Higher Body Mass Index Shows No Evidence of Association with Histopathologic Markers of Aggressiveness in Early-Stage Papillary Thyroid Carcinoma by Aliki Economides, Demetris Lamnisos, Paris Vogazianos, Konstantinos Giannakou, Savvas Frangos, Vasilis Constantinides, Panagiotis Papageorgis, Panayiotis A. Economides

“…<b>Background:</b> Obesity has been implicated in the pathogenesis and progression of several malignancies, including papillary thyroid carcinoma (PTC), but its role in tumor aggressiveness remains controversial. …”
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Handgrip strength and risk of cognitive impairment across different glucose metabolism statuses: insights from the CHARLS study by Shiqi Wang, Liangchen Li, Jia Yu, Xianli Sun, Jianqiao Chen

“…BackgroundBoth low handgrip strength (HGS) and abnormal glucose metabolism have been implicated in an increased risk of cognitive impairment. …”
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Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database. by Balachandran Kumarendran, Michael W O'Reilly, Konstantinos N Manolopoulos, Konstantinos A Toulis, Krishna M Gokhale, Alice J Sitch, Chandrika N Wijeyaratne, Arri Coomarasamy, Wiebke Arlt, Krishnarajah Nirantharakumar

“…Limitations of this study include its retrospective nature, absence of detailed information on criteria used to diagnosis PCOS and NAFLD, and absence of data on laboratory assays used to measure serum androgens.…”
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Irisin protects against cerebral ischemia reperfusion injury in a SIRT3-dependent manner by Yushuang Cong, Ruichun Guo, Chenglong Li, Qi Li, Sihua Qi

“…SIRT3, a mitochondrial deacetylase, is similarly implicated in mitigating ischemia-reperfusion injury. …”
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Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma by Qianqian Cao, Yuzhe Zhang, Cheng Cheng, Xiaoyang Wang, Panlong Fan, Jincheng Huang, Zhipeng Dai

“…Abstract Lymphocyte activation gene 3 (LAG3) is a member of the immunoglobulin superfamily and has been implicated in the development, growth, and progression of several cancers. …”
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Selective Inhibitors of Kv11.1 Regulate IL-6 Expression by Macrophages in Response to TLR/IL-1R Ligands by Cheryl Hunter, Tejas B. Kadakia, Dianne Cooper, Mauro Perretti, Richard C. Schwartz, Simon B. Brown

“…Our data might also explain the altered phenotypes displayed by PECAM-1 knockout mice in several disease models.…”
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Stressor‐Evoked Brain Activity, Cardiovascular Reactivity, and Subclinical Atherosclerosis in Midlife Adults by Javier Rasero, Timohy D. Verstynen, Caitlin M. DuPont, Thomas E. Kraynak, Emma Barinas‐Mitchell, Mark R. Scudder, Thomas W. Kamarck, Amy I. Sentis, Regina L. Leckie, Peter J. Gianaros

“…Importantly, this effect held in sensitivity analyses. Implicated brain areas in this mediation included the ventromedial prefrontal cortex, anterior cingulate cortex, insula, and amygdala. …”
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ANTIBIOTICS USE AND AWARENESS OF RISKS ASSOCIATED WITH ANTIMICROBIAL RESISTANCE AMONG FISH FARMERS IN KATSINA STATE, NIGERIA by Akeem Babatunde Dauda, Abdulsalam Sani Nababa, Justina Omolegho Oshoke, Hauwau Abubakar Salele, Ismail Ayoade Odetokun, Ibraheem Ghali-Mohammed, Oluwasesan M. Bello, Awawu Dasuki

“…Methodology Semi-structured questionnaires were  administered to the active and accessible fish farms in the state, The data collected were presented and analyzed using descriptive statistics and binary logistic regression. …”
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Long-term risk of allergic disorders following Kawasaki disease: a population-based cohort study by Jae-Hee Seol, Lucy Youngmin Eun, Ji-Ho Lee

“…Methods A nationwide population-based cohort study was conducted utilizing data from the Korean National Health Insurance database. …”
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Genetic variants of SLC6A4 and risk of coronary artery disease: insights from North Indian population by Jyotdeep Kour Raina, Minakashee Sharma, Ravi Sharma, Rohit Bhardwaj, Parvinder Kumar, Santasree Banerjee, Rakesh Kumar Panjaliya

