottah, Enoch Boadi, Yeduah Quansah, Ejike F. Chukwurah, Boniface N. Ukwah, Victor U. Usanga

“…ABSTRACT Background Soluble forms of progenitor cell receptors may be implicated in the delayed erythropoietic response during severe anemia. …”
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Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways by Liya Liu, Liya Liu, Liya Liu, Ying Cheng, Ying Cheng, Guosheng Lin, Guosheng Lin, Huifang Zheng, Huifang Zheng, Xinran Zhang, Xinran Zhang, Peilin Zhao, Peilin Zhao, Meixuan Guo, Meixuan Guo, Qihong Liu, Qihong Liu, Wenyi Fang, Wenyi Fang, Wenrong Wang, Wenrong Wang, Anjum Jafri, Aling Shen, Aling Shen, Xiao Ke, Xiao Ke, Youqin Chen

“…The pivotal lncRNA-miRNA and miRNA-mRNA networks were predicted from sequencing data and bioinformatic analysis, and the results were exported using Cytoscape software. …”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. by Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty

“…We analyzed single-cell RNA sequencing (scRNA-Seq) data to compare brain BA receptor gene expression between AD and CON samples from the Religious Orders Study and Memory and Aging Project (ROSMAP) cohort (N = 46). …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Ideally, coding, study selection, data extraction and bias assessment would be done independently by two reviewers. …”
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DETERMINATION OF FREQUENCY AND RISK FACTORS OF SECONDARY MALIGNANCY DEVELOPMENT IN HEMATOLOGICAL MALIGNANCIES by Ennur Ramadan, Güven Çetin, Özge Pasin

“…Additionally, most studies on this topic conducted on data from the SEER (Surveillance, Epidemiology, and End Results) database. …”
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How lived experiences of illness trajectories, burdens of treatment, and social inequalities shape service user and caregiver participation in health and social care: a theory-info... by Carl R May, Katja C Gravenhorst, Alyson Hillis, Mick Arber, Carolyn A Chew-Graham, Katie I Gallacher, Frances S Mair, Ellen Nolte, Alison Richardson

“…We recorded country of origin, topic, sample size and data collection, sample composition (gender, age range and ethnicity), study design, mode of analysis and presentation of results. …”
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Historical trends and controlling factors of isoprene emissions in CMIP6 Earth system models by N. T. N. Do, K. Sudo, K. Sudo, A. Ito, A. Ito, A. Ito, L. K. Emmons, V. Naik, K. Tsigaridis, K. Tsigaridis, Ø. Seland, G. A. Folberth, D. I. Kelley

“…Models without CO<span class="inline-formula">₂</span> effects implicate climate change as the driver, but other models with CO<span class="inline-formula">₂</span> effects (fertilization only/fertilization and inhibition) indicate CO<span class="inline-formula">₂</span> and LULCC as the primary drivers. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…The value-based payment modifier: Program outcomes and implications for disparities. Ann Intern Med. 2018;168(4):255-265. doi:10.7326/M17-1740 [34] Bazzoli GJ, Thompson MP, Waters TM. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…The value-based payment modifier: Program outcomes and implications for disparities. Ann Intern Med. 2018;168(4):255-265. doi:10.7326/M17-1740 [34] Bazzoli GJ, Thompson MP, Waters TM. …”
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