Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B−/− mouse model of autism spectrum disorder by Giselle C. Wong, Giselle C. Wong, Yewon Jung, Yewon Jung, Kevin Lee, Kevin Lee, Chantelle Fourie, Chantelle Fourie, Kim M. Handley, Johanna M. Montgomery, Johanna M. Montgomery, Michael W. Taylor, Michael W. Taylor

“…Shank gene variants are implicated in ~1% of people with autism, and mice lacking Shank3 exhibit autism-like behaviours. …”
Get full text

Systematic Review of Proteomics in Age-Related Macular Degeneration and Pathway Analysis of Significant Protein Changes by Olympia Sideri, MD, MSc, Victor Correa, MD, Nikolaos Ziakas, MD, PhD, Ioannis Tsinopoulos, MD, PhD, Joan W. Miller, MD, PhD, Demetrios G. Vavvas, MD, PhD

“…However, there is a scarcity of data available for early AMD from ocular biofluids, and it should be the aim of future proteomics studies. …”
Get full text

Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation by Victòria Ayala, Laia Fontdevila, Santiago Rico-Rios, Mònica Povedano, Pol Andrés-Benito, Pascual Torres, José C. E. Serrano, Reinald Pamplona, Manuel Portero-Otin

“…The gut microbiota, a community of microorganisms in the digestive tract, has recently been implicated in ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. …”
Get full text

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis by Oliver J. Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie-Claude Potier, John Hardy, Dervis A. Salih, Paul Whiting, Fiona Ducotterd, Rickie Patani, Selina Wray, Charles Arber

“…Current research into late onset Alzheimer’s disease implicates inflammation in both disease onset and progression. …”
Get full text

A bedside-to-bench translational analysis of NF1 alterations and CDK4/6 inhibitor resistance in hormone receptor-positive metastatic breast cancerResearch in context by Maxwell R. Lloyd, Rosario Chica-Parrado, Caroline M. Weipert, Todd C. Knepper, Emily L. Podany, Fabiana Napolitano, Dan Ye, Chang-Ching Lin, Yasuaki Uemoto, Jiemin Liao, Claire Wegrzyn, Christine M. Walko, Lianne Y. Ryan, Jennifer C. Keenan, Arielle J. Medford, Shiyuan A. Liu, Gerburg M. Wulf, Katherine K. Clifton, Cynthia X. Ma, Hyo S. Han, Nicole Zhang, Leif W. Ellisen, Aditya Bardia, Carlos L. Arteaga, Ariella B. Hanker, Seth A. Wander

“…We analysed multi-institutional data, real-world evidence, and preclinical models to characterise the impact of pNF1m on CDK4/6i sensitivity. …”
Get full text

Evaluation of Screening Tool of Older People’s Prescriptions (STOPP) Criteria in an Urban Cohort of Older People with HIV by Lauren F. O’Connor, Jenna B. Resnik, Sam Simmens, Vinay Bhandaru, Debra Benator, La’Marcus Wingate, Amanda D. Castel, Anne K. Monroe

“…STOPP is particularly important for people aging with HIV and comorbidities, since PIP may exacerbate symptoms and decrease adherence. Methods: We analyzed data from the DC Cohort, a longitudinal cohort of people with HIV (PWH). …”
Get full text

The Association Between Serum Uric Acid Levels and the 10‐Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP) by Hamidreza Mohammadi, Seyed Reza Mirjalili, Pedro Manuel Marques‐Vidal, Marzieh Azimizadeh, Seyede Mahdiah Nemayandah, Mohammadtaghi Sarebanhassanabadi, Sedighe Sadeghi

“…Methods This cohort study uses data from the Yazd Healthy Heart Project (YHHP). …”
Get full text

Genotype-Based Housing as a Potential Confounder in Studies Using Transgenic Mouse Models—Insight from the A53T Mouse Model of Parkinson’s Disease by Olga Dubljević, Miodrag Dragoj, Milica Potrebić Stefanović, Maja Srbovan, Miloš Stanojlović, Željko Pavković

