Association of anthropometric indices with rs9939609 FTO gene polymorphism among overweight/obese women with breast cancer: a case-control study by Huma Naqeeb, Bismillah Sehar, Sami Siraj, Ali Madi Almajwal, Bibi Hajira, MoezAlIslam Faris, Sharifa AlBlooshi, Ali Saad R. Alsubaie, Mahpara Safdar, Iftikhar Alam, Falak Zeb

“…Physical activity was assessed using validated questionnaire. Data on body mass index (BMI, kg/m2), waist-to-hip ratio (WHR, cm), sociodemographic, and blood samples were collected from both groups. …”
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Reduced interhemispheric connectivity in traumatic brachial plexopathies after bionic reconstruction by Galia V Anguelova, Agnes Sturma, Oskar Aszmann, Mehmet S Yildirim, Anna Boesendorfer, Victor Schmidbauer, Karl-Heinz Nenning, Gregor Kasprian

“…This cross-sectional study aimed to assess (sub)cortical motor activity and functional connectivity changes after TBPL and bionic reconstruction.Cortical activity was measured with functional MRI (fMRI) during execution, and imagery of hand closing movements with the affected and healthy arm and single subject analysis was performed on the fMRI data. An electromyography training session was performed before fMRI to ensure correct task performance. …”
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High-throughput sequencing unravels placental vascular dysfunction and oxidative stress as mechanistic drivers of advanced maternal age-associated pregnancy by Xin Sun, Yao Chen, Feifei Hu, Yumeng Qiao, He Wu, Yao Su, Yue Hu, Jie Wu, Jie Wu, Mingli Huang

“…While placental dysfunction is implicated, the underlying mechanisms remain unclear. …”
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Helicobacter pylori induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway by Jianhui Zhang, Shuzhen Liu, Juan Zhang, Mingzhu Feng, Shu Chen, Yinuo Zhang, Zekun Sun, Xinying Cao, Chao Gao, Xiaofei Ji, Xiaofei Ji, Huilin Zhao, Huilin Zhao

“…TLE4 was confirmed as a direct target of miR-362-5p, and miR-362-5p/TLE4 axis implicated in H. pylori-driven neoplastic transformations in GC cells. …”
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD by Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

“…The upregulation of Nup153 in AD organoids recovered the formation of neural-like tubes and differentiation. Conclusions Our data suggest that the positive effect of Nup153 on neurogenesis is based on a complex regulatory network orchestrated by Nup153 and that this protein is a valuable disease target.…”
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Alternative splicing analysis in a Spanish ASD (Autism Spectrum Disorders) cohort: in silico prediction and characterization by S. Dominguez-Alonso, M. Tubío-Fungueiriño, J. González-Peñas, M. Fernández-Prieto, M. Parellada, C. Arango, A. Carracedo, C. Rodriguez-Fontenla

“…., genes harboring de novo and inherited coding variants not predicted to alter splicing), which have been mainly implicated in chromatin remodeling processes. In conclusion, this study advances our comprehension of the role of AS in ASD and calls for further investigations, including in vitro validation and integration with multi-omics data, to elucidate the functional roles of the highlighted genes and the intricate interplay of the splicing process with other regulatory mechanisms and tissues in ASD.…”
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Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-versus-host disease with MSCs treatment by Zixuan Lu, Yuming Zhou, Yuming Zhou, Chengyu Li, A. M. Abd El-Aty, A. M. Abd El-Aty, Chengxia Liu, Xiying Luan, Bin Wang, Guoyan Wang, Guoyan Wang

“…The genome-wide H3K27ac data revealed lobe-specific patterns in the lobe behind the heart (H) and the left lobe (L) in the control and hPMSC groups, whereas these patterns were confused in the GVHD and PBS groups. …”
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Long read whole genome sequencing-based discovery of structural variants and their role in aetiology of non-syndromic autism spectrum disorder in India by Jhanvi Shah, Debasrija Mondal, Deepika Jain, Priti Mhatre, Ketan Patel, Anand Iyer, Manoj Pandya, Bhargavi Menghani, Gayatri Dave, Jayesh Sheth, Frenny Sheth, Shweta Ramdas, Harsh Sheth

“…Despite the small sample size, low-pass genome coverage, and modest N50 read length, the study indicates a modest contribution of SVs in the aetiology of non-syndromic ASD. Dearth of data supporting the role of SVs in non-syndromic ASDs in other cohorts from around the world further supports our conclusion.…”
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A Meta‐Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long‐Term Downregulation of Myelin‐Related Gene Expression by Toni Q. Duan, Megan H. Hagenauer, Elizabeth I. Flandreau, Anne Bader, Duy Manh Nguyen, Pamela M. Maras, Randriely Merscher S. De Lima, Trevonn Gyles, Christabel Mclain, Michael J. Meaney, Eric J. Nestler, Stanley J. Watson Jr., Huda Akil

“…The prefrontal cortex (PFC) is a key brain region implicated in the effects of ELS. Methods To better understand the effects of ELS on the PFC, we ran a meta‐analysis of publicly available transcriptional profiling datasets. …”
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Characterization of lysine crotonylation-related lncRNAs for prognostic assessment and immune response in glioma by Miaomiao Song, Juan Xu, Zhonghao Gui, Yun Wu, Feifei Wang, Hongmei Sheng, Xueyong Huang, Junyu Qian, Haotian Qin, Ying Wang, Ying Wang

