Exploring the desire of Filipino engineering professionals to work abroad using the ECT-TPB Theory by Rex Revian A. Guste, Ardvin Kester S. Ong, John Francis T. Diaz, Maela Madel L. Cahigas, Ma. Janice J. Gumasing

“…The study revealed that confirmation indirectly affected behavioral intentions more than expectation, implicating to be the driver of satisfaction among Filipino engineering professionals interested in working overseas. …”
Get full text

MiR-195 Inhibits Tumor Growth and Metastasis in Papillary Thyroid Carcinoma Cell Lines by Targeting CCND1 and FGF2 by Yali Yin, Shubin Hong, Shuang Yu, Yanrui Huang, Shuwei Chen, Yujie Liu, Quan Zhang, Yanbing Li, Haipeng Xiao

“…MicroRNA (miRNA) dysregulation was commonly seen in papillary thyroid carcinoma (PTC), and miR-195 was verified to be downregulated in PTC by the large data set analysis from The Cancer Genome Atlas (TCGA). …”
Get full text

p75NTR Modulation Reduces Oxidative Stress and the Expression of Pro-Inflammatory Mediators in a Cell Model of Rett Syndrome by Michela Varone, Giuseppe Scavo, Mayra Colardo, Noemi Martella, Daniele Pensabene, Emanuele Bisesto, Andrea Del Busso, Marco Segatto

“…Emerging evidence highlights that the p75 neurotrophin receptor (p75NTR) is implicated in the regulation of oxidative stress (OS) and inflammation. …”
Get full text

Optimizing supply chain performance through sustainable manufacturing practices and capabilities in emerging markets: an integrated linear (PLS-SEM) and non-linear (fsQCA) approach by Jewel Rana, Md Zubair Ahmad, Mohammad Fakhrul Islam, Md Nazmul Islam Jihad, Md. Rashed, Mohammed Kamruzzaman

“…The results show that management capability, data-driven culture, supply chain management, and sustainable manufacturing process significantly impact supply chain performance using the PLS-SEM model. …”
Get full text

Synergetic evolution of energy-economy-environment-society system: A case study of Chengdu-Chongqing urban agglomeration, China by Min An, Wei Xu, Xiaoyan Wang, Weijun He, Xue Fang, Mengfei Song, Bei Wang

“…This paper uses the statistical and nighttime light data of Chengdu-Chongqing urban agglomeration (CCUA) from years 2006–2020. …”
Get full text

Neuroplasticity and Mechanisms of Action of Acute and Chronic Treatment with Antidepressants in Preclinical Studies by Gilberto Uriel Rosas-Sánchez, León Jesús Germán-Ponciano, Gabriel Guillen-Ruiz, Jonathan Cueto-Escobedo, Ana Karen Limón-Vázquez, Juan Francisco Rodríguez-Landa, César Soria-Fregozo

“…Studies included had to investigate antidepressant effects experimentally, with full-text access, while excluding those that did not. Data extraction focused on study design, findings, and relevance to understanding treatment differences. …”
Get full text

Structural insights into retinoic acid receptor activation and selective modulators by Yining Song, Wenrui Zhao, Xuan Huang, Lai Wei, Jingyi Han, Jiayun Hou, Min Li, Xin Cao

“…The potential for developing selective RAR modulators is highlighted, along with the need for comprehensive structural data to enhance our understanding of RAR functions in disease contexts. …”
Get full text

Distinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica. by Rays H Y Jiang, Irene de Bruijn, Brian J Haas, Rodrigo Belmonte, Lars Löbach, James Christie, Guido van den Ackerveken, Arnaud Bottin, Vincent Bulone, Sara M Díaz-Moreno, Bernard Dumas, Lin Fan, Elodie Gaulin, Francine Govers, Laura J Grenville-Briggs, Neil R Horner, Joshua Z Levin, Marco Mammella, Harold J G Meijer, Paul Morris, Chad Nusbaum, Stan Oome, Andrew J Phillips, David van Rooyen, Elzbieta Rzeszutek, Marcia Saraiva, Chris J Secombes, Michael F Seidl, Berend Snel, Joost H M Stassen, Sean Sykes, Sucheta Tripathy, Herbert van den Berg, Julio C Vega-Arreguin, Stephan Wawra, Sarah K Young, Qiandong Zeng, Javier Dieguez-Uribeondo, Carsten Russ, Brett M Tyler, Pieter van West

“…S. parasitica possesses one of the largest repertoires of proteases (270) among eukaryotes that are deployed in waves at different points during infection as determined from RNA-Seq data. In contrast, despite being capable of living saprotrophically, parasitism has led to loss of inorganic nitrogen and sulfur assimilation pathways, strikingly similar to losses in obligate plant pathogenic oomycetes and fungi. …”
Get full text

Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…These triggers should be transparent to the public, validated, and updated over time with evolving data. These automatic triggers would prevent confusion, inconsistent guidelines, and inequitable contingency allocation at the hands of distressed providers when crisis standards are needed. …”
Get full text

