Exploring autism spectrum disorder and co-occurring trait associations to elucidate multivariate genetic mechanisms and insights by Karoliina Salenius, Niina Väljä, Sini Thusberg, Francois Iris, Christine Ladd-Acosta, Christophe Roos, Matti Nykter, Alessio Fasano, Reija Autio, Jake Lin, the GEMMA study

“…Pathway, QTL and cell type enrichment implicated microbiome, enteric inflammation, and central nervous system enrichments. …”
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Histone H4 lysine 20 methylation marks genes dynamically regulated during erythroid maturation by Kristin Murphy, Michael Getman, Xiurui Lv, Zachary Murphy, Deanna Abid, Nabil Rahman, Michael Bulger, Laurie Steiner

“…Abstract Background Methylation of H4K20 has been implicated in the regulation of gene expression but also plays essential roles in numerous cellular functions, making studies of its effects on transcription challenging. …”
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Charcot-Marie-Tooth Disease vs Idiopathic: A Comparison of Pes Cavovarus Using Known and Novel Measurements by Eli Schmidt BS, Nolan M. Schonhorst, Andrew Behrens BS, Grayson M. Talaski, Jason Wilken MPT, PhD, Donald D. Anderson PhD, Cesar de Cesar Netto MD, PhD, Bopha Chrea MD

“…We hypothesize that CMT PC will be more severe than idiopathic PC, as evidenced by preliminary underpowered data, and that CMT PC will have a more pronounced transverse arch. …”
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Comprehensive bioinformatics analysis of MEX3 family genes in hepatocellular carcinoma by Xuezhong Zhang, Peng Sun, Tingting Chu, Yuling Feng, Xuebin Zhang

“…The MEX3 family genes has been implicated in various cancers; however, their roles in HCC remain largely unexplored. …”
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SETD2 drives METTL14-mediated m6A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension by Shuai-shuai Zhao, Chuan Yuan, Jin-long Liu, Qi-cai Wu, Xue-liang Zhou

“…While METTL14-mediated N6-methyladenosine (m6A) RNA modification has been implicated in PAH, the upstream regulators and downstream effectors linking m6A to PASMC dysregulation remain unclear. …”
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Study of Drug Utilisation and Adverse Drug Reaction Pattern of Anti-glaucoma Drugs in Patients with Primary Open Angle Glaucoma Attending the Glaucoma Clinic at a Tertiary Care Ins... by Nitu Pandey, Sachin Kumar, Vidya Bhushan Kumar, Rinky Thakur

“…All data were entered into Microsoft Excel and statistically analysed. …”
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The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population. by Nathalie Chami, Michael Preuss, Ryan W Walker, Arden Moscati, Ruth J F Loos

“…<h4>Conclusions</h4>We showed that large-scale data are needed to validate the impact of mutations observed in small-scale and case-focused studies. …”
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Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. by Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice, Ci Song, Teresa Nutile, Albert Vernon Smith, Maria Pina Concas, Michela Traglia, Caterina Barbieri, Ndeye Coumba Ndiaye, Maria G Stathopoulou, Vasiliki Lagou, Giovanni Battista Maestrale, Cinzia Sala, Stephanie Debette, Peter Kovacs, Lars Lind, John Lamont, Peter Fitzgerald, Anke Tönjes, Vilmundur Gudnason, Daniela Toniolo, Mario Pirastu, Celine Bellenguez, Ramachandran S Vasan, Erik Ingelsson, Anne-Louise Leutenegger, Andrew D Johnson, Anita L DeStefano, Sophie Visvikis-Siest, Sudha Seshadri, Marina Ciullo

“…We sought to identify novel loci associated with circulating VEGF levels through a genome-wide association meta-analysis combining data from European-ancestry individuals and using a dense variant map from 1000 genomes imputation panel. …”
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Association between Helicobacter pylori infection, serum thyroid-stimulating hormone, and thyroxine in the National Health and Nutrition Examination Survey 1999–2000 by Ting Lu, Shunshun Lu, Jieqiong Lin, Xiaona Shao, Dahua Chen, Jianwei Shen

“…BackgroundHelicobacter pylori has been increasingly implicated in extra-gastric diseases. Current evidence regarding the association between serum thyroid-stimulating hormone (TSH), thyroxine (T4), and H. pylori infection remains inconclusive. …”
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Improving outcomes for people with autism spectrum disorders by reducing mental health problems: the IAMHealth research programme including one RCT by Emily Simonoff, Gillian Baird, Bryony Beresford, Tony Charman, Martin Knapp, Andrew Pickles, Carol Povey, Tom Purser, Paramala Santosh, Vicky Slonims, Stephen Scott

“…In-depth interviews explored how they understood and managed MHP. Data were analysed thematically, and this framework was shared at an early stage with the patient and public involvement (PPI) panels. …”
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Outdoor Air Pollution Is Related to Amygdala Subregion Volume and Apportionment in Early Adolescence by Jessica Morrel, L. Nate Overholtzer, Kirthana Sukumaran, Devyn L. Cotter, Carlos Cardenas-Iniguez, J. Michael Tyszka, Joel Schwartz, Daniel A. Hackman, Jiu-Chiuan Chen, Megan M. Herting

