Vascular Endothelial Growth Factor and the Pathogenesis of Intracranial Aneurysms: A Systematic Review on the Missing Link in a Complex Pathway by Peyton L. Nisson, Michael T. Lawton, Oscar Cisneros, Takuma Maeda, Nestor R. Gonzalez, Juhana Frösen, Tomoki Hashimoto

“…Recent research has increasingly implicated vascular endothelial growth factor (VEGF) in the development and rupture of intracranial aneurysms. …”
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Transcriptional regulatory network analysis identifies GRN as a key regulator bridging chemotherapy and immunotherapy response in small cell lung cancer by Seungyeul Yoo, Ayushi S. Patel, Sarah Karam, Yi Zhong, Li Wang, Feng Jiang, Ranran Kong, Sharon Bikvan, Wenhui Wang, Abhilasha Sinha, Charles A. Powell, Jun Zhu, Hideo Watanabe

“…GRN and its associated genes were linked to cancer cell intrinsic immunogenicity, and single-cell RNA-seq data revealed that GRN expression is particularly high in subsets of tumor-associated macrophages. …”
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Genome-wide identification, transcriptional profiling, and miRNA-binding site analysis of the LBD gene family in the camphor tree by Jiaqi Zhang, Luyang Shan, Haoran Qi, Haoran Qi, Caihui Chen, Yongda Zhong, Meng Xu

“…Integrative omics analyses (small RNA-seq and degradome data) further implicated miR408 and miR2950c in post-transcriptional regulation of CcLBD5 via mRNA cleavage. …”
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PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling by Ruida Yang, Huanhuan Wang, Cong Wu, Yu Shi, Hanqi Li, Xinyue Bao, Yuqian Yang, Shaoshan Han, Xue Yang, Jie Tao, Hao Sun, Shaobo Wu, Liankang Sun

“…Abstract Background Progesterone and adipose Q receptor 5 (PAQR5), a membrane receptor characterized by seven transmembrane domains, has been indirectly implicated in pro-carcinogenic activities, though its specific role in hepatocellular carcinoma (HCC) remains to be defined. …”
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Association of CD33 genetic variants with neurocognitive profiles in chronic viral hepatitis by Wei-Fang Tsai, Rwei-Ling Yu, Wan-Long Chuang, Jee-Fu Huang, Chia-Yen Dai, Yu-Wen Alvin Huang, Chun-Hsiang Tan

“… Background CD33 has been implicated in the pathogenesis of Alzheimer’s disease primarily through its role in inhibiting the clearance of beta-amyloid (Aβ). …”
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Associations of circulating insulin-like growth factor-1 and insulin-like growth factor binding protein-3 with the expression of stem cell markers in benign breast tissue by Lusine Yaghjyan, Yujing J. Heng, Brian R. Sardella, Divya Murthy, Matt B. Mahoney, Bernard Rosner, Kornelia Polyak, Maisey Ratcliff, Rulla M. Tamimi

“…Abstract Background The insulin-like growth factor (IGF) pathway is implicated in a naturally occurring process of tissue remodeling during which cells acquire stem cell-like characteristics. …”
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MOWAT-WILSON SYNDROME: DEEP PHENOTYPING AND MOLECULAR CHARACTERISATION OF TWELVE NEW INDIVIDUALS by Umut Altunoğlu, Nilay Güneş, Gözde Tutku Turgut, Tuğba Kalaycı, Ayça Dilruba Aslanger, Murat Derbent, Serpil Eraslan, Birsen Karaman, Zehra Oya Uyguner, Beyhan Tüysüz, Yasemin Alanay, Hülya Kayserili Karabey

“…Pathogenic variants in the ZEB2 gene are implicated in the aetiology, with nearly all cases arising sporadically due to de novo variants. …”
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Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume by Weijia Gao, Kejing Zhang, Qing Jiao, Linyan Su, Dong Cui, Shaojia Lu, Rongwang Yang

