Cathepsin K null mice show reduced adiposity during the rapid accumulation of fat stores. by Marcella Funicello, Michela Novelli, Maurizio Ragni, Teresa Vottari, Cesare Cocuzza, Joaquin Soriano-Lopez, Chiara Chiellini, Federico Boschi, Pasquina Marzola, Pellegrino Masiello, Paul Saftig, Ferruccio Santini, Rene St-Jacques, Sylvie Desmarais, Nicolas Morin, Joseph Mancini, M David Percival, Aldo Pinchera, Margherita Maffei

“…Growing evidences indicate that proteases are implicated in adipogenesis and in the onset of obesity. …”
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Novel Prognostic Markers for Skin Cutaneous Melanoma by Zhang Y, Xie A, Wang D, Deng W

“…In this study, our objective was to pinpoint pivotal genes implicated in SKCM pathogenesis and ascertain their potential as prognostic biomarkers.Methods: Leveraging data from 1809 normal skin samples and 471 SKCM samples, we identified differentially expressed genes (DEGs). …”
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Sequencing of Argonaute-bound microRNA/mRNA hybrids reveals regulation of the unfolded protein response by microRNA-320a. by Christopher J Fields, Lu Li, Nicholas M Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S Kilberg, Rolf Renne, Mingyi Xie

“…MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. …”
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Mendelian randomization and genetic analyses reveal causal roles of immune cells and inflammatory proteins in keratoconus by Jialin Chen, Yanni Jia, Xiaolin Qi

“…We conducted a comprehensive Mendelian randomization (MR) analysis using GWAS data to investigate the causal effects of inflammatory and immune factors on KC. …”
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Involvement of the kynurenine pathway in human glioma pathophysiology. by Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin

“…IDO-1 and TDO-2 induction in tumors are crucial mechanisms implicated to play pivotal roles in suppressing anti-tumor immunity. …”
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Electronic Human Resource Management (e-HRM) and Organisational Performance by Olufemi Epebinu, Adeyemi Adepoju, Modupe Ajayi

“…Questions were framed to assess the extent to which they agree or disagree with the use and effect of e-HRM on organizational performance. Data collected was analysed using inferential statistical techniques of Partial Least Squares-Structural Equation Modelling to test the significance of e-HRM on organizational performance. …”
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High prevalence of extrapulmonary tuberculosis in dairy farms: Evidence for possible gastrointestinal transmission. by Fang Xu, Lili Tian, Yan Li, Xuelian Zhang, Yayin Qi, Zhigang Jing, Yangyang Pan, Li Zhang, Xiaoxu Fan, Meng Wang, Qiaoying Zeng, Weixing Fan

“…Phylogenetic analysis based on whole genome sequencing unraveled that six isolates were closely related to M. bovis AF2122/97 originated from UK, whereas four isolates shared close relation to M. bovis 30 from China, respectively. Our data demonstrate that the increase of EPTB transmitted by digestive tract is implicated in the current high prevalence rate of bTB in China, which also provides leads for bTB control in other countries with high prevalence of bTB in the future.…”
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Effect of High-Intensity Interval Training and unification training on Aerobic Capacity and Muscle Strength in Intermediate Distance Runners- a systematic review by Ricky Susiono, FX Sugiyanto, Ria Lumintuarso, Tomoliyus Tomoliyus

“…Methodology: This study was a systematic review that followed the PRISMA guidelines. Data were obtained from PubMed, Scopus, and Google Scholar databases with inclusion criteria including experimental studies published in the last 10 years. …”
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The role of UPK1B in gastric cancer: multi-omics analysis and experimental validation by Haixing Zhu, Wen Jiang, Qian Zhang, Changjun Yu

“…Abstract Background UPK1B has been implicated in various cancers; however, its mechanism of action in gastric cancer remains elusive. …”
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Evidential Reasoning Approach for Predicting Popularity of Instagram Posts by L. Rivadeneira, I. Loor

