Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk by Zuyou Wu, Yang Yang, Caibo Ning, Jiali Li, Yimin Cai, Yanmin Li, Zilong Cao, Shuangshuang Tian, Jingyi Peng, Qianying Ma, Chunyi He, Shuting Xia, Jun Chen, Xiaoping Miao, Zhen Li, Ying Zhu, Qian Chu, Jianbo Tian

“…Abstract Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. …”
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Altered Local Spontaneous Brain Activity in Juvenile Myoclonic Epilepsy: A Preliminary Resting-State fMRI Study by Sisi Jiang, Cheng Luo, Zhixuan Liu, Changyue Hou, Pu Wang, Li Dong, Chengqing Zhong, Yongxiu Lai, Yang Xia, Dezhong Yao

“…Methods. Resting-state fMRI data were acquired from twenty-one patients with JME and twenty-two healthy subjects. …”
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Congenital uterine anomalies and perinatal outcomes: a retrospective single-center cohort study by Elisa Zambrotta, Luisa Maria Di Gregorio, Federica Di Guardo, Roberta Agliozzo, Giuliana Chiara Maugeri, Ferdinando Antonio Gulino, Silvia Cutello, Maria Cecilia Cerana, Marco Palumbo

“…Uterine anomalies are implicated as cause of reduced fertility as well as early pregnancy loss. …”
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Corticolimbic Structural Deficits in Violent Patients with Schizophrenia by Maria Athanassiou, Alexandre Dumais, Inès Zouaoui, Alexandra Fortier, Luigi de Benedictis, Olivier Lipp, Andràs Tikàsz, Stéphane Potvin

“…Structural neuroimaging analyses were performed across groups to assess gray matter volume (GMV) and cortical thickness (CT) differences in regions previously implicated in aggressive behaviors. <b>Results</b>: The data revealed significant reductions in GMV in the right amygdala and diminished cortical thickness (CT) in the bilateral dorsolateral prefrontal cortices (dlPFC) in patients with Sch+V compared to patients with Sch-V and HCs. …”
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Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity by Jeffrey Schlom, Claudia Palena, Kristen Fousek, Zhen Su, Duane H Hamilton, Hanne Lind, Lucas A Horn, Jeffrey Riskin, Heidi A Hempel, Kristen K McCampbell, Dean Y Maeda, John A Zebala

“…Emerging evidence has implicated the phenomenon of cancer plasticity or acquisition of mesenchymal features by epithelial tumor cells, as an immune resistance mechanism.Methods Two soluble factors that mediate tumor cell plasticity in the context of epithelial-mesenchymal transition are interleukin 8 (IL-8) and transforming growth factor beta (TGF-β). …”
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KRas plays a negative role in regulating IDO1 expression by Xiandong Peng, Eunji Lee, Jialu liang, Tania Colon, Franklin Tran, Byeong H. Choi, Wei Dai

“…Mutations within Ras and its associated signaling pathways are implicated in various human pathologies, including inflammatory disorders and malignancies. …”
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AERIFY-1/2: two phase 3, randomised, controlled trials of itepekimab in former smokers with moderate-to-severe COPD by Klaus F. Rabe, Fernando J. Martinez, Surya P. Bhatt, Tomotaka Kawayama, Borja G. Cosio, Robert M. Mroz, Maarten M. Boomsma, Helene Goulaouic, Michael C. Nivens, Michel Djandji, Xavier Soler, Ying Liu, Matthew P. Kosloski, Christine R. Xu, Nikhil Amin, Heribert Staudinger, David J. Lederer, Raolat M. Abdulai

“…Background Accumulating data implicate interleukin (IL)-33, a proinflammatory cytokine released locally upon epithelial cell damage, in the pathogenesis of COPD. …”
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Repetitive transcranial magnetic stimulation elicits weight loss and improved insulin sensitivity in type 2 diabetic rats by Xuanjin Chen, Ruru Wang, Xin Wang, Ming Liu, Zhipeng Liu, Tao Yin, Chen Li

“…Altered expression of hypothalamic genes that are related to appetite regulation, neural activity and ether lipid metabolism were also implicated. Conclusion In summary, our data report a positive impact of rTMS on systemic insulin sensitivity and weight management of T2D rats. …”
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APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses by Cassi M. Friday, Isaiah O. Stephens, Cathryn T. Smith, Sangderk Lee, Diksha Satish, Nicholas A. Devanney, Sarah Cohen, Josh M. Morganti, Scott M. Gordon, Lance A. Johnson

“…Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accumulation remain unclear. …”
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Computational analysis of Annona muricata phytochemicals for targeted modulation of endocrine networks in polycystic ovary syndrome by Babatunji Emmanuel Oyinloye, Oluwaseun Emmanuel Agboola, Aderonke Moyosola Ayeni, Oluwatoyin Mary Oyinloye, Samuel Sunday Agboola, Olajumoke Tolulope Idowu, Makhosazana Siduduzile Mathenjwa-Goqo, Olutunmise Victoria Owolabi, Bolajoko Idiat Ogunyinka, Foluso Oluwagbemiga Osunsanmi, Basiru Olaitan Ajiboye, Olaposi Idowu Omotuyi