“…All T1-weighted imaging data were processed by FreeSurfer 7.4.0 software. …”
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Cost‐Effectiveness of Drug‐Coated Balloons in the Treatment of Coronary Small Vessel Disease: A Report From the BASKET‐SMALL 2 Randomized Controlled Trial by Marco E. G. V. Cattaneo, Michael Coslovsky, Samuel J. P. Malkin, Gregor Fahrni, Christoph Kaiser, Nicole Gilgen, Bruno Scheller, Raban V. Jeger

“…A cost‐effectiveness analysis was performed using German diagnosis‐related group data to evaluate total expected costs and quality‐adjusted life expectancy, expressed in quality‐adjusted life‐years, for the entire cohort and each treatment option. …”
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Association of Ulcerative Colitis with FOXP3 Gene Polymorphisms and Its Colonic Expression in Chinese Patients by Sheng-Long Xia, Shi-Jie Ying, Qian-Ru Lin, Xiao-Qi Wang, Wei-Jun Hong, Zi-Jian Lin, Jia-Kai Luo, Yi Jiang

“…Abnormalities of forkhead box P3 (FOXP3) are implicated in various autoimmune diseases. This study is aimed at investigating the association of ulcerative colitis (UC) with FOXP3 polymorphisms and its colonic expression in Chinese patients. …”
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Trichothiodystrophy‐associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation by Arjan F Theil, Alex Pines, Tuğba Kalayci, José M Heredia‐Genestar, Anja Raams, Marion H Rietveld, Sriram Sridharan, Sabine EJ Tanis, Klaas W Mulder, Nesimi Büyükbabani, Birsen Karaman, Zehra O Uyguner, Hülya Kayserili, Jan HJ Hoeijmakers, Hannes Lans, Jeroen AA Demmers, Joris Pothof, Umut Altunoglu, Abdoelwaheb El Ghalbzouri, Wim Vermeulen

“…Using Human Skin Equivalents (HSEs), we observed impaired keratinocyte differentiation associated with compromised splicing and eventually, an imbalanced proteome affecting skin development and, interestingly, also the immune system. Our data show that MPLKIP, through its DBR1 stabilizing role, is implicated in mRNA splicing, which is of particular importance in highly differentiated tissue.…”
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A genome-wide screen identifies genes required for erythroid differentiation by Greggory Myers, Ann Friedman, Lei Yu, Narges Pourmandi, Claire Kerpet, Masaki A. Ito, Rilie Saba, Vi Tang, Ayse Bilge Ozel, Ingrid L. Bergin, Craig N. Johnson, Chia-Jui Ku, Yu Wang, Ginette Balbin-Cuesta, Kim-Chew Lim, Zesen Lin, Claire Drysdale, Beth McGee, Ryo Kurita, Yukio Nakamura, Xiaofang Liu, David Siemieniak, Sharon A. Singh, Costas A. Lyssiotis, Ivan Maillard, Lois S. Weisman, James Douglas Engel, Rami Khoriaty

“…NHLRC2, which was previously implicated in hemolytic anemia, was a highly ranked gene. …”
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Phenotypic screens for SIRPA expression reveal RAB21 as a general regulator of macrophage surface identity by Adrian Granda Farias, Brian Feng, Shahbaz Khan, Wayne Ngo, Jamie L.Y. Wu, Magali Aguilera-Uribe, Shan Grewal, Patricia Mero, Sheila K. Singh, Thomas Kislinger, Warren C.W. Chan, Jason Moffat

“…Here, we use genome-wide phenotypic screens to identify genes affecting the accessibility and surface expression of macrophage signal regulatory protein alpha (SIRPA). Our data are consistent with previous evidence but also implicate glutaminyl-peptide cyclotransferase-like (QPCTL) in cis CD47-SIRPA interactions. …”
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Stress adaptation under in vitro evolution influences survival and metabolic phenotypes of clinical and environmental strains of Vibrio cholerae El-Tor by Nana Eghele Adade, Stephen Dela Ahator, Inmaculada García-Romero, Macarena Algarañás, Vincent Appiah, Miguel A. Valvano, Samuel Duodu

