The Genetic Puzzle of the Stress-Induced Cardiomyopathy (Takotsubo Syndrome): State of Art and Future Perspectives by Domenico Lio, Letizia Scola, Giusi Irma Forte, Loredana Vaccarino, Manuela Bova, Patrizia Di Gangi, Giorgia Santini, Daniela di Lisi, Cristina Madaudo, Giuseppina Novo

“…We conclude that innovative approaches based on data-mining algorithms and nonlinear analytic methods applied to large patient datasets may be instrumental in resolving the genetic complexity of TS.…”
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Mapping early corpus callosum development to identify neurodevelopmental risk by Boyang Mao, Hongxi Zhang, Haitao Wang, Zhi Yang

“…This study investigated early childhood corpus callosum development, a critical process for cognitive maturation and implicated in Autism Spectrum Disorder (ASD), using sex-specific growth curve models. …”
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The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells by Ludovica Altieri, Michela Damizia, Paola Rovella, Vincenzo Costanzo, Morena Mancini, Patrizio Di Micco, Matteo Marzi, Daniela Trisciuoglio, Veronica Morea, Patrizia Lavia

“…Furthermore, induction of importin beta overexpression influences CENP-F at two levels: it alters CENP-F mitotic localisation, promoting its accumulation at spindle poles and decreasing its association with kinetochores, and also causes its persistence in the late mitotic window in which CENP-F normally disappears, in a process that requires microtubule integrity and dynamics. These data implicate therefore importin beta in spatial and temporal control of CENP-F during mitosis, and uncover a functional interplay between CENP-F’s ability to regulate mitotic microtubules and, in turn, a protective role of microtubules against CENP-F premature ubiquitination.…”
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Targetable Brg1‐CXCL14 axis contributes to alcoholic liver injury by driving neutrophil trafficking by Nan Li, Hong Liu, Yujia Xue, Zheng Xu, Xiulian Miao, Yan Guo, Zilong Li, Zhiwen Fan, Yong Xu

“…Finally, a positive correlation between Brg1 expression, CXCL14 expression, and neutrophil infiltration was detected in ALD patients. In conclusion, our data provide proof‐of‐concept for targeting the Brg1‐CXCL14 axis in ALD intervention.…”
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Prenatal substance exposure and infant neurodevelopment: a review of magnetic resonance imaging studies by Leela Shah, Leela Shah, Christy D. Yoon, Alessandra M. LaJeunesse, Lilly G. Schirmer, Emma W. Rapallini, Elizabeth M. Planalp, Douglas C. Dean, Douglas C. Dean, Douglas C. Dean

“…Particular attention was given to studies that paired infant MRI data with developmental outcomes. Existing research has implicated cortical and sub-cortical gray and white matter regions across substance exposures, with associations between MRI findings and developmental outcomes in infancy. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Accuracy data were extracted on a case-by-case basis due to reporting differences. …”
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Associations of Haplotypes Upstream of IRS1 with Insulin Resistance, Type 2 Diabetes, Dyslipidemia, Preclinical Atherosclerosis, and Skeletal Muscle LOC646736 mRNA Levels by Selma M. Soyal, Thomas Felder, Simon Auer, Hannes Oberkofler, Bernhard Iglseder, Bernhard Paulweber, Silvia Dossena, Charity Nofziger, Markus Paulmichl, Harald Esterbauer, Franz Krempler, Wolfgang Patsch

“…The genomic region ~500 kb upstream of IRS1 has been implicated in insulin resistance, type 2 diabetes, adverse lipid profile, and cardiovascular risk. …”
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Transcriptome analysis reveals that regulation network of the genes related to unique double flowers in tropical viviparous water lily by Qun Su, Min Tian, Hongyan Wang, Zhanwen Huang, Muhammad Awais, Xiaoqing Xu, Lingyun Wang, Zhongxiong Lai, Zhaoyang Bu

“…Additionally, our data suggest potential involvement of other transcription factor families including WOX, NAC, TCP, MYB, and bHLH in this specialized floral morphogenesis. …”
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An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo by Giorgia Gazzaroli, Camilla Tavani, Serena Filiberti, Maria Luisa Massardi, Marta Turati, Giulia Garattini, Thomas S. Peat, Giuseppe Pieraccini, Andrea Angeli, Claudiu T. Supuran, Fabrizio Carta, Arianna Giacomini, Roberto Ronca

“…Abstract Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic and stem-like features, drug resistance and recurrence. …”
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Metachronous mucinous breast carcinoma and mucinous pancreatic cystadenoma in a patient with metabolic comorbidities; case report and a literature review by Teodora Gabriela Alexescu, Irina Obada, Angela Cozma, Mirela Georgiana Perne, Olga Hilda Orășan, Vasile Negrean, Iacob Domșa, Victoria Ruta, Simina Felicia Țărmure