“…These polymorphisms have been implicated in the development of vascular diseases. …”
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The Impact of Hydrogen Sulfide Regulatory Gene Alterations on Head and neck squamous cell carcinoma prognosis and tumor microenvironment by Mohamed Rizwan Ghouse, Santhakumar Egambaram, Arunkumar Ramachandran, Rajesh Parsanathan

“…Materials and methods Gene expression and promoter methylation data were analysed using GEPIA2 and UALCAN. Kaplan–Meier survival analysis assessed prognostic relevance. …”
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Potential protective association of the AA genotype and a allele of CXCR4 rs2228014 polymorphism with COVID-19 severity in adult egyptians by Osama H. Korayem, Amr E. Ahmed, Mohamed H. Meabed, Doaa M. Magdy, Wafaa M. Abdelghany

“…Several genetic factors have been implicated in diverse responses to SARS-CoV-2 infection, such as the C-X-C chemokine receptor 4 (CXCR4) rs2228014 polymorphism, which has been previously studied in various diseases but has not been explored in the context of COVID-19 severity. …”
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CircBAZ1B stimulates myocardial ischemia/reperfusion injury (MI/RI) by modulating miR-1252-5p/ATF3-mediated ferroptosis by Ruili Wei, Tianxiao Yang, Weihong Li, Xiqian Wang

“…Introduction Circular RNAs (circRNAs) have been implicated in myocardial ischemia (MI)/reperfusion injury (RI), yet their essential roles in MI/RI-induced ferroptosis have not been fully elucidated. …”
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Association analysis between the C516T polymorphism in the 5-HT2A receptor gene and schizophrenia Análise de associação entre o polimorfismo C516T do gene do receptor 5-HT2A e esqu... by Vivian Bertola, Quirino Cordeiro, Stevin Zung, Elisabete Cristina Miracca, Homero Vallada

“…Data from epidemiological studies have demonstrated that genetics is an important risk factor for schizophrenia. …”
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Metagenomics-assembled genomes reveal microbial metabolic adaptation to athalassohaline environment, the case Lake Barkol, China by Maripat Xamxidin, Xuanqi Zhang, Gang Zheng, Can Chen, Min Wu

“…The integration of functional and taxonomic data highlights the metabolic versatility and ecological roles of microbial taxa in sustaining biogeochemical processes under hypersaline conditions. …”
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Empagliflozin Repurposing for Lafora Disease: A Pilot Clinical Trial and Preclinical Investigation of Novel Therapeutic Targets by Giuseppe d’Orsi, Antonella Liantonio, Paola Imbrici, Nicola Gambacorta, Giorgia Dinoi, Cosimo Damiano Altomare, DEFEAT-LD Study Group, Massimo Carella

“…Results: The expected outcome of this study is twofold, i.e., (i) assessing the safety and tolerability of empagliflozin in LD patients and (ii) gathering preliminary data on its potential efficacy in improving clinical and neurologic features. …”
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Preterm birth and childhood wheezing disorders: a systematic review and meta-analysis. by Jasper V Been, Marlies J Lugtenberg, Eline Smets, Constant P van Schayck, Boris W Kramer, Monique Mommers, Aziz Sheikh

“…<h4>Background</h4>Accumulating evidence implicates early life factors in the aetiology of non-communicable diseases, including asthma/wheezing disorders. …”
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Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition by Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue

“…Overall, these data, for the first time, advanced our perspective on PrsA function and elucidated that PrsA-induced cell death requires its flanking N- or C-terminal domain but is dispensable for recognizing TLR2. …”
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Primary healthcare professionals’ awareness of management guidelines for type-2 diabetes mellitus and erectile dysfunction in Indonesia: a focus group discussion during the COVID-1... by Setho Hadisuyatmana, Gulzar Malik, Ferry Efendi, Sonia Reisenhofer, James H. Boyd

“…The category “Engaging with T2DM guidelines” emerged, encompassing HCPs’ understanding, adherence, and clinical implication of the recommended T2DM guidelines. A significant barrier identified was the HCPs’ lack of familiarity with the national T2DM management guidelines, primarily due to their release during the COVID-19 pandemic. …”
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Serum proteomic correlates of mental health symptoms in a representative UK population sample by Anna Dearman, Yanchun Bao, Leonard Schalkwyk, Meena Kumari

“…Here we perform exploratory factor analyses of 184 proteins from two panels (cardiometabolic and neurology-related) measured using proximity extension assays from Understanding Society (the UK Household Longitudinal Study; UKHLS). Data reduction results in 28 factors that explain 55–59% of the variance per panel. …”
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