Prevalence of cognitive impairment and metabolic syndrome among older adults in calabar metropolis and the associated risk factors by Idongesit KokoAbasi Isong, Kingsley John Emmanuel, Iya Eze Bassey, Mercy Etim Jackson, Unwana Paul Obadare, Ifure Uwem KokoAbasi, Glory Okoi Abam

“…CI was assessed using the Mini-Cog™ test, with scores ≤ 3 indicating poor cognitive status. Data analysis utilized SPSS version 26.0, employing chi-square tests and binary logistic regression. …”
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A Comparative Analysis of Genetic and Epigenetic Factors in METH Addiction: A Focus on SLC (SLC6A4) and COMT Genes by Haider K. Hussain, Yolanda Loarce Tejada, Anna Barbaro

“…Genetic and epigenetic factors, particularly involving the SLC6A4 and COMT genes, are implicated in individual vulnerability to METH addiction. …”
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GATA1-mediated macrophage polarization via TrkB/cGMP–PKG signaling pathway to promote the development of preeclampsia by Wushan Li, Fei Hou, Di Cheng, Fengchun Gao, Jin Wang, Baoxia Cui

“…Recent studies have indicated that the transcription factor GATA1 may be implicated in the pathological processes of PE, but the underlying mechanism remains elusive. …”
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Comprehensive analysis of long non-coding RNA and mRNA expression patterns during seminiferous tubules maturation in Guanzhong dairy goats by Fa Ren, Que Zhang, Yu Jiang, Wenling Xie, Pengyun Qiao, Jianhong Hu

“…Additionally, single-cell transcriptome data validated the expression of key genes, revealing that Piwil4 and Dnmt3l were specifically expressed in spermatogonial clusters, whereas Piwil1, Piwil2, and Gtsf1 were predominantly expressed in spermatocyte clusters. …”
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The mechanism of high mobility group box-1 in the proliferation and macrophage polarization in esophageal squamous cell carcinoma cells by Liling Luo, Chao Jiang, Songxi Xie

“…Abstract Background Previous studies showed that high mobility group box-1 (HMGB1) facilitates the initiation and progression of esophageal squamous cell carcinoma (ESCC), and the current research investigated the detailed mechanisms implicated. Methods The impact of HMGB1 and IGFBP3 levels on the survival of ESCC was examined by plotting Kaplan–Meier (KM) curves based on the data collected from The Cancer Genome Atlas (TCGA). …”
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TRPC6 is a Biomarker for Prognosis and Immunotherapy of Stomach Adenocarcinoma Based on Bioinformatic Analysis and Experimental Validation by Hu X, Wang H, Sun H, Zhang J, Ye Z, Huang Z

“…Although previous studies have implicated TRPC6 in the progression of stomach adenocarcinoma (STAD), its precise functions and mechanisms remain unclear. …”
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Molecular Determinants for the Binding of the Highly Infectious SARS-CoV-2 Omicron (BA.1) Variant to the Human ACE2 Receptor by Majed S. Aljohani, Pawan Bhatta, Xiche Hu

“…The strong correlation between calculated energy differences and experimental deep mutational scanning (DMS) data underscores the robustness of the theoretical framework in predicting the effects of RBD mutations on ACE2 binding affinity. …”
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Treatment Outcomes and Associated Factors among Patients with Drug-Resistant Tuberculosis (DR-TB) at a Tertiary Government Hospital in Nueva Ecija: A Seven-Year Retrospective Study by Dr Kelvin Clein Curitana

“…The study was submitted to Institutional Review Board for ethics assessment and clearance. Data collected were encoded and analyzed using SPSS V25. …”
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Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study by Chengrong Wu, Qian Pu, Yalin Zou, Juan Jin, Yu Lei, Yaxin Hu, Zhuo Chen, Lei Yu

“…Observational studies implicated dyslipidaemia as a risk factor for CAVS. …”
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Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas Expressão de p53, Ki-67 e c-erb B2 em adenomas hipofisários secretores de prol... by Carlos Henrique A. Botelho, Albino Verçosa de Magalhães, Paulo Andrade de Mello, Fernando C. Schmitt, Luiz Augusto Casulari