“…<b>Conclusions</b>: This study highlights the importance of considering environmental factors in studies using transgenic animal models. The obtained data suggests that GbH can influence the parameters of interest in preclinical research, implicating the need for the optimization of future study designs.…”
Get full text

Petrology of the Pan-African high-K alkali-calcic Bocaranga plutonic complex in the Adamawa-Yadé domain (Central African Republic): Nature, origin and contribution to geodynamic re... by Rodrigue Martial Topien, Jules Tcheumenak Kouémo, José Kpéou, Gaetan Moloto-A-Kenguemba, Maurice Kwékam

“…However, the presence of gneiss xenoliths and mafic enclaves within the plutonic complex, combined to the geochemical data, indicate that the Bocaranga plutonic complex is most likely the result of mixing between mantle- and crust-derived magmas, with high crustal implication for coarse-grained biotite granite, fine-grained biotite granite and two micas granite and high mantle one for hornblende-biotite granite. …”
Get full text

Landscape as a Shared Space for Badgers and Cattle: Insights Into Indirect Contact and Bovine Tuberculosis Transmission Risk by Emma L. Holmes, Maria J. H. O’Hagan, Fraser D. Menzies, Andrew W. Byrne, Kathryn R. McBride, Charles M. McCormick, David M. Scantlebury, Neil Reid

“…ABSTRACT Though the magnitude of effect is uncertain, badger–cattle indirect contact has been implicated in bovine tuberculosis (bTB) transmission risk to cattle despite a paucity of data on badger space use. …”
Get full text

NSDHL contributes to breast cancer stem-like cell maintenance and tumor-initiating capacity through TGF-β/Smad signaling pathway in MCF-7 tumor spheroid by So-Hyun Yoon, Sangeun Lee, Hoe Suk Kim, Junhyuk Song, Moonjou Baek, Seungyeon Ryu, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh, Sangyong Jon, Wonshik Han

“…Abstract Background NAD(P)-dependent steroid dehydrogenase-like protein (NSDHL), which is involved in breast tumor growth and metastasis, has been implicated in the maintenance of cancer stem cells. …”
Get full text

An integrated approach to predict genetic risk for Mosquito-Borne diseases in the local Population of Tehsil Haripur, Khyber Pakhtunkhwa, Pakistan by Rabea Basri, Muslim Bin Aqeel, Faryal Mehwish Awan, Sadiq Noor Khan, Ayesha Obaid, Rubina Parveen, Muhammad Mohsin, Wajeeha Akhtar, Abdal Hussain Shah, Tahira Sher Afghan, Amir Alam, Saira Khan, Anam Naz

“…The findings of this study revealed overlapping genes most implicated in mosquito-borne disease linked with susceptibility and protection across different ethnic ancestries. …”
Get full text

Low expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemia by Jing-dong Zhou, Dong-ming Yao, Li Han, Gao-fei Xiao, Hong Guo, Ting-juan Zhang, Xi-xi Li, Qian Yuan, Lei Yang, Jiang Lin, Jun Qian

“…However, the status of NKD1 expression and its clinical implication in acute myeloid leukemia remain largely elusive. …”
Get full text

Next-generation sequencing reveals viral aetiologies of encephalitis in Ghana: a prospective cross-sectional study by Richmond Yeboah, Richmond Gorman, Philip El-Duah, James Osei-Mensa, Henry Kyeremateng Acheampong, Emmanuella Nyarko-Afriyie, Michael Owusu, Yaw Ampem Amoako, Kwasi Obiri-Danso, Richard Odame Phillips, Victor Max Corman, Christian Drosten, Augustina Angelina Sylverken

