Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal by Sabin Shrestha, Sandesh Rimal, Anjana Kharbuja, Manoj Kumar Ray, Susmita Shrestha, Anjali Dulal, Suprabha Subedi, Ashma Khadka, Nabaraj Adhikari, Meghnath Dhimal, Basu Dev Pandey, Takeshi Urano, Kouichi Morita, Mya Myat Ngwe Tun, Shyam Prakash Dumre

“…These findings underscore the need of nation-wide integrated surveillance, including genomic data generation, in Nepal for disease control, prevention, and potential vaccine implication.…”
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Association between RBC folate and lumbar bone mineral density in postmenopausal women, a cross-sectional study from NHANES 2009–2018 by Hua Wei, Ziqi Jin, Ziqi Jin, Liangji Zhou, Liangji Zhou, Gangjian Tang, Sheng Chai, Xiaoqiao Che, Yongxing Tan, Weiqing Zeng

“…BackgroundPostmenopausal women are at an increased risk of bone density reduction, with multiple factors implicated, including folate, a B vitamin whose impact on bone health is gaining attention. …”
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Altered expression and potential role of N6-methyladenosine mRNA methylation in abdominal aortic aneurysm mouse model by Julin Wang, Tianyu Miao, Yanyun Wang, Tiehao Wang, Zhangyu He, Fei Xiong, Ding Yuan, Qiang Guo, Yi Yang, Zhichen Tang, Bin Huang, Jichun Zhao

“…The pathogenesis of AAA has not been fully elucidated, and m6A RNA methylation regulators have never been implicated in AAA development. This study aimed to explore the expression profile, potential functions and regulated mechanism of m6A RNA methylation in the abdominal aortic aneurysm mice model. …”
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Identification of novel MYO19 variants in neonatal hypertrophic cardiomyopathy: a familial analysis revealing oligogenic contributors to disease severity by Hye-Won Cho, Hyeseon Kim, Jeong-Min Kim, Dong Mun Shin, Oc-Hee Kim, Misun Yang, Heui Seung Jo, Mi-Ae Jang, Ja-Hyun Jang, Hyun-Young Park, Yun Sil Chang, Mi-Hyun Park

“…Hence, this study aims to investigate the genetic architecture in a family with a history of cardiac disease and neonatal HCM, focusing on oligogenic inheritance of non-sarcomeric variants. Methods Clinical data and blood samples were collected for genetic analysis. …”
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CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage by Yu Xu, Yu Xu, Jing Peng, Yizhong Yan, Min Gao, HongJing Zang, Lamei Cheng, Lamei Cheng, Lamei Cheng, Yu Zhou, Yu Zhou, Yu Zhou

“…B cells, in particular, have been implicated in stroke pathogenesis, although their exact role remains contentious. …”
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The Arabic Satisfaction with Life Scale (SWLS) and its three-item version: Factor structure and measurement invariance among university students by Amira Mohammed Ali, Saeed A. Al-Dossary, Musheer A. Aljaberi, Maha Atout, Rasmieh Alamer, Mohamed M.H. Suliman, Feten Fekih-Romdhane

“…Satisfaction with life implicates the psychological, social, and educational functioning of students—justifying its use for clinical screening and monitoring of treatment outcomes. …”
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Spotted! Remote camera traps used in a novel design reveal a perilous situation for the Critically Endangered Northwest African cheetah (Acinonyx jubatus hecki) in a conflict‐affec... by Marine Drouilly, Audrey Ipavec, Oksana Grente, Robin Horion, Aurlus Ouindeyama, Philipp Henschel, Vincent Lapeyre, Yekini Chabi N'Diaye, Ali Shams, Christine Breitenmoser, Sarah M. Durant

“…Violent extremism and insecurity are widespread across the remaining distribution of A. j. hecki and hence, we recommend that our approach, which minimises on‐the‐ground fieldwork, be used to provide vital data to prioritise and assess conservation interventions. …”
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Emerging Therapies in the Treatment of Prurigo Nodularis: Biological Therapy and Systematic Review of Literature by Gaetano Licata, Mariachiara Arisi, Caterina Mariarosaria Giorgio, Cesare Ariasi, Cesare Tomasi, Simone Soglia, Sara Mezzana, Benedetta Galli, Grazia Linda Artelli, Mariateresa Rossi, Cecilia Catapano

“…Integrating clinical efficacy, immunologic endotyping, and real-world data will be pivotal to optimizing therapeutic strategies, enhancing outcomes, and personalizing care in prurigo nodularis.…”
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Baicalin Alleviates Piglet Immunosuppression Induced by <i>Glaesserella parasuis</i> via Promoting CD163/Tumor Necrosis Factor-like Weak Inducer of Apoptosis-Mediated Autophagy by Shulin Fu, Ronghui Luo, Jingyang Li, Yunjian Fu, Qiaoli Dong, Siyu Liu, Yamin Sun, Ling Guo, Jin Hu, Yinsheng Qiu

