The burden and trend prediction of atrial fibrillation and flutter associated with lead exposure: insights from the global burden of disease study 2021 by Lili Deng, Qinhong Li, Hongyan Li, Bin Li, Zugen Cheng, Ying Xiao

“…BackgroundAtrial fibrillation and flutter (AF/AFL) are increasingly recognized as major contributors to global cardiovascular morbidity and mortality. Emerging evidence implicates environmental lead exposure as a modifiable risk factor for AF/AFL, yet the global burden and trends of AF/AFL attributable to lead exposure remain poorly characterized.MethodsWe used data from the Global Burden of Disease Study 2021 to estimate mortality, disability-adjusted life years (DALYs), and temporal trends in AF/AFL attributable to lead exposure from 1990 to 2021, with projections to 2030. …”
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Epigenetic modifications in the murine liver upon depletion of transcriptional coregulator host cell factor 1 by Shruti Kaushal, Debashruti Bhattacharya, Saran Kumar, Winship Herr, Jaspreet Kaur Dhanjal, Shilpi Minocha

“…HCF-1 (Host Cell Factor 1), a conserved transcriptional co-regulator, has been implicated in cell cycle progression, liver metabolism, and regeneration. …”
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Telenursing as an Effective Ally for Improving Patient Outcomes in Diabetes? An Umbrella Review by Marika Lo Monaco, Arianna Profeta, Salvatore Corrao

“…AMSTAR 2 was used to assess the quality of the included studies. Data Sources We conducted an umbrella review from July 2023 to May 2024, searching Cochrane Library, PubMed, SCOPUS, and PROSPERO for systematic reviews published from inception to May 10, 2024. …”
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Overweight and glucose/lipid metabolism abnormality associated with SSRIs: a pharmacovigilance study based on the FDA adverse event reporting system by Jinming Cao, Zhicong Chen, Yan Wang, Yunpeng Ma, Zhen Yang, Jian Cai, Zhijun Xiao, Feng Xu

“…Our main goal was to evaluate adverse events related to SSRIs, with a particular focus on abnormal weight gain and glucose/lipid metabolism disorders.MethodThe adverse event data for representative SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) was extracted from the FAERS database from 2004Q1 to 2023Q4. …”
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Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights by Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

“…PTPN7, a tyrosine phosphatase implicated in MAPK signaling, is known to play roles in various malignancies but remains underexplored in gliomas. …”
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Evaluation of commercial diets on fecal consistency and defecation frequency in rhesus macaques (Macaca mulatta) with chronic intermittent idiopathic diarrhea by Annemiek Maaskant, Niels R. Blees, Antoine Smits, Ronald J. Corbee, Jaco Bakker, Jan A. M. Langermans, Edmond J. Remarque

“…Aside from infectious causes, dietary factors have been implicated in diarrhea. Therefore, the main objective of this study was to evaluate commercially available pelleted diets in rhesus macaques with chronic intermittent idiopathic diarrhea. …”
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Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs by Mohammed Dashti, Naser M. Ali, Hussain Alsaleh, Sumi Elsa John, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

“…Complete mitochondrial genomes were derived from whole exome sequencing data to examine the associations between T2D and haplogroups and mitochondrial DNA variants.ResultsThe analysis revealed a significant protective effect of haplogroup H against T2D (odds ratio [OR] = 0.65; P = 0.022). …”
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KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells by Bishu Zhang, Tuoya Qi, Jiewei Lin, Shuyu Zhai, Xuelong Wang, Leqi Zhou, Xiaxing Deng

“…Abstract Histone lysine succinylation, an emerging epigenetic marker, has been implicated in diverse cellular functions, yet its role in cancer drug resistance is not well understood. …”
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The Pleiotropic Effect of ANRIL in Glaucoma and Cardiovascular Disease by Luke O’Brien, Daire J. Hurley, Michael O’Leary, Liam Bourke, Colm O’Brien

“…Phenotypic associations were assessed using PheWAS data. <b>Results</b>: We identified 20 GWAS SNPs significantly associated with both glaucoma and CVD. …”
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A multi-omics exploration of PPARG activation in colon cancer: kinases featuring a PPRE sequence within regulatory regions by Pritha Saha, Palaniyandi Ravanan, Priti Talwar

“…Peak calling analysis from ChIP-seq data identified 14,000 to 34,000 binding sites for PPARG across different experimental conditions. …”
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Genome-Wide Identification of <i>PP2C</i> Gene Family in Oat (<i>Avena sativa</i> L.) and Its Functional Analyses in Response to ABA and Abiotic Stresses by Panpan Huang, Kuiju Niu, Jikuan Chai, Wenping Wang, Yanming Ma, Yanan Cao, Guiqin Zhao

