Elucidating the role of KCTD10 in coronary atherosclerosis: Harnessing bioinformatics and machine learning to advance understanding by Xiaomei Hu, Fanqi Liang, Man Zheng, Juying Xie, Shanxi Wang

“…Validation of these findings was conducted using data from the GSE9820 dataset. Among 10 DEGs linked with KCTD10, 13 were identified as hub genes through LASSO and SVM-RFE analyses. …”
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A genome-wide investigation of SNPs and CNVs in schizophrenia. by Anna C Need, Dongliang Ge, Michael E Weale, Jessica Maia, Sheng Feng, Erin L Heinzen, Kevin V Shianna, Woohyun Yoon, Dalia Kasperaviciūte, Massimo Gennarelli, Warren J Strittmatter, Cristian Bonvicini, Giuseppe Rossi, Karu Jayathilake, Philip A Cola, Joseph P McEvoy, Richard S E Keefe, Elizabeth M C Fisher, Pamela L St Jean, Ina Giegling, Annette M Hartmann, Hans-Jürgen Möller, Andreas Ruppert, Gillian Fraser, Caroline Crombie, Lefkos T Middleton, David St Clair, Allen D Roses, Pierandrea Muglia, Clyde Francks, Dan Rujescu, Herbert Y Meltzer, David B Goldstein

“…On balance, these data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens.…”
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EFFECTIVENESS OF PHARMACOTHERAPY FOR NORMALIZATION OF THE BRAIN NATRIURETIC PEPTIDE, RENINE-ANGIOTENSINALDOSTERONE SYSTEM ACTIVATION AFTER SURGICAL REVASCULARIZATION OF MYOCARDIUM... by S. A. Kovalev, V. Е. Malikov, V. Yu. Merzlyakov, A. A. Bulynin, A. В. Bulynin, E. A. Krasyukova, E. V. Malyutin, М. А. Arzumanyan

“…The data obtained makes it to recommend  Adenotsin® for presurgery  medication and postsurgery  therapy in cardiovascular diseases.…”
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Expression patterns and clinical significance of vasculogenic mimicry-related genes in patients with head and neck squamous cell carcinoma by Rui Lai, Xuanyu Gu, Yueyue Cai, Qiang Li

“…However, research on the association between vasculogenic mimicry-related genes (VMRGs) and HNSCC is currently limited, and the impact of vasculogenic mimicry on HNSCC requires further investigation.MethodsTranscriptome and clinical data for HNSCC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. …”
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Unveiling new insights into migraine risk stratification using machine learning models of adjustable risk factors by Yu-Chen Liu, Ye-Hai Liu, Hai-Feng Pan, Wei Wang

“…Finally, spatiotemporal burden mapping synthesized global incidence, prevalence, and disability-adjusted life years (DALYs) data to project region-specific risk and burden trajectories through 2050. …”
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Exploring the Role of N-WASP in Breast Cancer Metastasis through Mass Spectrometry and Potential Signalling Pathway Analysis by Rhiannon Yannan Yu, Wenguo Jiang, Tracey Martin

“…<b>Background:</b> Neural Wiskott–Aldrich Syndrome Protein (N-WASP) is a key regulator of the actin cytoskeleton and is implicated in various cellular processes, including cell motility and invasion. …”
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Racial and ethnic disparities in social isolation and 11-year dementia risk among older adults in the United States by J. Grullon, D. Soong, R. Wong

“…Methods We analyzed 11 years (2011–2021) of National Health and Aging Trends Study (NHATS) data, a prospective nationally representative cohort of U.S. …”
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Multi-omics analysis of the effects of pla2g4a on the prognosis of various cancers and its experimental validation in breast cancer cell lines by Yao Qian, Quan Yuan, Hao Yu, Rongjie Ye, Ming Niu, Feng Liu

“…Methods Download cancer-related data from databases such as UCSC Xena and ExMdb, use LASSO Cox regression and various machine learning algorithms to screen genes associated with BC survival, and perform functional and pathway enrichment analysis. …”
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Elucidating the role of AC026412.3 in hepatocellular carcinoma: a prognostic disulfidptosis-related LncRNAs model perspective by Qinghua Ji, Chuanbing Shi, Xuefeng Gu, Ling Yang, Yintao Sun

“…Integrating transcriptomic and clinical data from The Cancer Genome Atlas, we identified 807 DRLs and constructed a prognostic signature via univariate Cox regression, LASSO-Cox penalisation, and multivariate Cox analysis. …”
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Pleiotrophin promote glioma proliferation and invasion by enhancing NF-κB/SLUG mediated epithelial–mesenchymal transition by Hong-Xing Ye, Chao Zhang, Long-Yuan He, Ping Lan, Feng Wang, Ren-Ya Zhan, Xiu-Jue Zheng

“…Methods The expression levels of PTN in glioma samples were analyzed using data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA). …”
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The effect of hope-based counseling on perceived stress and the quality of life in pregnant women experiencing nausea and vomiting: a randomized control trial by Mahsa Piri, Azam Maleki, Omid Saed