“…The combined analysis of the metabolic and genomic data pointed to pathways implicated in stress survival. …”
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Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube by Ian Beddows, Svetlana Djirackor, Dalia K. Omran, Euihye Jung, Natalie NC Shih, Ritu Roy, Aaron Hechmer, Adam Olshen, Guillaume Adelmant, Ann Tom, Jacob Morrison, Marie Adams, Daniel C. Rohrer, Lauren E. Schwartz, Celeste Leigh Pearce, Heidi Auman, Jarrod A. Marto, Charles W. Drescher, Ronny Drapkin, Hui Shen

“…We have generated comprehensive whole-genome bisulfite sequencing, RNA-seq, and proteomic data of over 100 human FTs, with detailed clinical covariate annotations. …”
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CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis by Mingrui Du, Xuesan Zhang, Menglin Cong, Chengkui Cai, Qingxiang Zhang, Haixia Xin, Lanbo Yang, Qingqing Geng, Mingfu Shang, Zheng Zhang, Le Shen, Shusen Tan, Kang Han

“…Summary: Circular RNAs (circRNAs) are implicated in the progression of various malignancies, including osteosarcoma. …”
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STIL Overexpression Is Associated with Chromosomal Numerical Abnormalities in Non-Small-Cell Lung Carcinoma Through Centrosome Amplification by Shunsuke Ohtsuka, Hisami Kato, Rei Ishikawa, Hirofumi Watanabe, Ryosuke Miyazaki, Shin-ya Katsuragi, Katsuhiro Yoshimura, Hidetaka Yamada, Yasuhiro Sakai, Yusuke Inoue, Yusuke Takanashi, Keigo Sekihara, Kazuhito Funai, Haruhiko Sugimura, Kazuya Shinmura

“…STIL is a regulatory protein essential for centriole biogenesis, and its dysregulation has been implicated in various diseases, including malignancies. …”
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Copper supplementation mitigates Parkinson-like wild-type SOD1 pathology and nigrostriatal degeneration in a novel mouse model by Benjamin D. Rowlands, Benjamin G. Trist, Connor Karozis, Greta Schaffer, David Mor, Richard Harwood, Sarah A. Rosolen, Veronica Cottam, Freyja Persson-Carboni, Miriam Richardson, Anne A. Li, Michael P. Gotsbacher, Amr H. Abdeen, Rachel Codd, Kay L. Double

“…Abstract Misfolded wild-type superoxide dismutase 1 (disSOD1) protein is implicated in the death of substantia nigra (SN) dopamine neurons in Parkinson disease. …”
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The role of teichoic acids of bifidobacteria in driving the interaction with the human host by Giulia Longhi, Laura Maria Vergna, Gabriele Andrea Lugli, Gabriele Andrea Lugli, Massimiliano Giovanni Bianchi, Massimiliano Giovanni Bianchi, Chiara Tarracchini, Christian Milani, Christian Milani, Francesca Turroni, Francesca Turroni, Ovidio Bussolati, Ovidio Bussolati, Douwe van Sinderen, Marco Ventura, Marco Ventura

“…We furthermore revealed that some of the key genes implicated in TA synthesis by PRL2010 are overexpressed under in vivo conditions when the microorganism is colonizing the murine gut, which further confirms a host modulatory effect on the production of these extracellular structures in bifidobacteria.…”
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Epidemiological and Clinical Characteristics of Pediatric Acute Drug Intoxications: A Retrospective Analysis by Cristina Elena Singer, Renata-Maria Văruț, Maria Singer, Simona Cosoveanu, Jaqueline Abdul Razzak, Madalina Elena Popescu, Simina Gaman, Ileana Octavia Petrescu, Cristina Popescu

“…Clinical severity was classified using the Poisoning Severity Score (PSS). Data on demographics, substances involved, clinical presentations, interventions, and outcomes were analyzed. …”
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