CPT1C-positive cancer-associated fibroblast facilitates immunosuppression through promoting IL-6-induced M2-like phenotype of macrophage by Rongyuan Wei, Junquan Song, Hongda Pan, Xiaowen Liu, Jianpeng Gao

“…Cancer-associated fibroblasts (CAFs) exhibit remarkable phenotypic heterogeneity, with specific subsets implicated in immunosuppression in various malignancies. …”
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Molecular Docking of Key Compounds from Acacia Honey and <i>Nigella sativa</i> Oil and Experimental Validation for Colitis Treatment in Albino Mice by Mehwish Bibi, Irfan Baboo, Hamid Majeed, Santosh Kumar, Maximilian Lackner

“…Molecular docking studies were conducted to identify the binding affinities and interaction mechanisms between the bioactive compounds in AH and NSO and proteins implicated in colitis, such as those involved in inflammation and oxidative stress pathways. …”
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Investigating the impact of microcalcification size and volume on collagenous matrix and tissue mechanics using a tissue-engineered atherosclerotic cap model by Imke L. Jansen, Deniz Șahin, Frank J. H. Gijsen, Frank J. H. Gijsen, Eric Farrell, Kim van der Heiden

“…Microcalcification characteristics, such as particle size and volume fraction, have been implicated to affect cap stresses. However, the effect of these characteristics on tissue mechanics within a collagenous matrix, has not been investigated experimentally. …”
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Simvastatin modulates osteogenic differentiation in Stem Cells isolated from Apical Papilla by Paak Rewthamrongsris, Suphalak Phothichailert, Uraiwan Chokechanachaisakul, Prim Janjarussakul, Chatvadee Kornsuthisopon, Lakshman Samaranayake, Thanaphum Osathanon

“…Conclusions Simvastatin enhances osteogenic differentiation in SCAPs, potentially via TGF-β signalling, implicating its potential role as an adjunctive molecule in dental pulp healing and regeneration in vital pulp treatment approaches. …”
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The role of oxidative stress-related genes in idiopathic pulmonary fibrosis by Wenfei Zhao, Bing Bai, Hongyun Li, Yonghai Feng, Jun Sun, Yang Fang, Pengyuan Zheng, Guojun Zhang

“…We used transcriptome sequencing data (GSE70866) and oxidative stress-related genes from GeneCards. …”
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Genome wide detection of CNV and their association with body size in Danzhou chickens by Xinfeng Xie, Liguang Shi, Guanyu Hou, Ziqi Zhong, Ziyi Wang, Deyou Pan, Wei Na, Qian Xiao

“…Furthermore, we discovered several significantly associated CNV segments with body size traits located proximal to genes such as IHH, WNT6, WNT10A, LPR4, FZD2, WNT7B, and GNAS that have been extensively implicated in skeletal development and growth processes. …”
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Deciphering bidirectional causal links between oxidative stress and lung cancer risk through Mendelian randomization by XueLian Chen, JianRong Zeng, FengYun Cao, Jun Cai, Xin Ma, ChangYu Pu

“…Methods A two-sample bidirectional MR approach was used to assess causal effects of 16 OSIBs on lung cancer subtypes (small cell lung cancer, squamous cell carcinoma, and adenocarcinoma) and vice versa. Genetic data were derived from large-scale genome-wide association studies in European populations. …”
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Comprehensive analysis of cuproptosis and m6A-Target gene signatures for diagnostic significance and immune microenvironment characterization in polycystic ovary syndrome by Yang Liu, Yujie Gengxiao, Yanzhi Wu, Yan Li, Xi Hu, Jia Bie

“…This study aimed to construct integrated diagnostic signatures based on cuproptosis- and m6A-related gene expression. Transcriptome data from GEO datasets (GSE95728, GSE106724, GSE114419) comprising 28 PCOS and 22 control granulosa cell samples were merged and batch-corrected. …”
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Factors affecting performance excellence in Indonesian state-owned enterprises by Muhammad Iqbal, Yudi Azis, Sucherly, Umi Kaltum

“…This paper aims to explore the factors affecting performance excellence in Indonesian SOEs, namely business environment and innovation capability through business strategy. Data were obtained from questionnaires distributed to 100 directors/managers representing SOEs in 12 clusters. …”
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The Targets of Deep Brain Stimulation in the Treatment of Treatment‐Resistant Depression: A Review by Jianyang Dong, Mengying Dai, Zinan Guo, Ting Xu, Fangming Li, Jianjun Li

“…., SCG, NAcc) and stimulation parameter optimization data. Examining the therapeutic mechanisms of DBS, the neuroanatomical targets utilized, and the clinical outcomes observed. …”
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Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia by Fatemeh Manafzadeh, Behzad Baradaran, Seyed Gholamreza Noor Azar, Kamran Javidi Aghdam, Reza Dabbaghipour, Asghar Shayannia, Soudeh Ghafouri-Fard

