Maternal PRDM10 activates essential genes for oocyte-to-embryo transition by Michelle K. Y. Seah, Brenda Y. Han, Yan Huang, Louise J. H. Rasmussen, Andrina J. Stäubli, Judith Bello-Rodríguez, Andrew Chi-Ho Chan, Maxime Gasnier, Heike Wollmann, Ernesto Guccione, Daniel M. Messerschmidt

“…Several members such as PRDM1, PRDM14 and PRDM9, have been implicated in germ cell specification and homoeostasis and are essential to fertility-related processes. …”
Get full text

Weighted gene co-expression network analysis reveals key stromal prognostic markers in pancreatic cancer by G. Mantini, A. Agostini, M. Tufo, S. Rossi, M. Kulesko, C. Carbone, L. Salvatore, G. Tortora, G. Scambia, L. Giacò

“…HPGDS and ITGA9-AS1 emerged as significant indicators of favorable prognosis while KCMF1 and YARS1 were implicated in poorer prognostic outcomes. Importantly, HPGDS was found to be stromal-specific in the TMA cohort of Human Protein Atlas. …”
Get full text

Therapeutic strategies for adrenocortical carcinoma: integrating genomic insights, molecular targeting, and immunotherapy by Jing Sun, Jing Sun, Jiaxuan Huai, Wenhui Zhang, Tianyu Zhao, Run Shi, Xuanbin Wang, Minglun Li, Xuehua Jiao, Xiqiao Zhou

“…This review discusses the complex molecular pathogenesis of ACC, focusing on critical pathways implicated in the tumorigenesis and providing potential targets for therapy: the Wnt/β-catenin signaling pathway, the IGF2/IGF1R axis, and the apoptosis pathway regulated by p53. …”
Get full text

NSD2 and miRNAs as Key Regulators of Melanoma Response to Romidepsin and Interferon‐α2b Treatment by Alessandro De Santis, Lucrezia De Santis, Francesca Rossi, Silvia Gasparini, Valerio Licursi, Vito Antonio Amico, Imerio Capone, Alessandra Fragale, Stefania D'atri, Lucia Gabriele, Carlo Presutti

“…Methods RNA‐seq and TCGA transcriptomic data were re‐analyzed to identify miRNAs and NSD2 expressions. …”
Get full text

Pulses of ocean acidification at the Triassic–Jurassic boundary by Molly Trudgill, James W. B. Rae, Ross Whiteford, Markus Adloff, Jessica Crumpton-Banks, Michael Van Mourik, Andrea Burke, Marieke Cuperus, Frank Corsetti, Daniel Doherty, William Gray, Rosanna Greenop, Wei-Li Hong, Aivo Lepland, Andrew McIntyre, Noor Neiroukh, Catherine V. Rose, Micha Ruhl, David Saunders, Magali M.F.R. Siri, Robert C. J. Steele, Eva E. Stüeken, A. Joshua West, Martin Ziegler, Sarah E. Greene

“…Ocean acidification has been implicated during Triassic–Jurassic environmental perturbations, but this interval lacks direct reconstructions of ocean pH. …”
Get full text

Single-nucleus and spatial transcriptomics identify brain landscape of gene regulatory networks associated with behavioral maturation in honeybees by Xiaohuan Mu, Zijing Zhang, Qun Liu, Jie Ma, Yating Qin, Haoyu Lang, Yingying Zhang, Nannan Zhang, Qunfei Guo, Pei Zhang, Denghui Li, Ruihua Zhang, Qianyue Ji, Aijun Jiang, Yang Wang, Shanshan Pan, Xiawei Liu, Xuemei Liu, Jiahui Sun, Yan Liu, Hao Chen, Li Zheng, Liang Meng, Haorong Lu, He Zhang, Yifan Zhai, Qiye Li, Junnian Liu, Huanming Yang, Jian Wang, Xiaosong Hu, Xun Xu, Shanshan Liu, Hao Zheng

“…Integrating spatial and cellular data uncovered cell-type and spatial heterogeneity in GRN organization. …”
Get full text

Genetic and clinical insights into MAST4-related neurodevelopmental disorders by Xiaohong Zheng, Foyang Fan, Bin Lei, Yao Xu, Min Peng, Youfeng Zhou

“…ObjectiveDe novo variants in MAST4 are increasingly implicated in neurodevelopmental disorders (NDDs), but the associated phenotypic spectrum remains incompletely characterized. …”
Get full text

Starlike Au nanoparticle unleashing siDDIT3 and photothermal power to combat ferroptosis - driven osteoarthritis by Chenfeng Wang, Shiyuan Hua, Ting Feng, Yixin Zheng, Yunqi Hu, Chenchen Zhao, Sihao Wang, Yihe Hu, Min Zhou, Feng Liang

“…Abstract Osteoarthritis (OA), the most common degenerative joint disease globally, has garnered increasing attention, and emerging evidence implicated ferroptosis played an important role in both its onset and progression. …”
Get full text

ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice by Monika Svecla, Annalisa Moregola, Lorenzo Da Dalt, Jasmine Nour, Andrea Baragetti, Patrizia Uboldi, Alessandra Idini, Manfred Wuhrer, Giangiacomo Beretta, David Falck, Fabrizia Bonacina, Giuseppe Danilo Norata

“…Abstract Abstract The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implicated in modulating the lipid metabolism and reducing cardiovascular disease burden. …”
Get full text

Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis by Gracious D. S. Kasheke, Basmah A. M. Hendy, Gabriel G. Dorighello, Nonthué A. Uccelli, Jean-David M. Gothié, Robyn J. Novorolsky, Madison J. Oulton, Jude Asainayagam, Adam I. Makarov, Kaitlyn S. Fraser, Vidyasagar Vuligonda, Martin E. Sanders, Timothy E. Kennedy, George S. Robertson

“…This clinically promising remyelinating agent activates multiple nuclear hormone receptor subtypes implicated in myelin repair. However, BXT produces unacceptable hyperlipidemia. …”
Get full text

Essentiality of CTNNB1 in Malignant Transformation of Human Embryonic Stem Cells under Long-Term Suboptimal Conditions by Jie Liu, Sicong Zeng, Yang Wang, Juan Yu, Qi Ouyang, Liang Hu, Di Zhou, Ge Lin, Yi Sun

“…Previous studies demonstrated that the activation of CTNNB1 might be implicated in this process. Hence, the hESC line with stably silenced CTNNB1 was established to further explore the role of CTNNB1 in the malignant transformation of hESCs. …”
Get full text

Multi-omics analysis reveals key immunogenic signatures induced by oncolytic Zika virus infection of paediatric brain tumour cells by Matthew Sherwood, Thiago G. Mitsugi, Carolini Kaid, Brandon Coke, Mayana Zatz, Kevin Maringer, Oswaldo K. Okamoto, Rob M. Ewing

“…We assess publicly available scRNA-Seq data to model how ZIKV-induced secretome paracrine and endocrine signalling may orchestrate the anti-tumoural immune response during oZIKV infection of brain tumours. …”
Get full text

Epigenomic and 3D genomic mapping reveals developmental dynamics and subgenomic asymmetry of transcriptional regulatory architecture in allotetraploid cotton by Xianhui Huang, Yuejin Wang, Sainan Zhang, Liuling Pei, Jiaqi You, Yuexuan Long, Jianying Li, Xianlong Zhang, Longfu Zhu, Maojun Wang

“…Abstract Although epigenetic modification has long been recognized as a vital force influencing gene regulation in plants, the dynamics of chromatin structure implicated in the intertwined transcriptional regulation of duplicated genes in polyploids have yet to be understood. …”
Get full text

Diverse ancestral representation improves genetic intolerance metrics by Alexander L. Han, Chloe F. Sands, Dorota Matelska, Jessica C. Butts, Vida Ravanmehr, Fengyuan Hu, Esmeralda Villavicencio Gonzalez, Nicholas Katsanis, Carlos D. Bustamante, Quanli Wang, Slavé Petrovski, Dimitrios Vitsios, Ryan S. Dhindsa

“…Abstract The unprecedented scale of genomic databases has revolutionized our ability to identify regions in the human genome intolerant to variation—regions often implicated in disease. However, these datasets remain constrained by limited ancestral diversity. …”
Get full text

Free fatty acid receptor 2 promotes cardiomyocyte hypertrophy by activating STAT3 and GATA4 by Hui Gao, Kunming Tian, Xiaojun Feng, Mengqing Yan, Chen Gao, Yisheng Jiang, Chenhao Zhu, Huzhe Zhu, Xueping Liu, Yingfu Peng

“…Taken together, these data indicate that FFA2 can enhance cardiomyocyte hypertrophy by activating STAT3 and GATA4 via ERK1/2, providing a potential new target for therapy.…”
Get full text

Association of Post Kala-Azar Dermal Leishmaniasis pathogenesis with prolonged sunlight (ultraviolet radiations) exposure in VL endemic population of Bihar by Sachidananda Behera, Mehar Darukhshan Kalim, Naveen Kumar, Vidya Nand Ravi Das, Niyamat Ali Siddiqui, Krishna Pandey, Shubhankar Kumar Singh, Vahab Ali

“…We have measured sun-light UVR intensities by UV light meters and satellite-based methods. Our data showed a concerning increase in the UV index (> 12.0–14.5) during summer and pre-monsoon season. …”
Get full text

CEBPB promotes transformation of endometrial complex atypical hyperplasia to endometrial cancer by Jiahong Tan, Lin Zhao, Daoqi Wang, Xiaodie Wu, Yongxiang Bi, Hanying Wang, Na Ma, Dehong Yang, Wei Dong, Jie Zhang

“…Results By integrating RNA sequencing data, CEBPB was identified as implicated in the transformation from endometrial CAH to EC. …”
Get full text

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions by Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm

“…Abstract Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear. ANO1 is implicated as a potential target to treat incontinence, thus this is an important issue to resolve. …”
Get full text

Impact of Financial Literacy on Saving Decisions: Insight from Aseman Project Operated by Barkat Foundation by VAhid Moghadam, Hadi Amiri, Sahar Baharipour, Fatemeh Bagheri, Parisa GHasemian

“…Materials & MethodsThe study sample consisted of 113 individuals aged 18 years and above selected from 4 villages (Sohrofiroozan, Tad, Ardal, and Bajgerd) that were part of Aseman Project's microfinance fund member population of 185 people. Data were collected through semi-structured interviews and observations using a questionnaire as the primary data collection tool. …”
Get full text

Antioxidant therapy for infertile couples: a comprehensive review of the current status and consideration of future prospects by Ramadan Saleh, Ramadan Saleh, Hassan Sallam, Hassan Sallam, Mohamad AlaaEldein Elsuity, Mohamad AlaaEldein Elsuity, Sulagna Dutta, Sulagna Dutta, Pallav Sengupta, Ahmed Nasr

“…Despite several findings suggesting improvements in fertility potential with AOX therapy, the data remains inconclusive regarding optimal dosage and combination, duration of treatment, and the specific patient populations most likely to benefit. …”
Get full text