Joint Effects of Lifestyle Habits and Heavy Metals Exposure on Chronic Stress Among U.S. Adults: Insights from NHANES 2017–2018 by Esther Ogundipe, Emmanuel Obeng-Gyasi

“…This study aims to investigate the joint effects of lifestyle habits and environmental factors on AL, using data from the NHANES 2017–2018 cycle. By employing linear regression and Bayesian Kernel Machine Regression (BKMR), we identify key predictors and explore interaction effects, providing new insights into how cumulative exposures contribute to chronic stress. …”
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A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma by Yuan Zhang, Xiaochen Du, Yujuan Yang, Yaqiong Ren, Lijun Zhou, Jun Hua, Hongying Wang

“…Conclusions This study systematically identifies and validates STX4 as a key genetic regulator in childhood asthma by integrating large-scale genetic, epigenetic, and immune regulatory data. These findings provide strong evidence for STX4’s role in childhood asthma pathogenesis, highlighting STX4 as a potential target for future precision therapies in childhood asthma.…”
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A telomere-associated molecular landscape reveals immunological, microbial, and therapeutic heterogeneity in colorectal cancer by Yinmeng Zhang, Jiawei Fan, Jiahui Zhao, He Zhu, Yan Xia, Hong Xu

“…Chemotherapeutic drug sensitivity was evaluated using pharmacogenomic data from the Genomics of Drug Sensitivity in Cancer (GDSC) database. …”
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Identification of novel metabolism-related biomarkers of Kawasaki disease by integrating single-cell RNA sequencing analysis and machine learning algorithms by Chenhui Feng, Zhimiao Wei, Xiaohui Li, Xiaohui Li

“…BackgroundThe bile acid metabolism (BAM) and fatty acid metabolism (FAM) have been implicated in Kawasaki disease (KD), but their precise mechanisms remain unclear. …”
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Exploration of epileptic networks in temporal lobe encephaloceles with stereotactic EEG: Electroclinical characteristics and surgical outcomes by Andrew J. Zillgitt, Eric R. Mong, Angelique M. Manasseh, Hannah C. Guider, Nour Baki, Michael D. Staudt

“…Medical charts were reviewed for demographic data, the results of noninvasive and invasive investigations, and operative details. …”
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Does Bilirubin Have a Causal Relationship With Vitiligo? A Mendelian Randomization Study and Bioinformatics Analysis by Xu D, Yin Y, Teng Y, Huang Y, Yu Y, Tao X, Fan Y, Ding X

“…Although bilirubin, a potent endogenous antioxidant, has been implicated in various dermatological conditions, its specific role in vitiligo remains poorly defined. …”
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Identification of cancer cell-intrinsic biomarkers associated with tumor progression and characterization of SFTA3 as a tumor suppressor in lung adenocarcinomas by Yu Zhao, Chengcheng Zhou, Ling Zuo, Haoming Yan, Yuhan Gu, Hong Liu, Guiping Yu, Xiaorong Zhou

“…Methods Single-cell RNA sequencing data were utilized to identify novel cancer cell-intrinsic gene signatures associated with the progression of LUAD, and their roles in LUAD were comprehensively analyzed. …”
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Pharmacogenomics for treatment response in patients with Stevens-Johnson syndrome: An updated review by Budiawan Prasetya Henry, Prasetyaning Amukti Danang, Muhammad Irham Lalu, Adikusuma Wirawan, Mazaya Maulida, Chong Rockie, Mutiara Rina, Darmawi Darmawi, Khairi Sabiah, Sarasmita Made Ary, Djaka Purwanto Barkah, Siswanto Lalu Muhammad Harmain, Hasan Faizul, Dani Satria Rahmat, Rungprai Daraporn

