Aortic shape with high-acute isthmic angle post frozen elephant trunk reconstruction is associated with worse postoperative outcomes: Multisite, principal component analysis, retro... by Michal Schäfer, MD, PhD, Jason P. Glotzbach, MD, Sara J. Pereira, MD, Vikas Sharma, MD, Matthew L. Goodwin, MD, Joseph C. Cleveland, Jr., MD, Craig H. Selzman, MD, Adam Carroll, MD, Alex J. Barker, PhD, Muhammad Aftab, MD, T. Brett Reece, MD

“…These results add to the increasing amount of evidence implicating acute isthmic angle from overt downstream aortic remodeling postcomplex aortic repair. …”
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Minimally invasive hepatectomy vs. thermoablation for single small (≤3 cm) hepatocellular carcinoma: A weighted real-life national comparison by Felice Giuliante, Simone Famularo, Sara Grasselli, Angelo Sangiovanni, Alessandro Vitale, Giuseppe Cabibbo, Andrea Lauterio, Federica Cipriani, Alice Saccomandi, Marco Arru, Elisa Pinto, Maurizia Rossana Brunetto, Maria Stella Franzè, Camilla Graziosi, Claudia Campani, Fabio Marra, Mariella Di Marco, Mariarosaria Marseglia, Valentina Santi, Mario Capasso, Alberto Masotto, Andrea Fontana, Maurizio Iaria, Alba Rocco, Matteo Serenari, Andrea Mega, Antonio Gasbarrini, Maria Corina Plaz Torres, Mattia Garancini, Simone Conci, Elton Dajti, Pasquale Perri, Rodolfo Sacco, Mariano Giglio, Cecilia Ferari, Michela De Angelis, Albert Troci, Donatella Magalotti, Daniele Nicolini, Giuseppe Zimmitti, Paola Germani, Laura Schiadà, Maria Conticchio, Matteo Zanello, Maurizio Romano, Flavio Milana, Quirino Lai, Stefan Patauner, Antonio Frena, Massimo Rossi, Guido Torzilli, Giacomo Zanus, Elio Jovine, Riccardo Memeo, Gianluca Svegliati-Baroni, Paola Tarchi, Moh’d Abu Hilal, Marco Vivarelli, Michele Crespi, Luigi Boccia, Guido Griseri, Roberto Ivan Troisi, Gian Luca Grazi, Francesco Azzaroli, Andrea Ruzzenente, Fabrizio Romano, Edoardo G. Giannini, Matteo Cescon, Gerardo Nardone, Raffaele Dalla Valle, Alessandro Ferrero, Filomena Morisco, Fabio Piscaglia, Giorgia Ghittoni, Carlo Saitta, Filippo Pelizzaro, Gianpaolo Vidili, Francesco Giuseppe Foschi, Luca Aldrighetti, Luciano De Carlis, Umberto Cillo, Elisabetta Biasini, Davide Bernasconi, Francesco Ardito, Franco Trevisani, Francesco Razionale, Gabriele Missale, Andrea Olivani, Gloria Allegrini, Pierluigi Romano, Calogero Cammà, Ciro Celsa, Paolo Giuffrida, Carmelo Marco Giacchetto, Gabriele Rancatore, Maria Vittoria Grassini, Roberta Ciccia, Alessandro Grova, Mauro Salvato, Riccardo De Carlis, Francesca Ratti, Lucia Napoli, Alberto Borghi, Fabio Conti, Luca Ielasi, Marco Ferronato, Nicola Reggidori, Fabio Farinati, Federica Bertellini, Giorgio Palano, Maria Piera Kitenge, Filippo Oliveri, Gabriele Ricco, Veronica Romagnoli, Roberto Filomia, Concetta Pitrone, Giovanni Raimondo, Valentina Lauria, Giorgio Pelecca, Tancredi Li Cavoli, Lucia Ragozzino, Stefano Gitto, Martina Rosi, Valentina Adotti, Alessandro Granito, Francesco Tovoli, Bernardo Stefanini, Maurizio Biselli, Lorenzo Lani, Benedetta Stefanini, Maria Guarino, Valentina Cossiga, Alessandro Inno, Fabiana Marchetti, Nadia Russolillo, Mario Giuffrida, Pietro Coccoli, Alba Rocco, Luca Marzi, Nicoletta de Matthaeis, Francesca Romana Ponziani, Andrea Pasta, Giulia Pieri, Cristina Ciulli, Mauro Scotti, Ivan Marchitelli, Alberto Porro, Valerio De Peppo, Ester Marina Cela, Antonio Facciorusso, Renato Patrone, Angelo Franceschi, Laura Marinelli, Davide Cosola, Chiara Scorzoni, Giulia Scandali, Annachiara Casella, Patrizia Pelizzo, Fabio Procopio, Zoe Larghi Laurerio, Francesca Notte