“…Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in immunosuppression. CD163, a scavenger receptor expressed on macrophages that acts as a decoy receptor for TWEAK, plays a crucial role in the regulation of autophagy and inflammation. …”
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Induction of significant neutralizing antibodies against SARS-CoV-2 by a highly attenuated pangolin coronavirus variant with a 104nt deletion at the 3'-UTR by Shanshan Lu, Shengdong Luo, Chang Liu, Muli Li, Xiaoping An, Mengzhe Li, Jun Hou, Huahao Fan, Panyong Mao, Yigang Tong, Lihua Song

“…SARS-CoV-2 related coronaviruses (SARS-CoV-2r) from Guangdong and Guangxi pangolins have been implicated in the emergence of SARS-CoV-2 and future pandemics. …”
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Phylogenetic taxonomy of the Zambian Anopheles coustani group using a mitogenomics approach by Soha Usmani, Mary E. Gebhardt, Limonty Simubali, Kochelani Saili, Westone Hamwata, Hunter Chilusu, Mbanga Muleba, Conor J. McMeniman, Anne C. Martin, William J. Moss, Douglas E. Norris, Reneé L. M. N. Ali

“…Abstract Background Mosquito species belonging to the Anopheles coustani group have been implicated in driving residual malaria transmission in sub-Saharan Africa and are regarded as an established primary vector in Madagascar. …”
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Single-Cell Transcriptomics Unveils the Mechanistic Role of FOSL1 in Cutaneous Wound Healing by Jingbi Meng, Ge Zheng, Yinli Luo, Ling Ge, Zhiqing Liu, Wenhua Huang, Meitong Jin, Yanli Kong, Shanhua Xu, Zhehu Jin, Longquan Pi

“…To elucidate biological pathway activities from gene expression data, we deployed the ‘PROGENy’ package, complemented by machine learning for precise pathway identification. …”
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Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis by Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

“…And, we confirmed that data found in patient fibroblasts were reproduced in iPSC-MNs model. …”
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Mind–body therapy for cardiometabolic risk in U.S. middle-aged Black adults: a scoping review by Danielle A. Martin, Jane Hook, Sunny Wonsun Kim, Sunny Wonsun Kim, Linda Larkey, Linda Larkey, Rebecca E. Lee, Rebecca E. Lee

“…Independent reviewers selected articles for inclusion and data extraction, with a third reviewer providing consensus.ResultsFourteen articles met the eligibility criteria (n = 14). …”
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Immunogenicity of monovalent and multivalent subunit vaccines against SARS-CoV-2 variants in mice with divergent vaccination history by Rui Wang, Yuan Lyu, Meng Chen, Lili Sun, Shaozheng Zhou, Yudi Cui, Juan Ma, Desheng Kong, Jianbo Lu, Xuefeng Li, Liangzhi Xie

“…In this study, we evaluated humoral immune responses induced by variant-based monovalent vaccines as booster shots in mice previously vaccinated with an ancestral strain-based vaccine with or without Omicron BA.5 exposure. Our data suggest that immunological biases toward earlier variants attenuated the potency of variant-based vaccines as a booster dose against subsequent variants, whereas a second booster dose mitigated this effect. …”
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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation by Yazhe Ma, Youcheng Wang, Yuanjia Ke, Yuanjia Ke, Yuanjia Ke, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao, Jie Fan, Yang Chen

“…Lactylation, a novel post-translational modification, has been implicated in immune regulation, but its association with AF remains unexplored. …”
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Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by SPP1+ macrophages by Jie-Yuan Jin, Jie-Yuan Jin, Shuai Guo, Yao Deng, Ya-Qin Chen, Chen Liang, Yu-Jie Jiang, Wang Zhao, Rong Xiang

“…We discovered genetic determinants potentially underlying SPP1+ macrophage activation in arrhythmic hearts—a known mediator implicated in both inflammatory processes and fibrotic remodeling. …”
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Skeletal Muscle‐Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength by Hye Rim Jang, Shi‐Young Park, Yeonmi Lee, Dongjin Lee, Jongjun Lee, Yoonil Cho, Cheol Soo Choi, Hui‐Young Lee

“…The MKO mice also revealed enhanced mitochondrial function, energy expenditure and whole‐body insulin sensitivity. Transcriptomic data supported the muscle phenotype observed in the MKO mice. …”
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TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord by Emily Feneberg, Alexander G. Thompson, Philip D. Charles, Iolanda Vendrell, Benedikt M. Kessler, Roman Fischer, Olaf Ansorge, Elizabeth Gray, Kevin Talbot, Martin R. Turner

“…Data are available via ProteomeXchange with identifier PXD067060.…”
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Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation by Florian Reisch, Marjann Schäfer, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn

“…Abstract Background Mammalian arachidonic acid lipoxygenases (ALOXs) have previously been implicated in the pathogenesis of inflammatory disease, and pro- as well as anti-inflammatory activities have been reported. …”
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