Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes by Michelle Horan, Michelle Horan, Daniel Carey, Daniel Carey, Silvin Knight, Silvin Knight, A. Fagan, James F. M. Meaney, James F. M. Meaney, Rose Anne Kenny, Rose Anne Kenny, Rose Anne Kenny, Céline De Looze, Céline De Looze

“…The hippocampus has been implicated in memory and cognitive decline. In this study, we investigate the independent and moderating effects of increased arterial stiffness (AS) and reduced cerebral blood flow (CBF) on hippocampal volume (HV) in a large MRI sample of community-dwelling older adults from the Irish Longitudinal Study on Ageing (TILDA).MethodsLongitudinal data from study participants for Wave 1 (2009–2011) and Wave 3 (2014-2015) were included. …”
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Oral microbiota related to allergy in Norwegian adults by Mikyeong Lee, PhD, Hilde Kristin Vindenes, MD, PhD, Farnaz Fouladi, PhD, Rajesh Shigdel, PhD, James M. Ward, MSc, Shayamal D. Peddada, PhD, Stephanie J. London, MD, DrPH, Randi Jacobsen Bertelsen, PhD

“…Some, including Streptococcus, were previously implicated in respiratory health, whereas others were novel. …”
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ROS1 Expression Correlates With Inguinal Lymph Node Affection in Vulvar Cancer Patients: A Retrospective Study by Meletios P. Nigdelis, Annick Bitterlich, Mariam Parvanta, Bashar Haj Hamoud, Erich Franz Solomayer, Martin Ertz, Laura Schnöder, Annette Hasenburg, Bernd Holleczek, Mathias Wagner, Gilbert Georg Klamminger

“…ROS1, a tyrosine kinase implicated, for example, in non‐small cell lung cancer (NSCLC), has recently shown responsiveness to tyrosine kinase inhibitors. …”
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Multi-omic analyses reveal PTPN6’s impact on tumor immunity across various cancers by Yuchen Zhong, Weiyuan Zhang, Chaojing Zheng, Hongyu Wu, Jun Luo, Ziming Yuan, Hao Zhang, Chunlin Wang, Haiyang Feng, Meng Wang, Qian Zhang, Haixing Ju, Guiyu Wang

“…We analyzed PTPN6 expression data from open access databases using various statistical techniques, including survival analysis, genetic heterogeneity analysis, immune profiling, single-cell analysis, drug sensitivity analysis, and protein interaction analysis. …”
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Genetic evidence for causal relationships between vegetarian biomarkers and esophageal cancer risk by Xinqi Liu, Xu Xu, Zhenglong Jiang, Ning Du, Jiayang Chen, Jinyuan Chang, Lixing Liu, Li Feng

“…While biomarkers specific to vegetarian populations have been implicated in cancer development, their causal relationship with EC remains unclear. …”
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Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers by Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro

“…Downregulated genes included GAS2L2, TRIM67, IL1RAPL1, MAP1LC3B2, and NTNG1, implicated in neuronal development and autophagy, while upregulated genes were linked to immune responses. …”
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Search for High-excitation Emission Lines from a Quasar-scale Active Nucleus in Arp 220 by Charles E. Goldberg, Victorine A. Buiten, George H. Rieke, Almudena Alonso-Herrero, A. Paggi, Paul van der Werf, Meredith A. Stone, Jane E. Morrison, Stacey Alberts, Dan Dicken, Gillian Wright

“…The most diagnostic nondetections are of the [Ne vi ] λ 7.652 μ m and [Ne v ] λ 14.32 μ m lines, for which the combined upper limit is ∼10–20 times fainter than the equivalent limit from Spitzer data. We also use X-ray measurements of the reflected Fe K α line to suggest a relatively low X-ray luminosity. …”
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A genome-wide investigation of Mycoplasma hominis genes associated with gynecological infections or infertility by Salim Chibani, Elhem Yacoub, Safa Boujemaa, Helmi Mardassi, Julien Guglielmini, Amaury Vaysse, Nadine Khadraoui, Béhija Mlik, Boutheina Ben Abdelmoumen Mardassi

“…Here, based on whole genome sequencing (WGS) data, we sought to provide a more refined picture of the phylogenetic relationship between these two M. hominis pathotypes, with the aim to delineate the underlying genetic determinants.MethodsWe carried out WGS of 62 Tunisian M. hominis clinical strains collected over a 17-year period. …”
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Older people and stroke: a machine learning approach to personalize the rehabilitation of gait by Elvira Maranesi, Federico Barbarossa, Leonardo Biscetti, Marco Benadduci, Elisa Casoni, Ilaria Barboni, Fabrizia Lattanzio, Lorenzo Fantechi, Daniela Fornarelli, Enrico Paci, Sara Mecozzi, Manuela Sallei, Mirko Giannoni, Giuseppe Pelliccioni, Giovanni Renato Riccardi, Valentina Di Donna, Roberta Bevilacqua

“…Notably, RF outperformed others, suggesting its efficacy in handling complex and nonlinear data relationships.DiscussionThe clinical implication emphasized a connection between gait parameters and cerebral lesion location, notably linking basal ganglia lesions to prolonged double support time. …”
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The multifaceted role of vitreous hyalocytes: Orchestrating inflammation, angiomodulation and erythrophagocytosis in proliferative diabetic retinopathy by Stefaniya K. Boneva, Julian Wolf, Malte Jung, Gabriele Prinz, Toco Y. P. Chui, Jacqueline Jauch, Anne Drougard, J. Andrew Pospisilik, Anja Schlecht, Felicitas Bucher, Richard B. Rosen, Hansjürgen Agostini, Günther Schlunck, Clemens A. K. Lange