“…Methods: The study is a retrospective collection with subsequent survival analysis. Data were collected from two Italian HCC registries, ITA.LI.CA and HE.RC.O.LE.S. …”
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The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence by Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo deCárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto

“…In conclusion, our report proposes a molecular mechanism, based on the signalling axis CDK12–BRCA1, involved in this newly identified therapeutic effect of dinaciclib, although other players implicated in HR should not be discarded. In addition, our data provide a rationale for more selective and personalised chemo/radiotherapy treatment according to the genetic background of the tumour.…”
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Hymecromone Promotes Longevity and Insulin Sensitivity in Mice by Nadine Nagy, Kathryn S. Czepiel, Gernot Kaber, Darko Stefanovski, Aviv Hargil, Nina Pennetzdorfer, Robert Targ, Saranya C. Reghupaty, Thomas N. Wight, Robert B. Vernon, Rebecca L. Hull-Meichle, Payton Marshall, Carlos O. Medina, Hunter Martinez, Anissa Kalinowski, Rudolph D. Paladini, Stavros Garantziotis, Joshua W. Knowles, Paul L. Bollyky

“…Given that the extracellular matrix polymer hyaluronan (HA) has been implicated in longevity, we asked whether 4-methylumbelliferone (4-MU), an inhibitor of HA synthesis, impacts lifespan in mice. …”
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Oxidative balance and survival in osteoporosis: how antioxidant diets and lifestyles reduce mortality risk by Ziyao Ding, Ziyao Ding, Ziyao Ding, Haixu Qi, Haixu Qi, Haixu Qi, Wenbo Li, Wenbo Li, Wenbo Li, Changchang Chen, Youwei Li, Jun Sun, Jun Sun, Maji Sun, Maji Sun, Maji Sun, Shuo Feng, Shuo Feng, Shuo Feng, Feng Yuan, Feng Yuan, Feng Yuan

“…Oxidative stress is implicated in OP pathogenesis, and antioxidant diets and lifestyles may mitigate these effects. …”
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Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis by Linhu Liu, Yucheng Ma, Zhongyu Jian, Banghua Liao, Ya Li, Lede Lin, Menghua Wang, Jiawei Chen, Jingwen Wei, Mengzhu Yang, Yu Liu, Yiqiong Yuan, Jun Wen, Liyuan Xiang, Shiqian Qi, Xi Jin, Kunjie Wang

“…Summary: The gut microbiota and its metabolites have been implicated in calcium oxalate (CaOx) nephrolithiasis, while the precise mechanism remains unclear. …”
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Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study by Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu, Xi Dong, Yue Zhao, Liangshan Mu

“…Methods We applied two‐sample Mendelian randomization (MR) and colocalization analysis using summary‐level data from genome‐wide association studies of GCKR and GDM. …”
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The Correlations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Bone Mineral Density in Postmenopausal Women: A Cross-Sectional Study by Pierpaolo Panebianco, Gianluca Testa, Giulia Barbagallo, Luciano Costarella, Alessia Caldaci, Sveva Condorelli, Marco Sapienza, Vito Pavone

