Ion-Channel-Targeting Scorpion Recombinant Toxin as Novel Therapeutic Agent for Breast Cancer by Natalia Mata de los Rios, Argel Gastelum-Arellanez, Herlinda Clement, Karely Álvarez-Cruz, Diana Romero-Terrazas, Carolina Alvarado-González, Luis Carlos Hinojos-Gallardo, Gerardo Corzo, Gerardo Pável Espino-Solis

“…Voltage-gated potassium (Kv) and sodium (Nav) channels have been implicated in oncogenic signaling pathways. Scorpion venom peptides, known for their selective ion-channel-blocking properties, have demonstrated promising antineoplastic activity. …”
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Unraveling anoikis in glioblastoma: insights from single-cell sequencing and prognostic modeling by Qikai Tang, Chenfeng Ma, Jiaheng Xie, Qixiang Zhang, Bingtao Zhang, Weiqi Bian, Qingyu Lu, Zeyu Wan, Wei Wu

“…Methods Utilizing single-cell sequencing and bulk-transcriptome sequencing data from TCGA, GEO, and CGGA databases, we performed comprehensive bioinformatics analyses. …”
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IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway by Lingwei Zhou, Miao Pei, Tian Qi, Yu Liu, Xiaoyue Li, Xuan Li, Qinghe Chen, Feihong Jin, Shaozhong Yang, Feng Qi

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Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis by Yanyan Zhu, Yike Gao, Xiaoqing Huang, Bowang Chen, Bowang Chen, Xinyi Wang, Ying Wu, Jian Sun, Xiaoyun Huang, Xiaoyun Huang

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Determination of Voriconazole Plasma Concentration by HPLC Technique and Evaluating Its Association with Clinical Outcome and Adverse Effects in Patients with Invasive Aspergillosi... by Sahar Yousefian, Farzaneh Dastan, Majid Marjani, Payam Tabarsi, Saghar Barati, Nahid Shahsavari, Farzad Kobarfard

“…Demographic characteristics and clinical data, outcome, and adverse effects were documented. …”
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A novel approach to enhance glioblastoma multiforme treatment efficacy: non-coding RNA targeted therapy and adjuvant approaches by Meijun Liu, Yuying Wang, Xiaoli Chen, Yu Zeng, Wenqiong Huang, Jiawen Yang, Hong Dai, Lixin Cheng, Claudio Mauro, Kenneth Chat Pan Cheung

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Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissue by N Matyasovska, N Valkova, M Gala, S Bendikova, A Abdulhamed, V. Palicka, Neil Renwick, Pavol Čekan, Evan Paul

“…Because miRs are key regulators of mRNA expression, we sought to integrate expression data from both RNA species into miR-mRNA interaction networks to advance our understanding of PanNET biology. …”
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Metabolomic profiles underlying gout flares: a prospective study of people with gout by Zhen Liu, Hui Zhang, Rui Li, Can Wang, Jie Lu, Nicola Dalbeth, Lin Han, Changgui Li, Lingling Cui, Huiyong Yin, Wenyan Sun, Haibing Chen

“…In cross-sectional analysis, data were analysed according to the presence of gout flare (acute group) or absence of gout flare (intercritical group) at the time of enrolment. …”
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NLRP3, conveyed via extracellular vesicles from metabolic syndrome patients, is involved in atherosclerosis development by Xavier Vidal-Gómez, Luisa Vergori, Séverine Dubois, Frédéric Gagnadoux, Samir Henni, Reuben Veerapen, Olivier Meilhac, Mercedes Muñoz-Picos, Concepción Peiró, M. Carmen Martinez, Ramaroson Andriantsitohaina, on behalf of Metabol Study Group

“…Conclusions Our data demonstrate that NLRP3-inflammasome, carried by EVs, is actively involved in vascular inflammation and atherosclerosis development in MetS. …”
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Genome-Wide Association Integrating a Transcriptomic Meta-Analysis Suggests That Genes Related to Fat Deposition and Muscle Development Are Closely Associated with Growth in Huaxi... by Cheng-Li Liu, Tao Ren, Peng-Cheng Ruan, Yong-Fu Huang, Simone Ceccobelli, De-Jun Huang, Lu-Pei Zhang, Guang-Xin E

“…Additionally, publicly available RNA-seq data from the longissimus dorsi muscle of both young and adult cattle were analyzed to identify key genes and genetic markers associated with growth in Huaxi cattle. …”
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Dysbiosis in the Gut Microbiome of Pembrolizumab‐Treated Non‐Small Lung Cancer Patients Compared to Healthy Controls Characterized Through Opportunistic Sampling by Haris Charalambous, Cameron Brown, Paris Vogazianos, Kyriaki Katsaounou, Elpiniki Nikolaou, Ioannis Stylianou, Elisavet Papageorgiou, Dimitris Vraxnos, Aristos Aristodimou, Jianxiang Chi, Paul Costeas, Christos Shammas, Yiorgos Apidianakis, Athos Antoniades

“…Conclusion The observed differences indicate dysbiosis and a compromised intestinal health status in the metastatic NSCLC Pembrolizumab‐treated patients. This data could inform future studies of immunotherapy treatment responses and modulation of the gut microbiome to minimise dysbiosis prior or concurrent to treatment. …”
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Genome-Wide Identification and Expression Analyses of the MADS-Box Gene During Flowering in <i>Primulina huaijiensis</i> by Jie Zhang, Xinxia Cai, Qin Liu, Ziyi Lei, Chen Feng