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Suppressing recurrence in Sonic Hedgehog subgroup medulloblastoma using the OLIG2 inhibitor CT-179 by Yuchen Li, Chaemin Lim, Taylor Dismuke, Daniel S. Malawsky, Sho Oasa, Zara C. Bruce, Carolin Offenhäuser, Ulrich Baumgartner, Rochelle C. J. D’Souza, Stacey L. Edwards, Juliet D. French, Lucy S. H. Ock, Sneha Nair, Haran Sivakumaran, Lachlan Harris, Andrey P. Tikunov, Duhyeong Hwang, Coral Del Mar Alicea Pauneto, Mellissa Maybury, Timothy Hassall, Brandon Wainwright, Santosh Kesari, Gregory Stein, Michael Piper, Terrance G. Johns, Marina Sokolsky-Papkov, Lars Terenius, Vladana Vukojević, Leon F. McSwain, Timothy R. Gershon, Bryan W. Day

“…Single cell transcriptomic studies (scRNA-seq) confirm that CT-179 increases differentiation and implicate Cdk4 up-regulation in maintaining proliferation during treatment. …”
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Therapeutic Effects of Forest Bathing on Human Health: A Systematic Review by Adrianna Samoraj, Jakub Zajączkowski, Paulina Krzeszowska, Kacper Stępniak, Karolina Marrodán-Wojtczak, Jan Wilk, Jakub Jarmołowicz, Aleksandra Kujawa, Karolina Krochmal, Radosław Kuźma

“…Results: The analysis of the retrieved data revealed a consistent pattern of beneficial physiological effects associated with forest bathing. …”
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LncRNA ZNF674-AS1 drives cell growth and inhibits cisplatin-induced pyroptosis via up-regulating CA9 in neuroblastoma by Kunming Zhao, Xinyi Wang, Yaqiong Jin, Xiaoxiao Zhu, Tao Zhou, Yongbo Yu, Xiaoying Ji, Yan Chang, Jiao Luo, Xin Ni, Yongli Guo, Dianke Yu

“…Here, we analyzed our RNA sequencing data and identified the upregulated lncRNA ZNF674-AS1 in chemotherapy non-responsive NB patients. …”
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Defining Predictive Factors for Permanent Chemotherapy-Induced Alopecia: Trichoscopy, Reflectance Confocal Microscopy and Histopathology Study on 77 Patients by Michela Starace, Victor Desmond Mandel, Marco Ardigo, Miriam Anna Carpanese, Federico Quadrelli, Francesca Pampaloni, Kaleci Shaniko, Aurora Alessandrini, Francesca Bruni, Alfredo Rossi, Maria Caterina Fortuna, Gemma Caro, Norma Cameli, Martina Silvestri, Gabriella Fabbrocini, Maria Carmela Annunziata, Mariateresa Cantelli, Maria Vastarella, Daniela Rubino, Claudio Zamagni, Giovanni Pellacani, Bianca Maria Piraccini

“…Abstract Introduction Literature about trichoscopy of permanent chemotherapy-induced alopecia (pCIA) is still scarce, while no data were published regarding reflectance confocal microscopy (RCM). …”
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m6A modification regulates cell proliferation via reprogramming the balance between glycolysis and pentose phosphate pathway by Jian-Fei Xi, Biao-Di Liu, Guo-Run Tang, Ze-Hui Ren, Hong-Xuan Chen, Ye-Lin Lan, Feng Yin, Zigang Li, Wei-Sheng Cheng, Jinkai Wang, Lili Chen, Shao-Chun Yuan, Zhang Zhang, Guan-Zheng Luo

“…Aberrant m6A has been implicated in abnormal cellular phenotypes, including defects in stem cell differentiation and tumorigenesis. …”
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Pathogenic PDE12 variants impair mitochondrial RNA processing causing neonatal mitochondrial disease by Lindsey Van Haute, Petra Páleníková, Jia Xin Tang, Pavel A Nash, Mariella T Simon, Angela Pyle, Monika Oláhová, Christopher A Powell, Pedro Rebelo-Guiomar, Alexander Stover, Michael Champion, Charulata Deshpande, Emma L Baple, Karen L Stals, Sian Ellard, Olivia Anselem, Clémence Molac, Giulia Petrilli, Laurence Loeuillet, Sarah Grotto, Tania Attie-Bitach, Jose E Abdenur, Robert W Taylor, Michal Minczuk

