CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. by John T Loffredo, Thomas C Friedrich, Enrique J León, Jason J Stephany, Denise S Rodrigues, Sean P Spencer, Alex T Bean, Dominic R Beal, Benjamin J Burwitz, Richard A Rudersdorf, Lyle T Wallace, Shari M Piaskowski, Gemma E May, John Sidney, Emma Gostick, Nancy A Wilson, David A Price, Esper G Kallas, Helen Piontkivska, Austin L Hughes, Alessandro Sette, David I Watkins

“…<h4>Conclusions</h4>Together, our data suggest that Mamu-B*08-restricted CD8+ T cell responses effectively control replication of pathogenic SIV(mac)239. …”
Get full text

Controversies in the Application of AI in Radiology—Is There Medico-Legal Support? Aspects from Romanian Practice by Ana-Maria Ungureanu, Sergiu-Ciprian Matei, Daniel Malita

“…In the radiological diagnostic process, there are five levels of AI system implication. Until now, completely autonomous AI systems have not been used. …”
Get full text

CLDN9 and hsa-miR-4496 as non-invasive biomarkers for gastric cancer detection by Qiongxia Hu, Lu Han, Jinglin Wang, Fei Li, Hongfei Pu, Yue Shi

“…Claudin-9 (CLDN9), a protein implicated in epithelial-mesenchymal transition (EMT), has shown elevated expression in various cancers. …”
Get full text

Relationship between Heightened Level of Aggression and Lower Digit Ratio in a Cohort of Children in Conflict with the Law by Isyaku Gwarzo Mukhtar, Hassan Sani Umar, Safiyyu Mujitapha Umar

“…Background and Aim: Digit ratio (2D:4D) has been linked to prenatal exposure to androgen and by implication, aggression, however, results have been inconsistent. …”
Get full text

A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. by Anne M Meehan, Dyana T Saenz, Rebekah Guevera, James H Morrison, Mary Peretz, Hind J Fadel, Masakazu Hamada, Jan van Deursen, Eric M Poeschla

“…Experiments with cylosporine, viruses with capsids that do not bind cyclophilins, and growth arrest did not uncover viral dependency on the C-terminal domains of Nup358. Our data reinforce the virological importance of TNPO3 and show that Nup358 supports nuclear transport functions important for cellular homeostasis and for HIV-1 nuclear import. …”
Get full text

High immunisation coverage but sporadic outbreaks of vaccine-preventable diseases: the structural gaps in vaccination uptake in central highlands, Vietnam by Thanh Ha Nguyen, Thi Phuoc Loan Mai, C. Louise Thwaites, Jennifer Ilo Van Nuil, Mary Chambers

“…Methods We used qualitative data collected between 2018 and 2022 from in-depth interviews, focus group discussions, and participant observation with different stakeholders of the EPI programme. …”
Get full text

TIMM23 overexpression drives NSCLC cell growth and survival by enhancing mitochondrial function by Jianhua Zha, Jiaxin Li, Hui Yin, Mingjing Shen, Yingchen Xia

“…Abstract Mitochondrial hyperfunction is implicated in promoting non-small cell lung cancer (NSCLC) cell growth. …”
Get full text

The relationship between serum irisin levels and renal function in patients with type 2 diabetes mellitus by Robab Beigom Aboutorabi, Golrokh Hariri, Zahra Mazloum Khorasani, Hassan Mehrad-Majd

“…Demographic, anthropometric, and clinical data were recorded. Fasting blood samples were collected to determine serum irisin levels using the ELISA method. …”
Get full text

The effect of XPD/ERCC2 polymorphisms on gastric cancer risk among different ethnicities: a systematic review and meta-analysis. by Huiping Xue, Yan Lu, Bing Lin, Jinxian Chen, Feng Tang, Gang Huang

“…<h4>Background</h4>Potential xeroderma pigmentosum group D (XPD), also called excision repair cross-complimentary group two (ERCC2), Lys751Gln and Asp312Asn polymorphisms have been implicated in gastric cancer risk among different ethnicities.…”
Get full text

The transcriptional response to low temperature is weakly conserved across the Enterobacteriaceae by Johnson Hoang, Daniel M. Stoebel

“…Using de novo-generated parallel RNA-seq data sets, we found that the six species in this study change the level of expression of many of their genes in response to a shift from human body temperature (37°C) to a temperature that might be found out of doors (15°C). …”
Get full text

Gut microbiota composition and phylogenetic analysis in autism spectrum disorder: a comparative study by Fangtao Xiang, Mei Zhang, Xin Wei, Jiali Chang

“…BackgroundAutism spectrum disorder (ASD) is frequently associated with gastrointestinal (GI) disturbances, implicating the gut microbiota and its metabolites, short-chain fatty acids (SCFAs), in disease pathology via the gut-brain axis. …”
Get full text