“…The proteins were taken from the RCSB Protein Data Bank with IDs 1A28, 2AM9, and 3RUK. Over 50% of phytochemicals from Annona muricata were predicted to have binding affinities comparable to reference compounds. …”
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A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes by Jessica Bomyea, Morgan M. Caudle, Nathalie Dugas, Raeanne C. Moore, Alan N. Simmons, Michael L. Thomas

“…Dysfunction in executive functioning processes, particularly the ability to regulate the contents of working memory, are implicated in the development and maintenance of RNT. …”
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Impaired intestinal permeability in patients with multiple sclerosis by Lenka Fialova, Pavla Barilly, Ivana Stetkarova, Ales Bartos, Libuse Noskova, Denisa Zimova, Michal Zido, Iva Hoffmanova

“…A number of recent studies have shown that the intestinal microbiome, part of the brain-gut axis, is implicated in the pathophysiology of multiple sclerosis. …”
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The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker by Alondra Albarado-Ibañez, Rosa Elena Arroyo-Carmona, Rommel Sánchez-Hernández, Geovanni Ramos-Ortiz, Alejandro Frank, David García-Gudiño, Julián Torres-Jácome

“…With 15 years of DM development, the data showed an age-dependent increase in HRV due to the axon retraction of ANS neurons from its effectors. …”
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Chemerin-9 is neuroprotective in APP/PS1 transgenic mice by inhibiting NLRP3 inflammasome and promoting microglial clearance of Aβ by Jiawei Zhang, Yaxuan Zhang, Lan Liu, Mengyuan Zhang, Xiaojie Zhang, Jiangshan Deng, Fei Zhao, Qing Lin, Xue Zheng, Bing Fu, Yuwu Zhao, Xiuzhe Wang

“…Chemerin, an adipokine, has been implicated in inflammatory diseases and central nervous system disorders, yet its precise function on microglial response in AD remains unknown. …”
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The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma by Xi Zhang, Xi Zhang, Yan Liu, Yan Liu, Bai-Zhao Peng, Xing-hong Zhou, Yan-ting You, Ying Yang, Shuai Ji, Tian-yu Zhong, Xiao-hu Chen, Yan-yan Liu, Xiao-shan Zhao

“…First, we explored prognostic data and predicted the function of TSHZ3 in lung cancer through bioinformatics analysis. …”
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Damage and immunosuppression to Mytilus galloprovincialis hemocytes caused by chronic tris(chloropropyl)phosphate exposure by Ruixue Ma, Shubao Zhang, Quansheng Zhang, Huifeng Wu, Menghan Zhou, Yue Zhou, Yushun Yong, Junyi Wang, Lihao Guo, Jiatong Ma, Mingyu Zhong

“…Protein association analysis identified DEPs implicated in ROS homeostasis and glycometabolism as central network hubs. …”
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Microbiota Dysbiosis: A Key Modulator in Preeclampsia Pathogenesis and Its Therapeutic Potential by Johnatan Torres-Torres, Jorge Alberto Basurto-Serrano, Zaira Alexi Camacho-Martinez, Francisco Rafael Guadarrama-Sanchez, Irma Eloisa Monroy-Muñoz, Javier Perez-Duran, Juan Mario Solis-Paredes, Raigam Martinez-Portilla, Salvador Espino-y-Sosa, Andrea Ramirez-Gonzalez, Rodrigo Guadarrama-Mora, Lourdes Rojas-Zepeda

“…A systematic search using MeSH terms related to “preeclampsia”, “microbiota”, and “dysbiosis” identified studies on microbiota and preeclampsia pathophysiology. Data extraction focused on microbial alterations and mechanistic insights. …”
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Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats by Laurent Martin, Harrison J. Stratton, Lyuba Y. Salih, Nicolas LA. Dumaire, Kimberly Gomez, Le Duy Do, Santiago Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, Shreya S. Bellampalli, Liberty François-Moutal, Shizhen Luo, Frank Porreca, Mohab Ibrahim, Véronique Rogemond, Jérôme Honnorat, Rajesh Khanna, Aubin Moutal

“…These effects from patient-derived Abs are recapitulated in rats immunized with a DNA vaccine for CRMP5, in which therapeutic treatment with anti-CD20 depleting B cells ameliorates autoimmunity and neuropathy. Our data thus reveal a mechanism of neuropathic pain in patients with paraneoplastic neurological syndromes and implicates CV2/CRMP5-Abs as a potential target for treating paraneoplastic neurological syndromes.…”
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Integrated transcriptomic and metabolomic analysis of goose epididymis reveals molecular markers associated with sperm mobility by Xiaofang Ren, Ke Jiang, Jiaxin Yin, Zhigang Ma, Zhifeng Chen, Kun Yang, Shengjun Liu

“…Integration of transcriptomic and metabolomic data revealed critical gene-metabolite pairs, including CNDP1–citric acid, implicated in SM regulation. …”
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Clinical experience of primary subcutaneous mycoses in Shanghai: a retrospective analysis by Qian Yu, Lulu Li, Yuanyuan Wang, Zhiqin Gao, Siyu Liu, Jingwen Tan, Xiaoping Liu, Wei Li, Lianjuan Yang

“…Their medical histories, clinical features, histopathological findings, etiological characteristics, drug sensitivity tests, therapeutic regimens, and follow-up data were recorded.ResultsIdentification of pathogens from skin tissue cultures revealed distinct colonial morphologies across diverse mycological species. …”
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