Comparative Transcriptome and Weighted Gene Co-Expression Network Analysis of Eggplant (<i>Solanum melongena</i> L.) Reveals Key Genes Responding to <i>Ralstonia solanacearum</i> I... by Chuying Yu, Weiliu Li, Rui Xiang, Qihong Yang, Yaqin Jiang, Guiyun Gan, Liangyu Cai, Wenjia Li, Yikui Wang

“…Subsequently, seven hub genes were selected for validation using RT-qPCR, and the results were consistent with the RNA-seq data. Notably, upon gene annotation, a significant proportion of the hub genes were annotated as heat shock proteins (HSPs) or heat shock transcription factors (HSFs). …”
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VCAM-1 predicts poor prognosis and modulates immune infiltration in gastric cancer: a TCGA-based bioinformatics study by Cheng Wu, Cheng Wu, Yungeng Liu, Yungeng Liu, Chuanyuan Liu, Chuanyuan Liu, Chuanfa Fang, Chuanfa Fang

“…Vascular cell adhesion molecule (VCAM)-1, an immune cell adhesion mediator, is implicated in tumor progression; however, its prognostic and immunomodulatory roles in GC remain unclear.MethodsIn this study, we analyzed VCAM-1 expression and its clinical relevance in GC using RNA-sequencing data from The Cancer Genome Atlas. …”
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A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1 by Weiqiang Xu, Junxuan Yi, Xinfeng Wei, Mingwei Wang, Mingqi Zhao, Mengdie Zhao, Xinyan Wang, Yannan Shen, Zhicheng Wang, Shunzi Jin

“…Abstract Background N6-methyladenosine (m6A) modification is implicated in various diseases pathogenesis and physiological processes. …”
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Prognostic value and immune infiltration analysis of a novel lactylation-related gene signature in endometrial cancer by Liqin Gu, Chunnian Zhang, Minjuan Xu, Fang Peng, Ruo-Hui Huang, Deping Luo

“…Background: Lactylation has been implicated in tumor growth, proliferation, and metastasis; however, its precise relationship with cancer remains poorly understood. …”
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Unlocking the biochemical and computational parameters of Ceropegia foetida: A scientific approach for functional bioactive compounds from a medicinal food plant by Fawaz Alheibshy, Abdulwahab Alamri, Saad Saeed Saad Alshahrani, Ahmed Awadh Saleh Alamri, Nasser A.Awadh Ali, Abdulwali Al-Khulaidi, Arshad Hussain, Sirajudheen Anwar

“…Such computational insights, alongside empirical data, suggest that C. foetida merits further exploration as a natural source of therapeutic agents. …”
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Increased circulating platelet-derived extracellular vesicles in severe COVID-19 disease by Tuukka Helin, Mari Palviainen, Marja Lemponen, Katariina Maaninka, Pia Siljander, Lotta Joutsi-Korhonen

“…Coagulation disturbances are major contributors to COVID-19 pathogenicity, but limited data exist on the involvement of extracellular vesicles (EVs) and residual cells (RCs). …”
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The role of bile acid metabolism-related genes in prognosis assessment of hepatocellular carcinoma and identification of NPC1 as a biomarker by Maosen Xu, Maosen Xu, Yu Zhang, Yan Tie, Yiqiao Luo, Yang Wang, Ziqi Zhang

“…Bile acids (BAs), as critical regulators of liver metabolism and inflammation, have recently been implicated in tumorigenesis and cancer progression. …”
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Cell based high-throughput screening for small molecule inhibitors of ATE1 by Claudia McCown, Evan A. Ambrose, Devang M. Patel, Hassan Al-Ali, Louis Scampavia, Fangliang Zhang, Timothy P. Spicer

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Hydnocarpin, a Natural Flavonolignan, Induces the ROS-Mediated Apoptosis of Ovarian Cancer Cells and Reprograms Tumor-Associated Immune Cells by Jae-Yoon Kim, Yejin Kim, Soo-Yeon Woo, Jin-Ok Kim, Hyunsoo Kim, So-Ri Son, Dae Sik Jang, Jung-Hye Choi

“…Mechanistically, hydnocarpin triggered caspase-dependent apoptosis, as evidenced by the activation of caspase-9 and -3, with limited involvement of caspase-8, indicating the activation of the intrinsic apoptotic pathway. Experimental data implicated reactive oxygen species generation as a key mediator of hydnocarpin cytotoxicity, and reactive oxygen species inhibition significantly inhibited this cytotoxicity. …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