Diagnostic value of IL-17 in neurointoxication with mercury by B. G. Michailovna, B. E. Valerevna

“…Over last 20 years, an increased interest was shown for interleukin 17 (IL-17) and its role in a number of inflammatory and autoimmune diseases. However, there is no data on its role in neurointoxication with mercury. …”
Get full text

Evidence that the periaqueductal gray matter mediates the facilitation of panic-like reactions in neonatally-isolated adult rats. by Jeyce Willig Quintino-dos-Santos, Cláudia Janaína Torres Müller, Cristie Setúbal Bernabé, Caroline Azevedo Rosa, Sérgio Tufik, Luiz Carlos Schenberg

“…Most importantly, results implicate the DPAG not only in panic attacks but also in separation-anxious children's predispositions to the late development of PD.…”
Get full text

COMPARATIVE CLINICAL, LABORATORY, AND INSTRUMENTAL EVALUATION OF INTERSTITIAL LUNG CHANGES IN RHEUMATOID ARTHRITIS by D. V. Bestaev, L. A. Bozhyeva, N. O. Nikonorova, S. I. Glukhova, D. E. Karateev, E. L. Nasonov

“…Objective: to study the associations of the data of high-resolution computed tomography (HRCT) and the esti- mate of diffusing lung capacity (DLC) with clinical and laboratory parameters in RA patients with and without ILD. …”
Get full text

Occupational injuries, mental workload and coping strategies among the nursing workforce in the Eastern Region of Ghana: a multi-centre study by Collins Atta Poku, Abital Ayergo Ahulu, Janet Otomo, Doris Hagan, Catherine Kroamah Dwumfour, Joseph Shahadu Issifu, Veronica Dzomeku

“…Descriptive statistics, Pearson moment-product correlations, and regression analysis were used to analyse the data at a statistical significance of 0.05. Results Needle pricks, injuries from sharps, exposure to blood and other body fluids, and back pain and injury from patient handling tasks were shared among participants in the past year. …”
Get full text

Polycystins Expression in Astrocytic Gliomas by Martha Assimakopoulou, Konstantina Soufli, Maria Melachrinou

“…Until recently, the role of <i>PKD1</i> and <i>PKD2</i> has been associated with the pathogenesis of the kidney since mutations in these genes cause autosomal dominant polycystic kidney disease (ADPKD). Recent data implicates polycystins in the pathogenesis of solid tumors. …”
Get full text

Continuous Gastric pH Monitoring in Children Facilitates Better Understanding of Gastroesophageal Reflux Disease: A Prospective Observational Study by Shiva Sharma, Devendra I. Mehta, Nishant Patel, Arun Ajmera, Jeffrey Bornstein, Florence George

“…Exclusions included patients taking acid suppressants prior to the start of this study. The data were analyzed for subjects completing at least 18 h of the study protocol. …”
Get full text

Identification and Characterization of SQUAMOSA Promoter Binding Protein-like Transcription Factor Family Members in <i>Zanthoxylum bungeanum</i> and Their Expression Profiles in R... by Shengshu Wang, Weiming Hu, Xueli Zhang, Yulin Liu, Fen Liu

“…This study used transcriptomic and bioinformatics data to conduct a thorough genomic identification and expression investigation of the <i>ZbSPL</i> gene family. …”
Get full text

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma by Shengchen Lin, Chongbiao Huang, Jianwei Sun, Oana Bollt, Xiuchao Wang, Eric Martine, Jiaxin Kang, Matthew D Taylor, Bin Fang, Pankaj K Singh, John Koomen, Jihui Hao, Shengyu Yang

“…Here, we investigated the role of the DGUOK in the self‐renewal of lung cancer stem‐like cells (CSC). Our data support that DGUOK overexpression strongly correlates with cancer progression and patient survival. …”
Get full text

Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations by Vickram Tejwani, Nirupama Putcha, Han Woo, Chen Liu, David Lafon, Neil E. Alexis, Antoine Azar, R. Graham Barr, Igor Barjaktarevic, Russell P. Bowler, Alejandro Comellas, David J. Couper, Ashraf Fawzy, MeiLan K. Han, Nadia N. Hansel, Robert J. Kaner, Jerry A. Krishnan, Nathaniel Marchetti, Fernando J. Martinez, Jill Ohar, Wanda O’Neal, Victor E. Ortega, Robert Paine III, Tess D. Pottinger, Martin Stämpfli, Lisa Ruvuna, Prescott G. Woodruff, Christine M. Freeman, Yvonne J. Huang, Jeffrey L. Curtis

“…Available BAL microbiome data (n = 107) showed that reduced lung bacterial diversity associated with lower serum IgG, but not with serum IgA, BAL IgA, or BAL IgG concentrations. …”
Get full text