“…Yet, current data are insufficient to provide recommendations for the screening of malignant mucinous tumors in subjects with significant cardiometabolic risk factors.…”
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Clusterin knockdown sensitizes prostate cancer cells to taxane by modulating mitosis by Nader Al Nakouzi, Chris Kedong Wang, Eliana Beraldi, Wolfgang Jager, Susan Ettinger, Ladan Fazli, Lucia Nappi, Jennifer Bishop, Fan Zhang, Anne Chauchereau, Yohann Loriot, Martin Gleave

“…While CLU inhibition potentiates activity of taxanes and other anti‐cancer therapies in preclinical models, progression to treatment‐resistant disease still occurs implicating additional compensatory survival mechanisms. …”
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Aβ-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer’s disease by Vibhavari Aysha Bansal, Jia Min Tan, Hui Rong Soon, Norliyana Zainolabidin, Takaomi Saido, Toh Hean Ch'ng

“…As a result of the NPC dysfunction App KI neurons become more vulnerable to inflammation-induced necroptosis – a programmed cell death pathway where the core components are activated via phosphorylation through nucleocytoplasmic shutting. Collectively, our data implicates Aβ in progressive impairment of nuclear pore function and further confirms that the protein complex is vulnerable to disruption in various neurodegenerative diseases and is a potential therapeutic target.…”
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Assessing Supraspinatus Tendon Elasticity at Different Locations and Loading Conditions Using Ultrasound Shear-Wave Elastography in Young Healthy Population by Arash Azhideh, Peyman Mirghaderi, Sara Haseli, William D. Lack, Karen C. Takatani, Liisa C. Hammer, Kevin F. Malik, Hannah Tifft, Kyle Griffith, Majid Chalian

“…<b>Conclusions</b>: SWE is a feasible and promising technology for the collection of data on how the supraspinatus tendon behaves under loading conditions. …”
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Adoption of halal Korean cosmetics among Muslim students: Insights from Islamic private universities by Heri Sudarsono, Jannahar Saddam Ash Sidiqie, Kinanthi Putri Ardiami, Rusny Istiqomah Sujono, Siti Aisiyah Suciningtias, Yeni Fitriyani, Miftakhul Khasanah, Retty Ikawati, Asri Noer Rahmi

“…Methodology – This study involved 287 Muslim students from eight private Islamic universities in Indonesia. Data were analyzed using Structural Equation Modeling (SEM) with Partial Least Squares (PLS) to examine the relationships between the variables. …”
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Mapping DNA methylation to cardiac pathologies induced by beta-adrenergic stimulation in a large panel of mice by Caitlin Lahue, Eleanor Wong, Aryan Dalal, Wilson Tan Lek Wen, Shuxun Ren, Roger Foo, Yibin Wang, Christoph D. Rau