“…Methods: Cross-sectional data from 4473 (55.4% male) Adolescent Brain Cognitive Development (ABCD) Study participants were leveraged. …”
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Deciphering the role of Wnt/β-catenin and miR-214 in knee osteoarthritis: molecular and clinical insights by Waad A. Samman, Esraa M. Mosalam, Esraa M. Mosalam, Dalia S. Saif, Mahmoud S. Abdallah, Mahmoud S. Abdallah, Abdel-Aziz A. Zidan, Amany Said Sallam, Shimaa Abdelsattar, Fatma Omar Khalil, Amany E. Elashkar, Somia Mokabel Mohamed, Mohamed Al-Ghannam, Hend E. Abo Mansour, Hend E. Abo Mansour

“…Besides, a correlation between Western Ontario and McMaster Universities (WOMAC) score, clinical, and radiological data, and the measured parameters was conducted.Results and discussionPatients with KOA showed downregulated miR-214 with upregulated β-catenin, Wnt4, MMP3, Bax, caspase 3, and pGSK3β compared to healthy individuals. …”
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Eimeria tenella aspartyl protease is identified as a potential TLR15 ligand and activates macrophages and dendritic cells in chickens by Chen Chen, Zhichao Men, Xianglin Pu, Mingmin Lu, Lixin Xu, Ruofeng Yan, Xiangrui Li, Xiaokai Song

“…Collectively, these findings establish EteASP as a potent immunomodulator capable of activating key innate immune effector functions in macrophages and dendritic cells, and bridging to adaptive immunity. Our data implicate TLR15 as a potential receptor contributing to these responses, broadening the investigation of TLR15 ligands in protozoa and offering novel insights into Eimeria-host immune interactions. …”
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Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture by Rajendra A. Morey, Yuanchao Zheng, Henry Bayly, Delin Sun, Melanie E. Garrett, Marianna Gasperi, Adam X. Maihofer, C. Lexi Baird, Katrina L. Grasby, Ashley A. Huggins, Courtney C. Haswell, Paul M. Thompson, Sarah Medland, Daniel E. Gustavson, Matthew S. Panizzon, William S. Kremen, Caroline M. Nievergelt, Allison E. Ashley-Koch, Mark W. Logue

“…The multivariate GWASs of the GIBNs identified 74 genome-wide significant (GWS) loci (p < 5 × 10− 8), including many previously implicated in neuroimaging phenotypes, behavioral traits, and psychiatric conditions. …”
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Vesicular Stomatitis Virus Transmission Dynamics Within Its Endemic Range in Chiapas, Mexico by Lawrence H. Zhou, Federico Valdez, Irene Lopez Gonzalez, Willian Freysser Urbina, Ariadna Ocaña, Cristell Tapia, Armando Zambrano, Edilberto Hernandez Solis, Debra P. C. Peters, Chad E. Mire, Roberto Navarro, Luis L. Rodriguez, Kathryn A. Hanley

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Identification of diagnostic biomarkers for fibromyalgia using gene expression analysis and machine learning by Fuyu Zhao, Fuyu Zhao, Fuyu Zhao, Jianan Zhao, Jianan Zhao, Jianan Zhao, Yang Li, Chenyang Song, Chenyang Song, Chenyang Song, Yaxin Cheng, Yaxin Cheng, Yaxin Cheng, Yunshen Li, Yunshen Li, Yunshen Li, Shiya Wu, Bingheng He, Juan Jiao, Cen Chang, Cen Chang

“…This study aims to identify and validate potential genetic markers for FM to facilitate earlier diagnosis and intervention.MethodsWe analyzed gene expression data from the Gene Expression Omnibus (GEO) to identify differentially expressed genes (DEGs) associated with FM. …”
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Test-retest reliability of diffusion kurtosis imaging metrics in the healthy adult brain by Liu-Yang Wu, Yao Xu, Lan-Lan Chen, Wen-Rui Yang, Yan Li, Song-An Shang, Xian-Fu Luo, Wei Xia, Jing Xia, Hong-Ying Zhang

“…The kurtosis-related metrics presented lower reliability compared to the tensor-related metrics from DKI data. Default mode-related areas exhibited higher reliability than other brain cortices in terms of implicated microstructural DKI property. …”
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A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. by Olivia Adams, Félice A Janser, Bastian Dislich, Sabina Berezowska, Magali Humbert, Christian A Seiler, Dino Kroell, Julia Slotta-Huspenina, Marcus Feith, Katja Ott, Mario P Tschan, Rupert Langer

“…Defective autophagy has been implicated in cancer biology and therapy resistance. …”
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Immunoglobulins G from Patients with Systemic Sclerosis Modify the Molecular Signatures of Endothelial Cells by Eric Hachulla, David Launay, Alain Lescoat, Valérie Lecureur, Vincent Sobanski, Sylvain Dubucquoi, Martin Figeac, Aurélien Chepy, Solange Vivier, Fabrice Bray, Clément Chauvet, Abderrahmane Elhannani, Lucile Guilbert, Frédéric Leprêtre, Louisa Bourel, Christian Rolando

“…Functional antibodies (FA) might be implicated in vasculopathy, in which endothelial cells (EC) are key players. …”
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PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway by Xiaojin Liu, Bangxin Liu, Junwen Wang, Hongbin Liu, Jiasheng Wu, Yiwei Qi, Yuan Liu, Hongtao Zhu, Chaoxi Li, Liu Yang, Jian Song, Guojie Yao, Weidong Tian, Kai Zhao, Lin Han, Kai Shu, Suojun Zhang, Jianghong Man, Chao You, Haohao Huang, Ran Li

“…Methods In silico analysis of GBM patient data assessed SSP enrichment and PHGDH expression linked with tumor stemness. …”
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