Aberrant expression of CNTRL was associated with poor prognosis, immune response and progression in glioma by Xiaoping Mei, Deyuan Qin, Min Zou, Hongli Teng, Yang Zhai

“…Abstract This study investigated the biological functions and prognostic significance of centromere protein L (CNTRL) in glioma. mRNA expression data and clinical information were obtained from TCGA, CGGA, and an independent cohort of 207 glioma patients. …”
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Vaginal practices among women at high risk of HIV infection in Uganda and Tanzania: recorded behaviour from a daily pictorial diary. by Suzanna C Francis, Kathy Baisley, Shelley S Lees, Bahati Andrew, Flavia Zalwango, Janet Seeley, Judith Vandepitte, Trong T Ao, Janneke van de Wijgert, Deborah Watson-Jones, Saidi Kapiga, Heiner Grosskurth, Richard J Hayes

“…Women were given diaries to record IVP daily for six weeks. Baseline data showed that Ugandan participants had more lifetime partners and transactional sex than Tanzanian participants. …”
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High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration. by Laura Pertl, Sabine Kern, Martin Weger, Silke Hausberger, Markus Trieb, Vanessa Gasser-Steiner, Anton Haas, Hubert Scharnagl, Akos Heinemann, Gunther Marsche

“…<h4>Purpose</h4>High-density lipoproteins (HDL) have long been implicated in the pathogenesis of age-related macular degeneration (AMD). …”
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The Sero-epidemiology of Coxiella burnetii in Humans and Cattle, Western Kenya: Evidence from a Cross-Sectional Study. by Nicola A Wardrop, Lian F Thomas, Elizabeth A J Cook, William A de Glanville, Peter M Atkinson, Claire N Wamae, Eric M Fèvre

“…Questionnaires covering demographic, socio-economic and husbandry information were also administered. These data were linked to environmental datasets based on geographical locations (e.g., land cover). …”
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Abnormal response to chronic social defeat stress and fear extinction in a mouse model of Lynx2-based cholinergic dysregulation by Kristin R. Anderson, Peter J. Rogu, Talulla B. Palumbo, Julie M. Miwa

“…Dysregulation of this system, however, has been implicated in altered anxiety regulation and mood disorders. …”
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Functionally significant, rare transcription factor variants in tetralogy of Fallot. by Ana Töpf, Helen R Griffin, Elise Glen, Rachel Soemedi, Danielle L Brown, Darroch Hall, Thahira J Rahman, Jyrki J Eloranta, Christoph Jüngst, A Graham Stuart, John O'Sullivan, Bernard D Keavney, Judith A Goodship

“…We also analysed Illumina Human 660W-Quad SNP Array data for copy number variants in these genes; none were detected. …”
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Transmissible Viral Proventriculitis in Broiler Chickens from Bosnia and Herzegovina by Jovana Dervović, Šejla Goletić, Alma Šeho-Alić, Senad Prašović, Teufik Goletić, Amer Alić

“…The obtained results represent the first documented data on TVP and the first record of CPNV and GyV3 presence in broiler farms from Bosnia and Herzegovina.…”
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SUMO modification of a heterochromatin histone demethylase JMJD2A enables viral gene transactivation and viral replication. by Wan-Shan Yang, Mel Campbell, Pei-Ching Chang

“…Importantly, JMJD2A has been implicated as an oncogene in various cancers by regulating proliferation. …”
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The impact of dyspepsia on symptom severity and quality of life in adults with headache. by Mei-Ling Sharon Tai, Norbelinda Norhatta, Khean Jin Goh, Foong Ming Moy, Ramanujam Sujarita, Azman Ahmad Asraff, Qin Zhi Lee, Jiun Hoong Ng, Eugene Choon Li Tan, Sanjiv Mahadeva

“…Clinical, psychological and health-related quality of life (HRQOL) data were compared between subjects with headache and controls (non-headache subjects). …”
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Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. by Fabiola Martin, Hannah Castro, Carolyn Gabriel, Adine Adonis, Alexandra Fedina, Linda Harrison, Liz Brodnicki, Maria A Demontis, Abdel G Babiker, Jonathan N Weber, Charles R M Bangham, Graham P Taylor

“…Pathogenesis studies implicate activated T-lymphocytes and cytokines in tissue damage. …”
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PCK1 as a potential hub gene in distinguishing lactate metabolism between rheumatoid arthritis and osteoarthritis by Pengfei Xin, Shaoqiang Pei, Nanshan Ma, Lianbo Xiao