“…., MYB, MYC, ARE, and MBS), implicating <i>AsaPP2Cs</i> in hormones and biotic stress adaptation. …”
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DLEU2 facilitates bladder cancer progression through miR-103a-2-5p/SOS1 axis by Yinlong Liu, Jian Hu, Baochun Liao, Zhijian Zhu, Yong Liu, Qinghua Pan

“…LncRNA deleted in lymphocytic leukemia 2 (DLEU2) is implicated in the development of various cancers. However, its role and regulatory mechanisms in BC remain unclear. …”
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Investigation of the role of miRNA variants in neurodegenerative brain diseases by Alexandros Frydas, Alexandros Frydas, Rita Cacace, Rita Cacace, Julie van der Zee, Julie van der Zee, Christine Van Broeckhoven, Christine Van Broeckhoven, Eline Wauters, Eline Wauters

“…Here, we report rare miRNA variants in patients with Alzheimer’s dementia (AD) and frontotemporal dementia (FTD).MethodsWe initially used whole exome sequencing data in a subset of FTD patients (n = 209) from Flanders-Belgium. …”
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Meat and fish consumption, genetic risk and risk of severe metabolic-associated fatty liver disease: a prospective cohort of 487,875 individuals by Jianjin Wang, Jianshu Mo, Xuzhi Wan, Yilei Fan, Pan Zhuang

“…Abstract Background Diet, specifically meat consumption, has been implicated as a modifiable risk factor in the development of metabolic-associated fatty liver disease (MAFLD). …”
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Identification of signature genes and relationship with immune cell infiltration in intervertebral disc degeneration by Kun Mu, JingChao Geng, Yu Dong, Wei Guo, Wei Guo, Wei Guo

“…Function of the hub gene was confirmed by PCR, Western blotting and ELISA.Results2,254 DEGs were identified from GSE56081, and WGCNA grouped the data into 9 modules. MEbrown module had a significant correlation with IVD degeneration (cor = 0.99, P = 8.00 × 10−8). …”
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Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. by Alexandra Zhernakova, Eli A Stahl, Gosia Trynka, Soumya Raychaudhuri, Eleanora A Festen, Lude Franke, Harm-Jan Westra, Rudolf S N Fehrmann, Fina A S Kurreeman, Brian Thomson, Namrata Gupta, Jihane Romanos, Ross McManus, Anthony W Ryan, Graham Turner, Elisabeth Brouwer, Marcel D Posthumus, Elaine F Remmers, Francesca Tucci, Rene Toes, Elvira Grandone, Maria Cristina Mazzilli, Anna Rybak, Bozena Cukrowska, Marieke J H Coenen, Timothy R D J Radstake, Piet L C M van Riel, Yonghong Li, Paul I W de Bakker, Peter K Gregersen, Jane Worthington, Katherine A Siminovitch, Lars Klareskog, Tom W J Huizinga, Cisca Wijmenga, Robert M Plenge

“…We hypothesized that there are additional shared risk alleles and that combining genome-wide association study (GWAS) data from each disease would increase power to identify these shared risk alleles. …”
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Morpho-physiological, anatomical and molecular responses of Porang (Amorphophallus muelleri Blume) to drought stress by T. Nurhidayati, F. F. Nasich, T. B. Saputro, K. I. Purwani, N. D. Kuswytasari, W. Muslihatin, A. Solihah, A. Nafian

“…This study was conducted for 21 days with the treatment stress level based on field capacity of 75%, 50%, 25%, and 0%. Data were analyzed using ANOVA One-Way and followed by Tukey Test. …”
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Genome of the invasive North American Haemaphysalis longicornis tick as a template for bovine anti-tick vaccine discovery by Mohamed Abdallah Mohamed Moustafa, Miranda M. Barnes, Nicole E. Wagner, Deanna Bodine, Kylie Bendele, Pete D. Teel, Perot Saelao, Dana C. Price

“…Results Using a combination of PacBio HiFi single-molecule sequencing and Hi-C chromosome conformation capture data, our genome assembly contains 270 scaffolds and spans a haploid genome size of 3.09 Gbp with an N50 of 213.4 Mbp. …”
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High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently by Valeria De Matteis, Mariafrancesca Cascione, Agnese De Luca, Daniela Erminia Manno, Rosaria Rinaldi

“…The actin reorganization, nuclear morphology alteration, and cell membrane elasticity analyses confirmed the trend achieved from the biological assays. The obtained data demonstrate that the increase in cellular softness, i.e., the decrease in Young’s modulus, could be associated with the smaller and positive NPs, recording values of about 3 kPa. …”
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Rural or urban living and Parkinson's disease Antecedente de vida rural ou de vida urbana e doença de Parkinson by Henrique B. Ferraz, Luiz A. F. Andrade, Vítor Tumas, Leandro C. Calia, Vanderci Borges

“…Prior living in a rural area has been implicated as a possible risk factor for PD, particularly in the early onset type. …”
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