“…<i>Primulina huaijiensis</i> is a promising candidate for eco-bottle flowers, yet the genes related to flowering remain unexplored despite the availability of genomic data for several years. <i>MADS-box</i> genes constitute a large family of transcription factors that play crucial roles in plant growth and development, particularly in flower development. …”
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Enrichment of human IgA-coated bacterial vesicles in ulcerative colitis as a driver of inflammation by Himadri B. Thapa, Christina A. Passegger, Dominik Fleischhacker, Paul Kohl, Yi-Chi Chen, Ratchara Kalawong, Carmen Tam-Amersdorfer, Michael R. Gerstorfer, Jana Strahlhofer, Kristina Schild-Prüfert, Ellen L. Zechner, Andreas Blesl, Lukas Binder, Georg A. Busslinger, Leo Eberl, Gregor Gorkiewicz, Herbert Strobl, Christoph Högenauer, Stefan Schild

“…IgA-coated BEVs also exacerbate intestinal inflammation in a dextran sodium sulfate colitis model using transgenic mice expressing human CD89. Our data thus implicate a link between IgA-coated BEVs and intestinal inflammation via CD89+ immune cells, and also hint a potential new therapeutic target for UC.…”
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Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients by Justin Stebbing, Venkatesh Krishnan, Stephanie de Bono, Silvia Ottaviani, Giacomo Casalini, Peter J Richardson, Vanessa Monteil, Volker M Lauschke, Ali Mirazimi, Sonia Youhanna, Yee‐Joo Tan, Fausto Baldanti, Antonella Sarasini, Jorge A Ross Terres, Brian J Nickoloff, Richard E Higgs, Guilherme Rocha, Nicole L Byers, Douglas E Schlichting, Ajay Nirula, Anabela Cardoso, Mario Corbellino, the Sacco Baricitinib Study Group

“…In a case series of patients with bilateral COVID‐19 pneumonia, baricitinib treatment was associated with clinical and radiologic recovery, a rapid decline in SARS‐CoV‐2 viral load, inflammatory markers, and IL‐6 levels. Collectively, these data support further evaluation of the anti‐cytokine and anti‐viral activity of baricitinib and support its assessment in randomized trials in hospitalized COVID‐19 patients.…”
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A genome-wide association study identifies five loci influencing facial morphology in Europeans. by Fan Liu, Fan Liu, Fedde van der Lijn, Claudia Schurmann, Gu Zhu, M Mallar Chakravarty, Pirro G Hysi, Andreas Wollstein, Oscar Lao, Marleen de Bruijne, M Arfan Ikram, Aad van der Lugt, Fernando Rivadeneira, André G Uitterlinden, Albert Hofman, Wiro J Niessen, Georg Homuth, Greig de Zubicaray, Katie L McMahon, Paul M Thompson, Amro Daboul, Ralf Puls, Katrin Hegenscheid, Liisa Bevan, Zdenka Pausova, Sarah E Medland, Grant W Montgomery, Margaret J Wright, Carol Wicking, Stefan Boehringer, Timothy D Spector, Tomáš Paus, Nicholas G Martin, Reiner Biffar, Manfred Kayser

“…Phenotyping of facial shape features was based on landmark data obtained from three-dimensional head magnetic resonance images (MRIs) and two-dimensional portrait images. …”
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Does delocalised PCR for Streptococcus B in the labour ward allow adequate administration of antibiotics to prevent early neonatal infection? by Clémentine Guetat, Laetitia Roussel, Marie De Antonio, Marie Accoceberry, Céline Houlle, Fanny Petillon, Marion Rouzaire, Denis Gallot

“…Introduction: Streptococcus B is a commensal infectious agent of the intestinal and genitourinary tract. It is often implicated in early neonatal infections. Some 10 %–30 % of women are colonised by this bacterium. …”
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Potential role of photobiomodulation as a prevention and treatment strategy for radiation induced fibrosis: a review of effectiveness and mechanisms by Rachita Gururaj, Betty Thomas, Manur Gururajachar Janaki, Vinay Martin D’sa Prabhu, Rakesh Nagaraju, Stephen Rajan Samuel, Sundar Kumar Veluswamy

“…Retrieved studies underwent independent title, abstract, full text screening and data extraction. Quality analysis was performed for human studies to assess methodological rigor. …”
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Multimodal neuroimaging investigation of post-stroke fatigue in middle-aged and older adults: combining resting-state fMRI and DTI-ALPS analysis by Jingjing Sun, Yanlin Tang, Wenni Wang, Yong Zhang, Hengshan Ji, Peng Wang

“…The findings provide novel insights into the complex pathophysiology of PSF in the aging brain, implicating both functional brain networks and the glymphatic system. …”
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GLUT1 and prorenin receptor mediate differential regulation of TGF-β and CTGF in renal inner medullary collecting duct cells during high glucose conditions by Paulina E. Larenas, Pilar Cárdenas, Monserrat Aguirre-Delgadillo, Carlos Moris, Dulce E. Casarini, Zoe Vallotton, Minolfa C. Prieto, Alexis A. Gonzalez

“…Additionally, long-term exposure to HG increases lipid peroxidation and reduced cell viability. Conclusions The data indicate that glucose transportation via GLUT1 is implicated in the PRR-dependent upregulation of TGF-β while CTGF is mediated mainly via a mechanism depending on ROS formation in renal medullary collecting duct cells.…”
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Higher remnant cholesterol increases the risk of coronary heart disease and diabetes in postmenopausal women by Yan Zhang, Kexin Song, Shuli Bi, Mingyang Li, Zhuhua Yao, Zhuhua Yao, Zhuhua Yao

“…Elevated levels of remnant cholesterol (RC) have been implicated in atherosclerosis and insulin resistance.MethodsThis study aimed to investigate the relationship between RC and the prevalence of coronary heart disease (CHD), diabetes, and CHD combined with diabetes in a nationally representative sample of US postmenopausal women using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. …”
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