“…Chronic inflammation is implicated in osteoporosis pathogenesis, with inflammatory mediators promoting bone resorption. …”
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Exploring the oncogenic role and prognostic value of CKS1B in human lung adenocarcinoma and squamous cell carcinoma by Md. Solayman Hossain, Tariqul Islam Tusar, Nairita Ahsan Faruqui, Tanjim Ishraq Rahaman, Yasin Arafath Sharker, Shimran Saharia Santo, Abu Tayab Moin, Yusha Araf, Ibrahim Khalil Afif, Shoaib Saikat, Mohammad Jakir Hosen

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Human lung cancer neutrophils generate NETs with preserved anti-tumor cytotoxicity but impaired anti-migratory activity by Nuha Alsharif, Nuha Alsharif, Mohamad Qaisi, Merav Shaul, Naomi Kaisar-Iluz, Naomi Kaisar-Iluz, Dan Padawer, Dan Padawer, Osnath Bouhanna, Osnath Bouhanna, Yael Volman, Yael Volman, Zvi G. Fridlender, Zvi G. Fridlender

“…While NETs have been implicated in both tumor inhibition and promotion, their functional role in cancer remains ambiguous. …”
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Blood Pressure and Late Pregnancy Circulating miRNAs in the MADRES Study by Elizabeth C. Anderson, Meghan E. Muse, Zhongzheng Niu, Helen B. Foley, Joshua J. Levy, Megan E. Romano, Jiang Gui, Jessica L. Bentz, Shohreh F. Farzan, Theresa M. Bastain, Carmen J. Marsit, Carrie V. Breton, Caitlin G. Howe

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Identification and Expression Analysis of C2H2-Type Zinc Finger Protein (C2H2-ZFP) Genes in <i>Bougainvillea</i> in Different Colored Bracts by Yushan Wang, Yanping Hu, Wen Liu, Wengang Yu, Jian Wang, Yang Zhou

“…Zinc finger proteins (ZFPs), one of the most extensive transcription factor families in plants, are implicated in diverse biological functions, including plant morphogenesis, transcriptional regulation, and responses to abiotic stress. …”
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Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia by Toni T. Saari, Teemu Palviainen, Mikko Hiltunen, Sanna‐Kaisa Herukka, Tarja Kokkola, Sari Kärkkäinen, Mia Urjansson, Aino Aaltonen, Aarno Palotie, Heiko Runz, Jaakko Kaprio, Valtteri Julkunen, Eero Vuoksimaa, for FinnGen

“…Heritability of p‐tau217 was 56% and a genome‐wide association study (GWAS) implicated genes around the APOE region.…”
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T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination by Ji-Li Chen, Beibei Wang, Yongxu Lu, Elie Antoun, Olivia Bird, Philip G. Drennan, Zixi Yin, Guihai Liu, Xuan Yao, Maya Pidoux, Adam Bates, Deshni Jayathilaka, Junyuan Wang, Brian Angus, Sally Beer, Alexis Espinosa, J. Kenneth Baillie, Malcolm G. Semple, ISARIC4C Investigators, Timothy Rostron, Craig Waugh, Paul Sopp, Julian C. Knight, James N. Fullerton, Mark Coles, Geoffrey L. Smith, Alexander J. Mentzer, Yanchun Peng, Tao Dong