“…Key genes, including Prkag2, Anks1a, and Mospd3, were implicated through integration with gene expression and phenotypic data. …”
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Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world by Francesca Terracciani, Antonio De Vincentis, Daphne D’Amato, Laura Cristoferi, Alessio Gerussi, Pietro Invernizzi, Miki Scaravaglio, Ester Vanni, Daniela Campion, Anna Morgando, Vincenzo Valiani, Vincenzo Boccaccio, Filomena Morisco, Lorenzo Surace, Ilaria Cavalli, Guido Delle Monache, Federico Salomone, Donatella Ieluzzi, Debora Angrisani, Raffaella Tortora, Biagio Cuffari, Alessandra Moretti, Gerardo Nardone, Stefano Fagiuoli, Mauro Viganò, Giovanni Vettori, Federica Cerini, Giancarlo Gimignani, Alberto Mattalia, Fabrizio Pizzolante, Nicoletta De Matthaeis, Cristina Rigamonti, Giulia Francesca Manfredi, Valentina Boano, Paola Begini, Ana Lleo, Francesca Colapietro, Riccardo Plebani, Domenico Alvaro, Rosanna Venere, Elisabetta Degasperi, Marta Borghi, Pietro Lampertico, Edoardo Giovanni Giannini, Sara Labanca, Raffaella Viganò, Federico D'Amico, Antonino Castellaneta, Francesco Squeo, Luca Cadamuro, Luigi Capodicasa, Marco Marzioni, Valerio Buzzanca, Guido Poggi, Alessandro Mussetto, Raffaele Cozzolongo, Francesco Losito, Gaetano Bertino, Maurizio Russello, Mariarita Cannavò, Paolo Scivetti, Maurizio Pompili, Annalisa Tortora, Anna Grazia Niro, Rosa Cotugno, Pietro Pozzoni, Alessia Riva, Luchino Chessa, Michela Miglianti, Giuseppe Cuccorese, Valeria Pace Palitti, Ludovico Abenavoli, Natalia Terreni, Teresa Zolfino, Olivia Morelli, Carlo Saitta, Silvia Casella, Adriano Pellicelli, Maurizia Brunetto, Barbara Coco, Andrea Galli, Fabio Marra, Armando Curto, Annarosa Floreani, Nora Cazzagon, Paolo Rollo, Emanuela Bonaiuto, Loredana Simone, Luigi Muratori, Floriano Rosina, Marco Distefano, Elisa Capello, Valentina Bellia, Rodolfo Sacco, Giuliano Alagna, Leonardo Baiocchi, Lory Saveria Crocé, Chiara Ricci, Paolo Poisa, Antonio Izzi, Sara Boninsegna, Vincenza Calvaruso, Marco Carbone, Umberto Vespasiani-Gentilucci, Giulia Di Pasquale, Paolo Gallo, Cossiga Valentina, Falbo Elisabetta, Tatonetti Riccardo, Musumeci Martina, Christou Chrysanthi, Paolo Villa, Eugenia Pesatori, Alessandro Loglio, Alessandro Conforti, Valentina Feletti, Alessandra Garriba, Evelise Frazzetto, Sara Alecci, Annalisa Ardiri, Martina Costanzo, Francesca Romana Ponziani, Francesca Fianchi, Niccolò Bina, Francesca Zani, Barbara Omazzi, Olga Falco, Jessica Piroddu, Anna Rocca, Paola Carnì, Giuseppe Grassi, Francesco Pezzato, Erica D'Ovidio, Matteo Peviani, Alessandro Bellia, Maria Cristina Sapere, Massimiliano Loreno, Masutti Flora, Fusaro Lisa, Riccardo Perbellini, Roberta Soffredini, Concetta Pitrone, Roberto Filomia, Alba Rocco, Pasquale De Crescenzo, Pasquale Piscitelli, Francesca Toffolon, Fabiana Marchetti, Alessandro Inno, Marco Guarracino, Giovan Giuseppe Di Costanzo, Nicola Alessi, Maria Cristina Neglia, Scudu Chiara

“…In the largest real-world series of patients treated with OCA to date, we confirm that the drug's effectiveness and safety profiles are maintained over a medium-to-long follow-up period. Valuable data for the management of the drug in relevant subgroups of patients, such as those with cirrhosis and autoimmune hepatitis/PBC overlap syndrome, are also provided. …”
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Potential protective regulatory effects on radiation−induced esophageal injury in TUT4−/− mice by Huiwen Ren, Wei Li, Zhigang Fan, Jianlin Wang, Zhiqiang Sun, Renhua Huang, Judong Luo, Bo Gao

“…Notably, DEmRNAs in TUT4–/– esophageal tissues showed marked enrichment in the renin–angiotensin system and peroxisome proliferator-activated receptor signaling pathways, implicating their potential roles in the pathogenesis of radiation-induced esophageal injury. …”
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An in silico evaluation of lorlatinib as a potential therapy for novel amino acid substitutions in the tyrosine kinase domain of the ALK protein associated with cancer by Richard Junior Zapata Dongo, Julio A. Poterico, Diletta Fontana, Luca Mologni, Carla Alvarez-Chacon, Juan Rojas-Armas, Jaeson Calla

“…Mutations in alk have been implicated in multiple cancers, including non-small cell lung cancer (NSCLC) and anaplastic large cell lymphoma. …”
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Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer’s disease cohort by Elizabeth M. Planalp, Rebecca E. Langhough, Erin M. Jonaitis, Carol A. Van Hulle, Rachael E. Wilson, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Ozioma C. Okonkwo, Barbara B. Bendlin, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson

“…This work provides support for potentially useful biomarkers of synaptic function implicated in the clinical syndrome of AD, aiding in future diagnosis and staging efforts.…”
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TNFRSF1A and NCF1 May Act as Hub Genes in Mastitis by Mohammad Soleiman Ekhtiyari, Maryam Yousefi, Farhad Samadian, Mostafa Ghaderi‐Zefrehei, Saied Neysi, Javad Shirani Shamsabadi, Arash Javanmard, Hamed Shahriarpour, Bluma Lesch

“…Methods We integrated data from three BM expression datasets and applied weighted gene co‐expression network analysis (WGCNA) to identify specific modules and hub genes related to BM. …”
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