“…Within this group, an increasing number of families have been identified, where Mendelian genetic disorders implicate defective mitochondrial RNA biology. The PDE12 gene encodes the poly(A)-specific exoribonuclease, involved in the quality control of mitochondrial non-coding RNAs. …”
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Hypothalamic volume is associated with age, sex and cognitive function across lifespan: a comparative analysis of two large population-based cohort studiesResearch in context by Peng Xu, Santiago Estrada, Rika Etteldorf, Dan Liu, Mohammad Shahid, Weiyi Zeng, Deborah Früh, Martin Reuter, Monique M.B. Breteler, N. Ahmad Aziz

“…Methods: We used cross-sectional data from the Rhineland Study (N = 5812, 55.2 ± 13.6 years, 58% women) and the UK Biobank Imaging Study (UKB) (N = 45,076, 64.2 ± 7.7 years, 53% women), two large-scale population-based cohort studies. …”
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Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop by Minghai Ma, Jianpeng Li, Xing Li, Minxuan Jing, Lu Wang, Yunzhong Jiang, Zezhong Yang, Jiale He, Min Wang, Hang Liu, Yutong Chen, Kaibo Mi, Lei Wang, Jinhai Fan, Hongxia Du

“…ABSTRACT Background Emerging evidence implicates mechanotransduction pathways in modulating bladder carcinoma (BLCA) pathogenesis. …”
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INTERNALIZATION OF ANTIMICROBIAL PEPTIDE ACIPENSIN 1 INTO HUMAN TUMOR CELLS by E. S. Umnyakova, I. V. Kudryavtsev, N. A. Grudinina, S. V. Balandin, I. A. Bolosov, P. V. Panteleev, T. A. Filatenkova, D. S. Orlov, E. V. Tsvetkova, T. V. Ovchinnikova, V. N. Kokryakov, O. V. Shamova

“…The maximum of fluorescence was reached within a period of approx. 45 seconds, with further “plateau” at the terms of >100 seconds following cell stimulation with the test compound. These data support the concept, that the antimicrobial peptides of innate immunity system possess the features of cell-penetrating peptides, and allow us to consider the studied sturgeon peptide a promising template for development of new drugs with increased ability to enter the cells implicated into pathological processes, and, therefore, higher therapeutic efficiency.…”
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Persistent Fibrosis in Heart Failure With a Reduced Ejection Fraction Linked to Phenotypic Differences in Human Cardiac Fibroblast Populations by Rachel M. Biggs, Yuhua Zhang, Daniel N. Silverman, Catalin F. Baicu, An O. Van Laer, Lauren Wakefield, Devki Bhatt, Stephanie Masline, Lily S. Neff, Arman Kilic, Lucas J. Witer, Brian A. Houston, Samuel J. Coeyman, William J. Richardson, Michael R. Zile, Amy D. Bradshaw

“…Conclusions These data support that sustained cardiac hemodynamic overload leads to a phenotypic conversion in fibroblasts in which the capacity to detect changes in mechanical input is muted, thus contributing to retention of collagen content and stiffness in both pre‐ and post‐LVAD hearts.…”
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Endothelial cells expressing CPE and vWF are involved in the Immunopathogenesis of primary biliary cholangitis by Lin-Xiang Huang, Zi-Xuan Qiu, Xiao-Xiao Wang, Zi-Long Wang, Bo Feng

“…We hypothesize that LSECs may be implicated in the pathogenesis of PBC. Single-cell RNA sequencing (scRNA-seq) data were initially analyzed using R statistical software and Cell Ranger. …”
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Bulk- and single cell-RNA sequencing reveal KIF20A as a key driver of hepatocellular carcinoma progression and immune evasion by Zhixiong Su, Zhixiong Su, Yaqi Zhong, Yufang He, Lijie You, Fuli Xin, Fuli Xin, Lei Wang, Zhihua Liu

“…IntroductionKinesin family member 20A (KIF20A) is essential for cell proliferation and is implicated in promoting tumor progression, but its role in hepatocellular carcinoma (HCC) remains poorly studied.MethodsThrough the analysis of bulk RNA-sequencing (bulk RNA-seq) and single-cell RNA sequencing (scRNA-seq) data, the expression of KIF20A and its relationship with diagnosis, prognosis, and the immune microenvironment were examined. …”
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