Association Between Uric Acid to HDL-C Ratio and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Cross-Sectional Study by Zhu X, Yin H, Han J, Zhang X, Han Q, Sun W, Liu Y, Tao W, Liu X, Wang G, Li L

“…The uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a novel metabolic biomarker implicated in MASLD pathogenesis. This study aimed to evaluate the association between UHR and MASLD in a T2DM population.Methods: In this cross-sectional study, we analyzed clinical data from 1081 T2DM patients (464 without MASLD, 617 with MASLD). …”
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Comprehensive Bioinformatics Analyses and Experimental Validation of the Cell Cycle Related Protein SAPCD2 as a New Biomarker and Potential Therapeutic Target in Pancreatic Cancer by Liu Y, Li B, Ke L, Luo T, Wu H, Lin J, Deng Y, Huang X, Xu L, Liu Y, Qi J

“…SAPCD2, a cell cycle related gene, has been implicated in tumorigenesis and proposed as a potential therapeutic target in cancer. …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Abstract Background Tumor-derived small extracellular vesicles (sEVs) have been implicated in changes of the blood–brain barrier (BBB) during pre-metastatic niche formation. …”
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In-vitro immunomodulatory efficacy of extracellular vesicles derived from TGF-β1/IFN-γ dual licensed human bone marrow mesenchymal stromal cells by Jiemin Wang, Seyedmohammad Moosavizadeh, Manon Jammes, Abbas Tabasi, Trung Bach, Aideen E. Ryan, Thomas Ritter

“…Dimensionality reduction using t-distributed stochastic neighbor embedding (t-SNE) was applied to multiparametric flow cytometry data for immune profiling. In addition, publicly available transcriptomic datasets (GSE122091 and GSE46019) were analyzed to identify differentially expressed genes (DEGs) in IFN-γ– and TGF-β1–licensed MSCs, providing insight into potential molecular drivers of EV-mediated immunoregulation. …”
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Detection of Human Adenovirus from Clinical Samples of Conjunctivitis by Real-time PCR: A Cross-sectional Descriptive Study by Ashish Anshuman, MJ Praseetha, Ambica Rangaiah, G Nagaraju, M Swetha, Shantala Gowdara Basawarajappa

“…Introduction: Human Adenoviruses (HAdV) have been implicated in a variety of infections, including conjunctivitis, respiratory tract infections, genitourinary infections and gastroenteritis. …”
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Prevalence Of Diabetes Mellitus And Its Associated Factors Among Tuberculosis Cases in Taluk Tuberculosis Unit, India - A Hospital-based : Exploratory Cross-sectional Study by Md Alinawaz Khan, Ashok Dorle

“… BACKGROUND: As per WHO global reports, one in each third person of the current world population is infected with tuberculosis, asymptomatically. NTEP data states that 25,52,000Tuberculosis cases were reported in 2023. …”
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Prognostic value of lipoprotein(a) for cardiovascular events after lower limb revascularization in diabetic patients with chronic limb-threatening ischemia by Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

“…Lipoprotein(a) (Lp(a)) has been implicated in cardiovascular risk, but its role in patients with T2DM and CLTI undergoing revascularization remains unclear. …”
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Long-term risk of de novo malignancy with tumor necrosis factor alpha (TNF) inhibitor immunosuppression: a multicenter, retrospective cohort study by Conor B. Driscoll, Jordan M. Rich, Christopher Yang, Joseph Nicolas, Dylan Isaacson, Philip Silberman, Xinlei Mi, Sai Kaushik Shakar Ramesh Kumar, Hui Zhang, Steven Belknap, William H. Temps, Edward M. Schaeffer, Shilajit D. Kundu

“…This is consistent with previous melanoma, skin SCC and BCC data and demonstrates novel findings for leukemia, NHL, and PCa. …”
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Dracaena trifasciata (Prain) Mabb leaf extract protects MIN6 pancreas-derived beta cells against the diabetic toxin streptozotocin: role of the NF-κB pathway by Christiaan Warner Hoornenborg, Christiaan Warner Hoornenborg, Nur Qomariyah, Nur Qomariyah, Herson Antonio González-Ponce, André Petrus Van Beek, Han Moshage, Gertjan Van Dijk

“…To investigate the relevance of the NF-κB pathway in our findings, we treated MIN6 cells with the proteasome inhibitor MG132 (at doses ≥0.2 μM), and observed that ST extract was no longer able to block STZ toxicity in MIN6 cells (p < 0.05), and to block CIAP2 expression, an anti-apoptotic target downstream from NF-κB.ConclusionThese data suggest that a leaf extract of ST has anti-diabetogenic efficacy, which may depend on the integrity of the NF-κB pathway. …”
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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. by Benjamin I Perry, Stephen Burgess, Hannah J Jones, Stan Zammit, Rachel Upthegrove, Amy M Mason, Felix R Day, Claudia Langenberg, Nicholas J Wareham, Peter B Jones, Golam M Khandaker

“…Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. …”
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ANATOMICAL AND GENETIC PREDISPOSITION FOR CARIES IN PERMANENT DENTITION. REVIEW by K.A. Udaltsova, E.O. Pisarenko

“…Functional analyses of these 53 genes revealed three major clusters: cytokine network relevant genes, matrix metalloproteinases (MMPs) family, and transforming growth factor-beta (TGF-β) family, all of which have been previously implicated to play important roles in tooth development and carious lesions. …”
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Bioinformatics-based screening and validation of PANoptosis-related biomarkers in periodontitis by Qing Sun, Qing Sun, JinYue Hu, JinYue Hu, RuYue Wang, RuYue Wang, ShuiXiang Guo, ShuiXiang Guo, GeGe Zhang, GeGe Zhang, Ao Lu, Ao Lu, Xue Yang, Xue Yang, LiNa Wang, LiNa Wang