A Novel Transcription Factor of Regulating Ag-8 Biocontrol to Grapevine Crown Gall by Shiyu Li, Yaping Zhang, Zhenxing Liu, Yilin Gu, Yue Bi, Jianyu Yang, Weiwei Yu, Zhuoran Li, Yuanhong Wang

“…Therefore, <i>araH</i> may be implicated as a pivotal target gene of <i>ata</i> in modulating the biocontrol capability of Ag-8. …”
Get full text

Identification and characterization of new structured RNA classes in plants by Maximilian Sack, Maren Reinhardt, Rica Burgardt, Philipp Berg, Julia Bauer, Andreas Wachter, Zasha Weinberg

“…Other approaches of finding regulatory RNAs in plants might thus be needed, and more available genomic or transcriptomic data might improve the quality and quantity of promising candidates.…”
Get full text

Hippocampal volumes in UK Biobank are associated with APOE only in older adults by Ariya Chaloemtoem, Vera Thornton, Yoonhoo Chang, Andrey P. Anokhin, Michaël E. Belloy, Janine Bijsterbosch, Brian A. Gordon, Sarah M. Hartz, Laura J. Bierut

“…Abstract INTRODUCTION The hippocampus atrophies with age and is implicated in neurodegenerative disorders including Alzheimer's disease (AD). …”
Get full text

Relationship between Hand Eczema Severity and Occupational Stress: A Cross-Sectional Study by Meriam Hafsia, Imene Kacem, Olfa El Maalel, Maher Maoua, Aicha Brahem, Haifa Aroui, Sana El Guedri, Houda Kalboussi, Souhail Chatti, Najib Mrizek

“…Stress has been recently implicated as a contributing factor of hand eczema (HE) severity. …”
Get full text

Genetic insights into alcohol-associated liver disease: integrative transcriptome-wide analysis identifies novel susceptibility genes by Qianchang Wang, Zhe Wang, Minzhe Hu, Fangfeng Liu, Fangfeng Liu, Zhengjian Wang

“…HSD17B13 may reduce ALD risk via lipid metabolism and redox balance, while AFF1 is implicated in transcription regulation. C4orf36 requires further study. …”
Get full text

CCL3 correlates with ferroptosis in intervertebral disc degeneration and its prognostic significance by He Chen, Peng Xu, Leijing Mao, Yicong Wang, Zian Feng, Zhongxin Wang, Cailiang Shen, Yuanhong Xu

“…Single-cell sequencing data were acquired from the TCGA database, and a range of bioinformatics methods were employed for comprehensive analysis. …”
Get full text

Transcriptomic-based analysis of endometrial tissues from adenomyosis patients reveals significant inflammation biomarkers: A bioinformatics study by Marni Sianturi, Alauddin Syaifulanwar, Darmawi Darmawi, Wirawan Adikusuma, Lalu Muhammad Irham, Muhammad Yusuf, Rifia Tiara Fani, Febriani Febriani

“…Subsequently, pathways implicated in adenomyosis were analyzed through the Kyoto Encyclopedia of Genes and Genomes and gene ontology. …”
Get full text

SEgene identifies links between super enhancers and gene expression across cell types by Norio Shinkai, Ken Asada, Hidenori Machino, Ken Takasawa, Satoshi Takahashi, Nobuji Kouno, Masaaki Komatsu, Ryuji Hamamoto, Syuzo Kaneko

“…Super-enhancers have been implicated in oncogenesis, and their identification is achievable through histone mark chromatin immunoprecipitation followed by sequencing data using existing analytical tools. …”
Get full text

Serum <i>p</i>-Cresyl Sulfate Is Independently Associated with Aortic Stiffness in Non-Dialysis Chronic Kidney Disease Patients by Yahn-Bor Chern, Ken Lee Chia, Chin-Hung Liu, Yu-Li Lin, Jen-Pi Tsai, Bang-Gee Hsu

“…<i>p</i>-Cresyl sulfate (PCS), a gut-derived uremic toxin with proinflammatory and cytotoxic effects, has been implicated in cardiovascular injuries among patients with chronic kidney disease (CKD). …”
Get full text

Clinical Profile and Treatment Outcome of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Hospital of Nepal by Anupa Khadka, Punam Mishra, Laxman Chapagain, Manisha Gartaula, Pooja Gupta, Dwarika Prasad Shrestha

“…Due to its rarity and severe acute nature, there is limited data from controlled trials. This study seeks to contribute to the existing knowledge on the etiology and treatment outcomes of SJS/TEN. …”
Get full text

From rare to recognized: enhanced detection uncovers Cryptosporidium endemicity and species diversity in Denmark by Tine Graakjær Larsen, Steen Ethelberg, Hans Linde Nielsen, Gitte Nyvang Hartmeyer, Lene Nielsen, Mike Zangenberg, Jonas Kähler, Jørgen Harald Engberg, Christen Rune Stensvold

Get full text