In Silico Analysis of s-DAPK-1: From Structure to Function and Regulation by Lilian Makgoo, Salerwe Mosebi, Zukile Mbita

“…To achieve this aim, various bioinformatics tools and in silico webservers, such as ProteinPrompt, ProtParam, ProtScale, ScooP, Hawkdock, Phyre2, I-TASSER, PSIPRED, SAVES, and PROCHECK, along with user-friendly databases, such as NCBI, TarBase, and Protein Data Bank (PDB), were employed. For miRNA prediction, we used TarBase, and identified the specific microRNAs targeting s-DAPK-1. …”
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Knowledge, attitudes, and practices toward cervical cancer among market women in the Nigerian federal capital territory, Abuja by Samuel O Azubuike, Patricia Azuh

“…Superstitious beliefs and poor knowledge of cervical cancer have been implicated in the cervical cancer prevalence in Africa. …”
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Na+/K+-ATPase is present in scrapie-associated fibrils, modulates PrP misfolding in vitro and links PrP function and dysfunction. by James F Graham, Dominic Kurian, Sonya Agarwal, Lorna Toovey, Lawrence Hunt, Louise Kirby, Teresa J T Pinheiro, Steven J Banner, Andrew C Gill

“…Since functional interactions between PrP(C) and Na(+)/K(+)-ATPase have previously been reported in astrocytes, our data highlight this molecule as a key link between PrP function, dysfunction and misfolding.…”
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Adverse Selection as a Barrier to Achieving Universal Public Health Insurance Coverage in China by Yang P, Zhong S, Wang X, Zhong R

“…This situation aligns with the market failure scenario predicted by adverse selection theory.Methods: This study’s research sample comprises individuals who are freelancers, self-employed, those who are not actively employed, elderly persons not engaged in employment, and students aged 16 and above. Data from the 2020 wave of the China Family Panel Studies (CFPS) was used to investigate the presence of adverse selection in China’s PHI. …”
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Exploring the impact of PFAS exposure and sleep duration on kidney stone formation in the U.S. population by Jianbai Chen, Zhiming Zhang, Gongquan Xu, Qisheng Tang, Zhiyong Nie, Jianxin Qiu, Xiaoping Gao

“…Concurrently, sleep duration has been implicated in metabolic dysregulation, influencing kidney function. …”
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CD22 modulation alleviates amyloid β-induced neuroinflammation by Yu Dong Mai, Qingqing Zhang, Cheuk Lim Fung, Shui On Leung, Chi Ho Chong

“…Yet, therapeutic targets for neurodegenerative diseases based on neuroinflammation still warrant investigation. CD22 has been implicated in neuroinflammatory diseases, namely AD. …”
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The Role of Environmental-Friendly Factors and Islamic Religiosity in Achieving Sustainable Consumption by Febrina Mahliza, Prita Prasetya, Riska Rosdiana, Putri Dwi Wahyuni

“…A total of 218 respondents were selected through purposive sampling. Data were collected through questionnaire distribution and analyzed using Partial Least Squares (PLS) structural equation modeling. …”
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Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Although microglia possess phagocytic capacity and have been implicated in Aβ clearance, accumulating evidence suggests their contribution to AD pathogenesis is more complex than initially anticipated. …”
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Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma. by Yulou Luo, Yinghui Ye, Yilina Saibaidoula, Yuting Zhang, Yan Chen

“…Transcriptomic profiles and clinical data of patients with THCA were retrieved from The Cancer Genome Atlas (TCGA) database to facilitate comprehensive analysis. …”
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Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. by Aniekanabassi N Udoko, Candice A Johnson, Andrey Dykan, Girish Rachakonda, Fernando Villalta, Sammed N Mandape, Maria F Lima, Siddharth Pratap, Pius N Nde

“…The transcriptome microarray data, validated by quantitative Real-Time PCR, was also confirmed by immunoblotting and customized Enzyme Linked Immunosorbent Assays (ELISA) array showing significant increases in the protein expression levels of fibrogenic EGR1, SNAI1 and IL 6. …”
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Integrative analysis reveals key molecular mechanisms and prognostic model for Ethylnitrosourea-induced gliomagenesis by Bo Tan, Tao Chen, Peng Song, Feng Lin, Shuangyin He, Shiyuan Zhang, Xiaohong Yin