“…The mechanism and etiology of schizophrenia are extremely complex and multiple signaling pathways recruit genes implicated in the etiology of this disease. While the role of Wnt/β-catenin signaling in this disorder has been verified, the impact of long noncoding RNAs (lncRNAs) associated with this pathway has not been studied in schizophrenia. …”
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New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology by Monika Mrozowska, Tomasz Górnicki, Mateusz Olbromski, Aleksandra Izabela Partyńska, Piotr Dzięgiel, Agnieszka Rusak

“…Tetraspanins have been implicated in cancer progression and have been shown to have multiple binding partners and to promote cancer progression and metastasis. …”
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Endangered Pinto/Northern Abalone (Haliotis kamtschatkana) are Panmictic Across Their 3700 km Range Along the Pacific Coast of North America by J. L. Dimond, J. V. Bouma, F. Lafarga‐De la Cruz, K. J. Supernault, T. White, D. A. Witting

“…Outlier analysis did not identify consensus loci implicated in adaptive variation, suggesting limited adaptive differentiation. …”
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Salivary Basic Fibroblast Growth Factor Expression: A Gateway to Early Detection of Oral Submucous Fibrosis by Shafaq Saeed Roghay, Afifa Razi, Hira Batool, Saima Akram Butt, Fizza Abidi

“… Background: Basic fibroblast growth factor (bFGF) is a cytokine, mainly secreted by fibroblast cells which are implicated as a source of extracellular matrix in fibrotic regions. …”
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‘Why do GPs want to come here?’: residents’ intentions to register with new-coming GPs in a disadvantaged neighbourhood in Copenhagen with a GP shortage: a qualitative study by Stine Dandanell Garn, Sarah Fredsted Villadsen, Charlotte Glümer, Kristina Johansen, Ulla Christensen

“…Objective and intervention To explore contextual factors influencing residents’ intentions to register with one of the new-coming GPs established as a result of a municipally driven GP coverage intervention in a disadvantaged neighbourhood in Copenhagen with a GP shortage.Design A qualitative study design informed by realist methodology was used to conduct the study. Data were obtained through a survey with residents (n = 67), two focus group interviews with residents (n = 21), semi-structured interviews with the project- and local community stakeholders (n = 8) and participant observations in the neighbourhood. …”
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Association between vitamin D deficiency, inflammatory markers, and knee osteoarthritis: a retrospective study by Khaled Swailem, Mohammed Sadhan, Gehad Abdullah Al-Mashramah, Mohammed Ali Saghir

“…Vitamin D deficiency has been implicated in OA, but its role in disease severity and associated symptoms remains unclear. …”
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Talus Position Correlates With Dorsiflexion Range of Motion Following a Lateral Ankle Sprain: A Cross‐Sectional Study by Takeshi Toyooka, Eiki Tsushima, Shiro Sugiura, Yukio Matsushita, Akito Takata, Yasutaka Omori, Yuzuru Okamoto, Satoru Nishikawa

“…Methods We reviewed 36 medical records and MRI images of outpatients diagnosed with a lateral ankle sprain. The data recorded were weight‐bearing lunge test (WBLT), talus alignment, and ATFL tear. …”
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A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans. by Sarah A Pendergrass, Steven Buyske, Janina M Jeff, Alex Frase, Scott Dudek, Yuki Bradford, Jose-Luis Ambite, Christy L Avery, Petra Buzkova, Ewa Deelman, Megan D Fesinmeyer, Christopher Haiman, Gerardo Heiss, Lucia A Hindorff, Chun-Nan Hsu, Rebecca D Jackson, Yi Lin, Loic Le Marchand, Tara C Matise, Kristine R Monroe, Larry Moreland, Kari E North, Sungshim L Park, Alex Reiner, Robert Wallace, Lynne R Wilkens, Charles Kooperberg, Marylyn D Ritchie, Dana C Crawford

“…We further annotated these PheWAS-identified variants using publicly available functional data and local genetic ancestry. Amongst our novel findings is SPARC rs4958487, associated with increased glucose levels and hypertension. …”
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Association of HLA-DRA expression with prognosis and tumor microenvironment in clear cell renal cell carcinoma by Shu-Xin Qu, Xiang Wang, Wan-Ru Han, Yu-Chen Ge, Bei Feng, Hai-Ying Guo, Xiao-Chen Sun, Kai Wang, Rui Cui

“…Abstract Recombinant human leukocyte antigen class II histocompatibility antigen (HLA-DRA) has been implicated in the development of various cancers, but its specific role in clear cell renal cell carcinoma (ccRCC) remains unclear.Tissue samples and clinicopathological data from 78 ccRCC patients were collected. …”
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Personality Traits, Clinical Characteristics, and Health-Related Quality of Life of Patients with Hypertension in a Primary Hospital in Ghana by Irene A. Kretchy, Franklin Acheampong, Jane Laryea, Joseph Osafo, Emmanuel Asampong, Erica Dickson

“…A hospital-based cross-sectional quantitative study was conducted in a sample of 331 individuals with hypertension. Data on sociodemographic characteristics, clinical information, personality traits, and HRQoL were obtained from participants using an interviewer administered questionnaire. …”
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