“…The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. …”
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Sleep reduces CSF concentrations of beta-amyloid and tau: a randomized crossover study in healthy adults by Tim Lyckenvik, Martin Olsson, My Forsberg, Pontus Wasling, Henrik Zetterberg, Jan Hedner, Eric Hanse

“…Abstract Background Slow-wave sleep has been proposed to facilitate the removal of proteins, implicated in neurodegeneration, from the brain. While mechanistic evidence from animal models is accumulating, direct human data on how slow-wave sleep shapes cerebrospinal fluid (CSF) proteostasis remain limited, constraining our understanding of physiological resilience to neurodegenerative disease. …”
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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D by Yonglan Wang, Kun Cao

“…In the present study, we studied clinical data from The Cancer Genome Atlas (TCGA) database. …”
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The expression profiles and roles of microRNAs in cardiac glucose metabolism by Nan-Nan Shen, Hua Qian, Ya-Fang Zhu

“…BackgroundMicroRNAs (miRNAs) are a class of endogenous, non-coding RNAs, that have been implicated in cardiovascular diseases. Recent studies have suggested that dysregulated miRNAs accumulate in the heart and may be associated with impaired cardiac glucose metabolism. …”
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Based on bioinformatics analysis lncrna SNHG5 modulates the function of vascular smooth muscle cells through mir‐205‐5p/SMAD4 in abdominal aortic aneurysm by Han Nie, Wenpeng Zhao, Shizhi Wang, Weimin Zhou

“…The dataset included gene expression array data of 49 AAA patients and 10 control aortic specimens from organ donors. …”
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BET Protein Inhibition Relieves MDSC-Mediated Immune Suppression in Chronic Lymphocytic Leukemia by Erin M. Drengler, Audrey L. Smith, Sydney A. Skupa, Elizabeth Schmitz, Eslam Mohamed, Dalia El-Gamal

“…<b>Conclusions</b>: Altogether, these data support BET inhibition as a useful therapeutic approach to reverse MDSC-mediated immune suppression in CLL.…”
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Core histones govern echinocandin susceptibility in Candida glabrata by Aditi Pareek, Rupinder Kaur

“…Herein, we show that the reduced gene dosage of core histone proteins, but not of the linker histone, leads to echinocandin susceptibility, which is partly due to increased ROS levels. Additionally, our data implicate histone H3 acetylation at lysine-56 in the caspofungin response of C. glabrata. …”
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Epigenetic Signatures of Dental Stem Cells: Insights into DNA Methylation and Noncoding RNAs by Rosanna Guarnieri, Agnese Giovannetti, Giulia Marigliani, Michele Pieroni, Tommaso Mazza, Ersilia Barbato, Viviana Caputo

“…This study reanalyzed publicly available DNA methylation data generated with Illumina Infinium HumanMethylation450 BeadChip arrays (450K arrays) from DPSCs, PDLSCs, and DFPCs. …”
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Assessment of Pain Perception of Aesthetic Procedures During Menstrual Period in Comparison to Non- Menstrual Period days by Bin Rubaian NF, AlGhamdi NJ, AlHemli HA, AlHuraish DS, Bukhari AE, Amir BA

“…Recent literature has shined a light on the possible implication of female sex hormones on the perception of pain, but the influence of these hormones on pain perception secondary to aesthetic procedures have scarcely been studied. …”
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DNA methylation-regulated HLA-C expression modulates immune responses and metabolic alterations to influence prognosis in mesothelioma by Huilin Zhang, Luanxue Yu, Yunqing Guo, Jiawei Ming, Zhenying Guo

“…Survival analysis was conducted using data from the TCGA mesothelioma cohort to assess the clinical relevance of HLA-C expression. …”
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Transcriptome analysis of gills reveal the key metabolism-related genes and pathways response to ammonia nitrogen stress in Scylla paramamosain by Chaoyue Wang, Xiao Liu, Jie Zhou, Sixiang Wang, Xia Zheng, Zehao Li, Yuanyuan Fu, Zhongwen Jin, Lei Liu

“…A total of 184.66 Gb of clean data and 36,439 DEGs were obtained, including 7,880 DEGs in the anterior gill and 28,559 DEGs in the posterior gill, which were implicated in the regulation of ammonia nitrogen metabolism-related pathways. …”
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