Hypoxia-induced PYCR1 regulates glycolysis and histone lactylation to promote bladder cancer progression and metastasis via SLC6A14/Glutamine metabolism by Zhuo Li, Qinghua Jiang, Quan Yang, Yujie Zhou, Jiansong Wang

“…Hypoxia-induced Pyrroline-5-Carboxylate Reductase 1 (PYCR1) is implicated in bladder cancer (BC), but its specific role remains elusive. …”
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Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma by Ruopeng Liang, Xiaoxue Zhang, Shitao Wu, Jing Liu, Yunpeng Zhai, Chaojie Lin, Zhenya Wang, Yi Zhang, Hao Chen, Rongtao Zhu

“…Mitochondrial dysfunction promotes cellular transformation and cancer cell survival implicating its importance in cancer development. Previous studies have indicated that dynamin 1 like (DNM1L) is a key mediator of mitochondrial fission. …”
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Cardiac fibroblasts regulate myocardium and coronary vasculature development in the murine heart via the collagen signaling pathway by Yiting Deng, Yuanhang He, Juan Xu, Haoting He, Manling Zhang, Guang Li

“…Molecularly, through the analysis of single-cell mRNA sequencing (scRNA-seq) data, we unveiled collagen as the top signaling molecule derived from FBs influencing CM and Vas_EC development. …”
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Activin levels correlate with lymphocytic infiltration in epithelial ovarian cancer by Elizabeth T. Evans, Emily F. Page, Alex Seok Choi, Zainab Shonibare, Andrea G. Kahn, Rebecca C. Arend, Karthikeyan Mythreye

“…Methods Publicly available RNA sequencing data were accessed from GEO (#GSE143897) with normalization and quantification performed via DESeq2. …”
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Clinical and biological significance of estrogen receptor-positive/progesterone receptor-negative in invasive breast cancer: bioinformatic analysis by Maryam Althobiti, Raef Albugami, Mohammed Alnamnakani, Samir Alharbi, Michael Toss, Rajennder Kumar, Fahad Alkhureeb

“…An integrated bioinformatic approach was developed to assess the associations between clinical outcomes and data obtained from the Cancer Genome Atlas (TCGA). …”
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The morphogenesis and associated anomalous pulmonary venous drainage in sinus venosus defect by Hsin-Mao Hsu, Ya-Ting Chang, Wen-Jen Su, Jaw-Ji Chu, Yu-Sheng Chang, Mao-Sheng Hwang

“…Methods: We conducted a retrospective review of the echocardiograms, cardiac catheterization data, computed tomographic findings, and surgical notes of 44 children with surgery-confirmed isolated SVD from 1977 to 2016. …”
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Gut Microbiome dysbiosis and immune activation correlate with somatic and neuropsychiatric symptoms in COVID-19 patients by Paula L. Scalzo, Austin G. Marshall, Sirena Soriano, Kristen Curry, Mario Dulay, Timea Hodics, Eamonn M. M. Quigley, Todd J. Treangen, María M. Piskorz, Sonia Villapol

“…Gut dysbiosis, an imbalance in the gut microbiome, has been implicated in immune dysfunction and chronic inflammation in COVID-19 patients. …”
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Enhanced Quinolone Resistance and Differential Expression of Efflux Pump <i>nor</i> Genes in <i>Staphylococcus aureus</i> Grown in Platelet Concentrates by Carina Paredes, Que Chi Truong-Bolduc, Yin Wang, David C. Hooper, Sandra Ramirez-Arcos

“…<i>Staphylococcus aureus</i>, a predominant PC contaminant, has been implicated in several adverse transfusion reactions. …”
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Investigating the molecular mechanisms associated with ulcerative colitis through the application of single-cell combined spatial transcriptome sequencing by Hua Huang, Jiaze Ma, An Kang, Tianwei Guo, Wei Sun, Yan Xu, Lijiang Ji

“…To elucidate the cellular subtypes and gene expression profiles implicated in the pathogenesis of UC, we utilized single-cell and spatial transcriptomic analyses.MethodsWe conducted an analysis of single-cell data to identify cell types involved in the pathogenesis of UC. …”
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Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer by Dan Feng, Jian Zhang, Huanmin Niu, Xiaoxue Zheng, Mengqi Jia, Qiqi Lu, Jing Wang, Wenxue Guo, Qi Sun, Huiqing Yuan, Hongxiang Lou

“…The elevated polyamines, amine-rich molecules with diverse functions in pathophysiology processes, are implicated in contributing to tumorigenesis and progression. …”
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Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer’s Disease Individuals by Darine Villela, Rodrigo F. Ramalho, Aderbal R. T. Silva, Helena Brentani, Claudia K. Suemoto, Carlos Augusto Pasqualucci, Lea T. Grinberg, Ana C. V. Krepischi, Carla Rosenberg