“…PANoptosis, a recently characterized form of programmed cell death, has been implicated in various pathological processes; however, its mechanistic role in periodontitis remains unclear. …”
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Subsets of follicular lymphoma 3B have divergent outcomes: results from the prospective multicenter MER and LEO cohorts by Patrizia Mondello, Brianna Negaard, Andrew L. Feldman, Brian K. Link, Carla Casulo, Dai Chihara, David Russler-Germain, Jason Romancik, Caitlin Gribbin, Sara Haddadi, Eric Mou, Ivana N. Micallef, Patrick B. Johnston, Joseph Novak, Yucai Wang, Rebecca L. King, Anne J. Novak, Thomas M. Habermann, Peter Martin, Brad Kahl, Grzegorz S. Nowakowski, Loretta J. Nastoupil, James R. Cerhan, Christopher R. Flowers, Izidore S. Lossos, Richard W. Burack, Matthew J. Maurer, Stephen M. Ansell

“…Additional controversy involves the clinical implication of pure FL3B (FL3Bp) vs FL3B with concurrent diffuse large B cell lymphoma (DLBCL) (FL3Bc). …”
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Comprehensive plasma metabolomics analysis of berberine treatment in ulcerative colitis rats by LC-MS/MS by Baodong Feng, Baodong Feng, Linqi Su, Linqi Su, Yang Yang, Renyan Liu, Renyan Liu, Yu Zhang, Yu Zhang, Lingyi Xin, Lingyi Xin, Li Wang, Li Wang, Zhiming Yang, Xuemei Wei, Qinhua Chen, Qinhua Chen

“…This approach, characterized by its short analysis time of 20 min per sample, excellent reproducibility, and straightforward data processing, allowed for the comprehensive detection of a wide array of metabolites, including amino acids, lipids, and organic acids, many of which are implicated in the pathophysiology of UC.ResultsOur results showed that berberine modulated the metabolic disturbances of 33 compounds in the plasma of UC rats, primarily including amino acids, pyrimidines, organic phosphoric acids, fatty acyls, and organonitrogen compounds. …”
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α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance by Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Richard Pestell, Shinya Tanaka, Celine Malleval, Jerome Honnorat, Ahmed Idbaih, Lucie Martin, Hélène Castel, Frédéric Checler, Cristine Alves da Costa

“…The purpose of this study is to determine the implication of α-syn in glioblastoma development and elucidate how it elicits a tumor suppressor function. …”
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NCK Associated Protein 1 Modulated by miRNA‐214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia by Tayyab Adeel Afzal, Le Anh Luong, Dan Chen, Cheng Zhang, Feng Yang, Qishan Chen, Weiwei An, Edmund Wilkes, Kenta Yashiro, Pedro R. Cutillas, Li Zhang, Qingzhong Xiao

“…Background MicroRNA miR‐214 has been implicated in many biological cellular functions, but the impact of miR‐214 and its target genes on vascular smooth muscle cell (VSMC) proliferation, migration, and neointima smooth muscle cell hyperplasia is unknown. …”
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Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells by Cheng Zheng, Jianmin Huang, Shengming Xu, Bin Lu, Hanxin Que, Tianhao Chen, Yubo Hou, Yubo Hou, Linlin He, Linlin He, Xia Fan, Fa-Ming Chen, Yi Wang, Yi Wang, Hui Deng, Hui Deng

“…IntroductionThe direct infection of endothelial cells by Porphyromonas gingivalis (P. gingivalis), a keystone periodontal pathogen, has been implicated in the development of atherosclerosis. While non-selective autophagy facilitates its intracellular persistence in endothelial cells, the role of selective autophagy in this process remains unclear. …”
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Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction by Junhong Geng, Quan Yuan, Chaofang Ni, Yarong Zhang, Xiaoli Liu, Xiaoying Zhu, Xueqin Hao, Gaofeng Liang, Dongmei Wang, Hua Fan

“…Recent studies have indicated that the receptor interacting protein kinase 1 (RIPK1)-mediated necroptosis is implicated in BDE-47 cytotoxicity. However, little is known about the underlying mechanism and whether the necroptosis participates in BDE-47-induced neuronal injury and cognitive impairment. …”
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Expression Profiles of Housekeeping Genes and Tissue-Specific Genes in Different Tissues of Chinese Sturgeon (<i>Acipenser sinensis</i>) by Yanping Li, Yunyun Lv, Peilin Cheng, Ying Jiang, Cao Deng, Yongming Wang, Zhengyong Wen, Jiang Xie, Jieming Chen, Qiong Shi, Hao Du

“…We collected eleven tissues to establish a transcriptomic repository, including data from Pacific Biosciences isoform sequencing (PacBio Iso-seq) and RNA sequencing (RNA-seq), and then obtained 25,434 full-length transcripts, with lengths from 307 to 9515 bp and an N50 of 3195 bp. …”
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Comprehensive immune ageing reveals TREM2/TIM3 myeloid cells drive brain immune evasionResearch in context by Berta Segura-Collar, Lucia Mondejar-Ruescas, Denisse Alcivar-López, María Garranzo-Asensio, Pablo Mata-Martinez, Ramón Garcia-Escudero, Aurelio Hernández-Laín, Juan M. Sepúlveda, Ángel Pérez Nuñez, Jesús Avila, Pilar Sánchez-Gómez, Ricardo Gargini

“…Vascular and immune abnormalities are implicated in the progression of gliomas and occur in the early stages of Alzheimer's disease (AD); however, the mechanisms by which these alterations manifest in the brain parenchyma remain unclear. …”
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