“…Methods We analyzed gene expression data from GSE16011 and GSE4290 datasets to identify differentially expressed genes (DEGs) associated with gliomagenesis. …”
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Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice. by Akshat Gupta, Lilin Huang, Jinpeng Liu, Ke Chen, Ren Xu, Wei Wu

“…Despite the inherent challenges of single-cell data, our approach identified reliable and reproducible GRN patterns across both the mouse groups. …”
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A nested case-control study evaluating the relationship between adverse childhood experiences and immune-mediated inflammatory disease in the Canadian Longitudinal Study on Aging by Charles N Bernstein, Ruth Ann Marrie, Julia O'Mahony

“…Objective Adverse childhood experiences (ACE) have inconsistently been implicated as risk factors for immune-mediated inflammatory diseases (IMID). …”
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The nuclear chaperone nucleophosmin escorts an Epstein-Barr Virus nuclear antigen to establish transcriptional cascades for latent infection in human B cells. by Cheng-Der Liu, Ya-Lin Chen, Yi-Li Min, Bo Zhao, Chi-Ping Cheng, Myung-Soo Kang, Shu-Jun Chiu, Elliott Kieff, Chih-Wen Peng

“…As in c-MYC, dramatic NPM1 expression was induced in EBV positively infected B cells after three days of viral infection, and both EBNA2 and EBNALP were implicated in the transactivation of the NPM1 promoter. …”
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Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. by Marieke C Verweij, Mary Wellish, Travis Whitmer, Daniel Malouli, Martin Lapel, Stipan Jonjić, Juergen G Haas, Victor R DeFilippis, Ravi Mahalingam, Klaus Früh

“…Since previous work implicated involvement of the VZV immediate early gene product ORF63 in preventing ISG-induction we studied the role of SVV ORF63 in generating resistance to IFN treatment. …”
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Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. by Charles R Farber, Brian J Bennett, Luz Orozco, Wei Zou, Ana Lira, Emrah Kostem, Hyun Min Kang, Nicholas Furlotte, Ani Berberyan, Anatole Ghazalpour, Jaijam Suwanwela, Thomas A Drake, Eleazar Eskin, Q Tian Wang, Steven L Teitelbaum, Aldons J Lusis

“…To begin to unravel the mechanism through which Asxl2 influenced BMD, a gene co-expression network was created using cortical bone gene expression microarray data from the HMDP strains. Asxl2 was identified as a member of a co-expression module enriched for genes involved in the differentiation of myeloid cells. …”
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The mediating effect of green self-efficacy in the impact of green inclusive leadership on green organizational citizenship behavior by Laurine Nwosu

“…Methods A quantitative, cross-sectional survey was conducted among 324 frontline hotel employees in Northern Cyprus. Data were analyzed using structural equation modeling (SEM). …”
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Prognostic significance of serum galectin-3 in predicting cardiovascular outcomes after percutaneous coronary intervention with drug-eluting stents by Yeon-Jik Choi, Suk Min Seo

“…Its pathophysiologic association with inflammation, cell proliferation, and fibrogenesis may implicate serum galectin-3 as a predictor of clinical outcomes in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). …”
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Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573. by Sabine S Neukamm, Rachel Toth, Nick Morrice, David G Campbell, Carol Mackintosh, Rainer Lehmann, Hans-Ulrich Haering, Erwin D Schleicher, Cora Weigert

“…To conclude, our data suggest a physiologically relevant role for IGF-1/insulin-dependent 14-3-3 binding to IRS-2 involving serine 573.…”
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Role of IGFBP7 in Diabetic Nephropathy: TGF-β1 Induces IGFBP7 via Smad2/4 in Human Renal Proximal Tubular Epithelial Cells. by Jun Watanabe, Yumi Takiyama, Jun Honjyo, Yuichi Makino, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda

“…Tubular injury is one of the important determinants of progressive renal failure in diabetic nephropathy (DN), and TGF-β1 has been implicated in the pathogenesis of tubulointerstitial disease that characterizes proteinuric renal disease. …”
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