Alzheimer's Prevention Initiative Generation Program: Development of an APOE genetic counseling and disclosure process in the context of clinical trials by Carolyn M. Langlois, Angela Bradbury, Elisabeth M. Wood, J. Scott Roberts, Scott Y.H. Kim, Marie‐Emmanuelle Riviere, Fonda Liu, Eric M. Reiman, Pierre N. Tariot, Jason Karlawish, Jessica B. Langbaum

“…Data assessing participant safety and psychological well‐being before and after APOE disclosure are still being collected and will be presented in a future publication.…”
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Analysis of the serum proteome profile of wild stump-tailed macaques (Macaca arctoides) seropositive for Zika virus antibodies in Thailand by Pakorn Ruengket, Sittiruk Roytrakul, Daraka Tongthainan, Kobporn Boonnak, Kanokwan Taruyanon, Bencharong Sangkharak, Wirasak Fungfuang

“…ZIKV is transmitted by Aedes mosquitoes, and it has been implicated in various neurological conditions associated with fetal brain development. …”
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Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity by Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu, Jianqing Wu

“…Our study thus identifies a potential mechanism responsible for altered Treg function in the context of immune aging, and also implicates SOAT2 as a potential target for tumor immunotherapy.…”
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Stage-Dependent Fibrotic Gene Profiling of WISP1-Mediated Fibrogenesis in Human Fibroblasts by Kirti Singh, Marta Witek, Jaladhi Brahmbhatt, Jacquelyn McEntire, Kannan Thirunavukkarasu, Sunday S. Oladipupo

“…Here, for the first time, using NanoString^® technology, we identified a novel WISP1-associated profibrotic gene signature and molecular pathways potentially involved in the initiation and progression of fibrosis in primary human dermal and lung fibroblasts from both healthy individuals and IPF patients. Our data demonstrate that WISP1 is upregulated in IPF-lung fibroblasts as compared to healthy control. …”
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Informal Settlement Characterization and Socio-Economic Vulnerability Assessment in Kolkata Metropolitan City, India by Shravani Banerjee, Diksha Diksha, Alisha Prasad, Amit Kumar

“…The study provides an insight into urban areas with special reference to informal settlements and necessitates the implication of effective policy for poverty alleviation. …”
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Conflict management strategies: the role of personality and specific social relation beliefs in Serbia and Italy by Džamonja Ignjatović Tamara, Petrović Danijela S., Kosić Ankica, Dimoski Jana, Knežević Goran

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Exploring the hepatic-ophthalmic axis through immune modulation and cellular dynamics in diabetic retinopathy and non-alcoholic fatty liver disease by Shuyan Zhang, Jiajun Wu, Leilei Wang, Cheng Zhang, Yinjian Zhang, Yibin Feng

“…This study leverages systematic analysis to elucidate the complex cross-talk and communication pathways among diverse cell populations implicated in the pathogenesis of DR and NAFLD. Methods Single-cell RNA sequencing data for proliferative diabetic retinopathy (PDR) and NAFLD were retrieved from the Gene Expression Omnibus (GEO) database. …”
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Unlocking the therapeutic potential of unexplored phytocompounds as hepatoprotective agents through integration of network pharmacology and in-silico analysis by Pranali A. Jadhav, Asha B. Thomas, Mohsin K. Pathan, Somdatta Y. Chaudhari, Ravindra D. Wavhale, Sohan S. Chitlange

“…The Gene Ontology, Kyoto Encyclopedia of Genes and Genome data were compiled and enrichment analysis was performed using the DAVID database. …”
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BRD4 as the key lactylation related gene in heart failure identified through bioinformatics analysis by Kaiyuan Li, Lingyu Han, Xiaowen Wang, Zhipeng Zheng, Min Sha, Jun Ye, Li Zhu

“…Immune cell infiltration and single-cell data analyses indicated that BRD4 exhibits a strong association with immune cells, including mast cells, T cells, and macrophages, and demonstrates significantly elevated expression in these immune cells as well as in cardiomyocytes. …”
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ELK4 induced upregulation of HOMER3 promotes the proliferation and metastasis in glioma via Wnt/β-catenin/EMT signaling pathway by Furong Wang, Hui Zhou, Yu Tian, Xiaoling Wang, Youcai Huang, Yanyang Tu, Liwen Li, Haining Zhen

“…The HOMER family, consisting of HOMER1, HOMER2, and HOMER3, has been implicated in various cancers, yet their specific roles in glioma remain inadequately understood. …”
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Integrated Transcriptomic and Proteomic Analysis Reveals Differential Gene and Protein Expression and Signaling Pathways During a 20 Km Endurance Exercise and Recovery in Mongolian... by Xinzhuang Zhang, Yuanyi Liu, Wei Ma, Lianhao Li, Dongyi Bai, Manglai Dugarjaviin