“…However, its application remains limited, and diagnosis is predominantly syndromic. Current data on encephalitis in Ghana are sparse and often restricted to sporadic cases, with improved PCR diagnostics elucidating some aetiological agents but leaving approximately 60% of cases undiagnosed. …”
Get full text

3-O Sulfated Heparan Sulfate (G2) Peptide Ligand Impairs the Infectivity of <i>Chlamydia muridarum</i> by Weronika Hanusiak, Purva Khodke, Jocelyn Mayen, Kennedy Van, Ira Sigar, Balbina J. Plotkin, Amber Kaminski, James Elste, Bajarang Vasant Kumbhar, Vaibhav Tiwari

“…<b>Background:</b> Heparan sulfate (HS) is widely implicated as a receptor for <i>Chlamydia</i> cell attachment and infectivity. …”
Get full text

Glioma-Associated Antigen HEATR1 Induces Functional Cytotoxic T Lymphocytes in Patients with Glioma by Zhe Bao Wu, Chao Qiu, An Li Zhang, Lin Cai, Shao Jian Lin, Yu Yao, Qi Sheng Tang, Ming Xu, Wei Hua, Yi Wei Chu, Ying Mao, Jian Hong Zhu, Jianqing Xu, Liang Fu Zhou

“…CTLs against HEATR1 peptides were capable of recognizing and lysing GBM cells and GSCs. These data are the first to demonstrate that HEATR1 could induce specific CTL responses targeting both GBM cells and GSCs, implicating that HEATR1 peptide-based immunotherapy could be a novel promising strategy for treating patients with GBM.…”
Get full text

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria by Tonia Dargham, John Jairo Aguilera-Correa, Romain Avellan, Ivy Mallick, Léa Celik, Pierre Santucci, Gael Brasseur, Isabelle Poncin, Vanessa Point, Stéphane Audebert, Luc Camoin, Wassim Daher, Jean-François Cavalier, Laurent Kremer, Stéphane Canaan

“…By identifying the proteins involved in the formation of intrabacterial lipid inclusions and revealing their impact on lipid metabolism, our data may lead to the development of new therapeutic strategies to target and control pathogenic mycobacteria, potentially improving outcomes for patients with mycobacterial infections.…”
Get full text

Genomic insights into multidrug-resistant Enterobacter hormaechei isolates from seafood at retail carrying the mcr-9 gene and other resistance determinants on IncHI2 plasmids by Valeria Michelacci, Silvia Pieralisi, Elisa Albini, Francesca Romana Massacci, Gabriele Angelico, Paola Chiani, Manuela Marra, Maria Carollo, Chiara Francesca Magistrali, Francesca Leoni

“…Sequence analysis showed mutations in genes implicated in colistin resistance, of which a non-conservative one was present in the qseB. …”
Get full text

Molecular landscape of the overlap between Alzheimer’s disease and somatic insulin-related diseases by I. Hyun Ruisch, Joanna Widomska, Ward De Witte, Nina R. Mota, Giuseppe Fanelli, Veerle Van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Abel Fóthi, Csaba Barta, Simone Berkel, Kazi A. Alam, Aurora Martinez, Jan Haavik, Aet O’Leary, David Slattery, Mairéad Sullivan, Jeffrey Glennon, Jan K. Buitelaar, Janita Bralten, Barbara Franke, Geert Poelmans

“…Subsequently, using (additional) GWAS data, we conducted shared genetic etiology analyses between AD and SID, on the one hand, and blood and cerebrospinal fluid (CSF) metabolite levels on the other hand. …”
Get full text

PRAGMATIC DEVIATIONS IN TRANSLATION OF LEXICAL BLENDS WITHIN POLITICAL DISCOURSE by Olena M. Medvid, Kateryna M. Vashyst

“…Regarding the focus of socio-political discourse on speech influence, the conveying of blend stylistics and the transfer of speech realia that form the basis of the blend implication and strengthen the socio-pragmatics of the given text cause difficulties in comprehending the English original and translation variants. …”
Get full text