“…The unique characteristics of type 3 deletions implicate the existence of a novel deletion pathway in mice and humans that is counteracted by DDT. …”
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Associations of cells from both innate and adaptive immunity with lower nerve conduction velocity: the Maastricht Study by Dan Ziegler, Michael Roden, Christian Herder, Haifa Maalmi, Kristiaan Wouters, Jeroen H P M van der Velde, Jos P H Reulen, Werner Mess, Casper G Schalkwijk, Nicolaas C Schaper

“…Therefore, we aimed to test whether leukocyte subsets are associated with NCV.Research design and methods This cross-sectional study analyzed data from 850 individuals (of whom 252 and 118 had type 2 diabetes and pre-diabetes, respectively) of the Maastricht Study. …”
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Revealing the Molecular Mechanisms of Ozone-Induced Pulmonary Inflammatory Injury: Integrated Analysis of Metabolomics and Transcriptomics by Xiaolei Zhou, Yunnian Guo, Xiaotong Jian, Xinyi Miao, Pengpeng Wang, Xiaoke Wang, Ling Wang, Huaiyong Chen, Feifei Feng

“…A comprehensive integration analysis of these omics data was conducted using Pearson correlation analysis. …”
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Therapeutic Potential of <i>Solenopsis invicta</i> Venom: A Scoping Review of Its Bioactive Molecules, Biological Aspects, and Health Applications by Mario Dioguardi, Stefania Cantore, Diego Sovereto, Lorenzo Sanesi, Angelo Martella, Lynn Almasri, Gennaro Musella, Lorenzo Lo Muzio, Andrea Ballini

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Small Molecule Derived From Carboxyethylpyrrole Protein Adducts Promotes Angiogenesis in a Mouse Model of Peripheral Arterial Disease by Luqia Hou, Guang Yang, Shibing Tang, Cynthia Alcazar, Prajakta Joshi, Zachary Strassberg, Michael Kim, Masashi Kawamura, Y. Joseph Woo, Joseph Shrager, Sheng Ding, Ngan F. Huang

“…Background CEP (ω‐[2‐carboxyethyl]pyrrole) protein adducts are the end products of lipid oxidation associated with inflammation and have been implicated in the induction of angiogenesis in pathological conditions such as tissue ischemia. …”
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Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia by Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small

“…Taken together, these data suggest that AXL plays a role in adaptive resistance in FLT3/ITD AML and that combined AXL and FLT3 inhibition might improve FLT3/ITD AML patient outcomes.…”
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Altered cerebellar activation patterns in Alzheimer’s disease: An activation likelihood estimation Meta-Analysis by Jessica A. Bernard, Ivan A. Herrejon, Emily An, Yamilet Cina, Sameera Dabbiru, Jack Dempsey, Elise Marrie, Michele Medina, Jessica Praytor

“…Emerging work across model systems and in humans has also implicated the cerebellum in Alzheimer’s Disease (AD) and in mild cognitive impairment (MCI). …”
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Parkin Exon Rearrangements and Sequence Variants in LRRK2 Mutations Carriers: Analysis on a Possible Modifier Effect on LRRK2 Penetrance by Paolo Solla, Antonino Cannas, Gianluca Floris, Maria Rita Murru, Daniela Corongiu, Stefania Tranquilli, Stefania Cuccu, Marcella Rolesu, Francesco Marrosu, Maria Giovanna Marrosu

“…Three single-nucleotide polymorphisms (SNPs) were identified both in patients and unaffected relatives but did not significantly differ between the two groups. These data provide no support to the hypothesis whereby such parkin gene mutations may be commonly implicated in possible effect on penetrance in LRRK2 mutation carriers.…”
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circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis by Chunjuan Yang, Biao Ni, Chaoran Li, Wenchang Sun, Zhangxue Wang, Hui Wang, Xinyue Hou, Shushan Yan, Xiaodong Wang, Donghua Xu

“…Accumulating studies have implicated that circular RNAs (circRNAs) play vital roles in the pathogenesis of rheumatoid arthritis (RA). …”
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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus by Sheng-Yan Lin, Yikai Yu, Daan Nie, Lili Yang, Yuxue Chen, Yu Chen, Cheng Wen, Zhipeng Zeng

“…Cross-analysis with bulk transcriptomic data highlighted JUN and HLA-A as hub regulators exhibiting elevated expression in SLE T cells. …”
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The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape by Jani Nöthling, Jacqueline Samantha Womersley, Shibe Mhlongo, Carl Lombard, Naeemah Abrahams, Soraya Seedat, Sian Megan Joanne Hemmings

“…Dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis, a core regulator of the stress response, has been implicated in the aetiology and chronicity of PTSD. …”
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