“…Long non-coding RNAs (lncRNAs) associated with lysine crotonylation (LCRlncRNAs) have been implicated in cancer progression, but their role in glioma remains largely unexplored.MethodsTranscriptomic and clinical data from The Cancer Genome Atlas (TCGA) glioma cohort were analyzed to identify prognostic LCRlncRNAs. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Methods The single-cell sequencing data from GSE152048 and GSE162454, along with RNA-seq from the TARGET and GSE21257 cohorts, were utilized for the analysis in this study. …”
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Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus by Guanfei Zhao, Haolong Li, Yutong Miao, Linlin Cheng, Yuying Chen, Yuan Huang, Hongyun Zhao, Yongmei Liu, Yipei Jing, Shasha Wang, Yongzhe Li, Rui Zhang

“…BackgroundMitochondrial dysfunction is implicated in the pathogenesis of systemic lupus erythematosus (SLE). …”
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DnaK of Parvimonas micra extracellular vesicles interacts with the host fibroblasts BAG3-IKK-γ axis to accelerate TNF-α secretion in oral lichen planus by Xiaoli Ji, Mengfan Zhi, Xiufeng Gu, Ying Han, Xiang Lan, Lixiang Song, Peipei Sun, Jingyuan Li, Xiangmin Qi, Qiang Feng

“…Single-cell RNA sequencing data implicated fibroblasts as potential targets, characterized by upregulation of the NF-κB pathway linked to TNF-α. …”
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Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation by Xulei Zuo, Shiyi Tan, Yuxi Zhang, Cong Zhang, Li Ma, Xiaoyu Hou, Wei Wang, Rongli Sun, Lihong Yin, Yuepu Pu, Juan Zhang

“…Perfluorooctane sulfonate (PFOS), a widely used persistent organic pollutant, has been implicated in multiple toxicities. However, its nephrotoxic mechanisms remain unclear. …”
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Exploration of circulating metabolites in infants with abusive head trauma by Estelle Maret, Tatjana Sajic, Kim Wiskott, Sylvain Le Gludic, Federica Gilardi, Youssef Daali, Tony Fracasso, Aurélien Thomas

“…Six metabolites were already known to be implicated in different gross pathologies associated with neurological diseases. …”
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Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism by Tasneem Cheytan, Martin Schneider, Roberto Würth, Paul Schwerd-Kleine, Ewgenija Gutjahr, Verena Thewes, Laura L. Michel, Rebecca Weber, Tim Vorberg, Sabrina Lohr, Katja Nitschke, Michelle Neßling, Peter Lichter, Andreas Schneeweiss, Karsten Richter, Dominic Helm, Martin Sprick, Andreas Trumpp

“…Organ-specific signatures generated from TuFMO-sEVP educated tumor cells were found to be increased in metastatic samples from breast cancer patients as compared to the primary tumor or normal tissue samples and these signatures also significantly correlated with poorer patient outcome. Collectively, our data reveals a novel facet of the metastatic cascade, implicating a role for TuFMO-sEVPs in directing metastasis and providing a potential therapeutic strategy for targeting this process.…”
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Unrecognised rural–urban disparities in epidemiology of metabolic-associated fatty liver disease in the representative area of China by Qing Li, Yi Zhang, Xing Chen, Xiaoyi Li, Tingfeng Wu, Junzhao Ye, Suilin Mo, Miaosheng Ye, Wengeng Wang, Qiaocong Zheng, Ke Luo, Shouwei Tu, Daituan Che, Rulong Gong, Rong Miu, Congxiang Shao, Yanhong Sun, Bihui Zhong

“…The participants’ demographic, socioeconomic and lifestyle data were collected. Fatty liver and liver stiffness were screened by FibroScan.Results A total of 7287 individuals were enrolled (rural: 2684; urban: 4603). …”
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Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds by John R Pruett Jr., Alexandre A Todorov, Zoë W Hawks, Muhamed Talovic, Tomoyuki Nishino, Steven E Petersen, Savannah Davis, Lyn Stahl, Kelly N Botteron, John N Constantino, Stephen R Dager, Jed T Elison, Annette M Estes, Alan C Evans, Guido Gerig, Jessica B Girault, Heather Hazlett, Leigh MacIntyre, Natasha Marrus, Robert C McKinstry, Juhi Pandey, Robert T Schultz, William D Shannon, Mark D Shen, Abraham Z Snyder, Martin Styner, Jason J Wolff, Lonnie Zwaigenbaum, Joseph Piven, for the IBIS Network

“…Functional connectivity for implicated connections in these networks was consistently lower in HLP and HLN than in LLN (p = 0.0461 and 0.0004). …”
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Maternal plasma extracellular vesicles tsRNA as potential biomarkers for assessing preterm labor risk by Xinrui Sun, Ying Feng, Liang Xie, Yilun Wu, Jia Mao, Yi Zhang, Linyu Zhang, Xin Yuan, Jiangping Ni, Xue Xiao, Hanmin Liu, Li Dai, Fang Ma

“…Transcriptomic sequencing was conducted to identify tsRNA1-mediated pathways, and DNA methylation patterns were predicted based on the transcriptomic data. Statistical significance was determined using Student’s t-test. …”
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Emerging Insights into Corynebacterium Kroppenstedtii Complex Associated Breast Abscesses: A Retrospective Study by Sasi S, Hamed MMM, Abdel Hadi HEA, Goravey W, Ibrahim E, Abid FB, Doiphode S, Wilson G, Kashaf ASA, Al-Maslamani M, Al-Khal A

“…Its lipophilic nature and association with specific populations necessitate targeted investigations.Materials and Methods: This retrospective study was conducted at Hamad Medical Corporation, Qatar, including all CKC isolates from breast tissue collected between October 2016 and March 2024. Data from electronic medical records were collected and anonymized. …”
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