“…Machine learning predictive models are increasingly used to analyse social media data. However, they often fall short in transparency and interpretability. …”
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Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessus. by Kelley Hurst-Hess, Charity McManaman, Yong Yang, Shamba Gupta, Pallavi Ghosh

“…Moreover, our CHIP-Seq data implicate additional roles of WhiB7 induced genes beyond antibiotic resistance. …”
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EFNB1 drives glioma progression and shapes the immune microenvironment: a potential prognostic biomarker by Yungui Zheng, Jiasong Shi

“…A retrospective RNA-seq analysis was conducted by utilizing the data from glioma patients in the TCGA and CGGA databases. …”
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Transcriptomic Dysregulation in Animal Models of Attention‐Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms by Sarah Van Horn, Heather Driscoll, Donna J Toufexis

“…Methods The present analysis compared transcriptomic data from the brains of rodent models of ADHD and those of ND, with a focus on striatal gene expression. …”
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The pathophysiological spectrum of maternal complications of pregnancy-induced hypertension: Review Article by Adedeji Okikiade, Chidinma Kanu, Oluwadamilare Iyapo, Ololade Omitogun

“…Methods: This narrative review examines existing literature on PIH, including epidemiological data, pathophysiological mechanisms, clinical management guidelines, and associated complications such as abnormal placentation, oxidative stress, and endothelial dysfunction. …”
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White matter properties in fronto-parietal tracts predict maladaptive functional activation and deficient response inhibition in ADHD by Daniel Smullen, Andrew P. Bagshaw, Lilach Shalev, Shlomit Tsafrir, Tamar Kolodny, Carmel Mevorach

“…Previous neuroimaging investigations implicate a myriad of brain networks in response inhibition, making it more difficult to understand and overcome response inhibition difficulties. …”
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TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo. by Fernando Gómez-Herreros, Rocío Romero-Granados, Zhihong Zeng, Alejandro Alvarez-Quilón, Cristina Quintero, Limei Ju, Lieve Umans, Liesbeth Vermeire, Danny Huylebroeck, Keith W Caldecott, Felipe Cortés-Ledesma

“…This characteristic underlies the clinical efficacy of TOP2 poisons, but is also implicated in chromosomal translocations and genome instability associated with secondary, treatment-related, haematological malignancy. …”
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Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells. by Rita Berkachy, Vishwas Mishra, Priyanka Biswas, Gad Frankel

“…IL-4, IL-5, IL-9 and IL-13), more recently they have been implicated in protection against Clostridium difficile and Helicobacter pylori infections. …”
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Appropriate use of the fixed-dose, extended-release combination of naltrexone and bupropion as treatment for obesity in primary care by Ethan Lazarus

“…As a result, patients who are differentially impacted by food cravings may have better outcomes with treatments targeting neural systems implicated in both homeostatic and hedonic food consumption or addictive behaviors. …”
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Genome-wide identification and expression analysis of the cellulose synthase gene family in potato (Solanum tuberosum L.) by Huiling Gong, Junxian Ma, Leonce Dusengemungu, Zaiping Feng

“…Notably, the putative promoter regions harbor numerous biologically functional cis-acting regulatory elements, suggesting diverse roles for StCesAs in potato growth and development. RNA-seq data further demonstrated distinct expression patterns of StCesAs across different tissues. …”
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Cruzipain promotes Trypanosoma cruzi adhesion to Rhodnius prolixus midgut. by Lívia Almeida Uehara, Otacílio C Moreira, Ana Carolina Oliveira, Patrícia Azambuja, Ana Paula Cabral Araujo Lima, Constança Britto, André Luis Souza dos Santos, Marta Helena Branquinha, Claudia Masini d'Avila-Levy

“…Cysteine peptidases are relevant to several aspects of the T. cruzi life cycle and are implicated in parasite-mammalian host relationships. …”
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