“…While resident vitreous macrophages called hyalocytes have been implicated in the pathophysiology of vitreoretinal proliferative disease previously, little is known about their exact role in PDR. …”
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Identification of novel candidate loci for Alzheimer’s disease and related dementias by leveraging the shared genetic basis with hippocampal volume by Chenyang Jiang, Sven J. van der Lee, Niccolò Tesi, Wiesje M. van der Flier, Betty M. Tijms, Lianne M. Reus

“…To identify shared genetic risk loci across late-onset ADRD and bilateral hippocampal volumes, we conducted a cross-trait analysis of existing GWAS data on the two traits using the conjunctional false discovery rate (conjFDR) framework. …”
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Which outcomes are key to the pre-intervention assessment profile of a child with developmental coordination disorder? A systematic review and meta-analysis by Bouwien Smits-Engelsman, Marisja Denysschen, Jessica Lust, Dané Coetzee, Ludvík Valtr, Marina Schoemaker, Evi Verbecque

“…Results: 121 papers were included for analyses. Data of 5923 children with DCD were included (59.8% boys) and 23 619 Typically Developing (TD) children (45.8% boys). …”
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The wheat receptor-like cytoplasmic kinase TaRLCK1B is required for host immune response to the necrotrophic pathogen Rhizoctonia cerealis by Tian-ci WU, Xiu-liang ZHU, Liang-jie LÜ, Xi-yong CHEN, Gang-biao XU, Zeng-yan ZHANG

“…Taken together, these data suggested that TaRLCK1B was required for the early immune response of wheat to R. cerealis through modulating ROS signaling in wheat.…”
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The role of ATP-binding Cassette subfamily B member 6 in the inner ear by Stefanie A. Baril, Katie A. Wilson, Md Munan Shaik, Yu Fukuda, Robyn A. Umans, Alessandro Barbieri, John Lynch, Tomoka Gose, Alexander Myasnikov, Michael L. Oldham, Yao Wang, Jingwen Zhu, Jie Fang, Jian Zuo, Ravi C. Kalathur, Robert C. Ford, Allison Coffin, Michael R. Taylor, Megan L. O’Mara, John D. Schuetz

“…Abstract ABCB6 has been implicated in dyschromatosis universalis hereditaria, a condition characterized by hyperpigmented and hypopigmented skin macules. …”
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Serum transgelin is a novel prognostic biomarker for COVID-19 patients by Lei Gao, Lei Gao, Ying Liu, Ying Liu, Qi-Yuan He, Qi-Yuan He, Yu Wang, Yu Wang, Ya-Lin Jiang, Jin Yang, Jin Yang, Lin Fu, Lin Fu, Hui Zhao, Hui Zhao

“…Peripheral blood was collected from the fasting patients at the onset and convalescent phases. Demographic data and clinical information were obtained. The expression of serum transgelin was estimated using ELISA.ResultsThe expression of serum transgelin on admission was gradually elevated in parallel with the increased severity scores of COVID-19. …”
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Integrated 4D label-free proteome and SUMOylated proteome in glioma uncover novel pathological mechanisms and pave the way for precision therapy by Jiazheng Wang, Zhuo Li, Kaijie Mu, Qichao Qi, Zeli Zhang, Can Yan, Xukai Jiang, Anjing Chen

“…By integrating proteomics and transcriptomics data, we pinpointed core proteins with consistent upregulation and assessed their potential as drug targets in glioma through virtual screening of eight cytoplasmic proteins with small molecule binding cavities. …”
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Reduction of elevated Gli3 does not alter the progression of autosomal recessive polycystic kidney disease by Lauren G. Russell, Maria Kolatsi‐Joannou, Laura Wilson, Jennifer C. Chandler, Nuria Perretta Tejedor, Georgie Stagg, Karen L. Price, Christopher J. Rowan, Tessa Crompton, Norman D. Rosenblum, Paul J. D. Winyard, David A. Long

“…Prior studies have implicated Hedgehog (Hh) signaling in ADPKD, with increased levels of Hh components in experimental ADPKD and reduced cystogenesis following pharmacological Hh inhibition. …”
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Alterations in sulcal depth and associated functional connectivity in schizophrenia with auditory verbal hallucinations by Zhenru Guo, Zimo Zhou, Shuai Wang, Lianlian Yang, Xiaoshan Gao, Yu Xia, Yuanyuan Yang, Zhangyan Shan, Haixia Huang, Lin Tian, Lin Tian

“…Magnetic resonance imaging data were collected on all participants, and clinical symptoms were assessed using standardized clinical scales. …”
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Drought-induced transposon expression reveals complex drought response mechanisms in Brassica napus by Manyi Chen, Dan Luo, Hanzhao Kong, Yan Lv, Chunsheng Li, Yongguo Zhao, Qian Huang, Guangyuan Lu, Guangyuan Lu

“…This study investigates the transcriptional dynamics of TEs in Brassica napus during drought stress in seed development, aiming to uncover their contributions to stress responses and seed germination. RNA-seq data were analyzed for TE transcriptional activity in wild-type (WT) and BnaABI5 CRISPR-edited mutant lines of B. napus. …”
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Atmospheric carbon monoxide and hospitalization for mental and behavioral disorders: insights from a longitudinal study in Shijiazhuang by Peihua Hu, Wenting Lu, Xian Gao, Yating Li, Yanli Yang, Wanyi Yin, Liang Dong, Ruojia Ren, Xueyi Wang

“…Background and aimCarbon monoxide (CO), a prevalent environmental pollutant, has been implicated in adverse mental health outcomes, but the mechanistic relationship between atmospheric CO levels and hospital admissions for mental and behavioral disorders remains unclear. …”
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