“…While tetramer+CD8+ T cells share similar differentiation and activation phenotypes, T cells from convalescent individuals show greater cytotoxicity, migratory potential to site of infection and TCR clonal expansion. Our data suggest that effective functional profiles of MPXV-specific memory T cells induced by Mpox infection may have an implication on the long-term protective responses to future infection.…”
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Genetic characterization of Plasmodium vivax linked to autochthonous malaria transmission in the US (2023) using Illumina AmpliSeq technology: a genetic epidemiology studyResearch... by Joel L.N. Barratt, David Jacobson, Edwin Pierre-Louis, Marko Bajic, Julia Kelley, Dhruviben S. Patel, Ira Goldman, Zhiyong Zhou, Ya Ping Shi, Alison Ridpath, Kimberly Mace, Christina Carlson, Alice Sutcliffe, Qiana Butler, Andrea Morrison, Danielle Stanek, Kelly Tomson, Carina Blackmore, Andrew Cannons, Susan Rollo, Chun Wang, Rashmi Tuladhar, Brooke Clemons, Susan Madison-Antenucci, Kimberly Mergen, Jennifer White, Mike Antwi, Laura Rothfeldt, Katelyn Lazenby, Stephen Hedges, Jennifer N. Shray, Ashleah Courtney, Bobby Boyanton, Yvonne Qvarnstrom, Molly Freeman, Brian H. Raphael

“…The aim of this study was to genetically characterize the implicated P. vivax isolates in order to complement epidemiologic investigations of these cases. …”
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Autism-Associated PTCHD1 Missense Variants Bind to the SNARE-Associated Protein SNAPIN but Exhibit Impaired Subcellular Trafficking by Stephen F. Pastore, Connie T.Y. Xie, Roya Derwish, Tahir Muhammad, Tereza Blahova, Sierra C. El-masri, Paul W. Frankland, Paul A. Hamel, John B. Vincent

“…However, 6 of the 12 missense variants tested exhibited pronounced retention within the endoplasmic reticulum and impaired neuronal and non-neuronal trafficking to the plasma membrane. Conclusions: These data yield insights into the role of PTCHD1 in neurodevelopment and neurotransmission and suggest a neuropathological mechanism for missense variants. …”
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MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers by Eva P. Cuevas, Enrique Madruga, Ignacio Valenzuela-Martínez, David Ramírez, Carmen Gil, Siranjeevi Nagaraj, Angeles Martin-Requero, Ana Martinez

“…The screening analysis of the NGS data identified a set of dysregulated miRNAs, of which nine candidates were selected for qRT-PCR validation, identifying for the first time the possible importance of hsa-miR-6821-5p as a potential ALS biomarker. …”
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Comprehensive Analysis of Congenital Aniridia and Differential Diagnoses: Genetic Insights and Clinical Manifestations by Jonathan Hall, Marta Corton, Fabian Norbert Fries, Jessica Obst, Clara Grünauer-Kloevekorn, Berthold Seitz, Maria della Volpe Waizel, Eszter Jávorszky, Kálmán Tory, Erika Maka, Maryam Amini, Shweta Suiwal, Tanja Stachon, Nóra Szentmáry

“…Methods We conducted a comprehensive literature review to compile and analyze clinical and genetic data related to CA and its differential diagnoses. …”
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Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial/ethnic cohort by Yeyi Zhu, Cuilin Zhang, Paul S Albert, Mohammad L Rahman, Fasil Tekola-Ayele, Michael Y Tsai, Xiaobin Wang, Yen-Chen A Feng, Oliver Fiehn, Liming Liang

“…Introduction Disruption of lipid metabolism is implicated in gestational diabetes (GDM). However, prospective studies on lipidomics and GDM risk in race/ethnically diverse populations are sparse. …”
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The Role of Potassium and KUP/KT/HAK Transporters in Regulating Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Fruit Development by José A. Mercado-Hornos, Claudia Rodríguez-Hiraldo, Consuelo Guerrero, Sara Posé, Antonio J. Matas, Lourdes Rubio, José A. Mercado

“…Furthermore, the slope of change in E_D at increasing external K⁺ concentration indicated a lower K⁺ permeability of the plasma membrane in white fruits, aligning with transcriptomic data. This study provides critical insights into the regulatory mechanisms of K⁺ transport during strawberry ripening and identifies potential targets for genetic modifications aimed at enhancing fruit firmness and shelf life.…”
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