“…For 6 of these miRNA genes (MIR9-1, MIR9-3, MIR181C, MIR124-1, MIR146B, and MIR451), the hypermethylation pattern is in agreement with previous results from literature that shows downregulation of miR-9, miR-181c, miR-124, miR-146b, and miR-451 in the AD brain. Our data implicate dysregulation of miRNA methylation as contributor to the pathogenesis of AD.…”
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Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4 by Qing Luo, Li Zhang, Yue Hao, Chunwei Xu, Xiaojia Wang, Zhen Jia, Xiandong Xie, Zhihong Huang, Xiaomin Gao, Yu Chen, Xue Zhu, Jing Fang, Ke Wang, Yongxiang Yin

“…Aberrant FGFR signaling has been implicated in TNBC; however, the therapeutic potential of targeting FGFRs for TNBC treatment remains unclear. …”
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Variations in dietary habits during cancer treatment: results of a cross-sectional survey by Sana Ennouri, Nouha Daoud, Yosra Berrazegua, Houda El Benna, Sinene Korbi, Haifa Rachdi, Nesrine Mejri, Soumaya Labidi, Hammouda Boussen

“…Th e survey included 42 items concerning demographic and clinical data, observed dietary modifications and oncologist implication. …”
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Molecular epidemiology of Ascaris lumbricoides following multiple rounds of community-wide treatment by Toby Landeryou, Rosie Maddren, Jack Hearn, Mahlet Belachew, Santiago Rayment Gomez, Ewnetu Firdawek Liyew, Kathryn Forbes, Birhan Mengistu, Scott P. Lawton, Jude Eze, Geremew Tasew, Ufaysa Angulo, Roy Anderson

“…Here, we utilise genomic data to understand parasite transmission within and between households in a community and the genomic impact of repeated MDA. …”
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From dysbiosis to precision therapy: decoding the gut-bladder axis in bladder carcinogenesis by Ze-qiang Liu, Xiao-ying Yang, Jia-hong Chen, Si-cheng Ge, Si-cheng Ge, Shi-xue Dai, Shi-xue Dai, Sheng-huang Zhu, Zhi-yong Xian, Zhi-yong Xian

“…Current studies, while revealing partial pathways, face methodological inconsistencies, particularly in urinary microbiome profiling, and a lack of longitudinal human data. Future breakthroughs will require multi-omics integration, organoid-based models, and interdisciplinary collaboration to address these gaps.…”
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A novel thermoregulatory role for PDE10A in mouse and human adipocytes by Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, Juliane Weiner, Sally Wagner, Winnie Deuther‐Conrad, Felix Bronisch, Karen Steinhoff, Julia Luthardt, Nora Klöting, Swen Hesse, John P Seibyl, Osama Sabri, John T Heiker, Matthias Blüher, Alexander Pfeifer, Peter Brust, Wiebke K Fenske

“…Preclinical studies implicate PDE10A in the regulation of energy homeostasis, but the mechanisms remain unclear. …”
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REMR: Identification of RNA Editing-mediated MiRNA Regulation in Cancers by Xu Zhou, Haizhou Liu, Fei Hou, Zong-Qing Zheng, Xinyu Cao, Quan Wang, Wei Jiang

“…Dysregulation of adenosine-to-inosine (A-to-I) RNA editing has been implicated in cancer progression. However, a comprehensive understanding of how A-to-I RNA editing is incorporated into miRNA regulation to modulate gene expression in cancer remains unclear, given the lack of effective identification methods. …”
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Association between matrix metalloproteinases polymorphisms and ovarian cancer risk: A meta-analysis and systematic review. by Xu-Ming Zhu, Wei-Feng Sun

“…<h4>Background</h4>Published data on the relationship between matrix metalloproteinases (MMPs) polymorphisms and ovarian cancer risk have implicated inconclusive results. …”
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Use of disease modifying anti-rheumatic drugs and risk of multiple myeloma in US Veterans with rheumatoid arthritis by Kate Tokareva, Alexander C. Peterson, Aaron Baraff, Sarah P. Chung, Jennifer Barton, Joshua F. Baker, Bryant R. England, Ted R. Mikuls, Nicholas L. Smith, David G. Coffey, Noel S. Weiss, Namrata Singh

“…Methods In this cohort study using Veterans Health Administration (VHA) data, we identified Veterans newly diagnosed with RA from 1/1/2002 to 12/31/2018 using diagnostic codes and medication fills. …”
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Screening and regulatory mechanism exploration of M1 macrophage polarization and efferocytosis-related biomarkers in coronary heart disease by Hong Gao, Junhua Li, Jianxin Huang, Xiaojie Jiang

“…BackgroundMacrophage polarization and efferocytosis have been implicated in CHD. However, the underlying mechanisms remain elusive. …”
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