“…The intervention group participated in eight group counseling sessions based on Snyder’s hope therapy, while the control group received standard care. Data were collected using the Perceived Stress Scale (PSS) and the Nausea and Vomiting of Pregnancy Quality of Life (NVP QOL) Questionnaire, both before and four weeks after the counseling sessions. …”
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Machine learning-based predictive modeling of angina pectoris in an elderly community-dwelling population: Results from the PoCOsteo study. by Shahrokh Mousavi, Zahrasadat Jalalian, Sima Afrashteh, Akram Farhadi, Iraj Nabipour, Bagher Larijani

“…Permutation feature importance revealed a handful of features that implicated the role of thrombotic vascular diseases, congestive heart failure, renal failure, and anemia.…”
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Identification of Exosome-Associated Biomarkers in Diabetic Foot Ulcers: A Bioinformatics Analysis and Experimental Validation by Tianbo Li, Lei Gao, Jiangning Wang

“…<b>Methods:</b> We analyzed transcriptomic data from GSE134431 (13 DFU vs. 8 controls) as a training set and validated findings in GSE80178 (6 DFU vs. 3 controls). …”
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MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. by Qing Ji, Xinbao Hao, Min Zhang, Wenhua Tang, Meng Yang, Ling Li, Debing Xiang, Jeffrey T Desano, Guido T Bommer, Daiming Fan, Eric R Fearon, Theodore S Lawrence, Liang Xu

“…<h4>Background</h4>MicroRNAs (miRNAs) have been implicated in cancer initiation and progression via their ability to affect expression of genes and proteins that regulate cell proliferation and/or cell death. …”
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Pro-inflammatory cytokine induction of 11β-hydroxysteroid dehydrogenase type 1 in A549 cells requires phosphorylation of C/EBPβ at Thr235. by Cristina L Esteves, Manu Verma, Ewa Róg-Zielińska, Val Kelly, Shuji Sai, Amandine Breton, Francesc X Donadeu, Jonathan R Seckl, Karen E Chapman

“…IL-1α/TNFα-induced phosphorylation of C/EBPβ at Thr235 was also attenuated by p38 MAPK inhibition suggesting involvement of a p38 MAPK-C/EBPβ pathway. siRNA-mediated knock-down of C/EBPβ and NF-κB/RelA implicated both transcription factors in the IL-1α/TNFα induction of HSD11B1 mRNA. …”
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Global trends and health workforce analysis of breast cancer burden from high red meat consumption 1990–2050 using machine learning approach by Yuzhou Cai, Jingxian Qian

“…BackgroundHigh red meat consumption has been implicated in breast cancer development, yet comprehensive global burden assessments and health system relationships remain limited.MethodsWe analyzed breast cancer mortality and disability-adjusted life years (DALYs) using Global Burden of Disease 2021 data across 204 countries. …”
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Low dietary magnesium and fiber intakes among women with metabolic syndrome in Kuwait by Dalal U. Z. Alkazemi, Tasleem A. Zafar, Nourah Y. Alsouri, Abeer A. Aljahdali, Abeer A. Aljahdali, Stan Kubow

“…Dietary magnesium and fiber have been implicated in reducing the risk of MetS; however, their specific effects on this population remain underexplored. …”
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<i>TRIB1</i> and <i>TRPS1</i> Gene Polymorphisms Are Associated with the Incidence of Acute Coronary Syndrome and Plasma Lipid Concentrations by Gilberto Vargas-Alarcón, Óscar Pérez-Méndez, Rosalinda Posadas-Sánchez, Héctor González-Pacheco, Teresa Juárez-Cedillo, Galileo Escobedo, Victoria López-Olmos, José Manuel Fragoso

“…In recent years, data from genome-wide association studies (GWAS) have shown that the genes coding for transcriptional repressor GATA binding 1 (<i>TRPS1</i>) and tribbles pseudokinase 1 (<i>TRIB1</i>) play an important role in plasma lipid profiles and act as risk factors for coronary heart disease (CHD). …”
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Transcriptomic sex differences in early human fetal brain development by Federica Buonocore, Jenifer P. Suntharalingham, Olumide K. Ogunbiyi, Aragorn Jones, Nadjeda Moreno, Paola Niola, Tony Brooks, Nita Solanky, Mehul T. Dattani, Ignacio del Valle, John C. Achermann

“…PCDH11Y (protocadherin11 Y-linked) regulates excitatory neurons; this gene is unique to humans and is implicated in language development. RP11-424G14.1 is a long non-coding RNA. …”
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Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques by Rocio A. Barahona, Nellie E. Kwang, Aashna R. Kono-Soosaipillai, Giovanna Rubio Salgado, Kristine M. Tran, Yueh-Hao Lu, Siddharth Reddy, Celia da Cunha, Eric Velazquez-Rivera, Joshua D. Crapser, Xiangmin Xu, Lindsay A. Hohsfield, Kim N. Green

“…Summary: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles. Recent evidence implicates extracellular matrix (ECM) dysfunction in disease pathogenesis, including extensive loss of perineuronal nets (PNNs). …”
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