“…By integrating the transcriptomic and proteomic data, we were able to pinpoint overlapping DEGs/DEPs and implicate crucial signaling pathways, including the HIF-1 signaling pathway and glycolysis, in the molecular response of Mongolian horses to exercise. …”
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Signs and symptoms of vulval lichen sclerosus in children and adolescents: a scoping review protocol by Alyssa Grimshaw, Anna Torres, Ewelina Grywalska, Alla Vash-Margita, Joanna Bartosińska, Joanna Brodowska, Joanna Pycka

“…Introduction Paediatric vulval lichen sclerosus (VLS) is a chronic disease with distressing symptoms and severe consequences when left untreated. Majority of existing data on pathophysiology and treatment is based on studies conducted among adult patients. …”
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Growth hormone treatment in Prader-Willi syndrome patients: systematic review and meta-analysis by Caroline de Gouveia Buff Passone, Ruth Rocha Franco, Simone Sakura Ito, Evelinda Trindade, Michel Polak, Durval Damiani, Wanderley Marques Bernardo

“…The databases used were MEDLINE, Embase and Cochrane Central.Results In 16 RCTs and 20 NRCTs selected, the treated group had an improvement in height (1.67 SD scores (SDS); 1.54 to 1.81); body mass index z-scores (−0.67 SDS; −0.87 to −0.47) and fat mass proportion (−6.5% SDS; −8.46 to −4.54) compared with the control group. Data about cognition could not be aggregated.ConclusionBased on high quality evidence, rhGH treatment favoured an improvement of stature, body composition and body mass index, modifying the disease’s natural history; rhGH treatment may also be implicated in improved cognition and motor development in PWS patients at a young age.Ethics and dissemination The current review was approved by the ethical committee of our institution. …”
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Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation by Zhuo Duan, Wen Zhao, Yixin Tong, Volker A. Coenen, Máté D. Döbrössy

“…In addition, clinical implication of the data is that unilateral stimulation had bilateral consequences on the gene expression, although the physiological and functional sequelae of this are yet unknown.…”
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CLN3 disease disrupts very early postnatal hippocampal maturation by Jeet B. Singh, Devin M. Burris, Sangeetha Bhuyan, Tegan Thurston, Anna Oschmann, Connor Jankowski, Wenyun Lu, Joshua D. Rabinowitz, Rebecca C. Ahrens-Nicklas

“…This aberrant development resulted in abnormal in vivo circuit function, with pathologic slowing observed on EEG recordings at p30. Collectively these data underscore the potential link between pathologic metabolism of GPI and functional defects in CLN3 disease. …”
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Isolation and Preliminary X-Ray Crystallographic Characterisation of the Periplasmic Ligand-Binding Domain of the Chemoreceptor Tlp3 from <i>Campylobacter hepaticus</i> by Diana Kovaleva, Yue Xin, Mohammad F. Khan, Yu H. Chin, Anna Roujeinikova

“…The <i>Campylobacter</i> genus includes many pathogenic species, with <i>Campylobacter hepaticus</i> primarily implicated in spotty liver disease in poultry. Chemotaxis is one of the well-established mechanisms of pathogenesis of <i>Campylobacter</i>. …”
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Double-negative T cells in pediatric rheumatic diseases by Dimitri Poddighe, Tilektes Maulenkul, Kuanysh Dossybayeva, Gulsamal Zhubanova, Zaure Mukusheva, Lyudmila Akhmaltdinova

“…Double-negative (CD4-CD8-) T (DNT) cells have been implicated in autoimmune lymphoproliferative syndrome (ALPS), where their expansion inside the circulating pool of T cells represents a diagnostic criterion. …”
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Spontaneous Adverse Drug Reaction Reporting of Congenital Malformations: A Danish National Register Study by Ulrik Lausten-Thomsen, Rasmus Huan Olsen, Michael Christiansen, Paula L. Hedley, Ida Marie Heerfordt, Jon Trærup Andersen, Christina Gade

“…Eighty-five different drugs from 58 ATC codes were implicated. Only three diagnoses were reported in five or more children. …”
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Bony Union and Flap Resorption in Cranioplasty with Autologous Subcutaneous Pocket Preserved Bone Flap: Early Report on an Ambidirectional CT Scan-Based Study by Sudip Kumar Sengupta, Andrews Navin Kumar, Vinay Maurya, Harish Bajaj, Krishan Kumar Yadav, Ashwath K. G., Dharamjeet Singh Faujdar

“…Conclusion Ours is a study with a small sample size, unable to put its weight on any side, but can surely add some more data to help the Neurosurgeons in choosing the best for their patients.…”
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Genome-wide identification and gene expression pattern analysis of the carotenoid cleavage oxygenase gene family in Fagopyrum tataricum by Huan Li, Xin Yao, Ailing He, Guoxing Xue, Haizhu Yang, Yu Fan, Sanwei Yang, Jingjun Ruan

“…Abstract Background Carotenoid cleavage oxygenases (CCOs) convert carotenoids into volatile aromatic compounds implicated in plant growth and development. They affect the synthesis of hormones, including abscisic acid (ABA) and strigolactone (SL). …”
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