“…This study aims to use Mendelian randomization (MR) to investigate their relationship with lactate and understand the genetic differences in lactate metabolism between them. Methods Genetic data for RA, OA, and lactate metabolism were obtained from GWAS, GEO, and MSigDB databases. …”
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Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. by Karianne Fjeld, Sebastian Beer, Marianne Johnstone, Constantin Zimmer, Joachim Mössner, Claudia Ruffert, Mario Krehan, Christian Zapf, Pål Rasmus Njølstad, Stefan Johansson, Peter Bugert, Fabio Miyajima, Triantafillos Liloglou, Laura J Brown, Simon A Winn, Kelly Davies, Diane Latawiec, Bridget K Gunson, David N Criddle, Munir Pirmohamed, Robert Grützmann, Patrick Michl, William Greenhalf, Anders Molven, Robert Sutton, Jonas Rosendahl

“…<h4>Background</h4>Carboxyl-ester lipase (CEL) contributes to fatty acid ethyl ester metabolism, which is implicated in alcoholic pancreatitis. The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11. …”
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Defining ecotourism for mainstream application and to support sustainable tourism governance by Andrew Torsney, Patrick O'Driscoll, Yvonne M. Buckley

“…We used thematic analysis of 31 semi‐structured interviews from cohorts of tourism (n = 15) and environmental (n = 16) professionals in Ireland. Data saturation was achieved for both cohorts. Participants identified that nature is often viewed as a tourism product and, without sustainable management practices, the long‐term economic viability of nature‐based tourism is questionable. …”
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The Ankle-brachial Index as a Predictor of Multivess el Coronary Disease in Patients with Acute Coronary Syndrome and Peripheral Arterial Disease by Tessa Negrín Valdés, Ailed Elena Rodríguez Jiménez, Raikel Fardales Rodríguez, Luis Alberto Castellanos Gallo, José Carlos Meneses Jiménez, Magda Alina López Callejas

“…<br /><strong>Method:</strong> an analytical observational study was carried out that included all the patients discharged from the coronary care unit of the Camilo Cienfuegos Gorriarán Provincial University Hospital, of the Sancti Spíritus province, in the period from March 1, 2011 to February 30 of 2018, with a diagnosis of acute coronary syndrome, with and without ST segment elevation. Clinical data, ankle-brachial index, echocardiography and coronary angiography were collected and the prognostic implication of the index in disease was determined through a classification tree with the variables included in the binary logistic regression model.…”
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Evaluation of common NLRP3 Q703K variant in pediatric patients with autoinflammatory disease: CAPS and PFAPA by Yasemin Kendir-Demirkol, Laura A Jenny, Ferhat Demir, Betül Sözeri

“…For the 68 patients carrying the only Q703K variant, their clinical and demographic information was evaluated. Genetic data from 1461 patients without autoinflammatory symptoms were used as the control group. …”
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Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2 by Walter Witke, Marina Di Domenico, Laura Maggi, Alessia Di Nardo, Valentin Stein, Pietro Pilo Boyl

“…PFN2 was also found in protein complexes with proteins that have been implicated in or are causative of autism spectrum disorder.MethodsWe employ a genetically engineered knock-out mouse line for Pfn2 that we previously generated to study the mouse social, vocal and motor behavior in comparison to wild type control littermates. …”
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Basal ganglia output (entopeduncular nucleus) coding of contextual kinematics and reward in the freely moving mouse by Anil K Verma Rodriguez, Josue O Ramírez-Jarquin, Román Rossi-Pool, Fatuel Tecuapetla

“…The rodent EPN has been implicated in reward and value coding whereas the primate analog internal Globus Pallidus has been found to be modulated by some movements and in some circumstances. …”
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Marine Bioactive Molecules as Inhibitors of the Janus Kinases: A Comparative Molecular Docking and Molecular Dynamics Simulation Approach by Emad A. Ahmed, Salah A. Abdelsalam

“…The intracellular tyrosine kinases family, Janus kinases (JAKs, includes JAK1, JAK2, and JAK3), is implicated in the pathogenesis of RA through regulating several cytokines and inflammatory processes. …”
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A systematic review of risks associated with environmental change on refractive and non-refractive ocular health: Special focus on Africa by Emmanuel Elochukwu Okenwa-Vincent, Nathan Riel, Linda S. Pagani

“…Climate change exacerbated by rising temperatures and UV radiation was implicated in 39% of studies, with a specific focus on its relation to cataracts (5·2%) and retinal-related disorders (10·4%). …”
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Development and validation of a prognostic model for efferocytosis-associated genes in cervical squamous cell carcinoma by Lan-lan Ma, Li-juan Zhao, Ying Zhang, Yan-fen Ma, Qi Shang, Xiao-li Liu

“…However, their prognostic relevance in cervical squamous carcinoma (CESC) is currently unclear. Methods Data from the Cancer Genome Atlas (TCGA) database were used to create the TCGA-CESC cohort. …”
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